Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass
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Background Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes.Methods We included 30 obese patients who underwent RYGB (BMI = 46.1 ± 5.9 kg/m(2)). Clinical measurements and laboratory determinations were performed before surgery and 1 year after surgery. Fasting serum bile acids were measured by an enzymatic method and individual bile acids were quantified by HLPC-tandem mass spectrometry. Indirect calorimetry was performed to measure the rates of energy expenditure and substrate oxidation.Results Fasting total serum bile acid levels increased twofold after RYGB (pre, 3.68 ± 2.03 vs. post, 7.06 ± 9.65 μmol/l, +92 %, p = 0.002). This increase in total bile acids was accompanied by a decrease in conjugated bile acids, which correlated with decreased glucose oxidation (r = 0.571, p = 0.002) and with increased lipid oxidation (r = -0.626, p = 0.0004). The change in taurine-conjugated bile acids correlated with altered DIO2 mRNA expression in adipose tissue (r = -0.498, p = 0.013) potentially linking bile acid conjugation to substrate oxidation through DIO2.Conclusions Fasting serum bile acid levels increase after RYGB. More specifically, changes in bile acid conjugation after RYGB associate with altered energy metabolism.
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Reduced RQ has been observed in humans after RYGB and associated to reduced glucose oxidation, increased lipid oxidation, and increased plasma levels of conjugated bile acids.
“Reduced RQ has been observed in humans after RYGB and associated to reduced glucose oxidation, increased lipid oxidation, and increased plasma levels of conjugated bile acids (Simonen et al., 2012).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Simonen et al., 2012
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- Authors
- Simonen, M., Dali-Youcef, N., Kaminska, D., Venesmaa, S., Käkelä, P., Pääkkönen, M., Hallikainen, M., Kolehmainen, M., Uusitupa, M., Moilanen, L., Laakso, M., Gylling, H., Patti, M. E., Auwerx, J., & Pihlajamäki, J.
- Affiliations
- University of Eastern Finland (FI)
- Joslin Diabetes Center (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Pihlajamäki, Jussi
- ORCID
- Venue
- Obesity Surgery
- Published
- 2012-05-26
- Volume
- 22
- Issue
- 9
- Pages
- 1473-1480
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- PMC
- PMC4426904
- OpenAlex
- W2074184643
- Semantic Scholar
- d183893f73d63f80f84e91075739cfa5654b3d25
- Cited by
- 145
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 13 · 2019: 15 · 2018: 6 · 2017: 25 · 2016: 13 · 2015: 23 · 2014: 12 · 2013: 12
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK036836)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- Roux-en-Y gastric bypass, bile acid conjugates
- MeSH terms
- Adipose Tissue, Bile Acids and Salts, Blood Glucose, Energy Metabolism, Female, Finland, Glucose, Humans, Liver, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Gastric Bypass, Biomarkers, Body Mass Index, Treatment Outcome, Lipid Metabolism
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