Lim, Wendell A.

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 5,016

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 3,696

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature

Marine Invertebrate Physiology and EcologyProtist diversity and phylogeny

Cited by 1,139

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

Zalatan, J. G., Lee, M. E., Almeida, R., Gilbert, L. A., Whitehead, E. H., La Russa, M., Tsai, J. C., Weissman, J. S., Dueber, J. E., Qi, L. S., et al. (2015) · Cell

CRISPR and Genetic EngineeringGene Regulatory Network Analysis

Cited by 938

Defining Network Topologies that Can Achieve Biochemical Adaptation

Ma, W., Trusina, A., El-Samad, H., Lim, W. A., & Tang, C. (2009) · Cell

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 919

Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation

Dominguez, A. A., Lim, W. A., & Qi, L. S. (2016) · Nature Reviews Molecular Cell Biology

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 832

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

Rupp, L. J., Schumann, K., Roybal, K. T., Gate, R. E., Ye, C. J., Lim, W. A., & Marson, A. (2017) · Scientific Reports

CAR-T cell therapy researchCancer Immunotherapy and Biomarkers

Cited by 757

Programming self-organizing multicellular structures with synthetic cell-cell signaling

Toda, S., Blauch, L. R., Tang, S. K. Y., Morsut, L., & Lim, W. A. (2018) · Science

Developmental Biology and Gene RegulationGene Regulatory Network Analysis

Cited by 470

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

Isaac, R. S., Jiang, F., Doudna, J. A., Lim, W. A., Narlikar, G. J., & Almeida, R. (2016) · eLife

CRISPR and Genetic EngineeringGenomics and Chromatin Dynamics

Cited by 234

Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species

Beltrao, P., Trinidad, J. C., Fiedler, D., Roguev, A., Lim, W. A., Shokat, K. M., Burlingame, A. L., & Krogan, N. J. (2009) · PLoS Biology

Fungal and yeast genetics researchAdvanced Proteomics Techniques and Applications

Cited by 188

Docking interactions in protein kinase and phosphatase networks

Reményi, A., Good, M. C., & Lim, W. A. (2006) · Current Opinion in Structural Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 188

The Role of Docking Interactions in Mediating Signaling Input, Output, and Discrimination in the Yeast MAPK Network

Reményi, A., Good, M. C., Bhattacharyya, R. P., & Lim, W. A. (2005) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingFungal and yeast genetics research

Cited by 154

The modular logic of signaling proteins: building allosteric switches from simple binding domains

Lim, W. A. (2002) · Current Opinion in Structural Biology

Protein Structure and DynamicsProtein Kinase Regulation and GTPase Signaling

Cited by 151

Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

Roybal, K. T., & Lim, W. A. (2017) · Annual Review of Immunology

CAR-T cell therapy researchBacterial Cancer Therapy

Cited by 124

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

Esensten, J. H., Bluestone, J. A., & Lim, W. A. (2017) · Annual Review of Pathology: Mechanisms of Disease

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 62