Cowan, Chad A.

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., et al. (2010) · Cell Stem Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 2,662

Disease-Specific Induced Pluripotent Stem Cells.

Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 2,196

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N. E., Ahfeldt, T., Sachs, K. V., Li, X., Li, H., Kuperwasser, N., Ruda, V. M., et al. (2010) · Nature

Genetic Associations and EpidemiologyCholesterol and Lipid Metabolism

Cited by 1,140

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 643

A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells

Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., & Hochedlinger, K. (2008) · Cell Stem Cell

Pluripotent Stem Cells ResearchMesenchymal stem cell research

Cited by 563

Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

Ding, Q., Strong, A., Patel, K. M., Ng, S.-L., Gosis, B. S., Regan, S. N., Cowan, C. A., Rader, D. J., & Musunuru, K. (2014) · Circulation Research

CRISPR and Genetic EngineeringLipoproteins and Cardiovascular Health

Cited by 522

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

Mandal, P. K., Ferreira, L. M. R., Collins, R., Meissner, T. B., Boutwell, C. L., Friesen, M., Vrbanac, V., Garrison, B. S., Stortchevoi, A., Bryder, D., et al. (2014) · Cell stem cell

CRISPR and Genetic EngineeringCAR-T cell therapy research

Cited by 475

Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing

Veres, A., Gosis, B. S., Ding, Q., Collins, R., Ragavendran, A., Brand, H., Erdin, S., Cowan, C. A., Talkowski, M. E., & Musunuru, K. (2014) · Cell Stem Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 474

Generation of hypoimmunogenic human pluripotent stem cells

Han, X., Wang, M., Duan, S., Franco, P. J., Kenty, J. H.-R., Hedrick, P., Xia, Y., Allen, A., Ferreira, L. M. R., Strominger, J. L., et al. (2019) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 363

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

Mae, S.-I., Shono, A., Shiota, F., Yasuno, T., Kajiwara, M., Gotoda-Nishimura, N., Arai, S., Sato-Otubo, A., Toyoda, T., Takahashi, K., et al. (2013) · Nature Communications

Pluripotent Stem Cells ResearchRenal and related cancers

Cited by 291

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

Warren, C. R., O’Sullivan, J. F., Friesen, M., Becker, C. E., Zhang, X., Liu, P., Wakabayashi, Y., Morningstar, J. E., Shi, X., Choi, J., et al. (2017) · Cell stem cell

Pluripotent Stem Cells ResearchGenetic Associations and Epidemiology

Cited by 191

Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants

Zhang, S., Zhang, H., Zhou, Y., Qiao, M., Zhao, S., Kozlova, A., Shi, J., Sanders, A. R., Wang, G., Luo, K., et al. (2020) · Science

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 127

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

Yu, H., Rimbert, A., Palmer, A. E., Toyohara, T., Xia, Y., Xia, F., Ferreira, L. M. R., Chen, Z., Chen, T., Loaiza, N., et al. (2019) · Cell

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 113

Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions

Hendriks, W. T., Warren, C. R., & Cowan, C. A. (2016) · Cell Stem Cell

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 110

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells

Peters, D. T., Henderson, C. A., Warren, C. R., Friesen, M., Xia, F., Becker, C. E., Musunuru, K., & Cowan, C. A. (2016) · Development

Pluripotent Stem Cells ResearchMesenchymal stem cell research

Cited by 68

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing

Veres, A., Gosis, B. S., Ding, Q., Collins, R., Ragavendran, A., Brand, H., Erdin, S., Cowan, C. A., Talkowski, M. E., & Musunuru, K. (2014) · Cell stem cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 37

Genome-edited human pluripotent stem cell–derived macrophages as a model of reverse cholesterol transport—brief report

Gupta, R. M., Meissner, T. B., Cowan, C. A., & Musunuru, K. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismPluripotent Stem Cells Research

Cited by 37