Goldberg, Alfred L.

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell

Muscle Physiology and DisordersFOXO transcription factor regulation

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994) · Cell

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 2,524

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 2,230

Protein degradation and protection against misfolded or damaged proteins.

Goldberg, A. L. (2003) · Nature

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 2,088

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism

Autophagy in Disease and TherapyMuscle Physiology and Disorders

Cited by 1,953

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 1,774

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 1,539

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism

Muscle Physiology and DisordersAutophagy in Disease and Therapy

Cited by 1,489

Proteasome inhibitors: valuable new tools for cell biologists.

Lee, D. H., & Goldberg, A. L. (1998) · Trends in Cell Biology

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 1,474

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

Lecker, S. H., Goldberg, A. L., & Mitch, W. E. (2006) · Journal of the American Society of Nephrology

Ubiquitin and proteasome pathwaysRespiratory Support and Mechanisms

Cited by 1,234

Muscle wasting in disease: molecular mechanisms and promising therapies

Cohen, S., Nathan, J. A., & Goldberg, A. L. (2015) · Nature Reviews Drug Discovery

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 1,089

PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

Sandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 974

The logic of the 26S proteasome.

Collins, G. A., & Goldberg, A. L. (2017) · Cell

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 933

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

Milan, G., Romanello, V., Pescatore, F., Armani, A., Paik, J.-H., Frasson, L., Seydel, A., Zhao, J., Abraham, R., Goldberg, A. L., et al. (2015) · Nature Communications

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 709

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1

Sacheck, J. M., Ohtsuka, A., McLary, S. C., & Goldberg, A. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 606

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 585

Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry

Smith, D. M., Chang, S.-C., Park, S., Finley, D., Cheng, Y., & Goldberg, A. L. (2007) · Molecular Cell

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 521

BMP signaling controls muscle mass

Sartori, R., Schirwis, E., Blaauw, B., Bortolanza, S., Zhao, J., Enzo, E., Stantzou, A., Mouisel, E., Toniolo, L., Ferry, A., et al. (2013) · Nature Genetics

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 467

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

Myeku, N., Clelland, C. L., Emrani, S., Kukushkin, N. V., Yu, W. H., Goldberg, A. L., & Duff, K. E. (2016) · Nature Medicine

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 446

Mechanism of work-induced hypertrophy of skeletal muscle

GOLDBERG, A. L., ETLINGER, J. D., GOLDSPINK, D. F., & JABLECKI, C. (1975) · Medicine and Science in Sports and Exercise

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 402

What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

Jagoe, R. T., & Goldberg, A. L. (2001) · Current Opinion in Clinical Nutrition and Metabolic Care

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 399

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation

Jagoe, R. T., Lecker, S. H., Gomes, M., & Goldberg, A. L. (2002) · The FASEB Journal

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 344

Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

Qian, M.-X., Pang, Y., Liu, C. H., Haratake, K., Du, B.-Y., Ji, D.-Y., Wang, G.-F., Zhu, Q.-Q., Song, W., Yu, Y., et al. (2013) · Cell

Ubiquitin and proteasome pathwaysGenomics and Chromatin Dynamics

Cited by 330

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential

Han, H. Q., Zhou, X., Mitch, W. E., & Goldberg, A. L. (2013) · The International Journal of Biochemistry & Cell Biology

Muscle Physiology and DisordersTGF-β signaling in diseases

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