Goldberg, Alfred L.

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7

Gaczynska, M., Rock, K. L., Spies, T., & Goldberg, A. L. (1994) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 312

Ubiquitin ligase Nedd4 promotes α-synuclein degradation by the endosomal–lysosomal pathway

Tofaris, G. K., Kim, H. T., Hourez, R., Jung, J.-W., Kim, K. P., & Goldberg, A. L. (2011) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 271

ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation

Benaroudj, N., Zwickl, P., Seemüller, E., Baumeister, W., & Goldberg, A. L. (2003) · Molecular Cell

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 245

The influence of skeletal muscle on systemic aging and lifespan

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Cited by 238

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models & Mechanisms

Muscle Physiology and DisordersGenetics, Aging, and Longevity in Model Organisms

Cited by 238

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

Altun, M., Besche, H. C., Overkleeft, H. S., Piccirillo, R., Edelmann, M. J., Kessler, B. M., Goldberg, A. L., & Ulfhake, B. (2010) · Journal of Biological Chemistry

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 226

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

Brault, J. J., Jespersen, J. G., & Goldberg, A. L. (2010) · Journal of Biological Chemistry

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 217

Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97

Sha, Z., & Goldberg, A. L. (2014) · Current Biology

Ubiquitin and proteasome pathwaysGenomics, phytochemicals, and oxidative stress

Cited by 215

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

Lee, D., & Goldberg, A. L. (2013) · Journal of Biological Chemistry

Muscle Physiology and DisordersSirtuins and Resveratrol in Medicine

Cited by 211

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

Cohen, S., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2012) · Journal of Cell Biology

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 205

Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia

Chain, D. G., Casadio, A., Schacher, S., Hegde, A. N., Valbrun, M., Yamamoto, N., Goldberg, A. L., Bartsch, D., Kandel, E. R., & Schwartz, J. H. (1999) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 186

JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy

Raffaello, A., Milan, G., Masiero, E., Carnio, S., Lee, D., Lanfranchi, G., Goldberg, A. L., & Sandri, M. (2010) · Journal of Cell Biology

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 156

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

VerPlank, J. J. S., Lokireddy, S., Zhao, J., & Goldberg, A. L. (2019) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 122

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

Cohen, S., Lee, D., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2014) · Journal of Cell Biology

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 103

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins

Piccirillo, R., & Goldberg, A. L. (2012) · The EMBO Journal

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 85

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., et al. (2015) · eLife

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 83

Mechanism of work-induced hypertrophy of skeletal muscle

GOLDBERG, A. L., ETLINGER, J. D., GOLDSPINK, D. F., & JABLECKI, C. (1975) · Medicine and Science in Sports and Exercise

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 59

ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation

Lee, D., Takayama, S., & Goldberg, A. L. (2018) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 58

Affinity Purification of Mammalian 26S Proteasomes Using an Ubiquitin-Like Domain

Besche, H. C., & Goldberg, A. L. (2012) · Methods in Molecular Biology

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 39

PSMC5 insufficiency and P320R mutation impair proteasome function

Yu, Z.-Q., Carmichael, J., Collins, G. A., D'Agostino, M. D., Lessard, M., Firth, H. V., Harijan, P., Fry, A. E., Dean, J., Zhang, J., et al. (2024) · Human Molecular Genetics

Ubiquitin and proteasome pathwaysGenetics and Neurodevelopmental Disorders

Cited by 4