The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Targeting HIF-1 for cancer therapy

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Exploiting tumour hypoxia in cancer treatment

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Purification and Characterization of Hypoxia-inducible Factor 1

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Oxygen sensing by HIF hydroxylases

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The CBP co-activator is a histone acetyltransferase

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Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

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Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology · doi:10.1038/35017054 · Cited by 1,577 · see citing works

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · see citing works

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385 · see citing works

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351 · see citing works

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

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Steroid receptor coactivator-1 is a histone acetyltransferase

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Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation

Gao, X., Wu, G., Gu, X., Fu, L., & Mei, C. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355743 · Cited by 1,036 · see citing works

The PAS Superfamily: Sensors of Environmental and Developmental Signals

Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,023 · see citing works

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the <i>VEGF</i> expression and is potentially involved in lung and vascular development

Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., & Fujii-Kuriyama, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4273 · Cited by 1,016 · see citing works

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors

Moeller, B. J., Cao, Y., Li, C. Y., & Dewhirst, M. W. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00115-1 · Cited by 996 · see citing works

Tumor microenvironmental physiology and its implications for radiation oncology

Vaupel, P. W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.008 · Cited by 948 · see citing works

Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

Fujio, Y., Nguyen, T. U., Wencker, D., Kitsis, R. N., & Walsh, K. (2000) · Circulation · doi:10.1161/01.cir.101.6.660 · Cited by 846 · see citing works

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survivalPreprint

Schipani, E., Ryan, H. E., Didrickson, S., Kobayashi, T., Knight, M. C., & Johnson, R. S. (2001) · Genes & Development · doi:10.1101/gad.934301 · Cited by 812 · see citing works

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781 · see citing works

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Compernolle, V., Brusselmans, K., Acker, T., Hoet, P., Tjwa, M., Beck, H., Plaisance, S., Dor, Y., Keshet, E., Lupu, F., et al. (2002) · Nature Medicine · doi:10.1038/nm721 · Cited by 733 · see citing works

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200273200 · Cited by 719 · see citing works

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., & Poellinger, L. (2001) · Nature · doi:10.1038/35107085 · Cited by 705 · see citing works

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, J. A., Sonenberg, N., Koromilas, A. E., & Wouters, B. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7405-7416.2002 · Cited by 688 · see citing works

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes &amp; Development · doi:10.1101/gad.12.21.3320 · Cited by 647 · see citing works

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

Kondo, K., Kim, W. Y., Lechpammer, M., & Kaelin, W. G. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000083 · Cited by 611 · see citing works

Untitled work

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Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300

Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L., & Fujii‐Kuriyama, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1905 · Cited by 588 · see citing works

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

Gu, Y.-Z., Moran, S. M., Hogenesch, J. B., Wartman, L. D., & Bradfield, C. A. (1998) · Europe PMC (PubMed Central) · Cited by 577 · see citing works

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R., & Kaelin, W. G. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00187-9 · Cited by 528 · see citing works

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

Hogenesch, J. B., Chan, W. K., Jackiw, V., Brown, R. C., Gu, Y.-Z., Pray-Grant, M. G., Perdew, G. H., & Bradfield, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8581 · Cited by 514 · see citing works

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.

Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics · doi:10.1038/ng1266 · Cited by 496 · see citing works

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212770200 · Cited by 463 · see citing works

The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling

Peng, J., Zhang, L., Drysdale, L., & Fong, G.-H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140087397 · Cited by 460 · cited 1× · see citing works

Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13

Yun, Z., Maecker, H. L., Johnson, R. S., & Giaccia, A. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00131-4 · Cited by 460 · see citing works

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Vascular tumors in livers with targeted inactivation of the von Hippel–Lindau tumor suppressor

Haase, V. H., Glickman, J. N., Socolovsky, M., & Jaenisch, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1583 · Cited by 421 · see citing works

Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

Carrero, P., Okamoto, K., Coumailleau, P., O’Brien, S. L., Tanaka, H., & Poellinger, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.402-415.2000 · Cited by 382 · see citing works

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

Minamino, T., Christou, H. A., Hsieh, C.-M., Liu, Y., Dhawan, V., Abraham, N. G., Perrella, M. A., Mitsialis, S. A., & Kourembanas, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161272598 · Cited by 366 · see citing works

Branching Morphogenesis of theDrosophilaTracheal System

Ghabrial, A. S., Luschnig, S., Metzstein, M. M., & Krasnow, M. A. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.031403.160043 · Cited by 339 · see citing works

Vascular‐targeting therapies for treatment of malignant disease

Siemann, D. W., Chaplin, D. J., & Horsman, M. R. (2004) · Cancer · doi:10.1002/cncr.20299 · Cited by 314 · see citing works

Topoisomerase I-Mediated Inhibition of Hypoxia-Inducible Factor 1

Rapisarda, A., Uranchimeg, B., Sordet, O., Pommier, Y., Shoemaker, R. H., & Melillo, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3139 · Cited by 301 · see citing works

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1αPreprint

Elson, D. A., Thurston, G., Huang, E. L., Ginzinger, D. G., McDonald, D. M., Johnson, R. S., & Arbeit, J. M. (2001) · Genes & Development · doi:10.1101/gad.914801 · Cited by 297 · see citing works

Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target

Potter, C. T., & Harris, A. L. (2004) · Cell Cycle · doi:10.4161/cc.3.2.618 · Cited by 279 · see citing works

O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1

Semenza, G. L. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00770.2003 · Cited by 268 · see citing works

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

Schroedl, C., McClintock, D. S., Budinger, G. R. S., & Chandel, N. S. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00014.2002 · Cited by 266 · see citing works

HIF activation by pH-dependent nucleolar sequestration of VHL

Mekhail, K., Gunaratnam, L., Bonicalzi, M.-E., & Lee, S. (2004) · Nature Cell Biology · doi:10.1038/ncb1144 · Cited by 260 · see citing works

Erratum: Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Compernolle, V., Brusselmans, K., Acker, T., Hoet, P., Tjwa, M., Beck, H., Plaisance, S., Dor, Y., Keshet, E., Lupu, F., et al. (2002) · Nature Medicine · doi:10.1038/nm1102-1329b · Cited by 237 · see citing works

Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity

Peng, Y., & Prabhakar, N. R. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00820.2003 · Cited by 234 · see citing works

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

McNEILL, L. A., HEWITSON, K. S., CLARIDGE, T. D., SEIBEL, J. F., HORSFALL, L. E., & SCHOFIELD, C. J. (2002) · Biochemical Journal · doi:10.1042/bj20021162 · Cited by 215 · see citing works

Cardiac myocyte‐specific HIF‐1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

Huang, Y., Hickey, R. P., Yeh, J. L., Liu, D., Dadak, A. M., Young, L. H., Johnson, R. S., & Giordano, F. J. (2004) · The FASEB Journal · doi:10.1096/fj.04-1510fje · Cited by 209 · see citing works

Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α

Park, S.-K., Dadak, A. M., Haase, V. H., Fontana, L., Giaccia, A. J., & Johnson, R. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.4959-4971.2003 · Cited by 170 · see citing works

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

Mack, F. A., Rathmell, W. K., Arsham, A. M., Gnarra, J., Keith, B., & Simon, M. C. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00240-4 · Cited by 160 · see citing works

Cancer and Leukemia Group B 90206

Rini, B. I., Halabi, S., Taylor, J., Small, E. J., Schilsky, R. L., & for the Cancer Leukemia Group B (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0605 · Cited by 153 · see citing works

Intracoronary, Adenovirus-mediated Akt Gene Transfer in Heart Limits Infarct Size Following Ischemia-reperfusion Injury in Vivo

Miao, W., Luo, Z., Kitsis, R. N., & Walsh, K. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1283 · Cited by 143 · see citing works

Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity

Vogel, J., Kiessling, I., Heinicke, K., Stallmach, T., Ossent, P., Vogel, O., Aulmann, M., Frietsch, T., Schmid-Schönbein, H., Kuschinsky, W., et al. (2003) · Blood · doi:10.1182/blood-2003-01-0283 · Cited by 124 · see citing works

Regulation of oxygen sensing by ion channels

López-Barneo, J., del Toro, R., Levitsky, K. L., Chiara, M. D., & Ortega-Sáenz, P. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00929.2003 · Cited by 106 · see citing works

Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism

Heacock, C. S., & Sutherland, R. J. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.264 · Cited by 90 · see citing works

Mechanisms of Telomerase Induction During Vascular Smooth Muscle Cell Proliferation

Minamino, T., & Kourembanas, S. (2001) · Circulation Research · doi:10.1161/hh1501.094267 · Cited by 86 · see citing works

Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5Preprint

Bemis, L., Chan, D. A., Finkielstein, C. V., Qi, L., Sutphin, P. D., Chen, X., Stenmark, K. R., Giaccia, A. J., & Zundel, W. (2004) · Genes & Development · doi:10.1101/gad.1180104 · Cited by 71 · see citing works

O2 sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens

Waypa, G. B., & Schumacker, P. T. (2002) · Respiratory Physiology & Neurobiology · doi:10.1016/s1569-9048(02)00051-4 · Cited by 69 · see citing works

Regulation of Drosophila Hypoxia-inducible Factor (HIF) Activity in SL2 Cells

Gorr, T. A., Tomita, T., Wappner, P., & Bunn, H. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405077200 · Cited by 67 · see citing works

O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide

Archer, S. L., Wu, X.-C., Thébaud, B., Moudgil, R., Hashimoto, K., & Michelakis, E. D. (2004) · Biological Chemistry · doi:10.1515/bc.2004.014 · Cited by 65 · see citing works

Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension.

McMurtry, I. F., Bauer, N. N., Fagan, K. A., Nagaoka, T., Gebb, S. A., & Oka, M. (2003) · PubMed · Cited by 61 · see citing works

Hypoxia and Rho/Rho-Kinase Signaling

McMurtry, I. F., Bauer, N. N., Fagan, K. A., Nagaoka, T., Gebb, S. A., & Oka, M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_9 · Cited by 53 · see citing works

Current Paradigms in Cellular Oxygen Sensing

Schumacker, P. T. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_5 · Cited by 50 · see citing works

Targeted Disruption of the Mouse PAS Domain Serine/Threonine Kinase PASKIN

Katschinski, D. M., Marti, H. H., Wagner, K. F., Shibata, J., Eckhardt, K., Martin, F., Depping, R., Paasch, U., Gassmann, M., Ledermann, B., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.19.6780-6789.2003 · Cited by 39 · see citing works

Oxygen-dependent signaling in pulmonary vascular smooth muscle

Raj, U. J., & Shimoda, L. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00177.2002 · Cited by 36 · see citing works

A Dominant-Negative Isoform of Hypoxia-Inducible Factor-1α Specifically Expressed in Human Testis1

Depping, R., Hägele, S., Wagner, K. F., Wiesner, R. J., Camenisch, G., Wenger, R. H., & Katschinski, D. M. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.027797 · Cited by 35 · see citing works

Dead Cells Don’t Form Tumors: HIF-Dependent Cytotoxins

Sutphin, P., Chan, D., & Giaccia, A. (2004) · Cell Cycle · doi:10.4161/cc.3.2.617 · Cited by 20 · see citing works

Lung development versus hypoxic pulmonary hypertension

McMurtry, I. F., Bauer, N. N., Fagan, K. A., Nagaoka, T., Gebb, S. A., & Oka, M. (2003) · Cited by 18 · see citing works

MicroRNAs in Cancer

Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,674 · see citing works

Tumor angiogenesis and vascular normalization: alternative therapeutic targets

Viallard, C., & Larrivée, B. (2017) · Angiogenesis · doi:10.1007/s10456-017-9562-9 · Cited by 1,435 · see citing works

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,131 · see citing works

Hypoxia-Induced Pulmonary Vascular Remodeling

Stenmark, K. R., Fagan, K. A., & Frid, M. G. (2006) · Circulation Research · doi:10.1161/01.res.0000243584.45145.3f · Cited by 1,001 · see citing works

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912 · see citing works

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658 · see citing works

MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia

Zhong, H., Lv, Q., Ye, W., Wong, C.-K. A., Cai, G., Gu, D., Ji, Y., Zhao, C., Wang, J., Yang, B. B., et al. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000116 · Cited by 653 · see citing works

SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia

Cheng, J., Kang, X., Zhang, S., & Yeh, E. T. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.045 · Cited by 624 · see citing works

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, J., Wang, Z., Nuyten, D. S. A., Rodriguez, E. H., Schaner, M. E., Salim, A., Wang, Y., Kristensen, G. B., Helland, Å., Børresen‐Dale, A., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030047 · Cited by 622 · see citing works

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works

Regulation of angiogenesis by hypoxia-inducible factor 1

Hirota, K., & Semenza, G. L. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.12.003 · Cited by 466 · see citing works

Acute postnatal ablation of <i>Hif-2</i> α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608382104 · Cited by 457 · see citing works

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Schipani, E., Maes, C., Carmeliet, G., & Semenza, G. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090602 · Cited by 407 · see citing works

The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0419 · Cited by 355 · see citing works

Side Effects of Radiographic Contrast Media: Pathogenesis, Risk Factors, and Prevention

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Regulation of the Pulmonary Circulation in the Fetus and Newborn

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