Genetics of Aging in the Fruit Fly,Drosophila melanogaster

Helfand, Stephen L.; Rogina, Blanka

doi:10.1146/annurev.genet.37.040103.095211

Cited by 152Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology ResearchTelomeres, Telomerase, and Senescence

Genetics of Aging in the Fruit Fly,Drosophila melanogaster

Helfand, Stephen L., Rogina, Blanka·2003·Annual Review of Genetics

DOI 10.1146/annurev.genet.37.040103.095211

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Abstract

▪ Abstract Research into the mechanisms underlying the process of aging is emerging as an exciting area of biomedical research. Observations challenging the fundamental assumptions of aging have begun to rejuvenate the field, opening up aging research to fresh ideas and approaches. Genetic approaches, which have been successfully used to understand other complex biological phenomena, are beginning to reveal important patterns and conservations between the processes of aging in a variety of species including yeast, nematodes, flies, and mice. A combination of candidate and random gene alteration approaches, particularly in the fruitfly model system, Drosophila melanogaster, should prove to be especially valuable for elucidating the primary physiological systems involved in aging and life span determination.

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Genes that regulate lifespan in animal models and human studies, and multiple experimental paradigms, have demonstrated that it is possible to manipulate ageing biology to rejuvenate physiological functioning in complex model organisms.
“Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”
From Measuring biological age using omics data (2022) · cites this paper as [7]

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Authors: Helfand, S. L., & Rogina, B.
Affiliations: UConn Health (US)
ORCID: Rogina, Blanka
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 2003-12
Volume: 37
Issue: 1
Pages: 329-348
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev.genet.37.040103.095211
OpenAlex: W2165469555
Cited by: 152
References: 100
Citations by year: 2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 12 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 7
FWCI: 0.59
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r03es011463-02, 1r03ag014532-01)
National Institute on Aging (AG14532, R03AG020816, R37AG016667, AG20816)
National Institute of Environmental Health Sciences (ES11463)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords: aging, Drosophila melanogaster, candidate gene approach, random mutagenesis
MeSH terms: Aging, Animals, Antioxidants, Chromatin, Drosophila melanogaster

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Genetics of Aging in the Fruit Fly,Drosophila melanogaster

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