Butterfield, D. Allan

Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated from Lymphocytes from Patients with Alzheimer's Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder

Sultana, R., Mecocci, P., Mangialasche, F., Cecchetti, R., Baglioni, M., & Butterfield, D. A. (2011) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 111

Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease

Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsRedox biology and oxidative stress

Cited by 105

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

Barone, E., Di Domenico, F., Cassano, T., Arena, A., Tramutola, A., Lavecchia, M. A., Coccia, R., Butterfield, D. A., & Perluigi, M. (2016) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 100

Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Aβ(1-42): Implications for Alzheimer’s Disease

Boyd-Kimball, D., Poon, H. F., Lynn, B. C., Cai, J., Pierce Jr., W. M., Klein, J. B., Ferguson, J., Link, C. D., & Butterfield, D. A. (2006) · Neurobiology of Aging

Alzheimer's disease research and treatmentsRedox biology and oxidative stress

Cited by 98

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

Perluigi, M., di Domenico, F., Fiorini, A., Cocciolo, A., Giorgi, A., Foppoli, C., Butterfield, D. A., Giorlandino, M., Giorlandino, C., Eugenia Schininà, M., et al. (2011) · PROTEOMICS – Clinical Applications

Down syndrome and intellectual disability researchRedox biology and oxidative stress

Cited by 97

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

Di Domenico, F., Pupo, G., Giraldo, E., Badìa, M.-C., Monllor, P., Lloret, A., Eugenia Schininà, M., Giorgi, A., Cini, C., Tramutola, A., et al. (2016) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 97

Vitamin Ε as an Antioxidant/Free Radical Scavenger Against Amyloid β-Peptide-Induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights into Alzheimer's Disease

Butterfield, D. A., Koppal, T., Subramaniam, R., & Yatin, S. (1999) · Reviews in the Neurosciences

Alzheimer's disease research and treatmentsAntioxidant Activity and Oxidative Stress

Cited by 97

Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer’s disease: Insights into memory loss in MCI

Aluise, C. D., Robinson, R. A. S., Cai, J., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A. (2011) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 94

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

Di Domenico, F., Tramutola, A., Foppoli, C., Head, E., Perluigi, M., & Butterfield, D. A. (2018) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 89

Antioxidants protect against reactive oxygen species associated with adriamycin-treated cardiomyocytes

DeAtley, S. M., Aksenov, M. Y., Aksenova, M. V., Harris, B., Hadley, R., Cole Harper, P., Carney, J. M., & Butterfield, D. A. (1999) · Cancer Letters

Chemotherapy-induced cardiotoxicity and mitigationBioactive Compounds and Antitumor Agents

Cited by 89

The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment (“chemobrain”) involving TNF-α

Ren, X., Keeney, J. T. R., Miriyala, S., Noel, T., Powell, D. K., Chaiswing, L., Bondada, S., St. Clair, D. K., & Butterfield, D. A. (2019) · Free Radical Biology and Medicine

Cancer-related cognitive impairment studiesChemotherapy-induced cardiotoxicity and mitigation

Cited by 88

Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study

Sultana, R., Reed, T., Perluigi, M., Coccia, R., Pierce, W. M., & Butterfield, D. A. (2007) · Journal of Cellular and Molecular Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 87

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

Barone, E., Tramutola, A., Triani, F., Calcagnini, S., Di Domenico, F., Ripoli, C., Gaetani, S., Grassi, C., Butterfield, D. A., Cassano, T., et al. (2019) · Molecular Neurobiology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 86

Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease

Butterfield, D. A., & Boyd-Kimball, D. (2020) · Antioxidants

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 85

Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders

Butterfield, D. A., Barone, E., & Mancuso, C. (2011) · Pharmacological Research

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 80

Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

Cenini, G., Sultana, R., Memo, M., & Butterfield, D. A. (2008) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 79

Biliverdin reductase‐A: a novel drug target for atorvastatin in a dog pre‐clinical model of Alzheimer disease

Barone, E., Mancuso, C., Di Domenico, F., Sultana, R., Murphy, M. P., Head, E., & Butterfield, D. A. (2012) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsHeme Oxygenase-1 and Carbon Monoxide

Cited by 75

Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer's Disease

Di Domenico, F., Pupo, G., Mancuso, C., Barone, E., Paolini, F., Arena, A., Blarzino, C., Schmitt, F. A., Head, E., Butterfield, D. A., et al. (2015) · Journal of Alzheimer’s Disease

Heme Oxygenase-1 and Carbon MonoxideDown syndrome and intellectual disability research

Cited by 75

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

Tramutola, A., Lanzillotta, C., Di Domenico, F., Head, E., Butterfield, D. A., Perluigi, M., & Barone, E. (2020) · Neurobiology of Disease

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 73

Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease

Sultana, R., Baglioni, M., Cecchetti, R., Cai, J., Klein, J. B., Bastiani, P., Ruggiero, C., Mecocci, P., & Butterfield, D. A. (2013) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 64

Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease

Triplett, J. C., Zhang, Z., Sultana, R., Cai, J., Klein, J. B., Büeler, H., & Butterfield, D. A. (2015) · Journal of Neurochemistry

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 58

HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology

Barone, E., Head, E., Butterfield, D. A., & Perluigi, M. (2017) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 53

Protective Effect of D609 Against Amyloid-Beta1-42-Induced Oxidative Modification of Neuronal Proteins: Redox Proteomics Study

Sultana, R., Newman, S. F., Abdul, H. M., Cai, J., Pierce, W. M., Klein, J. B., Merchant, M., & Butterfield, D. A. (2006) · Journal of Neuroscience Research

Alzheimer's disease research and treatmentsRedox biology and oxidative stress

Cited by 53

Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration

Di Domenico, F., Head, E., Butterfield, D. A., & Perluigi, M. (2014) · Advances in Geriatrics

Alzheimer's disease research and treatmentsHeat shock proteins research

Cited by 50