Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
Open accessAbstract
Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxidative modifications to aconitase, creatine kinase, and ATP synthase in brain mitochondria help explain reduced glucose metabolism and ATP production in amnestic mild cognitive impairment and Alzheimer disease.
“In addition, oxidative modifications to aconitase, a key iron-sulfur containing enzyme in the TCA cycle, creatine kinase (an enzyme which helps neurons to maintain ATP levels) and ATP synthase in brain mitochondria, help to explain decreased glucose metabolism and consequent decreased ATP production in the brains of people with aMCI and AD12,25,34.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [25]
The Discussion’s “Energy or mitochondrial dysfunction” section links nitration of energy-metabolism proteins in amnestic MCI to possible metabolic disruption and notes reduced cerebral glucose utilization in AD (page unavailable). But it identifies enolase, aldolase, a glucose-regulated protein, and MDH—not oxidative modifications to aconitase, creatine kinase, or ATP synthase—and does not establish that those three enzymes explain decreased ATP production. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHSP70 is modified by both HNE and 3-NT in an MCI hippocampus.
“while HSP70 is modified by both HNE and 3-NT in an MCI hippocampus [56,58]”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [58]
The Results identify HSPA8 (HSP70) as nitrated in MCI hippocampus and report an anti-3NT-positive spot at its position. The Discussion reports increased protein-bound HNE in MCI hippocampus generally, but does not identify HSPA8 as HNE-modified. Page numbers were not available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measured3-nitrotyrosine levels, indicating peroxynitrite damage, are elevated in Alzheimer disease and amnestic mild cognitive impairment.
“Elevated levels of 3-nitrotyrosine (3-NT), suggestive of damage by peroxynitrite (Table 1) are also observed in AD18,24 and aMCI25.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,495 · see citing works
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack, C. R., Petersen, R. C., Xu, Y. C., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Waring, S. C., Tangalos, E. G., & Kokmen, E. (1999) · Neurology · doi:10.1212/wnl.52.7.1397 · Cited by 1,404 · see citing works
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772 · see citing works
The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
Lu, P.-J., Wulf, G., Zhou, X. Z., Davies, P., & Lu, K. P. (1999) · Nature · doi:10.1038/21650 · Cited by 721 · see citing works
Evidence of neuronal oxidative damage in Alzheimer's disease.
Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works
Castegna, A., Aksenov, M. Y., Thongboonkerd, V., Klein, J. B., Pierce, W. M. J., Booze, R. M., Markesbery, W. R., & Butterfield, D. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01103.x · Cited by 581 · see citing works
Self-citationProtein Nitration in Parkinsonʼs Disease
Good, P. F., Hsu, A., Werner, P., Perl, D. P., & Olanow, C. W. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199804000-00006 · Cited by 540 · see citing works
Christen, S., Woodall, A., Shigenaga, M. K., Southwell‐Keely, P. T., Duncan, M. W., & Ames, B. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3217 · Cited by 537 · see citing works
Proteomic identification of nitrated proteins in Alzheimer's disease brain
Castegna, A., Thongboonkerd, V., Klein, J. B., Lynn, B. C., Markesbery, W. R., & Butterfield, D. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01786.x · Cited by 535 · see citing works
Self-citationDimeo, F. C., Stieglitz, R., Novelli‐Fischer, U., Fetscher, S., & Keul, J. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990515)85:10 · Cited by 531 · see citing works
Dougherty, M. K., & Morrison, D. K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01171 · Cited by 457 · see citing works
Ribosome Dysfunction Is an Early Event in Alzheimer's Disease
Ding, Q., Markesbery, W. R., Chen, Q., Li, F., & Keller, J. N. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3040-05.2005 · Cited by 433 · see citing works
Chapter 7 Protein Oxidation Processes in Aging Brain
Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390 · see citing works
Self-citationMild cognitive impairment: transition between aging and Alzheimer's disease.
Petersen, R. C. (2000) · PubMed · Cited by 383 · see citing works
Butterfield, D. A., Poon, H. F., St. Clair, D., Keller, J. N., Pierce, W. M., Klein, J. B., & Markesbery, W. R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.002 · Cited by 377 · see citing works
Self-citationRoles of fascin in cell adhesion and motility
Adams, J. C. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.07.009 · Cited by 374 · see citing works
Identification of nitrated proteins in Alzheimer’s disease brain using a redox proteomics approach
Sultana, R., Poon, H. F., Cai, J., Pierce, W. M., Merchant, M., Klein, J. B., Markesbery, W. R., & Butterfield, D. A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.10.004 · Cited by 364 · see citing works
Self-citationKeller, J. N., Mark, R. J., Bruce‐Keller, A. J., Blanc, E. M., Rothstein, J. D., Uchida, K., Waeg, G., & Mattson, M. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00065-1 · Cited by 358 · see citing works
Rukhsana Sultana, A., Debra Boyd-kimball, A., Poon, H. F., Cai, J., Pierce, W. M. J., Klein, J. B., Merchant, M. L., Markesbery, W. R., & Butterfield, D. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.021 · Cited by 334 · see citing works
Self-citationCarbon Dioxide Enhancement of Peroxynitrite-Mediated Protein Tyrosine Nitration
Gow, A. J., Duran, D., Thom, S. R., & Ischiropoulos, H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0362 · Cited by 302 · see citing works
Roles of fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?
Hashimoto, Y., Skacel, M., & Adams, J. C. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.05.004 · Cited by 275 · see citing works
Yamashiro, S., Yamakita, Y., Ono, S., et al. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.5.993 · Cited by 263 · see citing works
Rukhsana Sultana, A., Debra Boyd-kimball, A., Poon, H. F., Cai, J., Pierce, W. M. J., Klein, J. B., Markesbery, W. R., Zhou, X. Z., Lu, K. P., & Butterfield, D. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.005 · Cited by 255 · see citing works
Self-citationEffects of injected Alzheimer beta-amyloid cores in rat brain.
Frautschy, S. A., Baird, A., & Cole, G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8362 · Cited by 254 · see citing works
Szabó, C. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00170-0 · Cited by 252 · see citing works
Butterfield, D. A., Reed, T., Perluigi, M., De Marco, C., Coccia, R., Cini, C., & Sultana, R. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.017 · Cited by 246 · see citing works
Self-citationButterfield, D. A., Reed, T. T., Marzia Perluigi, A., Marco, C. M. D., Coccia, R., Keller, J. N., Markesbery, W. R., & Rukhsana Sultana, A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.084 · Cited by 238 · see citing works
Self-citationGlucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes
Messier, C., & Gagnon, M. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00153-0 · Cited by 237 · see citing works
MacMillan-Crow, L. A., & Thompson, J. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1202 · Cited by 227 · see citing works
14-3-3ζ Is an Effector of Tau Protein Phosphorylation
Hashiguchi, M., Sobue, K., & Paudel, H. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003738200 · Cited by 223 · see citing works
GAPDH as a sensor of NO stress
Hara, M. R., Cascio, M. B., & Sawa, A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.01.012 · Cited by 220 · see citing works
Pihlajam�ki, M., Tanila, H., H�nninen, T., Könönen, M., Laakso, M. P., Partanen, K. P. L., Soininen, H. S., & Aronen, H. J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 210 · see citing works
Hamajima, N., Matsuda, K., Sakata, S. F., et al. (1996) · Gene · doi:10.1016/s0378-1119(96)00445-3 · Cited by 210 · see citing works
Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins
Layfield, R., Fergusson, J., Aitken, A., Lowe, J. S., Landon, M., & Mayer, R. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12598-2 · Cited by 188 · see citing works
Niles, J. C., Wishnok, J. S., & Tannenbaum, S. R. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.11.001 · Cited by 187 · see citing works
The mitochondrial DNA polymerase as a target of oxidative damage
Graziewicz, M. A. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf392 · Cited by 187 · see citing works
Proteomic Analysis of Protein Expression and Oxidative Modification in R6/2 Transgenic Mice
Marzia Perluigi, A., Poon, H. F., Maragos, W. F., Pierce, W. M. J., Klein, J. B., Calabrese, V., Cini, C., Marco, C. M. D., & Butterfield, D. A. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500090-mcp200 · Cited by 184 · see citing works
Self-citationRedox proteomics: from protein modifications to cellular dysfunction and disease
Butterfield, D. A., & Dalle‐Donne, I. (2013) · Mass Spectrometry Reviews · doi:10.1002/mas.21404 · Cited by 180 · see citing works
Self-citationGlyceraldehyde-3-Phosphate Dehydrogenase Inactivation by Peroxynitrite
Souza, J. M., & Radí, R. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0932 · Cited by 179 · see citing works
Agarwal-Mawal, A., Qureshi, H. Y., Cafferty, P. W., Yuan, Z., Han, D. C., Lin, R., & Paudel, H. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211491200 · Cited by 174 · see citing works
Hoyer, S. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8969-7_8 · Cited by 173 · see citing works
Yoshida, H., Watanabe, A., & Ihara, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9761 · Cited by 173 · see citing works
Ralat, L. A., Manevich, Y., Fisher, A. B., & Colman, R. F. (2005) · Biochemistry · doi:10.1021/bi0520737 · Cited by 172 · see citing works
Nitration and Inactivation of Tyrosine Hydroxylase by Peroxynitrite
Blanchard-Fillion, B., Souza, J. M., Friel, T., Jiang, G. C. ‐., Vrana, K. E., Sharov, V. S., Barrón, L., Schöneich, C., Quijano, C., Álvarez, B., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105564200 · Cited by 172 · see citing works
Peshenko, I. V., & Shichi, H. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00579-2 · Cited by 170 · see citing works
Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease
Morris, J. C., & Cummings, J. L. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7306 · Cited by 167 · see citing works
Debra Boyd-kimball, A., Rukhsana Sultana, A., Poon, H. F., Lynn, B. C., Casamenti, F., Pepeu, G., Klein, J. B., & Butterfield, D. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.022 · Cited by 166 · see citing works
Self-citationPoon, H. F., Frasier, M. A., Shreve, N., Calabrese, V., Wolozin, B. L., & Butterfield, D. A. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.009 · Cited by 165 · see citing works
Self-citationMattson, M. P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.004 · Cited by 162 · see citing works
Poon, H. F., Castegna, A., Farr, S. A., Thongboonkerd, V., Lynn, B. C., Banks, W. A., Morley, J. E., Klein, J. B., & Butterfield, D. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.046 · Cited by 155 · see citing works
Self-citationSultana, R., & Butterfield, D. A. (2004) · Neurochemical Research · doi:10.1007/s11064-004-7028-0 · Cited by 153 · see citing works
Self-citationCSF detection of the 14-3-3 protein in unselected patients with dementia
Burkhard, P. R., Sanchez, J., Landis, T., et al. (2001) · Neurology · doi:10.1212/wnl.56.11.1528 · Cited by 143 · see citing works
β-Amyloid Mediated Nitration of Manganese Superoxide Dismutase
Muthuswamy, A., Tangpong, J., Keller, J. N., Murphy, M. P., Markesbery, W. R., Kiningham, K. K., & Clair, D. K. S. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051223 · Cited by 143 · see citing works
Debra Boyd-kimball, A., Castegna, A., Rukhsana Sultana, A., Poon, H. F., Petroze, R. T., Lynn, B. C., Klein, J. B., & Butterfield, D. A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.086 · Cited by 142 · see citing works
Self-citationInteraction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility
Anilkumar, N., Parsons, M., Monk, R. J., Ng, T., & Adams, J. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg521 · Cited by 136 · see citing works
Lübec, G., Nonaka, M., Krapfenbauer, K., Gratzer, M., Cairns, N. J., & Fountoulakis, M. (1999) · Springer eBooks · doi:10.1007/978-3-7091-6380-1_10 · Cited by 129 · see citing works
Adams, J. C. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.5.1977 · Cited by 125 · see citing works
Weitzdoerfer, R., Dierssen, M., Fountoulakis, M., & Lübec, G. (2001) · Springer eBooks · doi:10.1007/978-3-7091-6262-0_5 · Cited by 122 · see citing works
Drake, J., Kański, J., Varadarajan, S., Tsoras, M., & Butterfield, D. A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10266 · Cited by 110 · see citing works
Self-citationFluoride Exposure Attenuates Expression of Streptococcus pyogenes Virulence Factors
Thongboonkerd, V., Luengpailin, J., Cao, J., Pierce, W. M. J., Cai, J., Klein, J. B., & Doyle, R. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200746200 · Cited by 102 · see citing works
Self-citationEfficacy and Safety of OK-432 Sclerotherapy for Giant Cystic Hygroma in a Newborn
Samuel, M., McCarthy, L., & Boddy, S. A. (2000) · Fetal Diagnosis and Therapy · doi:10.1159/000020983 · Cited by 92 · see citing works
The 14-3-3 Proteins: Gene, Gene Expression, and Function
Takahashi, Y. (2003) · Neurochemical Research · doi:10.1023/a:1024296932670 · Cited by 85 · see citing works
Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism
Lu, K. P. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4253-7_8 · Cited by 84 · see citing works
Hazen, S. L., Gaut, J. P., Hsu, F., Crowley, J. R., d'Avignon, A., & Heinecke, J. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16990 · Cited by 83 · see citing works
Masuda, M., Nishino, H., & Ohshima, H. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00299-x · Cited by 83 · see citing works
Whiteman, M., Tritschler, H., & Halliwell, B. B. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01489-6 · Cited by 81 · see citing works
Pinkus, G. S., Lones, M. A., Matsumura, F., et al. (2002) · American Journal of Clinical Pathology · doi:10.1309/n2tw-enrb-1n1c-dwl0 · Cited by 73 · see citing works
Glucose intolerance, cognitive impairment and Alzheimer’s disease
Vanhanen, M., & Soininen, H. S. (1998) · Current Opinion in Neurology · doi:10.1097/00019052-199812000-00011 · Cited by 72 · see citing works
Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers
Hernández, F., Cuadros, R., & Ávila, J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.049 · Cited by 71 · see citing works
Rapoport, S. I. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014174 · Cited by 70 · see citing works
Peroxynitrite mediates TNF-α-induced endothelial barrier dysfunction and nitration of actin
Neumann, P. H., Gertzberg, N., Vaughan, E. E., Weisbrot, J., Woodburn, R., Lambert, W. M., & Johnson, A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00391.2005 · Cited by 63 · see citing works
Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses
Clements, M. K., Siemsen, D. W., Swain, S. D., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802401 · Cited by 60 · see citing works
Stasi, A. M. M. D., Mallozzi, C., Macchia, G., Maura, G., Petrucci, T. C., & Minetti, M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00980.x · Cited by 53 · see citing works
Sultana, R., Newman, S. F., Abdul, H. M., Cai, J., Pierce, W. M., Klein, J. B., Merchant, M., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20876 · Cited by 53 · see citing works
Self-citationSong, J. H., Houde, A., & Murphy, B. D. (1998) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199809)51:1 · Cited by 46 · see citing works
Reactivity of Peroxynitrite and Nitric Oxide with LDL
Botti, H., Trostchansky, A., Batthyány, C., & Rubbo, H. (2005) · IUBMB Life · doi:10.1080/15216540500137701 · Cited by 33 · see citing works
Hippocampal damage and cytoskeletal disruption resulting from impaired energy metabolism
Geddes, J. W., Pang, Z., & Wiley, D. H. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815206 · Cited by 27 · see citing works
[What is a mild cognitive impairment?].
Portet, F., Ousset, P., & Touchon, J. (2005) · PubMed · Cited by 11 · see citing works
Chételat, G., Desgranges, B., Sayette, V. D. L., Viader, F., & Eustache, F. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)70944-3 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [25]Chetelat G Desgranges B De La Sayette V Viader F Eustache F At the boundary between normal aging and Alzheimer disease Rev Neurol 2004 160 S55 63 15118553
Cited by
Sorted by citations
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954 · see citing works
Self-citationNitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., & Giuffrida Stella, A. M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2214 · Cited by 1,543 · see citing works
Self-citationOxidative stress hypothesis in Alzheimer’s disease: a reappraisal
Praticò, D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.001 · Cited by 606 · see citing works
Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works
Self-citationButterfield, D. A., & Boyd-Kimball, D. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170543 · Cited by 403 · see citing works
Self-citationOxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221 · see citing works
Perluigi, M., Sultana, R., Cenini, G., Di Domenico, F., Memo, M., Pierce, W. M., Coccia, R., & Butterfield, D. A. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800161 · Cited by 196 · see citing works
Self-citationReed, T. T., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.009 · Cited by 190 · see citing works
Terni, B., Boada, J., Portero‐Otin, M., Pamplona, R., & Ferrer, I. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00266.x · Cited by 159 · see citing works
Reed, T. T., Pierce Jr., W. M., Turner, D. M., Markesbery, W. R., & Allan Butterfield, D. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00478.x · Cited by 135 · see citing works
Self-citationDi Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6759 · Cited by 114 · see citing works
Self-citationRedox proteomics and amyloid β-peptide: Insights into Alzheimer disease
Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105 · see citing works
Self-citationMitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease
Butterfield, D. A., & Boyd-Kimball, D. (2020) · Antioxidants · doi:10.3390/antiox9090818 · Cited by 85 · see citing works
“Both HSP70 and HSP90 are significantly carbonylated in MCI IPL [59,60], while HSP70 is modified by both HNE and 3-NT in an MCI hippocampus [56,58].”
BackgroundSelf-citationCenini, G., Sultana, R., Memo, M., & Butterfield, D. A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.015 · Cited by 79 · see citing works
Self-citationShen, L., Chen, C., Yang, A., Chen, Y., Liu, Q., & Ni, J. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.04.005 · Cited by 73 · see citing works
Sultana, R., Robinson, R. A. S., Di Domenico, F., Abdul, H. M., Clair, D. K. S., Markesbery, W. R., Cai, J., Pierce, W. M., & Butterfield, D. A. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.015 · Cited by 41 · see citing works
Self-citationTramutola, A., Abate, G., Lanzillotta, C., Triani, F., Barone, E., Iavarone, F., Vincenzoni, F., Castagnola, M., Marziano, M., Memo, M., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.414 · Cited by 26 · see citing works
Self-citation
- Authors
- Sultana, R., Reed, T., Perluigi, M., Coccia, R., Pierce, W. M., & Butterfield, D. A.
- Affiliations
- University of Kentucky (US)
- University of Louisville (US)
- Corresponding author
- Butterfield, D. Allan
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2007-06-24
- Volume
- 11
- Issue
- 4
- Pages
- 839-851
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC3823261
- OpenAlex
- W2052209709
- Cited by
- 87
- References
- 82
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 4 · 2015: 9 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- University of Kentucky
- National Institute on Aging (P01AG010836, P01AG005119, AG 10836, AG0 5119)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitrated proteins, amnestic mild cognitive impairment, oxidative stress, Alzheimer's disease, hippocampus, inferior parietal lobule, protein nitration, brain proteomics, disease progression
- MeSH terms
- Aged, 80 and over, Amnesia, Brain, Cognition Disorders, Female, Hippocampus, Humans, Male, Nerve Tissue Proteins, Nitrates, Mass Spectrometry, Reproducibility of Results, Proteomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review