Gladyshev, Vadim N.

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,025

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 820

Loss of epigenetic information as a cause of mammalian aging

Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 643

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Kim, E. B., Fang, X., Fushan, A. A., Huang, Z., Lobanov, A. V., Han, L., Marino, S. M., Sun, X., Turanov, A. A., Yang, P., et al. (2011) · Nature

Genetics, Aging, and Longevity in Model OrganismsGenomics and Phylogenetic Studies

Cited by 576

Endogenous hydrogen sulfide production is essential for dietary restriction benefits

Hine, C., Harputlugil, E., Zhang, Y., Ruckenstuhl, C., Lee, B. C., Brace, L., Longchamp, A., Treviño-Villarreal, J. H., Mejia, P., Ozaki, C. K., et al. (2015) · Cell

Sulfur Compounds in BiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 558

LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation

Simon, M., Van Meter, M., Ablaeva, J., Ke, Z., Gonzalez, R. S., Taguchi, T., De Cecco, M., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 498

Using DNA methylation profiling to evaluate biological age and longevity interventions

Petkovich, D. A., Podolskiy, D. I., Lobanov, A. V., Lee, S.-G., Miller, R. A., & Gladyshev, V. N. (2017) · Cell Metabolism

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 398

From geroscience to precision geromedicine: Understanding and managing aging

Kroemer, G., Maier, A. B., Cuervo, A. M., Gladyshev, V. N., Ferrucci, L., Gorbunova, V., Kennedy, B. K., Rando, T. A., Seluanov, A., Sierra, F., et al. (2025) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 395

A comparative genomics multitool for scientific discovery and conservation

Zoonomia Consortium, Genereux, D. P., Serres, A., Armstrong, J., Johnson, J., Marinescu, V. D., Murén, E., Juan, D., Bejerano, G., Casewell, N. R., et al. (2020) · Nature

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 373

Validation of biomarkers of aging

Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., et al. (2024) · Nature Medicine

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 361

SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., et al. (2019) · Cell

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 353

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Carlson, B. A., Tobe, R., Yefremova, E., Tsuji, P. A., Hoffmann, V. J., Schweizer, U., Gladyshev, V. N., Hatfield, D. L., & Conrad, M. (2016) · Redox Biology

Selenium in Biological SystemsAntioxidant Activity and Oxidative Stress

Cited by 316

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress

Gerashchenko, M. V., Lobanov, A. V., & Gladyshev, V. N. (2012) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsBacterial Genetics and Biotechnology

Cited by 302

Human gut microbiome aging clock based on taxonomic profiling and deep learning

Galkin, F., Mamoshina, P., Aliper, A., Lane, E., Moskalev, V., Gladyshev, V. N., & Zhavoronkov, A. (2020) · iScience

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 292

Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics

Gobler, C. J., Berry, D. L., Dyhrman, S. T., Wilhelm, S. W., Salamov, A., Lobanov, A. V., Zhang, Y., Collier, J. L., Wurch, L. L., Kustka, A. B., et al. (2011) · Proceedings of the National Academy of Sciences

Marine Plankton and BiogeochemistryAquatic Ecosystems and Phytoplankton Dynamics

Cited by 285

Translation inhibitors cause abnormalities in ribosome profiling experiments

Gerashchenko, M. V., & Gladyshev, V. N. (2014) · Nucleic Acids Research

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 262

Biological age is increased by stress and restored upon recovery

Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T., Haghani, A., Gong, T., et al. (2023) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 246

Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

Galkin, F., Mamoshina, P., Aliper, A., de Magalhães, J. P., Gladyshev, V. N., & Zhavoronkov, A. (2020) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 189

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

Ogrodnik, M., Salmonowicz, H., & Gladyshev, V. N. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 184

A whole lifespan mouse multi-tissue DNA methylation clock

Meer, M. V., Podolskiy, D. I., Tyshkovskiy, A., & Gladyshev, V. N. (2018) · eLife

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 176

Protein synthesis and quality control in aging

Anisimova, A. S., Alexandrov, A. I., Makarova, N. E., Gladyshev, V. N., & Dmitriev, S. E. (2018) · Aging

Genetics, Aging, and Longevity in Model OrganismsRNA and protein synthesis mechanisms

Cited by 172

COVID‐19 is an emergent disease of aging

Santesmasses, D., Castro, J. P., Zenin, A. A., Shindyapina, A. V., Gerashchenko, M. V., Zhang, B., Kerepesi, C., Yim, S. H., Fedichev, P. O., & Gladyshev, V. N. (2020) · Aging Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 172

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 167

Distinct longevity mechanisms across and within species and their association with aging

Tyshkovskiy, A., Ma, S., Shindyapina, A. V., Tikhonov, S., Lee, S.-G., Bozaykut, P., Castro, J. P., Seluanov, A., Schork, N. J., Gorbunova, V., et al. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 162