Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

A Unified Approach to Interpreting Model Predictions

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Advances in Neural Information Processing Systems 29

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DNA methylation age of human tissues and cell types

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“Why Should I Trust You?”: Explaining the Predictions of Any Classifier

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Adversarial Discriminative Domain Adaptation

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Pleiotropy, natural selection, and the evolution of senescence.

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Genome-wide methylation profiles reveal quantitative views of human aging rates

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An epigenetic biomarker of aging for lifespan and healthspan

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CpG islands and the regulation of transcription

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DNA methylation-based biomarkers and the epigenetic clock theory of ageing

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Permutation importance: a corrected feature importance measure

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CyCADA: Cycle-Consistent Adversarial Domain Adaptation

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DNA methylation GrimAge strongly predicts lifespan and healthspan

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Generative Adversarial Text to Image Synthesis

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Pleiotropy, natural selection, and the evolution of senescence

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Association between telomere length in blood and mortality in people aged 60 years or older

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Deep learning enables rapid identification of potent DDR1 kinase inhibitors

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Biological Age Predictors

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Histone Deacetylase Inhibitors as Anticancer Drugs

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Domain-adversarial training of neural networks

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Epigenetic Predictor of Age

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Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

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Aging of blood can be tracked by DNA methylation changes at just three CpG sites

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A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study

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Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

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Meta-analysis of age-related gene expression profiles identifies common signatures of aging

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The transcriptional landscape of age in human peripheral blood

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Adult lean body mass declines with age: Some longitudinal observations

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Advances and Applications of Single-Cell Sequencing Technologies

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druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico

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"Why Should I Trust You?": Explaining the Predictions of Any ClassifierPreprint

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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936

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Telomere and telomerase in stem cells

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Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?

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Adversarial Discriminative Domain AdaptationPreprint

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Causal Interpretations of Black-Box Models

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Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence

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An Attempt to Prevent Senescence: A Mitochondrial Approach

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Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

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Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

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Personal aging markers and ageotypes revealed by deep longitudinal profiling

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Using DNA methylation profiling to evaluate biological age and longevity interventions

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The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

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Multi-tissue DNA methylation age predictor in mouse

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Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

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Reinforced Adversarial Neural Computer for de Novo Molecular Design

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Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall

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Deep biomarkers of human aging: Application of deep neural networks to biomarker development

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Transcriptome signature of cellular senescence

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Does oxidative stress shorten telomeres in vivo ? A review

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Single-cell chromatin modification profiling reveals increased epigenetic variations with aging

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Stress, cell senescence and organismal ageing

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Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population‐based study

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Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

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Comparison of telomere length measurement methods

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Recent results: Biomarkers of aging

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Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

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The ageing ovary and uterus: new biological insights

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DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

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Visualizing the Effects of Predictor Variables in Black Box Supervised Learning ModelsPreprint

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From Source to Target and Back: Symmetric Bi-Directional Adaptive GAN

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Assessment of Biological Age Using a Profile of Physical Parameters

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Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells

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Predicting age from the transcriptome of human dermal fibroblasts

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Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification

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Deep Feature Selection: Theory and Application to Identify Enhancers and Promoters

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A multi-tissue full lifespan epigenetic clock for mice

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Evolutionary Theories of Aging and Longevity

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Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans

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Chromatin structure as a mediator of aging

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Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations

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Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells

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Molecular and phenotypic biomarkers of aging

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Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

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Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis

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A whole lifespan mouse multi-tissue DNA methylation clock

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Detection of Senescence-Associated Heterochromatin Foci (SAHF)

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Telomere attrition as ageing biomarker.

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A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence

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Telomerase activity in ‘immortal’ fish1

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Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?

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CpG island density and its correlations with genomic features in mammalian genomes

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BERMUDA: a novel deep transfer learning method for single-cell RNA sequencing batch correction reveals hidden high-resolution cellular subtypes

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Coevolution of telomerase activity and body mass in mammals: From mice to beavers

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Telomeres and human reproduction

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Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth

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Age-associated telomere attrition of lymphocytes<i>in vivo</i>is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

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Blood Cell Telomere Length Is a Dynamic Feature

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Assessment of biological age by principal component analysis

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PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging

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Longevity of lobsters is linked to ubiquitous telomerase expression

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The Epidemiology of Human Telomeres: Faults and Promises

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Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks

Yusri, K., Kumar, S., Fong, S., Gruber, J., & Sorrentino, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126793 · Cited by 21 · see citing works

Estimation of physiological aging based on routine clinical biomarkers: a prospective cohort study in elderly Chinese and the UK Biobank

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The road ahead of dietary restriction on anti-aging: focusing on personalized nutrition

Duan, H., Li, J., Yu, L., & Fan, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2110034 · Cited by 20 · see citing works

Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects

Kriukov, D. V., Kuzmina, E., Efimov, E., Dylov, D. V., & Khrameeva, E. E. (2024) · Aging Cell · doi:10.1111/acel.14283 · Cited by 19 · see citing works

Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging

Okada, D., Cheng, J. H., Zheng, C., Kumaki, T., & Yamada, R. (2023) · Human Genomics · doi:10.1186/s40246-023-00453-z · Cited by 17 · see citing works

Association between telomere length, frailty and death in older adults

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Ageing and cancer: a research gap to fill

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AgingBank: a manually curated knowledgebase and high-throughput analysis platform that provides experimentally supported multi-omics data relevant to aging in multiple species

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Predicting healthspan and disease risks through biological age

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A new utilization of total flavonoids from Acer truncatum samara and leaves: Anti-aging and metabolic regulation

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Multimodal Transformers and Their Applications in Drug Target Discovery for Aging and Age-Related Diseases

Steurer, B., Vanhaelen, Q., & Zhavoronkov, A. A. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae006 · Cited by 16 · see citing works

Diagnostic and Therapeutic Roles of Extracellular Vesicles in Aging‐Related Diseases

Sun, Z., Hou, X., Zhang, J., Li, J., Wu, P., Yan, L., & Qian, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6742792 · Cited by 16 · see citing works

Energy Metabolism Focused Analysis of Sexual Dimorphism in Biological Aging and Hypothesized Sex-specificity in Sirtuin Dependency

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Study on the relationship between selenium and cadmium in diseased human lungs

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A metabolomic signature of decelerated physiological aging in human plasma

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Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis

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Increased Pace of Aging in COVID-Related Mortality

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An Updated Overview on the Role of Small Molecules and Natural Compounds in the “Young Science” of Rejuvenation

Ribaudo, G., & Gianoncelli, A. (2023) · Antioxidants · doi:10.3390/antiox12020288 · Cited by 14 · see citing works

Dietary diversity score and the acceleration of biological aging: a population-based study of 88,039 participants

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Association between cardiometabolic index and biological ageing among adults: a population-based study

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FTIR Spectroscopy as a Tool to Study Age-Related Changes in Cardiac and Skeletal Muscle of Female C57BL/6J Mice

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Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology

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Explainable machine learning framework for biomarker discovery by combining biological age and frailty prediction

Wang, X., & Ji, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-98948-3 · Cited by 12 · see citing works

Optimizing future well-being with artificial intelligence: self-organizing maps (SOMs) for the identification of islands of emotional stability

Galkin, F., Kochetov, K., Keller, M., Zhavoronkov, A. A., & Etcoff, N. L. (2022) · Aging · doi:10.18632/aging.204061 · Cited by 12 · see citing works

Natural products as geroprotectors: An autophagy perspective

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Changes in accelerated aging and risk of cardiovascular disease and mortality: three cohort studies

Zhang, J., Yu, H., Geng, T., Chen, S., Wang, Y., Guo, H., Zhang, X.-M., He, M., Gao, J.-L., Liu, G., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04365-8 · Cited by 11 · see citing works

Biomarkers of geroprotection and cardiovascular health: An overview of omics studies and established clinical biomarkers in the context of diet

Secci, R., Hartmann, A., Walter, M., Grabe, H. J., der Auwera, S. V., Kowald, A., Palmer, D. H., Rimbach, G. H., Fuellen, G., & Barrantes, I. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1975638 · Cited by 11 · see citing works

Analysis of variability and epigenetic age prediction across microarray and methylation sequencing technologies

Shokhirev, M. N., & Johnson, A. A. (2025) · GeroScience · doi:10.1007/s11357-025-01824-1 · Cited by 10 · see citing works

Associations between Differential Aging and Lifestyle, Environment, Current, and Future Health Conditions: Findings from Canadian Longitudinal Study on Aging

Song, Y., Liu, Y. S., Talarico, F., Zhang, Y., Hayward, J., Wang, M., Stroulia, E., Dixon, R. A., Greiner, R., Li, X., et al. (2023) · Gerontology · doi:10.1159/000534015 · Cited by 10 · see citing works

Novel Epigenetic Clock Biomarkers of Age-Related Macular Degeneration

Mallik, S., Grodstein, F., Bennett, D. A. A., Vavvas, D. G., & Lemos, B. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.856853 · Cited by 10 · see citing works

The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials

Harinath, G., Zalzala, S., Nyquist, A., Wouters, M. C. A., Isman, A., Moel, M., Verdin, E. M., Kaeberlein, M. R., Kennedy, B. K., & Bischof, E. Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102293 · Cited by 9 · see citing works

From clock to clock: Therapeutic target discovery for aging and age-related diseases

Chen, J., Leung, G. H. D., Leung, H., Ustiugova, A. S., Shneyderman, A., Korzinkin, M., Gennert, D. G., Pun, F. W., Aliper, A. M., Ren, F., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102871 · Cited by 9 · see citing works

Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks

Sandalova, E., & Maier, A. B. (2023) · Biogerontology · doi:10.1007/s10522-023-10077-4 · Cited by 9 · see citing works

Organ-specific proteomic aging and cognitive performance: Implications for risk prediction of Alzheimer’s disease and related dementias in older adults

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Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution

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Plasma Proteomics Reveals Biomarkers and Undulating Changes in Metabolic Aging

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Scale bar of aging trajectories for screening personal rejuvenation treatments

Shen, X., Wu, B., Jiang, W. M., Li, Y., Zhang, Y., Zhao, K., Nie, N., Gong, L., Liu, Y., Zou, X., et al. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.10.021 · Cited by 7 · see citing works

Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementation vs. Lifestyle Modifications

Fingelkurts, A. A., & Fingelkurts, A. A. (2023) · Brain Sciences · doi:10.3390/brainsci13030520 · Cited by 7 · see citing works

A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age

Martínez-Romero, J., Fernández, M. E., Bernier, M., Price, N. L., Mueller, W., Candia, J., Camandola, S., Meirelles, O., Hu, Y., Li, Z., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00728-7 · Cited by 12 · see citing works

Deep aging clocks: AI-powered strategies for biological age estimation

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Application of AI in biological age prediction

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Vascular Aging Across the Cardiovascular-Alzheimer’s Continuum: Hemodynamics and Artificial Intelligence

Zhou, Z., Zhang, R., Wang, J., Yu, Y., Wei, S., & Wan, W. (2026) · Aging and Disease · doi:10.14336/ad.2026.0539

modeling data of DNA methylation clock

Ni, X. (2022) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.6872712