Sato, Toshiro

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 7,204

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 3,753

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature

Wnt/β-catenin signaling in development and cancerDigestive system and related health

Cited by 2,510

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell

Developmental Biology and Gene RegulationCancer Cells and Metastasis

Cited by 1,951

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 1,555

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010) · Cell Stem Cell

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 1,547

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

Sato, T., & Clevers, H. (2013) · Science

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 1,170

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T., & Sato, T. (2015) · Nature Medicine

Cancer Cells and MetastasisCRISPR and Genetic Engineering

Cited by 1,135

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer

Cited by 935

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., et al. (2016) · Cell Stem Cell

Cancer Cells and MetastasisColorectal Cancer Treatments and Studies

Cited by 852

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., et al. (2012) · Nature Medicine

Cancer Cells and MetastasisPluripotent Stem Cells Research

Cited by 805

Visualization and targeting of LGR5+ human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T., & Sato, T. (2017) · Nature

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 728

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., et al. (2011) · Nature Medicine

Cancer Cells and MetastasisHematopoietic Stem Cell Transplantation

Cited by 709

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., et al. (2018) · Cell Stem Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 631

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S., & Sato, T. (2018) · Cell Stem Cell

Cancer Cells and MetastasisPluripotent Stem Cells Research

Cited by 558

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P.-S., Taniki, N., et al. (2019) · Nature Microbiology

Liver Diseases and ImmunityGut microbiota and health

Cited by 425

Efficient genetic engineering of human intestinal organoids using electroporation

Fujii, M., Matano, M., Nanki, K., & Sato, T. (2015) · Nature Protocols

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 364

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B.-K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H., & Clevers, H. (2012) · Nature Methods

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 320

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Marsee, A., Roos, F. J. M., Verstegen, M. M. A., Marsee, A., Roos, F., Verstegen, M., Clevers, H., Vallier, L., Takebe, T., Huch, M., et al. (2021) · Cell Stem Cell

3D Printing in Biomedical ResearchPancreatic function and diabetes

Cited by 310

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

Kawasaki, K., Toshimitsu, K., Matano, M., Fujita, M., Fujii, M., Togasaki, K., Ebisudani, T., Shimokawa, M., Takano, A., Takahashi, S., et al. (2020) · Cell

Neuroendocrine Tumor Research AdvancesGenetic factors in colorectal cancer

Cited by 238

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., et al. (2018) · Cell Stem Cell

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 196

An organoid-based organ-repurposing approach to treat short bowel syndrome

Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., et al. (2021) · Nature

Tissue Engineering and Regenerative MedicineClinical Nutrition and Gastroenterology

Cited by 175

SnapShot: Growing Organoids from Stem Cells

Sato, T., & Clevers, H. (2015) · Cell

Pluripotent Stem Cells ResearchCancer Cells and Metastasis

Cited by 168

Generation of human adult hepatocyte organoids with metabolic functions

Igarashi, R., Oda, M., Okada, R., Yano, T., Takahashi, S., Pastuhov, S., Matano, M., Masuda, N., Togasaki, K., Ohta, Y., et al. (2025) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 85