Cited by 313Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune DisordersAutophagy in Disease and Therapy

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

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de Luca, Antonella, Smeekens, Sanne P., Casagrande, Andrea, Iannitti, Rossana, Conway, Kara L., Gresnigt, Mark. S., Begun, Jakob, Plantinga, Theo S. +8 more·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: Chronic granulomatous disease (CGD) has an immunodeficiency component and, in addition, an autoinflammatory component in which autophagy and inflammasome activation are linked and amenable to IL-1 blockade. This study provides a rationale to perform clinical trials to investigate the efficacy of blocking IL-1 in CGD colitis and expands the therapeutic potential of IL-1 antagonists to inflammatory diseases with defective autophagy.

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Crossref · 10.1073/pnas.1322831111

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  • Activation of LAP in macrophages also regulates inflammatory signaling pathways.

    “Notably, activation of LAP in macrophages also regulates inflammatory signaling pathways (258, 259).”

    From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [258]

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  1. de Luca et al. PNAS | March 4, 2014 | vol. 111 | no. 9 | 3531 MEDICAL SCIENCES

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Authors
de Luca, A., Smeekens, S. P., Casagrande, A., Iannitti, R., Conway, K. L., Gresnigt, M. S., Begun, J., Plantinga, T. S., Joosten, L. A. B., van der Meer, J. W. M., Chamilos, G., Netea, M. G., Xavier, R. J., Dinarello, C. A., Romani, L., & van de Veerdonk, F. L.
Affiliations
  • Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy;
  • Radboud University Medical Center (NL)
  • University of Perugia (IT)
  • Harvard University (US)
  • Department of Medicine, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands;
  • University of Crete (GR)
Corresponding author
Dinarello, Charles A.
Venue
Proceedings of the National Academy of Sciences
Published
2014-02-18
Volume
111
Issue
9
Pages
3526-3531
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2153164696
Cited by
313
References
49
Citations by year
2026: 13 · 2025: 16 · 2024: 10 · 2023: 16 · 2022: 22 · 2021: 32 · 2020: 24 · 2019: 34 · 2018: 26 · 2017: 41 · 2016: 35 · 2015: 26 · 2014: 18
FWCI
18.28
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • Crohn's and Colitis Foundation
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI‑15614, AI-62773, R56AI015614, R01AI062773, R01AI015614)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083756, DK-60049, DK 83756, R01DK097485, DK 43351, R01DK060049, P30DK043351)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
chronic granulomatous disease, IL-1 receptor blockade, anakinra, autophagy, inflammasome activation, IL-1β, NADPH oxidase deficiency, colitis, invasive aspergillosis, macrophages, monocytes, neutrophil recruitment, Th17 response, reactive oxygen species
MeSH terms
Animals, Anti-Inflammatory Agents, Aspergillus fumigatus, Autophagy, Colitis, Enzyme-Linked Immunosorbent Assay, Granulomatous Disease, Chronic, Humans, Mice, Inbred C57BL, Mice, Mutant Strains, Microtubule-Associated Proteins, Phagosomes, Receptors, Interleukin-1, Statistics, Nonparametric, NADPH Oxidases, Mice, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein, Real-Time Polymerase Chain Reaction

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