IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
Open accessAbstract
Significance: Chronic granulomatous disease (CGD) has an immunodeficiency component and, in addition, an autoinflammatory component in which autophagy and inflammasome activation are linked and amenable to IL-1 blockade. This study provides a rationale to perform clinical trials to investigate the efficacy of blocking IL-1 in CGD colitis and expands the therapeutic potential of IL-1 antagonists to inflammatory diseases with defective autophagy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of LAP in macrophages also regulates inflammatory signaling pathways.
“Notably, activation of LAP in macrophages also regulates inflammatory signaling pathways (258, 259).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [258]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Autophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,441 · see citing works
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,549 · see citing works
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,020 · see citing works
Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Dinarello, C., Simon, A., & van der Meer, J. V. D. (2012) · Nature reviews. Drug discovery · doi:10.1038/nrd3800 · Cited by 1,813 · see citing works
Self-citationChronic Granulomatous Disease: Report on a National Registry of 368 Patients
Winkelstein, J. A., Marino, M. C., Johnston, R. B., Boyle, J., Curnutte, J., Gallin, J. I., Malech, H. L., Holland, S. M., Ochs, H., Quie, P., et al. (2000) · Medicine · doi:10.1097/00005792-200005000-00003 · Cited by 1,728 · see citing works
Beyond oxidative stress: an immunologist's guide to reactive oxygen species
Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619 · see citing works
Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature · doi:10.1038/nature06421 · Cited by 1,347 · see citing works
Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,144 · see citing works
Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease
Segal, B. H., Leto, T. L., Gallin, J. I., Malech, H. L., & Holland, S. M. (2000) · Medicine · doi:10.1097/00005792-200005000-00004 · Cited by 877 · see citing works
Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation
Harris, J., Hartman, M., Roche, C., Zeng, S. G., O'Shea, A., Sharp, F. A., Lambe, E. M., Creagh, E. M., Golenbock, D. T., Tschopp, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202911 · Cited by 794 · see citing works
IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S.-Y., Kurt-Jones, E. A., & Szabo, G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60777 · Cited by 735 · see citing works
Johnston, R. B., Keele, B. B., Misra, H. P., Lehmeyer, J. E., Webb, L., Baehner, R. L., & Rajagopalan, K. V. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108055 · Cited by 704 · see citing works
Holmes, B. M., Page, A. R., & Good, R. A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105634 · Cited by 687 · see citing works
Activation of antibacterial autophagy by NADPH oxidases
Huang, J., Canadien, V., Lam, G. Y., Steinberg, B. E., Dinauer, M. C., Magalhaes, M. A. O., Glogauer, M., Grinstein, S., & Brumell, J. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811045106 · Cited by 556 · see citing works
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Romani, L., Fallarino, F., De Luca, A., Montagnoli, C., D’Angelo, C., Zelante, T., Vacca, C., Bistoni, F., Fioretti, M. C., Grohmann, U., et al. (2008) · Nature · doi:10.1038/nature06471 · Cited by 535 · see citing works
Self-citationMahida, Y. R., Wu, K., & Jewell, D. P. (1989) · Gut · doi:10.1136/gut.30.6.835 · Cited by 427 · see citing works
Gastrointestinal Involvement in Chronic Granulomatous Disease
Marciano, B. E., Rosenzweig, S. D., Kleiner, D. E., Anderson, V., Darnell, D. N., Anaya‐O’Brien, S., Hilligoss, D. M., Malech, H. L., Gallin, J. I., & Holland, S. M. (2004) · PEDIATRICS · doi:10.1542/peds.114.2.462 · Cited by 417 · see citing works
The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicans
van de Veerdonk, F. L., Marijnissen, R. J., Kullberg, B. J., Koenen, H. J. P. M., Cheng, S., Joosten, I., van den Berg, W. B., Williams, D. L., van der Meer, J. W. M., Joosten, L. A. B., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.02.006 · Cited by 338 · see citing works
Self-citationLapaquette, P., Glasser, A.-L., Huett, A. S., Xavier, R. J., & Darfeuille–Michaud, A. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01381.x · Cited by 312 · see citing works
Self-citationPomerantz, B. J., Reznikov, L. L., Harken, A. H., & Dinarello, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041611398 · Cited by 310 · see citing works
Self-citationMeissner, F., Seger, R. A., Moshous, D., Fischer, A., Reichenbach, J., & Zychlinsky, A. (2010) · Blood · doi:10.1182/blood-2010-01-264218 · Cited by 269 · see citing works
Takedatsu, H., Michelsen, K. S., Wei, B., Landers, C. J., Thomas, L. S., Dhall, D., Braun, J. G., & Targan, S. R. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.037 · Cited by 254 · see citing works
van de Veerdonk, F. L., Smeekens, S. P., Joosten, L. A. B., Kullberg, B. J., Dinarello, C. A., van der Meer, J. W. M., & Netea, M. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914795107 · Cited by 248 · see citing works
Self-citationDivergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies
Brydges, S. D., Broderick, L., McGeough, M. D., Peña, C. A., Mueller, J. L., & Hoffman, H. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71543 · Cited by 228 · see citing works
Interleukin-1β and the Autoinflammatory Diseases
Dinarello, C. A. (2009) · New England Journal of Medicine · doi:10.1056/nejme0811014 · Cited by 224 · see citing works
Self-citationPlantinga, T., Crișan, T., Oosting, M., van de Veerdonk, F. L., de Jong, D. D., Philpott, D., van der Meer, J. V. D., Girardin, S., Joosten, L., & Netea, M. (2011) · Gut · doi:10.1136/gut.2010.228908 · Cited by 207 · see citing works
Self-citationHuman nlrp3 inflammasome activation is nox1-4 independent
van Bruggen, R., Köker, M. Y., Jansen, M., van Houdt, M., Roos, D., Kuijpers, T. W., & van den Berg, T. K. (2010) · Blood · doi:10.1182/blood-2009-10-250803 · Cited by 202 · see citing works
Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells
Crișan, T. O., Plantinga, T. S., van de Veerdonk, F. L., Farcas, M. F., Stoffels, M., Kullberg, B. J., van der Meer, J. W. M., Joosten, L. A. B., & Netea, M. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018666 · Cited by 185 · see citing works
Self-citationComplications of Tumor Necrosis Factor–α Blockade in Chronic Granulomatous Disease–Related Colitis
Uzel, G., Orange, J. S., Poliak, N., Marciano, B. E., Heller, T., & Holland, S. M. (2010) · Clinical Infectious Diseases · doi:10.1086/657308 · Cited by 185 · see citing works
Ellson, C. D., Davidson, K., Ferguson, G., O'Connor, R. P., Stephens, L., & Hawkins, P. T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052069 · Cited by 182 · see citing works
Kyrmizi, I., Gresnigt, M. S., Akoumianaki, T., Samonis, G., Sidiropoulos, P., Boumpas, D., Netea, M. G., van de Veerdonk, F. L., Kontoyiannis, D. P., & Chamilos, G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300132 · Cited by 142 · see citing works
Self-citationCurrent Concepts of Hyperinflammation in Chronic Granulomatous Disease
Rieber, N. P., Hector, A., Kuijpers, T. W., Roos, D., & Hartl, D. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/252460 · Cited by 140 · see citing works
Inflammation and repeated infections in CGD: two sides of a coin
Kuijpers, T. W., & Lutter, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0834-z · Cited by 77 · see citing works
Luca, A. D., Iannitti, R. G., Bozza, S., Beau, R., Casagrande, A., D’Angelo, C., Moretti, S., Cunha, C., Giovannini, G., Massi-Benedetti, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60862 · Cited by 77 · see citing works
Self-citationInvasive fungal infections in congenital immunodeficiencies
Antachopoulos, C. (2010) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2010.03289.x · Cited by 74 · see citing works
Infections associated with chronic granulomatous disease: linking genetics to phenotypic expression
Ben‐Ari, J., Wolach, O., Gavrieli, R., & Wolach, B. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.77 · Cited by 70 · see citing works
Autophagy as an important process in gut homeostasis and Crohn’s disease pathogenesis
Xavier, R. J., Huett, A. S., & Rioux, J. D. (2008) · Gut · doi:10.1136/gut.2007.134254 · Cited by 65 · see citing works
Self-citationRegulation Where Autophagy Intersects the Inflammasome
Rodgers, M. A., Bowman, J. W., Liang, Q., & Jung, J. U. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5347 · Cited by 61 · see citing works
Phagocyte dysfunction and inflammatory bowel disease
Rahman, F. Z., Marks, D. J., Hayee, B., Smith, A. M., Bloom, S. L., & Segal, A. W. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20449 · Cited by 55 · see citing works
Welch, K. M. A. (1993) · Cephalalgia · doi:10.1046/j.1468-2982.1993.1305306-3.x · Cited by 55 · see citing works
NADPH oxidases contribute to autophagy regulation
Huang, J., & Brumell, J. H. (2009) · Autophagy · doi:10.4161/auto.9125 · Cited by 54 · see citing works
Chronic granulomatous disease caused by a deficiency in p47phox mimicking Crohn’s disease
Huang, J. S., Noack, D., Rae, J., Ellis, B. A., Newbury, R., Pong, A. L., Lavine, J. E., Curnutte, J. T., & Bastian, J. F. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00292-7 · Cited by 53 · see citing works
Mitomi, H., Mikami, T., Takahashi, H., Igarashi, M., Katsumata, T., Ihara, A., Ohtani, Y., Ohta, T., & Okayasu, I. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026643609944 · Cited by 26 · see citing works
Anakinra for the inflammatory complications of chronic granulomatous disease.
van de Veerdonk, F. L., Netea, M. G., Dinarello, C. A., & van der Meer, J. W. M. (2011) · PubMed · Cited by 21 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- de Luca et al. PNAS | March 4, 2014 | vol. 111 | no. 9 | 3531 MEDICAL SCIENCES
Cited by
Sorted by citations
Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Self-citationPathway paradigms revealed from the genetics of inflammatory bowel disease
Graham, D. B., & Xavier, R. J. (2020) · Nature · doi:10.1038/s41586-020-2025-2 · Cited by 769 · see citing works
Self-citationMartinez, J., Malireddi, R. K. S., Lu, Q., Cunha, L. D., Pelletier, S., Gingras, S., Orchard, R., Guan, J.-L., Tan, H., Peng, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3192 · Cited by 758 · see citing works
RetractedNeutrophils: Between Host Defence, Immune Modulation, and Tissue Injury
Krüger, P., Saffarzadeh, M., Weber, A. N. R., Rieber, N. P., Radsak, M. P., von Bernuth, H., Benarafa, C., Roos, D., Skokowa, J., & Hartl, D. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004651 · Cited by 663 · see citing works
Aspergillus fumigatus morphology and dynamic host interactions
van de Veerdonk, F. L., Gresnigt, M. S., Romani, L., Netea, M. G., & Latgé, J.-P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.90 · Cited by 490 · see citing works
Self-citationCOVID-19-associated fungal infections
Hoenigl, M., Seidel, D., Sprute, R., Cunha, C., Oliverio, M., Goldman, G. H., Ibrahim, A. S., & Carvalho, A. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01172-2 · Cited by 482 · see citing works
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis
Cadwell, K. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.100 · Cited by 478 · see citing works
Strategies for targeting cytokines in inflammatory bowel disease
Neurath, M. F. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01008-6 · Cited by 433 · see citing works
COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment
Arastehfar, A. A., Carvalho, A., van de Veerdonk, F. L., Jenks, J. D., Koehler, P. A., Krause, R., Cornely, O. A., Perlin, D. S., Lass‐Flörl, C., & Hoenigl, M. (2020) · Journal of Fungi · doi:10.3390/jof6020091 · Cited by 417 · see citing works
Matsuzawa, Y., Hwang, S., & Cadwell, K. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053253 · Cited by 378 · see citing works
Modulation of inflammation by autophagy: Consequences for human disease
Netea-Maier, R. T., Plantinga, T. S., van de Veerdonk, F. L., Smit, J. W., & Netea, M. G. (2016) · Autophagy · doi:10.1080/15548627.2015.1071759 · Cited by 349 · see citing works
Self-citationInflammasome-independent regulation of IL-1-family cytokines
Netea, M. G., van de Veerdonk, F. L., van der Meer, J. W. M., Dinarello, C. A., & Joosten, L. A. B. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112306 · Cited by 326 · see citing works
Self-citationEgea, J., Fabregat, I., Frapart, Y., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K. I., Knaus, U. G., López, M. G., González, G. O., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.007 · Cited by 311 · see citing works
Li, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.622534 · Cited by 284 · see citing works
Yang, J., Liu, X., Fan, H., Tang, Q., Shou, Z., Zuo, D.-M., Zou, Z., Xu, M., Chen, Q.-Y., Peng, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140551 · Cited by 277 · see citing works
A Review of Chronic Granulomatous Disease
Arnold, D. E., & Heimall, J. R. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0636-2 · Cited by 251 · see citing works
The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease
Mao, L., Kitani, A., Strober, W., & Fuss, I. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02566 · Cited by 242 · see citing works
Iannitti, R. G., Napolioni, V., Oikonomou, V., LUCA, A. D., Galosi, C., Pariano, M., Massi-Benedetti, C., Borghi, M., Puccetti, M., Lucidi, V., et al. (2016) · Nature Communications · doi:10.1038/ncomms10791 · Cited by 233 · see citing works
Self-citationAnders, H., Suárez-Álvarez, B., Grigorescu, M., Foresto‐Neto, O., Steiger, S., Desai, J., Marschner, J. A., Honarpisheh, M. M., Shi, C., Jordan, J., et al. (2017) · Kidney International · doi:10.1016/j.kint.2017.09.022 · Cited by 226 · see citing works
Siew, J. J., Chen, H., Chen, H., Chen, H.-L., Chen, C., Soong, B., Wu, Y., Chang, C., Chan, Y., Lin, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11441-0 · Cited by 224 · see citing works
NOX2-dependent regulation of inflammation
Singel, K. L., & Segal, B. H. (2016) · Clinical Science · doi:10.1042/cs20150660 · Cited by 214 · see citing works
Roos, D. (2016) · British Medical Bulletin · doi:10.1093/bmb/ldw009 · Cited by 212 · see citing works
Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3
Houtman, J., Freitag, K., Gimber, N., Schmoranzer, J., Heppner, F. L., & Jendrach, M. (2019) · The EMBO Journal · doi:10.15252/embj.201899430 · Cited by 212 · see citing works
Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges
Cavazzana, M., Bushman, F. D., Miccio, A., André‐Schmutz, I., & Six, E. M. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0020-9 · Cited by 198 · see citing works
Chronic Granulomatous Disease: a Comprehensive Review
Yu, H.-H., Yang, Y.-H., & Chiang, B.-L. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08800-x · Cited by 197 · see citing works
Bode, S. F. N., Ammann, S., Al–Herz, W., Bataneant, M. T., Dvorak, C. C., Gehring, S., Gennery, A. R., Gilmour, K. C., González‐Granado, L. I., Gross‐Wieltsch, U., et al. (2015) · Haematologica · doi:10.3324/haematol.2014.121608 · Cited by 197 · see citing works
Neutrophils in traumatic brain injury (TBI): friend or foe?
Liu, Y., Li, S., & Dai, S.-S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1173-x · Cited by 191 · see citing works
Cicco, S., Cicco, G., Racanelli, V., & Vacca, A. (2020) · Mediators of Inflammation · doi:10.1155/2020/7527953 · Cited by 190 · see citing works
Autophagy and proinflammatory cytokines: Interactions and clinical implications
Ge, Y., Huang, M., & Yao, Y.-M. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.07.001 · Cited by 189 · see citing works
NADPH Oxidases Are Essential for Macrophage Differentiation
Xu, Q., Choksi, S., Qu, J., Jang, J., Choe, M., Bánfi, B., Engelhardt, J. F., & Liu, Z.-G. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.731216 · Cited by 184 · see citing works
The phagocyte respiratory burst: Historical perspectives and recent advances
Thomas, D. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.08.016 · Cited by 179 · see citing works
Pathogenic Fungal Infection in the Lung
Li, Z., Lu, G., & Meng, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01524 · Cited by 176 · see citing works
The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders
Arts, R. J. W., Joosten, L. A. B., & Netea, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00298 · Cited by 175 · see citing works
Self-citationThe roles of NADPH oxidase in modulating neutrophil effector responses
Zeng, M. Y., Miralda, I., Armstrong, C. L., Uriarte, S. M., & Bagaitkar, J. (2019) · Molecular Oral Microbiology · doi:10.1111/omi.12252 · Cited by 173 · see citing works
Xia, Y., Liu, N., Xie, X., Bi, G., Ba, H., Li, L., Zhang, J., Deng, X., Yao, Y., Tang, Z., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1569916 · Cited by 171 · see citing works
Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway
Crișan, T. O., Cleophas, M. C. P., Novakovic, B., Erler, K., van de Veerdonk, F. L., Stunnenberg, H. G., Netea, M. G., Dinarello, C. A., & Joosten, L. A. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620910114 · Cited by 168 · see citing works
Self-citationGenetic disorders coupled to ROS deficiency
O’Neill, S., Brault, J., Stasia, M.-J., & Knaus, U. G. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.009 · Cited by 164 · see citing works
Pathogenesis of Respiratory Viral and Fungal Coinfections
Salazar, F., Bignell, E., Brown, G. D., Cook, P. C., & Warris, A. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00094-21 · Cited by 155 · see citing works
Ritvo, P.-G., Churlaud, G., Quiniou, V., Flórez, L. V., Brimaud, F., Fourcade, G., Mariotti‐Ferrandiz, E., & Klatzmann, D. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan0368 · Cited by 150 · see citing works
Gazendam, R. P., van de Geer, A., Roos, D., van den Berg, T. K., & Kuijpers, T. W. (2016) · Immunological Reviews · doi:10.1111/imr.12454 · Cited by 146 · see citing works
Moderate Hypoxia Potentiates Interleukin-1β Production in Activated Human Macrophages
Folco, E. J. E., Sukhova, G. K., Quillard, T., & Libby, P. (2014) · Circulation Research · doi:10.1161/circresaha.115.304437 · Cited by 145 · see citing works
Chronic granulomatous disease: Clinical, molecular, and therapeutic aspects
Chiriaco, M., Salfa, I., Matteo, G. D., Rossi, P., & Finocchi, A. (2015) · Pediatric Allergy and Immunology · doi:10.1111/pai.12527 · Cited by 145 · see citing works
Mechanisms of Pediatric Inflammatory Bowel Disease
Peloquin, J. M., Goel, G., Villablanca, E. J., & Xavier, R. J. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112151 · Cited by 138 · see citing works
Self-citationKelsen, J. R., Sullivan, K. E., Rabizadeh, S., Singh, N., Snapper, S. B., Elkadri, A. A., & Grossman, A. B. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002567 · Cited by 137 · see citing works
From Flies to Men: ROS and the NADPH Oxidase in Phagocytes
Moghadam, Z. M., Henneke, P., & Kolter, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628991 · Cited by 136 · see citing works
Immunotherapeutic approaches to treatment of fungal diseases
Armstrong-James, D., Brown, G. D., Netea, M. G., Zelante, T., Gresnigt, M. S., van de Veerdonk, F. L., & Levitz, S. M. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30442-5 · Cited by 135 · see citing works
Self-citationBuvelot, H., Jaquet, V., & Krause, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9424-3_2 · Cited by 134 · see citing works
Caffrey, A. K., Lehmann, M. M., Zickovich, J. M., Espinosa, V., Shepardson, K. M., Watschke, C. P., Hilmer, K. M., Thammahong, A., Barker, B. M., Rivera, A., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004625 · Cited by 132 · see citing works
Genetics of inflammatory bowel disease from multifactorial to monogenic forms
Bianco, A. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i43.12296 · Cited by 125 · see citing works
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections
Deffert, C., Cachat, J., & Krause, K. (2014) · Cellular Microbiology · doi:10.1111/cmi.12322 · Cited by 123 · see citing works
Helyes, Z., Tékus, V., Szentes, N., Pohóczky, K., Botz, B., Kiss, T., Kemény, Á., Környei, Z., Tóth, K., Lénárt, N., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820168116 · Cited by 122 · see citing works
An Expanding Role for Interleukin-1 Blockade from Gout to Cancer
Dinarello, C. A. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00232 · Cited by 121 · see citing works
Self-citationObesity-induced inflammation exacerbates clonal hematopoiesis
Pasupuleti, S. K., Ramdas, B., Burns, S. S., Palam, L. R., Kanumuri, R., Kumar, R., Pandhiri, T. R., Davé, U. P., Yellapu, N. K., Zhou, X., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci163968 · Cited by 120 · see citing works
Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease
Mao, L., Kitani, A., Similuk, M. N., Oler, A. J., Albenberg, L. G., Kelsen, J. R., Aktay, A., Quezado, M., Yao, M. D., Montgomery-Recht, K., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98642 · Cited by 111 · see citing works
Elder, M. J., Webster, S. J., Chee, R., Williams, D. L., Gaston, H., & GOODALL, J. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00791 · Cited by 108 · see citing works
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production
Chen, F., Cao, A., Yao, S., Evans‐Marin, H., Liu, H., Wu, W. H., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501541 · Cited by 106 · see citing works
Blocking IL-1 to prevent respiratory failure in COVID-19
van de Veerdonk, F. L., & Netea, M. G. (2020) · Critical Care · doi:10.1186/s13054-020-03166-0 · Cited by 105 · see citing works
Self-citationLc3-associated phagocytosis—The highway to hell for phagocytosed microbes
Herb, M., Gluschko, A., & Schramm, M. (2020) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.04.016 · Cited by 103 · see citing works
An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease
Bolton, C., Smillie, C. S., Pandey, S., Elmentaite, R., Wei, G., Argmann, C., Aschenbrenner, D., James, K. R., McGovern, D. P. B., Macchi, M., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.11.014 · Cited by 97 · see citing works
Self-citationKyrmizi, I., Ferreira, H., Carvalho, A., Figueroa, J. A. L., Zarmpas, P., Cunha, C., Akoumianaki, T., Stylianou, K., Deepe, G. S., Samonis, G., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0167-x · Cited by 96 · see citing works
Self-citationLi, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.685133 · Cited by 90 · see citing works
Denson, L. A., Jurickova, I., Karns, R. A., Shaw, K. A., Cutler, D. J., Okou, D. T., Dodd, A., Quinn, K., Mondal, K., Aronow, B. J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.02.016 · Cited by 89 · see citing works
Self-citationRoudbary, M., Kumar, S., Kumar, A., Černáková, L., Nikoomanesh, F., & Rodrigues, C. F. (2021) · Journal of Fungi · doi:10.3390/jof7090720 · Cited by 89 · see citing works
Staphylococcus aureus, phagocyte NADPH oxidase and chronic granulomatous disease
Buvelot, H., Posfay-Barbe, K. M., Linder, P., Schrenzel, J., & Krause, K. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw042 · Cited by 88 · see citing works
Autoinflammatory diseases: update on classification diagnosis and management
Pathak, S., McDermott, M., & Savic, S. (2016) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2016-203810 · Cited by 87 · see citing works
Antifungal innate immunity: recognition and inflammatory networks
Becker, K. L., Ifrim, D. C., Quintin, J., Netea, M. G., & van de Veerdonk, F. L. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0467-z · Cited by 86 · see citing works
Self-citationAutophagy and microbial pathogenesis
Keller, M. D., Torres, V. J., & Cadwell, K. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-019-0481-8 · Cited by 83 · see citing works
Symington, J., Wang, C., Twentyman, J., Owusu‐Boaitey, N., Schwendener, R. A., Núñez, G., Schilling, J. D., & Mysorekar, I. U. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.7 · Cited by 81 · see citing works
Webster, S. J., Brode, S., Ellis, L., Fitzmaurice, T. J., Elder, M. J., Gekara, N. O., Tourlomousis, P., Bryant, C. E., Clare, S., Chee, R., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006383 · Cited by 81 · see citing works
How neutrophil extracellular traps orchestrate the local immune response in gout
Maueröder, C., Kienhöfer, D., Hahn, J., Schauer, C., Manger, B., Schett, G. A., i, M. H., & Hoffmann, M. H. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1295-x · Cited by 81 · see citing works
Zhao, J., Sun, Y., Shi, P., Dong, J.-N., Zuo, L.-G., Wang, H.-G., Gong, J.-F., Li, Y., Gu, L.-L., Li, N., et al. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.03.033 · Cited by 80 · see citing works
Noninfectious Manifestations and Complications of Chronic Granulomatous Disease
Henrickson, S. E., Jongco, A. M., Thomsen, K. F., Garabedian, E., & Thomsen, I. P. (2018) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piy014 · Cited by 78 · see citing works
The cellular autophagy/apoptosis checkpoint during inflammation
Messer, J. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2403-y · Cited by 78 · see citing works
Weisser, M., Demel, U. M., Stein, S., Chen-Wichmann, L., Touzot, F., Santilli, G., Sujer, S., Brendel, C., Siler, U., Cavazzana, M., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.028 · Cited by 77 · see citing works
Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection
Zou, C., Ma, Y., Dai, L.-L., & Zhang, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405032111 · Cited by 76 · see citing works
Aspergillosis in Chronic Granulomatous Disease
King, J., Henriet, S., & Warris, A. (2016) · Journal of Fungi · doi:10.3390/jof2020015 · Cited by 76 · see citing works
Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease
Opipari, A. W., & Franchi, L. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000230 · Cited by 73 · see citing works
The Inflammasome and IL-1β: Implications for the Treatment of Inflammatory Diseases
Satoh, T. K., Otsuka, A., Contassot, E., & French, L. E. (2015) · Immunotherapy · doi:10.2217/imt.14.106 · Cited by 73 · see citing works
Primary immune deficiencies with defects in neutrophil function
Dinauer, M. C. (2016) · Hematology · doi:10.1182/asheducation-2016.1.43 · Cited by 71 · see citing works
Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease
Ke, P., Shao, B., Xu, Z., Chen, X., & Liu, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00695 · Cited by 71 · see citing works
The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus
Dewi, I., Van de Veerdonk, F., & Gresnigt, M. (2017) · Journal of Fungi · doi:10.3390/jof3040055 · Cited by 69 · see citing works
Self-citationCole, J., Aberdein, J., Jubrail, J., & Dockrell, D. H. (2014) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2014.08.004 · Cited by 69 · see citing works
Inflammatory consequences of inherited disorders affecting neutrophil function
Dinauer, M. C. (2019) · Blood · doi:10.1182/blood-2018-11-844563 · Cited by 69 · see citing works
Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1
Oikonomou, V., Moretti, S., Renga, G., Galosi, C., Borghi, M., Pariano, M., Puccetti, M., Palmerini, C. A., Amico, L., Carotti, A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.10.012 · Cited by 68 · see citing works
Self-citationAbdelaziz, D. H., Khalil, H., Cormet‐Boyaka, E., & Amer, A. O. (2015) · Immunological Reviews · doi:10.1111/imr.12288 · Cited by 68 · see citing works
Recent advances in chronic granulomatous disease
Anjani, G., Vignesh, P., Joshi, V., Shandilya, J. K., Bhattarai, D., Sharma, J., & Rawat, A. K. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.07.010 · Cited by 66 · see citing works
Marsh, R. A., Leiding, J. W., Logan, B. R., Griffith, L. M., Arnold, D. E., Haddad, É., Falcone, E. L., Yin, Z., Patel, K., Arbuckle, E. P., et al. (2019) · Journal of Clinical Immunology · doi:10.1007/s10875-019-00659-8 · Cited by 65 · see citing works
Tegtmeyer, D., Seidl, M., Gerner, P., Baumann, U., & Klemann, C. (2017) · Pediatric Allergy and Immunology · doi:10.1111/pai.12734 · Cited by 63 · see citing works
Galactosaminogalactan of<i>Aspergillus fumigatus</i>, a bioactive fungal polymer
Briard, B., Muszkieta, L., Latgé, J.-P., & Fontaine, T. (2016) · Mycologia · doi:10.3852/15-312 · Cited by 61 · see citing works
The DNA methylation profile of activated human natural killer cells
Wiencke, J. K., Butler, R. A., Hsuang, G., Eliot, M., Kim, S. H., Sepúlveda, M. A., Siegel, D., Houseman, E. A., & Kelsey, K. T. (2016) · Epigenetics · doi:10.1080/15592294.2016.1163454 · Cited by 61 · see citing works
Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
Akoumianaki, T., Vaporidi, K., Diamantaki, E., Pène, F., Beau, R., Gresnigt, M. S., Gkountzinopulou, M., Venichaki, M., Drakos, E., Benna, J. E., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.06.002 · Cited by 60 · see citing works
Self-citationHahn, K. J., Ho, N., Yockey, L., Kreuzberg, S. A., Daub, J. R., Rump, A., Marciano, B. E., Quezado, M., Malech, H. L., Holland, S. M., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.135 · Cited by 60 · see citing works
Impellizzeri, D., Siracusa, R., Cordaro, M., Peritore, A. F., Gugliandolo, E., Mancuso, G., Midiri, A., Paola, R. D., & Cuzzocrea, S. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.06.029 · Cited by 59 · see citing works
Sprenkeler, E. G. G., Gresnigt, M. S., & van de Veerdonk, F. L. (2016) · Cellular Microbiology · doi:10.1111/cmi.12616 · Cited by 59 · see citing works
Self-citationPathogen control at the intestinal mucosa – H2O2to the rescue
Knaus, U. G., Hertzberger, R. Y., Pîrcălăbioru, G. G., Yousefi, S. P. M., & dos Santos, F. B. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1279378 · Cited by 58 · see citing works
Shanmugam, N. K. N., Chen, K., & Cherayil, B. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.689190 · Cited by 57 · see citing works
Wang, F., Liu, J., Chen, X., Zheng, X., Qu, N., Zhang, B., & Xia, C. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1952-5 · Cited by 57 · see citing works
Septins restrict inflammation and protect zebrafish larvae from Shigella infection
Mazón, M. J., Willis, A. R., Torraca, V., Boucontet, L., Shenoy, A. R., Colucci‐Guyon, E., & Mostowy, S. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006467 · Cited by 55 · see citing works
Menacing Mold: Recent Advances in Aspergillus Pathogenesis and Host Defense
Tischler, B. Y., & Hohl, T. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.03.027 · Cited by 55 · see citing works
Song, Z., Huang, G., Paracatu, L. C., Grimes, D., Gu, J., Luke, C. J., Clemens, R. A., & Dinauer, M. C. (2020) · Blood · doi:10.1182/blood.2019003525 · Cited by 54 · see citing works
- Authors
- de Luca, A., Smeekens, S. P., Casagrande, A., Iannitti, R., Conway, K. L., Gresnigt, M. S., Begun, J., Plantinga, T. S., Joosten, L. A. B., van der Meer, J. W. M., Chamilos, G., Netea, M. G., Xavier, R. J., Dinarello, C. A., Romani, L., & van de Veerdonk, F. L.
- Affiliations
- Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy;
- Radboud University Medical Center (NL)
- University of Perugia (IT)
- Harvard University (US)
- Department of Medicine, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands;
- University of Crete (GR)
- Corresponding author
- Dinarello, Charles A.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-02-18
- Volume
- 111
- Issue
- 9
- Pages
- 3526-3531
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3948220
- OpenAlex
- W2153164696
- Cited by
- 313
- References
- 49
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 10 · 2023: 16 · 2022: 22 · 2021: 32 · 2020: 24 · 2019: 34 · 2018: 26 · 2017: 41 · 2016: 35 · 2015: 26 · 2014: 18
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Crohn's and Colitis Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI‑15614, AI-62773, R56AI015614, R01AI062773, R01AI015614)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083756, DK-60049, DK 83756, R01DK097485, DK 43351, R01DK060049, P30DK043351)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- chronic granulomatous disease, IL-1 receptor blockade, anakinra, autophagy, inflammasome activation, IL-1β, NADPH oxidase deficiency, colitis, invasive aspergillosis, macrophages, monocytes, neutrophil recruitment, Th17 response, reactive oxygen species
- MeSH terms
- Animals, Anti-Inflammatory Agents, Aspergillus fumigatus, Autophagy, Colitis, Enzyme-Linked Immunosorbent Assay, Granulomatous Disease, Chronic, Humans, Mice, Inbred C57BL, Mice, Mutant Strains, Microtubule-Associated Proteins, Phagosomes, Receptors, Interleukin-1, Statistics, Nonparametric, NADPH Oxidases, Mice, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review