Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo
Open accessAbstract
Stem cell therapies have enormous potential for treating many debilitating diseases, including heart failure, stroke and traumatic brain injury. For maximal efficacy, these therapies require targeted cell delivery to specific tissues followed by successful cell engraftment. However, targeted delivery remains an open challenge. As one example, it is common for intravenous deliveries of mesenchymal stem cells (MSCs) to become entrapped in lung microvasculature instead of the target tissue. Hence, a robust, quantitative imaging method would be essential for developing efficacious cell therapies. Here we show that Magnetic Particle Imaging (MPI), a novel technique that directly images iron-oxide nanoparticle-tagged cells, can longitudinally monitor and quantify MSC administration in vivo. MPI offers near-ideal image contrast, depth penetration, and robustness; these properties make MPI both ultra-sensitive and linearly quantitative. Here, we imaged, for the first time, the dynamic trafficking of intravenous MSC administrations using MPI. Our results indicate that labeled MSC injections are immediately entrapped in lung tissue and then clear to the liver within one day, whereas standard iron oxide particle (Resovist) injections are immediately taken up by liver and spleen. Longitudinal MPI-CT imaging also indicated a clearance half-life of MSC iron oxide labels in the liver at 4.6 days. Finally, our ex vivo MPI biodistribution measurements of iron in liver, spleen, heart, and lungs after injection showed excellent agreement (R(2) = 0.943) with measurements from induction coupled plasma spectrometry. These results demonstrate that MPI offers strong utility for noninvasively imaging and quantifying the systemic distribution of cell therapies and other therapeutic agents.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tomographic imaging using the nonlinear response of magnetic particles
Gleich, B., & Weizenecker, J. (2005) · Nature · doi:10.1038/nature03808 · Cited by 2,011 · see citing works
Looking and listening to light: the evolution of whole-body photonic imaging
Ntziachristos, V., Ripoll, J., Wang, L. V., & Weissleder, R. (2005) · Nature Biotechnology · doi:10.1038/nbt1074 · Cited by 1,557 · see citing works
Mesenchymal Stem Cell Homing: The Devil Is in the Details
Karp, J. M., & Leng Teo, G. S. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.02.001 · Cited by 1,445 · see citing works
Fischer, U. M., Harting, M. T., Jimenez, F., Monzon-Posadas, W. O., Xue, H., Savitz, S. I., Laine, G. A., & Cox, C. S. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0253 · Cited by 1,292 · see citing works
The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion
Gao, J., Dennis, J. E., Muzic, R. F., Lundberg, M., & Caplan, A. I. (2001) · Cells Tissues Organs · doi:10.1159/000047856 · Cited by 952 · see citing works
Gupta, N., Su, X., Popov, B. V., Lee, J. W., Serikov, V. B., & Matthay, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1855 · Cited by 931 · see citing works
Bone Marrow–Derived Mesenchymal Stem Cells in Repair of the Injured Lung
Rojas, M., Xu, J., Woods, C. R., Mora, A. L., Spears, W., Roman, J., & Brigham, K. L. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0330oc · Cited by 849 · see citing works
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830 · see citing works
Eggenhofer, E., Benseler, V., Kroemer, A., Popp, F. C., Geissler, E. K., Schlitt, H. J., Baan, C. C., Dahlke, M. H., & Hoogduijn, M. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00297 · Cited by 804 · see citing works
Schlomka, J., Roessl, E., Dorscheid, R., Dill, S., Martens, G., Istel, T., Bäumer, C., Herrmann, C., Steadman, R., Zeitler, G., et al. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/15/002 · Cited by 803 · see citing works
Stem Cells in the Treatment of Refractory Chronic Migraines
Mauskop, A., & Rothaus, K. O. (2017) · Case Reports in Neurology · doi:10.1159/000477393 · Cited by 794 · see citing works
Kidd, S. M., Spaeth, E. L., Dembinski, J. L., Dietrich, M. F., Watson, K., Klopp, A. H., Battula, V. L., Weil, M., Andreeff, M., & Marini, F. C. (2009) · Stem Cells · doi:10.1002/stem.187 · Cited by 680 · see citing works
Stem Cell Transplantation: The Lung Barrier
Schrepfer, S., Deuse, T., Reichenspurner, H. C., Fischbein, M. P., Robbins, R. C., & Pelletier, M. P. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.12.019 · Cited by 666 · see citing works
Reimer, P., & Balzer, T. (2003) · European Radiology · doi:10.1007/s00330-002-1721-7 · Cited by 614 · see citing works
Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction
Kraitchman, D. L., Tatsumi, M., Gilson, W. D., Ishimori, T., Kedziorek, D., Walczak, P., Segars, W. P., Chen, H. H., Fritzges, D., Izbudak, I., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.537480 · Cited by 602 · see citing works
Ra, J. C., Shin, I. S., Kim, S. H., Kang, S. K., Kang, B. C., Lee, H. Y., Kim, Y. J., Jo, J. Y., Yoon, E. J., Choi, H.-J., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2010.0466 · Cited by 580 · see citing works
Tracking immune cells in vivo using magnetic resonance imaging
Ahrens, E. T., & Bulte, J. W. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3531 · Cited by 488 · see citing works
The Life and Fate of Mesenchymal Stem Cells
Eggenhofer, E., Luk, F., Dahlke, M. H., & Hoogduijn, M. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00148 · Cited by 446 · see citing works
Goodwill, P. W., & Conolly, S. (2010) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2010.2052284 · Cited by 395 · see citing works
Targeted delivery of magnetic aerosol droplets to the lung
Dames, P., Gleich, B., Flemmer, A. W., Hajek, K., Seidl, N., Wiekhorst, F., Eberbeck, D., Bittmann, I., Bergemann, C., Weyh, T., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.217 · Cited by 382 · see citing works
Nanoparticle contrast agents for computed tomography: a focus on micelles
Cormode, D. P., Naha, P. C., & Fayad, Z. A. (2014) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.1551 · Cited by 368 · see citing works
Signal encoding in magnetic particle imaging: properties of the system function
Rahmer, J., Weizenecker, J., Gleich, B., & Borgert, J. (2009) · BMC Medical Imaging · doi:10.1186/1471-2342-9-4 · Cited by 345 · see citing works
Multidimensional X-Space Magnetic Particle Imaging
Goodwill, P. W., & Conolly, S. (2011) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2011.2125982 · Cited by 320 · see citing works
Magnetic Particle Imaging (MPI) for NMR and MRI researchers
Sarıtaş, E. Ü., Goodwill, P. W., Croft, L. R., Konkle, J., Lu, K., Zheng, B., & Conolly, S. (2012) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2012.11.029 · Cited by 308 · see citing works
Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer
Nehmeh, S. A., Erdi, Y. E., Ling, C., Rosenzweig, K., Squire, O. D., Braban, L. E., Ford, E., Sidhu, K., Mageras, G. S., Larson, S. M., et al. (2002) · Medical Physics · doi:10.1118/1.1448824 · Cited by 297 · see citing works
Zheng, B., Vazin, T., Goodwill, P. W., Conway, A., Verma, A., Ulku Saritas, E., Schaffer, D., & Conolly, S. M. (2015) · Scientific Reports · doi:10.1038/srep14055 · Cited by 274 · see citing works
Self-citationIntravenous mesenchymal stem cell therapy for traumatic brain injury
Harting, M. T., Jiménez, F., Xue, H., Fischer, U. M., Baumgartner, J. E., Dash, P. K., & Cox, C. S. (2009) · Journal of neurosurgery · doi:10.3171/2008.9.jns08158 · Cited by 272 · see citing works
Stem Cell Imaging: From Bench to Bedside
Nguyen, P. K. P., Riegler, J., & Wu, J. C. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.03.009 · Cited by 232 · see citing works
Bos, C., Delmas, Y., Desmoulière, A., Solanilla, A., Hauger, O., Grosset, C. F., Dubus, I., Ivanović, Z., Rosenbaum, J., Charbord, P., et al. (2004) · Radiology · doi:10.1148/radiol.2333031714 · Cited by 232 · see citing works
Sarkar, D., Spencer, J. A., Phillips, J. A., Zhao, W., Schäfer, S., Spelke, D. P., Mortensen, L. J., Ruíz, J. P., Vemula, P. K., Sridharan, R., et al. (2011) · Blood · doi:10.1182/blood-2010-10-311464 · Cited by 227 · see citing works
Magnetic particle imaging with tailored iron oxide nanoparticle tracers
Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Arami, H., Saritas, E. U., Croft, L. R., Konkle, J., Goodwill, P. W., Halkola, A., Rahmer, J., et al. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2014.2375065 · Cited by 222 · see citing works
The Size of Mesenchymal Stem Cells is a Significant Cause of Vascular Obstructions and Stroke
Ge, J., Guo, L., Wang, S., Zhang, Y., Cai, T., Zhao, R. C. H., & Wu, Y. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9492-x · Cited by 218 · see citing works
Projection X-Space Magnetic Particle Imaging
Goodwill, P. W., Konkle, J., Zheng, B., Sarıtaş, E. Ü., & Conolly, S. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2185247 · Cited by 186 · see citing works
First experimental evidence of the feasibility of multi-color magnetic particle imaging
Rahmer, J., Halkola, A., Gleich, B., Schmale, I., & Borgert, J. (2015) · Physics in Medicine and Biology · doi:10.1088/0031-9155/60/5/1775 · Cited by 172 · see citing works
McNeil, B. J. (1976) · PubMed · Cited by 161 · see citing works
Mailänder, V., Lorenz, M. R., Holzapfel, V., Musyanovych, A., Fuchs, K., Wiesneth, M., Walther, P., Landfester, K., & Schrezenmeier, H. (2008) · Molecular Imaging and Biology · doi:10.1007/s11307-007-0130-3 · Cited by 140 · see citing works
The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium
Wu, Y., & Zhao, R. C. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9293-z · Cited by 140 · see citing works
Relaxation in X-Space Magnetic Particle Imaging
Croft, L. R., Goodwill, P. W., & Conolly, S. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2217979 · Cited by 127 · see citing works
Hsiao, J., Tai, M., Chu, H., Chen, S., Li, H., Lai, D., Hsieh, S., Wang, J., & Liu, H. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21377 · Cited by 126 · see citing works
Mesenchymal Stem Cells Induce an Inflammatory Response After Intravenous Infusion
Hoogduijn, M. J., Rhijn, M. R.-V., Engela, A. U., Korevaar, S. S., Mensah, F., Franquesa, M., de Bruin, R. W. F., Betjes, M. G. H., Weimar, W., & Baan, C. C. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0193 · Cited by 121 · see citing works
Schäfer, R., Kehlbach, R., Wiskirchen, J., Bantleon, R., Pintaske, J., Brehm, B. R., Gerber, A., Wolburg, H., Claussen, C. D., & Northoff, H. (2007) · Radiology · doi:10.1148/radiol.2442060599 · Cited by 110 · see citing works
Linearity and Shift Invariance for Quantitative Magnetic Particle Imaging
Lu, K., Goodwill, P. W., Sarıtaş, E. Ü., Zheng, B., & Conolly, S. (2013) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2013.2257177 · Cited by 103 · see citing works
Daldrup-Link, H. E., Rudelius, M., Metz, S., Piontek, G., Pichler, B. J., Settles, M., Heinzmann, U., Schlegel, J., Oostendorp, R. A. J., & Rummeny, E. (2004) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1484-2 · Cited by 91 · see citing works
Projection Reconstruction Magnetic Particle Imaging
Konkle, J., Goodwill, P. W., Carrasco‐Zevallos, O. M., & Conolly, S. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2227121 · Cited by 83 · see citing works
Kim, H. S., Oh, S. Y., Joo, H. J., Son, K.-R., Song, I. C., & Moon, W. K. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1487 · Cited by 70 · see citing works
Vandsburger, M. H., Radoul, M., Cohen, B., & Neeman, M. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2869 · Cited by 68 · see citing works
Application of Magnetic Particle Imaging to Pulmonary Imaging Using Nebulized Magnetic Nanoparticles
Nishimoto, K., Mimura, A., Aoki, M., Banura, N., & Murase, K. (2015) · Open Journal of Medical Imaging · doi:10.4236/ojmi.2015.52008 · Cited by 50 · see citing works
Skopalík, J., Poláková, K., Havrdová, M., Justan, I., Magro, M., Milde, D., Knopfová, L., Šmarda, J., Polakova, H., Gabrielová, E., et al. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s66986 · Cited by 40 · see citing works
Preliminary experimental X-space color MPI
Hensley, D. W., Goodwill, P. W., Croft, L., & Conolly, S. (2015) · International Workshop on Magnetic Particle Imaging · doi:10.1109/iwmpi.2015.7106993 · Cited by 31 · see citing works
Hitchens, T. K., Liu, L., Foley, L. M., Simplăceanu, V., Ahrens, E. T., & Ho, C. (2014) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25120 · Cited by 24 · see citing works
Grabtchak, S., Montgomery, L., & Whelan, W. M. (2014) · Physics in Medicine and Biology · doi:10.1088/0031-9155/59/10/2431 · Cited by 13 · see citing works
A custom low-noise preamplifier for Magnetic Particle Imaging
Zhang, W., Zheng, B., Goodwill, P. W., & Conolly, S. (2015) · International Workshop on Magnetic Particle Imaging · doi:10.1109/iwmpi.2015.7107027 · Cited by 8 · see citing works
Preliminary characterization of a laminated iron-core 6.3 T/m FFL magnet
Yu, E. Y., Goodwill, P. W., & Conolly, S. (2015) · International Workshop on Magnetic Particle Imaging · doi:10.1109/iwmpi.2015.7107023 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,076 · see citing works
Tay, Z. W., Chandrasekharan, P., Chiu-Lam, A., Hensley, D. W., Dhavalikar, R., Zhou, X. Y., Yu, E. Y., Goodwill, P. W., Zheng, B., Rinaldi, C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00893 · Cited by 459 · see citing works
Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection
Yu, E. Y., Bishop, M. D., Zheng, B., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Goodwill, P. W., & Conolly, S. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04865 · Cited by 371 · see citing works
Israel, L. L., Galstyan, A., Holler, E., & Ljubimova, J. Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.009 · Cited by 337 · see citing works
“Another study used quantitative MPI to monitor transplantation, bio-distribution, and clearance of ferucarbotran-labelled human stem cells in vivo [151].”
BackgroundEngineering applications of ferrofluids: A review
Kole, M., & Khandekar, S. (2021) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2021.168222 · Cited by 287 · see citing works
Song, G., Kenney, M. J., Chen, Y., Zheng, X., Deng, Y., Chen, Z., Wang, S. X., Gambhir, S. S., Dai, H., & Rao, J. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0506-0 · Cited by 263 · see citing works
Du, Y., Liu, X., Liang, Q. Y., Liang, X., & Tian, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00630 · Cited by 261 · see citing works
Song, G., Chen, M., Zhang, Y., Cui, L., Qu, H., Zheng, X., Wintermark, M., Liu, Z., & Rao, J. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03829 · Cited by 257 · see citing works
Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications
Mosayebi, J., Kiyasatfar, M., & Laurent, S. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700306 · Cited by 244 · see citing works
Magnetic particle imaging: from proof of principle to preclinical applications
Knopp, T., Gdaniec, N., & Möddel, M. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa6c99 · Cited by 239 · see citing works
Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends
Stueber, D. D., Villanova, J., Aponte, I., Xiao, Z., & Colvin, V. L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070943 · Cited by 227 · see citing works
Magnetic Particle Imaging for Real-Time Perfusion Imaging in Acute Stroke
Ludewig, P., Gdaniec, N., Sedlacik, J., Forkert, N. D., Szwargulski, P., Graeser, M., Adam, G., Kaul, M. G., Krishnan, K. M., Ferguson, R. M., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b05784 · Cited by 225 · see citing works
High-performance iron oxide nanoparticles for magnetic particle imaging – guided hyperthermia (hMPI)
Bauer, L. M., Situ, S. F., Griswold, M. A., & Samia, A. C. S. (2016) · Nanoscale · doi:10.1039/c6nr01877g · Cited by 221 · see citing works
A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging
Wu, L. C., Zhang, Y., Steinberg, G. K., Qu, H., Huang, S., Cheng, M., Bliss, T. M., Du, F., Rao, J., Song, G., et al. (2019) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5896 · Cited by 208 · see citing works
“Prototype scanners and, more recently, commercial animal scanners have yielded the first in vivo MPI studies demonstrating applications in vascular imaging,(2-4) oncology,(5-7) and cell-tracking.(8,9) Human scanners”
BackgroundMethodSuperparamagnetic iron oxides as MPI tracers: A primer and review of early applications
Bulte, J. W. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.007 · Cited by 204 · see citing works
“Systemically injected SPIO-labeled MSCs initially became entrapped within the lung vasculature, and then redistributed within one day to the liver and spleen (Figure 4)[21], which is a typical distribution pattern previously observed with single photon emission computed tomography (SPECT) of intravenously injected 111…”
BackgroundChandrasekharan, P., Tay, Z. W., Hensley, D. W., Zhou, X. Y., Fung, B. K., Colson, C., Lu, Y., Fellows, B. D., Huynh, Q., Saayujya, C., et al. (2020) · Theranostics · doi:10.7150/thno.40858 · Cited by 197 · see citing works
“MPI is reported to have the highest therapeutic cell tracking sensitivity of all positive-contrast imaging techniques, with a detection limit of 200 labeled cells [22].”
BackgroundIn vivo Biodistribution and Clearance of Magnetic Iron Oxide Nanoparticles for Medical Applications
Nowak‐Jary, J., & Machnicka, B. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s415063 · Cited by 181 · see citing works
Wang, Q., Ma, X., Liao, H., Liang, Z., Li, F., Tian, J., & Ling, D. (2020) · ACS Nano · doi:10.1021/acsnano.9b08660 · Cited by 167 · see citing works
Yu, E. Y., Chandrasekharan, P., Berzon, R., Tay, Z. W., Zhou, X. Y., Khandhar, A. P., Ferguson, R. M., Kemp, S. J., Zheng, B., Goodwill, P. W., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04844 · Cited by 161 · see citing works
“MPI is linearly quantitative and highly sensitive, detecting nanograms of iron (200 labeled cells) per voxel, which is equivalent to 130 nM.(23,24) As a comparison, the”
BackgroundEngineering of magnetic nanoparticles as magnetic particle imaging tracers
Lu, C., Han, L., Wang, J., Wan, J., Song, G., & Rao, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00260g · Cited by 154 · see citing works
Tomographic magnetic particle imaging of cancer targeted nanoparticles
Arami, H., Teeman, E., Troksa, A., Bradshaw, H., Saatchi, K., Tomitaka, A., Gambhir, S. S., Häfeli, U. O., Liggitt, D., & Krishnan, K. M. (2017) · Nanoscale · doi:10.1039/c7nr05502a · Cited by 148 · see citing works
In vivo imaging of nanoparticle-labeled CAR T cells
Kiru, L., Zlitni, A., Tousley, A. M., Dalton, G. N., Wu, W. E., Lafortune, F., Liu, A., Cunanan, K. M., Nejadnik, H., Sulchek, T., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102363119 · Cited by 152 · see citing works
“Ferumoxytol nanoparticles can also be detected with magnetic particle imaging (MPI), which provides high target to background contrast (29) and quantitative measurements (30).”
Combining magnetic particle imaging and magnetic fluid hyperthermia in a theranostic platform
Hensley, D. W., Tay, Z. W., Dhavalikar, R., Zheng, B., Goodwill, P. W., Rinaldi, C., & Conolly, S. (2016) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5601 · Cited by 149 · see citing works
Tong, W., Hui, H., Shang, W., Zhang, Y., Tian, F., Ma, Q., Yang, X., Tian, J., & Chen, Y. (2020) · Theranostics · doi:10.7150/thno.49812 · Cited by 133 · see citing works
“MPI has been utilized in various biomedical studies, including in cancer detection [39], stem cell imaging [43], exosome tracking [45], lung perfusion imaging [46, 47], and guidance of”
Magnetic Particle Imaging: Current Applications in Biomedical Research
Talebloo, N., Gudi, M., Robertson, N., & Wang, P. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26875 · Cited by 132 · see citing works
“Figure 2 shows a comparison between signal attenuation in fluorescence imaging and MPI that demonstrates MPI’s unlimited signal penetration capacity of MPI.8 PET and SPECT do not have the limitation of signal attenuation with depth.”
BackgroundMethodInfluentialClinical Tracking of Cell Transfer and Cell Transplantation: Trials and Tribulations
Bulte, J. W. M., & Daldrup-Link, H. E. (2018) · Radiology · doi:10.1148/radiol.2018180449 · Cited by 129 · see citing works
Zhou, X. Y., Tay, Z. W., Chandrasekharan, P., Yu, E. Y., Hensley, D. W., Orendorff, R. D., Jeffris, K. E., Mai, D., Zheng, B., Goodwill, P. W., et al. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.04.014 · Cited by 128 · see citing works
Biosynthesis of magnetic nanoparticles from nano-degradation products revealed in human stem cells
de Walle, A. V., Sangnier, A. P., Abou‐Hassan, A., Curcio, A., Hémadi, M., Menguy, N., Lalatonne, Y., Luciani, N., & Wilhelm, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816792116 · Cited by 126 · see citing works
First in vivo magnetic particle imaging of lung perfusion in rats
Zhou, X. Y., Jeffris, K. E., Yu, E. Y., Zheng, B., Goodwill, P. W., Nahid, P., & Conolly, S. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa616c · Cited by 124 · see citing works
Tracking adoptive T cell immunotherapy using magnetic particle imaging
Rivera‐Rodriguez, A., Hoang-Minh, L., Chiu‐Lam, A., Sarna, N. S., Marrero‐Morales, L., Mitchell, D. A., & Rinaldi, C. (2021) · Nanotheranostics · doi:10.7150/ntno.55165 · Cited by 119 · see citing works
Tay, Z. W., Chandrasekharan, P., Zhou, X. Y., Yu, E. Y., Zheng, B., & Conolly, S. (2018) · Theranostics · doi:10.7150/thno.26608 · Cited by 115 · see citing works
“standard deviation using a calibration curve as previously described in prior MPI studies from our group [18,51].”
BackgroundMethodTay, Z. W., Savliwala, S., Hensley, D. W., Fung, B. K., Colson, C., Fellows, B. D., Zhou, X. Y., Huynh, Q., Lu, Y., Zheng, B., et al. (2021) · Small Methods · doi:10.1002/smtd.202100796 · Cited by 116 · see citing works
The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
Zhao, K., & Liu, Q. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0276-z · Cited by 114 · see citing works
The future of mesenchymal stem cell-based therapeutic approaches for cancer – From cells to ghosts
Mohr, A., & Zwacka, R. M. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.025 · Cited by 114 · see citing works
Zhang, B., Yan, W., Zhu, Y., Yang, W., Le, W., Chen, B., Zhu, R., & Cheng, L. (2018) · Advanced Materials · doi:10.1002/adma.201705694 · Cited by 113 · see citing works
Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles
Abdollah, M. R. A., Carter, T. J., Jones, C. L., Kalber, T. L., Rajkumar, V. S., Tolner, B., Gruettner, C., Thin, M. Z., Torres, J. B., Ellis, M. J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b06734 · Cited by 113 · see citing works
Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges
Shan, Y., Zhang, M., Tao, E., Wang, J., Wei, N., Lü, Y., Liu, Q., Hao, K., Zhou, F., & Wang, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01936-8 · Cited by 123 · see citing works
First in vivo traumatic brain injury imaging via magnetic particle imaging
Orendorff, R. D., Peck, A. J., Zheng, B., Shirazi, S. N., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Goodwill, P. W., Krishnan, K. M., Brooks, G. A., et al. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa52ad · Cited by 111 · see citing works
Billings, C., Langley, M., Warrington, G., Mashali, F., & Johnson, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147651 · Cited by 106 · see citing works
“[74] demonstrated the ability to quantitatively track SPIOlabeled human mesenchymal stem cells (hMSCs) administered intravenously in a rat model utilizing MPI and CT.”
BackgroundKota, D. J., Prabhakara, K. S., Furman, N. E. T., Bhattarai, D., Chen, Q., DiCarlo, B., Smith, P., Triolo, F., Wenzel, P. L., Cox, C. S., et al. (2017) · Stem Cells · doi:10.1002/stem.2603 · Cited by 105 · see citing works
Tay, Z. W., Hensley, D. W., Vreeland, E. C., Zheng, B., & Conolly, S. (2017) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/aa6ab6 · Cited by 104 · see citing works
Harvell-Smith, S., Tung, L. D., & Thanh, N. T. K. (2021) · Nanoscale · doi:10.1039/d1nr05670k · Cited by 96 · see citing works
Kratz, H., Taupitz, M., Ariza de Schellenberger, A., Kosch, O., Eberbeck, D., Wagner, S., Trahms, L., Hamm, B., & Schnorr, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190214 · Cited by 92 · see citing works
Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells
Lemaster, J. E., Chen, F., Kim, T., Hariri, A., & Jokerst, J. V. (2018) · ACS Applied Nano Materials · doi:10.1021/acsanm.8b00063 · Cited by 89 · see citing works
Nanoparticle-based Cell Trackers for Biomedical Applications
Ni, J., Li, Y., Yue, W., Liu, B., & Li, K. (2020) · Theranostics · doi:10.7150/thno.39915 · Cited by 87 · see citing works
“used MPI technique to dynamically monitor and quantify the biodistribution of human mesenchymal stem cells (hMSCs) labeled by SPIONs (Figure 3) [47].”
MethodRahmer, J., Wirtz, D., Bontus, C., Borgert, J., & Gleich, B. (2017) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2017.2679099 · Cited by 86 · see citing works
Tay, Z. W., Chandrasekharan, P., Fellows, B. D., Rodrigo, I., Yu, E. Y., Olivo, M., & Conolly, S. (2021) · Cancers · doi:10.3390/cancers13215285 · Cited by 84 · see citing works
“2016 [8]—Comparison of MRI SPION contrast to MPI”
BackgroundA Perspective on Cell Tracking with Magnetic Particle Imaging
Sehl, O. C., Gevaert, J. J., Melo, K. P., Knier, N. N., & Foster, P. J. (2020) · Tomography · doi:10.18383/j.tom.2020.00043 · Cited by 79 · see citing works
“When SPION-labeled cells undergo apoptosis in vivo, they are taken up by phagocytes for clearance by the liver (5, 38).”
BackgroundKeselman, P., Yu, E. Y., Zhou, X. Y., Goodwill, P. W., Chandrasekharan, P., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Zheng, B., et al. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5f48 · Cited by 78 · see citing works
Pulsed Excitation in Magnetic Particle Imaging
Tay, Z. W., Hensley, D. W., Ma, J., Chandrasekharan, P., Zheng, B., Goodwill, P. W., & Conolly, S. (2019) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2019.2898202 · Cited by 77 · see citing works
“MAGNETIC particle imaging (MPI) is an emerging molecular imaging modality first described by Gleich and Weizenecker in 2005 [1] with applications in areas such as stem cell tracking [2], cancer imaging [3], gut bleed detection [4], lung imaging [5], [6], and stroke detection [7].”
Tay, Z. W., Goodwill, P. W., Hensley, D. W., Taylor, L. A., Zheng, B., & Conolly, S. (2016) · Scientific Reports · doi:10.1038/srep34180 · Cited by 76 · see citing works
Long circulating tracer tailored for magnetic particle imaging
Liu, S., Chiu‐Lam, A., Rivera‐Rodriguez, A., DeGroff, R., Savliwala, S., Sarna, N. S., & Rinaldi, C. (2021) · Nanotheranostics · doi:10.7150/ntno.58548 · Cited by 73 · see citing works
“In addition, because SPIONs can be used to label cells and other biomaterials, MPI has tremendous potential for applications such as cell tracking [3], nanoparticle drug delivery [4], image-guided procedures [5], monitoring tissue regeneration scaffolds [6], monitoring the brain [7], and blood pool imaging [8, 9].”
BackgroundCellular uptake of magnetic nanoparticles imaged and quantified by magnetic particle imaging
Paysen, H., Löwa, N., Stach, A., Wells, J., Kosch, O., Twamley, S., Makowski, M. R., Schaeffter, T., Ludwig, A., & Wiekhorst, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-58853-3 · Cited by 73 · see citing works
Lu, Y., Rivera‐Rodriguez, A., Tay, Z. W., Hensley, D. W., Fung, B. K., Colson, C., Saayujya, C., Huynh, Q., Kabuli, L., Fellows, B. D., et al. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2020.1853252 · Cited by 71 · see citing works
“MPI has demonstrated promise for applications such as angiography [32,33], stem cell tracking [34 – 36], brain perfusion [37,38], lung perfusion [39], lung ventilation [40,41], cancer imaging [42], gut bleed detection [43], remote magnetic actuation and magnetic catheter steering and guidance [44 –…”
Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration
Top, C. B., & Güngör, A. (2020) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2020.3014197 · Cited by 70 · see citing works
Relaxation-based viscosity mapping for magnetic particle imaging
Ütkür, M., Muslu, Y., & Sarıtaş, E. Ü. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/62/9/3422 · Cited by 69 · see citing works
The Applications of Magnetic Particle Imaging: From Cell to Body
Han, X. H., Li, Y., Liu, W., Chen, X., Song, Z., Wang, X., Deng, Y., Tang, X., & Jiang, Z. (2020) · Diagnostics · doi:10.3390/diagnostics10100800 · Cited by 68 · see citing works
Design analysis of an MPI human functional brain scanner
Mason, E. E., Cooley, C. Z., Cauley, S., Griswold, M. A., Conolly, S., & Wald, L. L. (2016) · International journal on magnetic particle imaging · doi:10.18416/ijmpi.2017.1703008 · Cited by 68 · see citing works
“The MPI literature contains sensitivity estimates for rodent scanners as sensitive as 1 pg Fe with high frequency detection, which corresponds to about 50 pg at a conventional (75 kHz) detection frequency [10] although actual animal imagers have not achieved this sensitivity [11, 12].”
BackgroundFerumoxytol Can Be Used for Quantitative Magnetic Particle Imaging of Transplanted Stem Cells
Nejadnik, H., Pandit, P., Lenkov, O. D., Lahiji, A. P., Yerneni, K., & Daldrup-Link, H. E. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1276-x · Cited by 67 · see citing works
Microwave-Driven Synthesis of Iron-Oxide Nanoparticles for Molecular Imaging
Fernández‐Barahona, I., Muñoz-Hernando, M., & Herranz, F. (2019) · Molecules · doi:10.3390/molecules24071224 · Cited by 66 · see citing works
“i particle imaging (MPI) image adapted with permission from Referenc [22].”
BackgroundMethodInfluentialJiang, Z., Han, X., Du, Y., Li, Y., Li, Y., Li, J., Tian, J., & Wu, A. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04455 · Cited by 66 · see citing works
Chandrasekharan, P., Tay, Z. W., Zhou, X. Y., Yu, E. Y., Orendorff, R. D., Hensley, D. W., Huynh, Q., Fung, B. K., Colson, C., Goodwill, P. W., et al. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180326 · Cited by 67 · see citing works
Wang, P., Goodwill, P., Pandit, P., Gaudet, J., Ross, A. W., Wang, J., Yu, E. Y., Hensley, D., Doyle, T. C., Contag, C., et al. (2018) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2018.02.06 · Cited by 59 · see citing works
Magnetic nanoparticles for magnetic particle imaging (MPI): design and applications
Rezaei, B., Tay, Z. W., Mostufa, S., Manzari, O. N., Azizi, E., Ciannella, S., Moni, H., Li, C., Zeng, M., Gómez‐Pastora, J., et al. (2024) · Nanoscale · doi:10.1039/d4nr01195c · Cited by 62 · see citing works
Stem Cell Tracking Technologies for Neurological Regenerative Medicine Purposes
Zheng, Y., Huang, J., Zhu, T., Li, R., Wang, Z., Ma, F., & Zhu, J. (2017) · Stem Cells International · doi:10.1155/2017/2934149 · Cited by 59 · see citing works
“As the SPIO tracers are detected directly with MPI, their quantification is simple and straightforward [21].”
BackgroundChallenges in the development of nanoparticle‐based imaging agents: Characterization and biology
Crist, R. M., Dasa, S. S. K., Liu, C. H., Clogston, J. D., Dobrovolskaia, M. A., & Stern, S. T. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1665 · Cited by 62 · see citing works
Jia, Y., Zhang, P., Sun, Y., Kang, Q., Xu, J., Zhang, C., & Chai, Y. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102040 · Cited by 59 · see citing works
Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality
Xie, X., Zhai, J., Zhou, X., Guo, Z., Lo, P., Zhu, G., Chan, K. W. Y., & Yang, M. (2023) · Advanced Materials · doi:10.1002/adma.202306450 · Cited by 57 · see citing works
Applications of Magnetic Particle Imaging in Biomedicine: Advancements and Prospects
Yang, X., Shao, G., Zhang, Y., Wang, W., Qi, Y., Han, S., & Li, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.898426 · Cited by 56 · see citing works
Franke, J., Baxan, N., Lehr, H., Heinen, U., Reinartz, S. D., Schnorr, J., Heidenreich, M., Kiessling, F. M., & Schulz, V. (2020) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2020.3017160 · Cited by 54 · see citing works
“First approaches to use MPI as a functional and molecular imaging modality have been presented in [8], [9].”
BackgroundMethodTomitaka, A., Ota, S., Nishimoto, K., Arami, H., Takemura, Y., & Nair, M. (2019) · Nanoscale · doi:10.1039/c9nr00242a · Cited by 54 · see citing works
Mason, E. E., Mattingly, E., Herb, K., Śliwiak, M., Franconi, S., Cooley, C. Z., Slanetz, P. J., & Wald, L. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-92644-8 · Cited by 53 · see citing works
Magnetic particle imaging in vascular medicine
Bakenecker, A. C., Ahlborg, M., Debbeler, C., Kaethner, C., Buzug, T. M., & Lüdtke‐Buzug, K. (2018) · Innovative Surgical Sciences · doi:10.1515/iss-2018-2026 · Cited by 53 · see citing works
3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice
Deng, J., Li, M., Meng, F., Liu, Z., Wang, S., Zhang, Y., Li, M., Li, Z., Zhang, L., & Tang, P. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04398-w · Cited by 52 · see citing works
“When digested into single cells, they were of smaller cell size, which might be of particular significance as this characteristic would be conducive to significant decrease in lung entrapment after intravenous infusion of cells suspension [57, 58].”
BackgroundEtemadi, H., Buchanan, J. K., Kandile, N. G., & Plieger, P. G. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00938 · Cited by 52 · see citing works
Sehl, O. C., & Foster, P. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-01642-3 · Cited by 51 · see citing works
Calibration-Free Relaxation-Based Multi-Color Magnetic Particle Imaging
Muslu, Y., Ütkür, M., Demirel, Ö. B., & Sarıtaş, E. Ü. (2018) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2018.2818261 · Cited by 51 · see citing works
“Hence, low-frequency focus fields are used to shift the FFP to regions that cannot be covered with the small FOV due to the drive field alone [13]–[15].”
BackgroundBuchholz, O., Sajjamark, K., Franke, J., Wei, H., Behrends, A., Münkel, C., Grüttner, C., LeVan, P., von Elverfeldt, D., Graeser, M., et al. (2023) · Theranostics · doi:10.7150/thno.86759 · Cited by 50 · see citing works
“S (starch coating); -CLD-redF (dextran coated and fluorescently labeled)) [15,36,38].”
BackgroundJacinto, C., Javed, Y., Lavorato, G. C., Tárraga, W. A., Conde, B. I. C., Henao, J. M. O., Picco, A. S., Garcia, J., Dias, C. S. B., Malik, S., et al. (2025) · Nanoscale Advances · doi:10.1039/d5na00195a · Cited by 54 · see citing works
Masterson, C. H., Curley, G. F., & Laffey, J. G. (2019) · Intensive Care Medicine Experimental · doi:10.1186/s40635-019-0235-4 · Cited by 51 · see citing works
Kaul, M. G., Mummert, T., Jung, C., Salamon, J., Khandhar, A. P., Ferguson, R. M., Kemp, S. J., Ittrich, H., Krishnan, K. M., Adam, G., et al. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5780 · Cited by 49 · see citing works
Tale of Two Magnets: An Advanced Magnetic Targeting System
Zhou, Z., Shen, Z., & Chen, X. S. (2019) · ACS Nano · doi:10.1021/acsnano.9b06842 · Cited by 49 · see citing works
Magnetic nanoparticles in theranostic applications
Coene, A., & Leliaert, J. (2022) · Journal of Applied Physics · doi:10.1063/5.0085202 · Cited by 48 · see citing works
In Vivo Tracking of Tissue Engineered Constructs
Gil, C. J., Tomov, M. L., Theus, A. S., Cetnar, A. C., Mahmoudi, M., & Serpooshan, V. (2019) · Micromachines · doi:10.3390/mi10070474 · Cited by 47 · see citing works
Salamon, J., Dieckhoff, J., Kaul, M. G., Jung, C., Adam, G., Möddel, M., Knopp, T., Draack, S., Ludwig, F., & Ittrich, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-64280-1 · Cited by 47 · see citing works
Barzegar, M., Wang, Y., Eshaq, R. S., Yun, J. W., Boyer, C. J., Cananzi, S. G., White, L. A., Chernyshev, O. Y., Kelley, R. E., Minagar, A., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103161 · Cited by 47 · see citing works
“Although we could not identify a final destination of injected hPMSCs, the spleen and lungs are possible additional end points [70,72].”
BackgroundChandrasekharan, P., Fung, B. K., Zhou, X. Y., Cui, W., Colson, C., Mai, D., Jeffris, K. E., Huynh, Q., Saayujya, C., Kabuli, L., et al. (2021) · Nanotheranostics · doi:10.7150/ntno.50721 · Cited by 47 · see citing works
“This has allowed for MPI studies that track SPIO-labeled stem cells for over ~87 days to monitor the long-term fate of therapeutic cells [15, 16].”
BackgroundBiomedical applications of magnetosomes: State of the art and perspectives
Ren, G., Zhou, X., Long, R., Xie, M., Kankala, R. K., Wang, S., Zhang, Y. S., & Liu, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.04.025 · Cited by 46 · see citing works
Magnetic particle imaging performance of liposomes encapsulating iron oxide nanoparticles
Rost, N. C. V., Sen, K., Savliwala, S., Singh, I., Liu, S., Unni, M., Raniero, L. J., & Rinaldi, C. (2020) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2020.166675 · Cited by 46 · see citing works
Huang, R.-Y., Lin, Y.-H., Lin, S.-Y., Li, Y., Chiang, C., & Chang, C. (2019) · Theranostics · doi:10.7150/thno.29326 · Cited by 45 · see citing works
Fast System Calibration With Coded Calibration Scenes for Magnetic Particle Imaging
İlbey, S., Top, C. B., Güngör, A., Çukur, T., Sarıtaş, E. Ü., & Güven, H. E. (2019) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2019.2896289 · Cited by 43 · see citing works
Chuang, C.-C., Chen, Y.-N., Wang, Y., Huang, Y.-C., Lin, S.-Y., Huang, R.-Y., Jang, Y.-Y., Yang, C.-C., Huang, Y., & Chang, C. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c03446 · Cited by 43 · see citing works
Magnetic nanoparticles and magnetic particle spectroscopy-based bioassays: a 15 year recap
Wu, K., Liu, J., Chugh, V. K., Liang, S. A., Saha, R., Krishna, V. D., Cheeran, M. C. ‐., & Wang, J. (2022) · Nano Futures · doi:10.1088/2399-1984/ac5cd1 · Cited by 43 · see citing works
“Nowadays, both prototypes and commercial MPI scanners have been reported for in vivo applications in vascular imaging [211–213], oncology [214–217], cell-tracking [211, 218–221], etc.”
Joint Reconstruction of Tracer Distribution and Background in Magnetic Particle Imaging
Straub, M., & Schulz, V. (2018) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2017.2777878 · Cited by 42 · see citing works
“long-term cell tracking [3], [4], lung perfusion [5] and cancer”
BackgroundVisualizing tumour self-homing with magnetic particle imaging
Parkins, K. M., Melo, K. P., Chen, Y., Ronald, J. A., & Foster, P. J. (2021) · Nanoscale · doi:10.1039/d0nr07983a · Cited by 40 · see citing works
Iron Oxide Nanoparticles as Theranostic Agents in Cancer Immunotherapy
Canese, R., Vurro, F., & Marzola, P. (2021) · Nanomaterials · doi:10.3390/nano11081950 · Cited by 40 · see citing works
Sun, A., Hayat, H., Liu, S., Tull, E., Bishop, J. O., Dwan, B. F., Gudi, M., Talebloo, N., Dizon, J. R., Li, W., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.704483 · Cited by 40 · see citing works
Seeing SPIOs Directly In Vivo with Magnetic Particle Imaging
Zheng, B., Yu, E. Y., Orendorff, R. D., Lu, K., Konkle, J., Tay, Z. W., Hensley, D. W., Zhou, X. Y., Chandrasekharan, P., Sarıtaş, E. Ü., et al. (2017) · Molecular Imaging and Biology · doi:10.1007/s11307-017-1081-y · Cited by 39 · see citing works
“b MPI/CT images of intravenously injected stem cells trapped in the lungs (at day 1) and then cleared to the liver (at day 12) [25].”
BackgroundSzwargulski, P., Möddel, M., Gdaniec, N., & Knopp, T. (2018) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2018.2875829 · Cited by 38 · see citing works
- Authors
- Zheng, B., von See, M. P., Yu, E., Gunel, B., Lu, K., Vazin, T., Schaffer, D. V., Goodwill, P. W., & Conolly, S. M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Zheng, Bo
- ORCID
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2016
- Volume
- 6
- Issue
- 3
- Pages
- 291-301
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC4737718
- OpenAlex
- W2275153700
- Cited by
- 322
- References
- 53
- Citations by year
- 2026: 18 · 2025: 25 · 2024: 29 · 2023: 36 · 2022: 37 · 2021: 35 · 2020: 34 · 2019: 30 · 2018: 30 · 2017: 35 · 2016: 13
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Theranostics (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- tub.dok (Hamburg University of Technology) (submittedVersion, cc-by-nc)
- TUHH Open Research
- Funders
- W. M. Keck Foundation (009323)
- ACT Government
- Siebel Scholars Foundation
- National Institutes of Health (009323, NIH-R01)
- National Institute of Mental Health (R24MH106053)
- National Institute of Biomedical Imaging and Bioengineering (R01EB019458, R01EB013689)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- magnetic particle imaging, mesenchymal stem cells, stem cell transplantation, cell biodistribution, cell clearance, stem cell therapy
- MeSH terms
- Animals, Diagnostic Imaging, Female, Ferric Compounds, Humans, Magnetics, Rats, Inbred F344, Staining and Labeling, Tissue Distribution, Mesenchymal Stem Cell Transplantation, Mice, Nanoparticles, Administration, Intravenous
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
