Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast
Open accessAbstract
We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the same study, when ferucarbotran-labeled NPC were injected near the lateral ventricle, an additional signal caudal/posterior to the injection site appeared, indicating gradual clearance of the labeled cells through the ventricle.
“For the other control group, an additional signal caudal/posterior to the injection site appeared, indicating gradual clearance of the labeled cells through the ventricle.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [198]
In the same study, when only ferucarbotran was injected into the forebrain, the MPI signal was not detectable for a prolonged period, indicating low retention of ferucarbotran itself in the brain.
“In case of the former, the MPI signal was not detectable for a prolonged period of time, indicating low retention of ferucarbotran itself in the brain.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [198]
In a study, ferucarbotran-labeled neuronal progenitor cells implanted in rat forebrain with ischemia could be sensitively and specifically detected with MPI for up to 87 days.
“After injection, the cells could be sensitively and specifically detected with MPI for up to 87 days.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [198]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620 · see citing works
Tomographic imaging using the nonlinear response of magnetic particles
Gleich, B., & Weizenecker, J. (2005) · Nature · doi:10.1038/nature03808 · Cited by 2,011 · see citing works
Björklund, L. M., Sánchez‐Pernaute, R., Chung, S., Andersson, T., CHEN, I. Y., McNaught, K. S. P., Brownell, A., Jenkins, B. G., Wahlestedt, C., Kim, K. S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022438099 · Cited by 1,170 · see citing works
de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821 · see citing works
Kelly, S., Bliss, T. M., Shah, A. K., Sun, G.-H., Ma, M., Foo, W. C., Masel, J., Yenari, M. A., Weissman, I. L., Uchida, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404474101 · Cited by 616 · see citing works
Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI
Arbab, A. S., Yocum, G. T., Kalish, H. R., Jordan, E. K., Anderson, S. A., Khakoo, A. Y., Read, E. J., & Frank, J. A. (2004) · Blood · doi:10.1182/blood-2004-02-0655 · Cited by 529 · see citing works
Noninvasive cell-tracking methods
Kircher, M. F., Gambhir, S. S., & Grimm, J. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.141 · Cited by 504 · see citing works
Tracking immune cells in vivo using magnetic resonance imaging
Ahrens, E. T., & Bulte, J. W. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3531 · Cited by 488 · see citing works
In vivo MRI cell tracking: clinical studies
Bulte, J. W. M. (2009) · American Journal of Roentgenology · doi:10.2214/ajr.09.3107 · Cited by 430 · see citing works
Progress in the preparation of magnetic nanoparticles for applications in biomedicine
Roca, A. G., Costo, R., Rebolledo, A. F., Veintemillas-Verdaguer, S., Tartaj, P., González-Carreño, T., Morales, M. P., & Serna, C. J. (2009) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/22/224002 · Cited by 412 · see citing works
Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles
Cunningham, C. H., Arai, T., Yang, P. C.-M., McConnell, M. V., Pauly, J. M., & Conolly, S. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20477 · Cited by 403 · see citing works
Self-citationGoodwill, P. W., & Conolly, S. (2010) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2010.2052284 · Cited by 395 · see citing works
Self-citationMultidimensional X-Space Magnetic Particle Imaging
Goodwill, P. W., & Conolly, S. (2011) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2011.2125982 · Cited by 320 · see citing works
Self-citationMagnetic Particle Imaging (MPI) for NMR and MRI researchers
Sarıtaş, E. Ü., Goodwill, P. W., Croft, L. R., Konkle, J., Lu, K., Zheng, B., & Conolly, S. (2012) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2012.11.029 · Cited by 308 · see citing works
Self-citationTechnology Insight: in vivo cell tracking by use of MRI
Rogers, W. J., Meyer, C. H., & Kramer, C. M. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0659 · Cited by 249 · see citing works
Stem Cell Imaging: From Bench to Bedside
Nguyen, P. K. P., Riegler, J., & Wu, J. C. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.03.009 · Cited by 232 · see citing works
Magnetic particle imaging with tailored iron oxide nanoparticle tracers
Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Arami, H., Saritas, E. U., Croft, L. R., Konkle, J., Goodwill, P. W., Halkola, A., Rahmer, J., et al. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2014.2375065 · Cited by 222 · see citing works
Self-citationEberbeck, D., Wiekhorst, F., Wagner, S., & Trahms, L. (2011) · Applied Physics Letters · doi:10.1063/1.3586776 · Cited by 192 · see citing works
Chu, K., Kim, M., Jeong, S., Kim, S. U., & Yoon, B. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00174-5 · Cited by 189 · see citing works
Projection X-Space Magnetic Particle Imaging
Goodwill, P. W., Konkle, J., Zheng, B., Sarıtaş, E. Ü., & Conolly, S. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2185247 · Cited by 186 · see citing works
Self-citationDe Feo, D., Merlini, A., Laterza, C., & Martino, G. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328352ec45 · Cited by 181 · see citing works
Optimizing magnetite nanoparticles for mass sensitivity in magnetic particle imaging
Ferguson, R. M., Minard, K. R., Khandhar, A. P., & Krishnan, K. M. (2011) · Medical Physics · doi:10.1118/1.3554646 · Cited by 162 · see citing works
Relaxation in X-Space Magnetic Particle Imaging
Croft, L. R., Goodwill, P. W., & Conolly, S. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2217979 · Cited by 127 · see citing works
Self-citationCharacterization of integrin engagement during defined human embryonic stem cell culture
Meng, Y., Eshghi, S., Li, Y. J., Schmidt, R. C., Schaffer, D. V., & Healy, K. E. (2009) · The FASEB Journal · doi:10.1096/fj.08-126821 · Cited by 126 · see citing works
Self-citationRahmer, J., Antonelli, A., Sfara, C., Tiemann, B., Gleich, B., Magnani, M., Weizenecker, J., & Borgert, J. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/12/3965 · Cited by 111 · see citing works
Viscous effects on nanoparticle magnetization harmonics
Rauwerdink, A. M., & Weaver, J. B. (2009) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2009.10.024 · Cited by 110 · see citing works
Linearity and Shift Invariance for Quantitative Magnetic Particle Imaging
Lu, K., Goodwill, P. W., Sarıtaş, E. Ü., Zheng, B., & Conolly, S. (2013) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2013.2257177 · Cited by 103 · see citing works
Self-citationBaker‐Jarvis, J., & Kim, S. (2012) · Journal of Research of the National Institute of Standards and Technology · doi:10.6028/jres.117.001 · Cited by 101 · see citing works
Sun, R., Dittrich, J., Le-Huu, M., Mueller, M. M., Bedke, J., Kartenbeck, J., Lehmann, W. D., Krueger, R., Bock, M., Huss, R., et al. (2005) · Investigative Radiology · doi:10.1097/01.rli.0000162925.26703.3a · Cited by 88 · see citing works
Human erythrocytes as nanoparticle carriers for magnetic particle imaging
Markov, D. E., Boeve, H., Gleich, B., Borgert, J., Antonelli, A., Sfara, C., & Magnani, M. (2010) · Physics in Medicine and Biology · doi:10.1088/0031-9155/55/21/008 · Cited by 85 · see citing works
Projection Reconstruction Magnetic Particle Imaging
Konkle, J., Goodwill, P. W., Carrasco‐Zevallos, O. M., & Conolly, S. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2227121 · Cited by 83 · see citing works
Self-citationEffects of MRI Contrast Agents on the Stem Cell Phenotype
Crabbe, A., Vandeputte, C., Dresselaers, T., Ayuso‐Sacido, Á., García‐Verdugo, J. M., Eyckmans, J., Luyten, F. P., Laere, K. V., Verfaillie, C. M., & Himmelreich, U. (2010) · Cell Transplantation · doi:10.3727/096368910x494623 · Cited by 81 · see citing works
Effects of iron oxide nanoparticles on cardiac differentiation of embryonic stem cells
Au, K., Liao, S.-Y., Lee, Y.-K., Lai, W., Ng, K., Chan, Y.-C., Yip, M.-C., Ho, C.-Y. J., Wu, E. X., Li, R. A., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.160 · Cited by 75 · see citing works
Kim, H. S., Oh, S. Y., Joo, H. J., Son, K.-R., Song, I. C., & Moon, W. K. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1487 · Cited by 70 · see citing works
Panizzo, R., Kyrtatos, P. G., Price, A. N., Gadian, D. G., Ferretti, P., & Lythgoe, M. F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.062 · Cited by 45 · see citing works
van Buul, G. M., Farrell, E., Kops, N., van Tiel, S. T., Bos, P. K., Weinans, H., Krestin, G. P., van Osch, G. J. V. M., & Bernsen, M. R. (2009) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.289 · Cited by 34 · see citing works
DEVELOPING CELLULAR MPI: INITIAL EXPERIENCE
Bulte, J. W. M., Walczak, P., Bernard, S., Gleich, B., Weizenecker, J., Borgert, J., AERTS, H., & Boeve, H. (2010) · doi:10.1142/9789814324687_0028 · Cited by 17 · see citing works
Guo, J., Shen, J., Wang, L., Li, X., Zhang, R.-J., Luo, W., Gong, Z., Sun, J. P., Xu, H., Sirois, P., et al. (2010) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-010-9069-y · Cited by 13 · see citing works
Synthesis of Single-Core Iron Oxide Nanoparticles as a Tracer for Magnetic Particle Imaging
Lak, A., Viereck, T., Ludwig, F., & Schilling, M. (2012) · Springer proceedings in physics · doi:10.1007/978-3-642-24133-8_15 · Cited by 4 · see citing works
Evaluation of Different Magnetic Particle Systems with Respect to Its MPI Performance
Eberbeck, D., Trahms, L., & Kratz, H. (2012) · Springer proceedings in physics · doi:10.1007/978-3-642-24133-8_9 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,076 · see citing works
Magnetic nanoparticles in nanomedicine: a review of recent advances
Wu, K., Su, D., Liu, J., Saha, R., & Wang, J.-P. (2019) · Nanotechnology · doi:10.1088/1361-6528/ab4241 · Cited by 552 · see citing works
Tay, Z. W., Chandrasekharan, P., Chiu-Lam, A., Hensley, D. W., Dhavalikar, R., Zhou, X. Y., Yu, E. Y., Goodwill, P. W., Zheng, B., Rinaldi, C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00893 · Cited by 459 · see citing works
Self-citationMagnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection
Yu, E. Y., Bishop, M. D., Zheng, B., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Goodwill, P. W., & Conolly, S. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04865 · Cited by 371 · see citing works
Self-citationHuman-sized magnetic particle imaging for brain applications
Graeser, M., Thieben, F., Szwargulski, P., Werner, F., Gdaniec, N., Boberg, M., Griese, F., Möddel, M., Ludewig, P., van de Ven, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09704-x · Cited by 339 · see citing works
Israel, L. L., Galstyan, A., Holler, E., & Ljubimova, J. Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.009 · Cited by 337 · see citing works
Zheng, B., von See, M. P., Yu, E., Gunel, B., Lu, K., Vazin, T., Schaffer, D. V., Goodwill, P. W., & Conolly, S. M. (2016) · Theranostics · doi:10.7150/thno.13728 · Cited by 322 · see citing works
Self-citationEngineering applications of ferrofluids: A review
Kole, M., & Khandekar, S. (2021) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2021.168222 · Cited by 287 · see citing works
Song, G., Kenney, M. J., Chen, Y., Zheng, X., Deng, Y., Chen, Z., Wang, S. X., Gambhir, S. S., Dai, H., & Rao, J. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0506-0 · Cited by 263 · see citing works
Du, Y., Liu, X., Liang, Q. Y., Liang, X., & Tian, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00630 · Cited by 261 · see citing works
Song, G., Chen, M., Zhang, Y., Cui, L., Qu, H., Zheng, X., Wintermark, M., Liu, Z., & Rao, J. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03829 · Cited by 257 · see citing works
Magnetic particle imaging: from proof of principle to preclinical applications
Knopp, T., Gdaniec, N., & Möddel, M. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa6c99 · Cited by 239 · see citing works
Development and MPI tracking of novel hypoxia-targeted theranostic exosomes
Jung, K. O., Jo, H., Yu, J. H., Gambhir, S. S., & Pratx, G. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.048 · Cited by 231 · see citing works
Magnetic Particle Imaging for Real-Time Perfusion Imaging in Acute Stroke
Ludewig, P., Gdaniec, N., Sedlacik, J., Forkert, N. D., Szwargulski, P., Graeser, M., Adam, G., Kaul, M. G., Krishnan, K. M., Ferguson, R. M., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b05784 · Cited by 225 · see citing works
High-performance iron oxide nanoparticles for magnetic particle imaging – guided hyperthermia (hMPI)
Bauer, L. M., Situ, S. F., Griswold, M. A., & Samia, A. C. S. (2016) · Nanoscale · doi:10.1039/c6nr01877g · Cited by 221 · see citing works
A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging
Wu, L. C., Zhang, Y., Steinberg, G. K., Qu, H., Huang, S., Cheng, M., Bliss, T. M., Du, F., Rao, J., Song, G., et al. (2019) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5896 · Cited by 208 · see citing works
Self-citationSuperparamagnetic iron oxides as MPI tracers: A primer and review of early applications
Bulte, J. W. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.007 · Cited by 204 · see citing works
Chandrasekharan, P., Tay, Z. W., Hensley, D. W., Zhou, X. Y., Fung, B. K., Colson, C., Lu, Y., Fellows, B. D., Huynh, Q., Saayujya, C., et al. (2020) · Theranostics · doi:10.7150/thno.40858 · Cited by 197 · see citing works
Self-citationWang, Q., Ma, X., Liao, H., Liang, Z., Li, F., Tian, J., & Ling, D. (2020) · ACS Nano · doi:10.1021/acsnano.9b08660 · Cited by 167 · see citing works
Yu, E. Y., Chandrasekharan, P., Berzon, R., Tay, Z. W., Zhou, X. Y., Khandhar, A. P., Ferguson, R. M., Kemp, S. J., Zheng, B., Goodwill, P. W., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04844 · Cited by 161 · see citing works
Self-citationEngineering of magnetic nanoparticles as magnetic particle imaging tracers
Lu, C., Han, L., Wang, J., Wan, J., Song, G., & Rao, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00260g · Cited by 154 · see citing works
Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering
Friedrich, R. P., Cicha, I., & Alexiou, C. (2021) · Nanomaterials · doi:10.3390/nano11092337 · Cited by 153 · see citing works
Zhu, X., Li, J., Peng, P., Hosseini-Nassab, N., & Smith, B. R. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01202 · Cited by 149 · see citing works
Combining magnetic particle imaging and magnetic fluid hyperthermia in a theranostic platform
Hensley, D. W., Tay, Z. W., Dhavalikar, R., Zheng, B., Goodwill, P. W., Rinaldi, C., & Conolly, S. (2016) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5601 · Cited by 149 · see citing works
Self-citationGraeser, M., Knopp, T., Szwargulski, P., Friedrich, T., von Gladiss, A., Kaul, M. G., Krishnan, K. M., Ittrich, H., Adam, G., & Buzug, T. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06992-5 · Cited by 144 · see citing works
Tong, W., Hui, H., Shang, W., Zhang, Y., Tian, F., Ma, Q., Yang, X., Tian, J., & Chen, Y. (2020) · Theranostics · doi:10.7150/thno.49812 · Cited by 133 · see citing works
Magnetic Particle Imaging: Current Applications in Biomedical Research
Talebloo, N., Gudi, M., Robertson, N., & Wang, P. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26875 · Cited by 132 · see citing works
Zhou, X. Y., Tay, Z. W., Chandrasekharan, P., Yu, E. Y., Hensley, D. W., Orendorff, R. D., Jeffris, K. E., Mai, D., Zheng, B., Goodwill, P. W., et al. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.04.014 · Cited by 128 · see citing works
Self-citationFirst in vivo magnetic particle imaging of lung perfusion in rats
Zhou, X. Y., Jeffris, K. E., Yu, E. Y., Zheng, B., Goodwill, P. W., Nahid, P., & Conolly, S. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa616c · Cited by 124 · see citing works
Self-citationTracking adoptive T cell immunotherapy using magnetic particle imaging
Rivera‐Rodriguez, A., Hoang-Minh, L., Chiu‐Lam, A., Sarna, N. S., Marrero‐Morales, L., Mitchell, D. A., & Rinaldi, C. (2021) · Nanotheranostics · doi:10.7150/ntno.55165 · Cited by 119 · see citing works
Tay, Z. W., Chandrasekharan, P., Zhou, X. Y., Yu, E. Y., Zheng, B., & Conolly, S. (2018) · Theranostics · doi:10.7150/thno.26608 · Cited by 115 · see citing works
Self-citationKim, T., Lee, N., Arifin, D. R., Shats, I., Janowski, M., Walczak, P., Hyeon, T., & Bulte, J. W. M. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201604213 · Cited by 114 · see citing works
TranSMS: Transformers for Super-Resolution Calibration in Magnetic Particle Imaging
Güngör, A., Askin, B., Soydan, D. A., Sarıtaş, E. Ü., Top, C. B., & Çukur, T. (2022) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2022.3189693 · Cited by 115 · see citing works
First in vivo traumatic brain injury imaging via magnetic particle imaging
Orendorff, R. D., Peck, A. J., Zheng, B., Shirazi, S. N., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Goodwill, P. W., Krishnan, K. M., Brooks, G. A., et al. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa52ad · Cited by 111 · see citing works
Self-citationA Magneto-Optical Nanoplatform for Multimodality Imaging of Tumors in Mice
Song, G., Zheng, X., Wang, Y., Xia, X., Chu, S., & Rao, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b01436 · Cited by 110 · see citing works
Billings, C., Langley, M., Warrington, G., Mashali, F., & Johnson, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147651 · Cited by 106 · see citing works
Díez, A. G., Rincón‐Iglesias, M., Lanceros-Méndez, S., Reguera, J., & Lizundia, E. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2022.101220 · Cited by 106 · see citing works
Tay, Z. W., Hensley, D. W., Vreeland, E. C., Zheng, B., & Conolly, S. (2017) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/aa6ab6 · Cited by 104 · see citing works
Self-citationEdge Preserving and Noise Reducing Reconstruction for Magnetic Particle Imaging
Storath, M., Brandt, C., Hofmann, M., Knopp, T., Salamon, J., Weber, A., & Weinmann, A. (2016) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2593954 · Cited by 95 · see citing works
Harvell-Smith, S., Tung, L. D., & Thanh, N. T. K. (2021) · Nanoscale · doi:10.1039/d1nr05670k · Cited by 96 · see citing works
Advances in imaging strategies for in vivo tracking of exosomes
Betzer, O., Barnoy, E. A., Sadan, T., Elbaz, I., Braverman, C. M., Liu, Z., & Popovtzer, R. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1594 · Cited by 93 · see citing works
Kratz, H., Taupitz, M., Ariza de Schellenberger, A., Kosch, O., Eberbeck, D., Wagner, S., Trahms, L., Hamm, B., & Schnorr, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190214 · Cited by 92 · see citing works
Cell tracking using gold nanoparticles and computed tomography imaging
Meir, R., & Popovtzer, R. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1480 · Cited by 90 · see citing works
Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells
Lemaster, J. E., Chen, F., Kim, T., Hariri, A., & Jokerst, J. V. (2018) · ACS Applied Nano Materials · doi:10.1021/acsanm.8b00063 · Cited by 89 · see citing works
Vaalma, S., Rahmer, J., Panagiotopoulos, N., Duschka, R. L., Borgert, J., Barkhausen, J., VOGT, F. M., & Haegele, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168902 · Cited by 81 · see citing works
Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges
Liu, X., Chen, S., Zhang, H., Zhou, J., Fan, H., & Liang, X. (2018) · Advanced Materials · doi:10.1002/adma.201804922 · Cited by 84 · see citing works
Li, X., Li, Y., Yu, C., Bao, H., Cheng, S., Huang, J., & Zhang, Z. (2023) · ACS Nano · doi:10.1021/acsnano.2c11112 · Cited by 84 · see citing works
Tay, Z. W., Chandrasekharan, P., Fellows, B. D., Rodrigo, I., Yu, E. Y., Olivo, M., & Conolly, S. (2021) · Cancers · doi:10.3390/cancers13215285 · Cited by 84 · see citing works
Self-citationMagnetic nanoparticles in regenerative medicine: what of their fate and impact in stem cells?
de Walle, A. V., Perez, J. E., Abou‐Hassan, A., Hémadi, M., Luciani, N., & Wilhelm, C. (2020) · Materials Today Nano · doi:10.1016/j.mtnano.2020.100084 · Cited by 82 · see citing works
A Perspective on Cell Tracking with Magnetic Particle Imaging
Sehl, O. C., Gevaert, J. J., Melo, K. P., Knier, N. N., & Foster, P. J. (2020) · Tomography · doi:10.18383/j.tom.2020.00043 · Cited by 79 · see citing works
Keselman, P., Yu, E. Y., Zhou, X. Y., Goodwill, P. W., Chandrasekharan, P., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Zheng, B., et al. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5f48 · Cited by 78 · see citing works
Self-citationTay, Z. W., Goodwill, P. W., Hensley, D. W., Taylor, L. A., Zheng, B., & Conolly, S. (2016) · Scientific Reports · doi:10.1038/srep34180 · Cited by 76 · see citing works
Self-citationLu, Y., Rivera‐Rodriguez, A., Tay, Z. W., Hensley, D. W., Fung, B. K., Colson, C., Saayujya, C., Huynh, Q., Kabuli, L., Fellows, B. D., et al. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2020.1853252 · Cited by 71 · see citing works
Self-citationTomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration
Top, C. B., & Güngör, A. (2020) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2020.3014197 · Cited by 70 · see citing works
Relaxation-based viscosity mapping for magnetic particle imaging
Ütkür, M., Muslu, Y., & Sarıtaş, E. Ü. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/62/9/3422 · Cited by 69 · see citing works
Deep learning for improving the spatial resolution of magnetic particle imaging
Shang, Y., Liu, J., Zhang, L., Wu, X., Zhang, P., Yin, L., Hui, H., & Tian, J. (2022) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ac6e24 · Cited by 68 · see citing works
Design analysis of an MPI human functional brain scanner
Mason, E. E., Cooley, C. Z., Cauley, S., Griswold, M. A., Conolly, S., & Wald, L. L. (2016) · International journal on magnetic particle imaging · doi:10.18416/ijmpi.2017.1703008 · Cited by 68 · see citing works
Self-citationOptimization of Drive Parameters for Resolution, Sensitivity and Safety in Magnetic Particle Imaging
Tay, Z. W., Hensley, D. W., Chandrasekharan, P., Zheng, B., & Conolly, S. (2019) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2019.2957041 · Cited by 66 · see citing works
Self-citationThin Film Magnetoelectric Sensors Toward Biomagnetism: Materials, Devices, and Applications
Dong, C., Liang, X., Gao, J., Chen, H., He, Y., Wei, Y., Zaeimbashi, M., Matyushov, A. D., Sun, C., & Sun, N. X. (2022) · Advanced Electronic Materials · doi:10.1002/aelm.202200013 · Cited by 68 · see citing works
Chandrasekharan, P., Tay, Z. W., Zhou, X. Y., Yu, E. Y., Orendorff, R. D., Hensley, D. W., Huynh, Q., Fung, B. K., Colson, C., Goodwill, P. W., et al. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180326 · Cited by 67 · see citing works
Self-citationWang, P., Goodwill, P., Pandit, P., Gaudet, J., Ross, A. W., Wang, J., Yu, E. Y., Hensley, D., Doyle, T. C., Contag, C., et al. (2018) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2018.02.06 · Cited by 59 · see citing works
Self-citationCooley, C. Z., Mandeville, J. B., Mason, E. E., Mandeville, E. T., & Wald, L. L. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.004 · Cited by 63 · see citing works
DEQ-MPI: A Deep Equilibrium Reconstruction With Learned Consistency for Magnetic Particle Imaging
Güngör, A., Askin, B., Soydan, D. A., Top, C. B., Sarıtaş, E. Ü., & Çukur, T. (2023) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2023.3300704 · Cited by 61 · see citing works
Magnetic Particle Imaging for High Temporal Resolution Assessment of Aneurysm Hemodynamics
Sedlacik, J., Frölich, A. M., Spallek, J., Forkert, N. D., Faizy, T. D., Werner, F., Knopp, T., Krause, D., Fiehler, J., & Buhk, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160097 · Cited by 61 · see citing works
Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology
Crist, R. M., Dasa, S. S. K., Liu, C. H., Clogston, J. D., Dobrovolskaia, M. A., & Stern, S. T. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1665 · Cited by 62 · see citing works
Cohen, O. M., Betzer, O., Elmaliach-Pnini, N., Motiei, M., Sadan, T., Cohen-Berkman, M., Dagan, O., Popovtzer, A., Yosepovich, A., Barhom, H., et al. (2021) · Biomaterials Science · doi:10.1039/d0bm01735c · Cited by 60 · see citing works
Them, K., Salamon, J., Szwargulski, P., Sequeira, S., Kaul, M. G., Lange, C., Ittrich, H., & Knopp, T. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/9/3279 · Cited by 58 · see citing works
Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles
Luengo, Y., Paredes, K. O., Chamizo, L. L., Marciello, M., & Filice, M. (2021) · Polymers · doi:10.3390/polym13172989 · Cited by 58 · see citing works
Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality
Xie, X., Zhai, J., Zhou, X., Guo, Z., Lo, P., Zhu, G., Chan, K. W. Y., & Yang, M. (2023) · Advanced Materials · doi:10.1002/adma.202306450 · Cited by 57 · see citing works
Online reconstruction of 3D magnetic particle imaging data
Knopp, T., & Hofmann, M. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/11/n257 · Cited by 57 · see citing works
Applications of Magnetic Particle Imaging in Biomedicine: Advancements and Prospects
Yang, X., Shao, G., Zhang, Y., Wang, W., Qi, Y., Han, S., & Li, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.898426 · Cited by 56 · see citing works
Mathematical models for magnetic particle imaging
Kluth, T. (2018) · Inverse Problems · doi:10.1088/1361-6420/aac535 · Cited by 55 · see citing works
Tomitaka, A., Ota, S., Nishimoto, K., Arami, H., Takemura, Y., & Nair, M. (2019) · Nanoscale · doi:10.1039/c9nr00242a · Cited by 54 · see citing works
Mason, E. E., Mattingly, E., Herb, K., Śliwiak, M., Franconi, S., Cooley, C. Z., Slanetz, P. J., & Wald, L. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-92644-8 · Cited by 53 · see citing works
Magnetic particle imaging in vascular medicine
Bakenecker, A. C., Ahlborg, M., Debbeler, C., Kaethner, C., Buzug, T. M., & Lüdtke‐Buzug, K. (2018) · Innovative Surgical Sciences · doi:10.1515/iss-2018-2026 · Cited by 53 · see citing works
Huang, X., Hui, H., Shang, W., Gao, P., Zhou, Y., Pang, W., Woo, C. M., Tian, J., & Lai, P. (2023) · Advanced Science · doi:10.1002/advs.202300854 · Cited by 52 · see citing works
Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging
Teeman, E., Shasha, C., Evans, J. E., & Krishnan, K. M. (2019) · Nanoscale · doi:10.1039/c9nr01395d · Cited by 52 · see citing works
Magnetic Particle Imaging–Guided Stenting
Herz, S., Vogel, P., Kampf, T., Dietrich, P., Veldhoen, S., Rückert, M. A., Kickuth, R., Behr, V. C., & Bley, T. A. (2019) · Journal of Endovascular Therapy · doi:10.1177/1526602819851202 · Cited by 52 · see citing works
Etemadi, H., Buchanan, J. K., Kandile, N. G., & Plieger, P. G. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00938 · Cited by 52 · see citing works
Sehl, O. C., & Foster, P. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-01642-3 · Cited by 51 · see citing works
Magnetic Particle Imaging Guided Real-Time Percutaneous Transluminal Angioplasty in a Phantom Model
Herz, S., Vogel, P., Dietrich, P., Kampf, T., Rückert, M. A., Kickuth, R., Behr, V. C., & Bley, T. A. (2018) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-018-1955-7 · Cited by 51 · see citing works
Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry
Prospero, A. G., Quini, C. C., Bakuzis, A. F., Fidelis-de-Oliveira, P., Moretto, G. M., Mello, F. P. F., Calabresi, M. F. F., Matos, R. V. R., Zandoná, E. A., Zufelato, N., et al. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0257-6 · Cited by 50 · see citing works
In Vivo Tracking of Tissue Engineered Constructs
Gil, C. J., Tomov, M. L., Theus, A. S., Cetnar, A. C., Mahmoudi, M., & Serpooshan, V. (2019) · Micromachines · doi:10.3390/mi10070474 · Cited by 47 · see citing works
Salamon, J., Dieckhoff, J., Kaul, M. G., Jung, C., Adam, G., Möddel, M., Knopp, T., Draack, S., Ludwig, F., & Ittrich, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-64280-1 · Cited by 47 · see citing works
Characterization of noise and background signals in a magnetic particle imaging system
Paysen, H., Kosch, O., Wells, J., Löwa, N., & Wiekhorst, F. (2020) · Physics in Medicine and Biology · doi:10.1088/1361-6560/abc364 · Cited by 47 · see citing works
Chandrasekharan, P., Fung, B. K., Zhou, X. Y., Cui, W., Colson, C., Mai, D., Jeffris, K. E., Huynh, Q., Saayujya, C., Kabuli, L., et al. (2021) · Nanotheranostics · doi:10.7150/ntno.50721 · Cited by 47 · see citing works
Self-citationNanotechnology in Drug Discovery and Development
Gutiérrez, L., Stepien, G., Gutiérrez, L., Pérez-Hernández, M., Pardo, J., Pardo, J., Grazú, V., & de la Fuente, J. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12292-9 · Cited by 46 · see citing works
Biomedical applications of magnetosomes: State of the art and perspectives
Ren, G., Zhou, X., Long, R., Xie, M., Kankala, R. K., Wang, S., Zhang, Y. S., & Liu, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.04.025 · Cited by 46 · see citing works
Magnetic Particle Imaging for Quantification of Vascular Stenoses: A Phantom Study
Herz, S., Vogel, P., Kampf, T., Rückert, M. A., Veldhoen, S., Behr, V. C., & Bley, T. A. (2017) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2017.2717958 · Cited by 46 · see citing works
Rivera‐Rodriguez, A., & Rinaldi, C. (2021) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-102720-015630 · Cited by 45 · see citing works
A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
Liu, X., Yang, Z., Sun, J., Ma, T., Hua, F., & Shen, Z. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s205574 · Cited by 45 · see citing works
Magnetic particle imaging for assessment of cerebral perfusion and ischemia
Ludewig, P., Graeser, M., Forkert, N. D., Thieben, F., Rández‐Garbayo, J., Rieckhoff, J., Lessmann, K., Foerger, F., Szwargulski, P., Magnus, T. U., et al. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1757 · Cited by 45 · see citing works
Pantke, D., Holle, N., Mogarkar, A., Straub, M., & Schulz, V. (2019) · Medical Physics · doi:10.1002/mp.13650 · Cited by 43 · see citing works
Long-term in vivo CT tracking of mesenchymal stem cells labeled with Au@BSA@PLL nanotracers
Ning, X., Bao, H., Liu, X., Fu, H., Wang, W., Huang, J., & Zhang, Z. (2019) · Nanoscale · doi:10.1039/c9nr05637h · Cited by 43 · see citing works
Magnetic nanoparticles and magnetic particle spectroscopy-based bioassays: a 15 year recap
Wu, K., Liu, J., Chugh, V. K., Liang, S. A., Saha, R., Krishna, V. D., Cheeran, M. C. ‐., & Wang, J. (2022) · Nano Futures · doi:10.1088/2399-1984/ac5cd1 · Cited by 43 · see citing works
Roadmap on magnetic nanoparticles in nanomedicine
Wu, K., Wang, J., Natekar, N. A., Ciannella, S., González‐Fernández, C., Gómez‐Pastora, J., Bao, Y., Liu, J., Liang, S. A., Wu, X. Z., et al. (2024) · Nanotechnology · doi:10.1088/1361-6528/ad8626 · Cited by 42 · see citing works
Self-citationJoint Reconstruction of Tracer Distribution and Background in Magnetic Particle Imaging
Straub, M., & Schulz, V. (2018) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2017.2777878 · Cited by 42 · see citing works
Bok, I., Haber, I., Qu, X., & Hai, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-12303-4 · Cited by 43 · see citing works
Makela, A. V., Schott, M. A., Madsen, C. S., Greeson, E. M., & Contag, C. H. (2022) · Nano Letters · doi:10.1021/acs.nanolett.1c05042 · Cited by 41 · see citing works
- Authors
- Zheng, B., Vazin, T., Goodwill, P. W., Conway, A., Verma, A., Ulku Saritas, E., Schaffer, D., & Conolly, S. M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Zheng, Bo
- Venue
- Scientific Reports
- Published
- 2015-09-11
- Volume
- 5
- Issue
- 1
- Pages
- 14055-14055
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4566119
- OpenAlex
- W2418720770
- Cited by
- 274
- References
- 40
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 16 · 2023: 23 · 2022: 29 · 2021: 35 · 2020: 31 · 2019: 30 · 2018: 26 · 2017: 35 · 2016: 12 · 2015: 1
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Science Foundation (1106400)
- W. M. Keck Foundation (009323)
- ACT Government
- Siebel Scholars Foundation
- National Institutes of Health (DGE 1106400, 009323, NIH-R01)
- National Institute of Mental Health (R24MH106053)
- National Institute of Biomedical Imaging and Bioengineering (R01EB019458, R01EB013689)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Geomagnetism and Paleomagnetism Studies
- Keywords
- magnetic particle imaging, cell tracking, long-term monitoring, single-cell tracking, non-invasive imaging, rat brain
- MeSH terms
- Animals, Cell Differentiation, Female, Humans, Iron, Magnetic Resonance Imaging, Sensitivity and Specificity, Staining and Labeling, Reproducibility of Results, Rats, Embryonic Stem Cells, Magnetite Nanoparticles, Cell Tracking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
