Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
Open accessAbstract
Summary: Chronic dietary restriction (DR) is considered among the most robust life‐extending interventions, but several reports indicate that DR does not always extend and may even shorten lifespan in some genotypes. An unbiased genetic screen of the lifespan response to DR has been lacking. Here, we measured the effect of one commonly used level of DR (40% reduction in food intake) on mean lifespan of virgin males and females in 41 recombinant inbred strains of mice. Mean strain‐specific lifespan varied two to threefold under ad libitum (AL) feeding and 6‐ to 10‐fold under DR, in males and females respectively. Notably, DR shortened lifespan in more strains than those in which it lengthened life. Food intake and female fertility varied markedly among strains under AL feeding, but neither predicted DR survival: therefore, strains in which DR shortened lifespan did not have low food intake or poor reproductive potential. Finally, strain‐specific lifespans under DR and AL feeding were not correlated, indicating that the genetic determinants of lifespan under these two conditions differ. These results demonstrate that the lifespan response to a single level of DR exhibits wide variation amenable to genetic analysis. They also show that DR can shorten lifespan in inbred mice. Although strains with shortened lifespan under 40% DR may not respond negatively under less stringent DR, the results raise the possibility that life extension by DR may not be universal.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Even among highly genetically similar strains of yeast or mice, dietary restriction is equally likely to shorten lifespan as to extend lifespan.
“Even among highly genetically similar strains of yeast or mice, dietary restriction is equally likely to shorten lifespan as to extend lifespan.76,77,78”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [78]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264 · see citing works
The retardation of aging and disease by dietary restriction
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5101 · Cited by 1,477 · see citing works
Longevity, senescence and the genome
(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90026-8 · Cited by 1,403 · see citing works
Overview of caloric restriction and ageing
Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 1,054 · see citing works
Nutrient Requirements of Laboratory Animals,
National Research Council (1995) · National Academies Press eBooks · doi:10.17226/4758 · Cited by 735 · see citing works
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.
Cm, M., Crowell, M. F., & MAYNARD, L. A. (1989) · PubMed · Cited by 670 · see citing works
Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program
Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 668 · see citing works
Yu, B. P., Masoro, E. J., Murata, I., Bertrand, H. A., & Lynd, F. T. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.2.130 · Cited by 580 · see citing works
Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396 · see citing works
Longevity, senescence, and the genome
Goldstein, S. (1992) · Choice Reviews Online · doi:10.5860/choice.29-3294 · Cited by 328 · see citing works
Holloszy, J. O., & Fontana, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.009 · Cited by 304 · see citing works
Influence of diet on survival of mice.
Fernandes, G., Yunis, E. J., & Good, R. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1279 · Cited by 264 · see citing works
Genotype and age influence the effect of caloric intake on mortality in mice
Forster, M. J., Morris, P., & Sohal, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0533fje · Cited by 236 · see citing works
Does caloric restriction extend life in wild mice?
Harper, J. M., Leathers, C. W., & Austad, S. N. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00236.x · Cited by 212 · see citing works
Influences of Aging and Dietary Restriction on Serum Thymosin l Levels in Mice
Weindruch, R., Naylor, P. H., Goldstein, A. L., & Walford, R. L. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.2.b40 · Cited by 207 · see citing works
Subfield History: Caloric Restriction, Slowing Aging, and Extending Life
Masoro, E. J. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.8.re2 · Cited by 149 · see citing works
Genetic differences in effects of food restriction on aging in mice
Harrison, D. E., & Archer, J. R. (1987) · The Journal of Nutrition · doi:10.1093/jn/117.2.376 · Cited by 133 · see citing works
Effect of caloric restriction on life span of the housefly, Musca domestica
Cooper, T. M., Mockett, R. J., Sohal, B. H., Sohal, R. S., & Orr, W. C. (2004) · The FASEB Journal · doi:10.1096/fj.03-1464fje · Cited by 115 · see citing works
Life history response of Mediterranean fruit flies to dietary restriction
Carey, J. R., Liedo, P., Harshman, L. G., Zhang, Y., Müller, H., Partridge, L., & Wang, J. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00019.x · Cited by 113 · see citing works
Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone‐Link, P., Rikke, B. A., Belknap, J. K., & Johnson, T. E. (2004) · Mammalian Genome · doi:10.1007/s00335-004-2380-6 · Cited by 100 · see citing works
Self-citationHousing Density Does Not Influence the Longevity Effect of Calorie Restriction
Ikeno, Y., Hubbard, G. B., Lee, S., Richardson, A., Strong, R., Diaz, V., & Nelson, J. F. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1510 · Cited by 83 · see citing works
Self-citationThe diet restriction paradigm: a brief review of the effects of every-other-day feeding
Anson, R. M., Jones, B., & de Cabo, R. (2005) · AGE · doi:10.1007/s11357-005-3286-2 · Cited by 78 · see citing works
The Effect of Reduced Dietary Intake on Enzymatic Activities and Life Span of Rats
Barrows, C. H., & Roeder, L. M. (1965) · Journal of Gerontology · doi:10.1093/geronj/20.1.69 · Cited by 61 · see citing works
Plasma Glucose and the Action of Calorie Restriction on Aging
McCarter, R., Mejia, W., Ikeno, Y., Monnier, V. M., Kewitt, K., Gibbs, M. A., McMahan, C. A., & Strong, R. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.10.1059 · Cited by 41 · see citing works
Bennett, B., Carosone‐Link, P., Zahniser, N. R., & Johnson, T. E. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103572 · Cited by 33 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585 · see citing works
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works
From discoveries in ageing research to therapeutics for healthy ageing
Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works
Mitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works
The Critical Role of Metabolic Pathways in Aging
Barzilai, N., Huffman, D. M., Muzumdar, R. H., & Bartke, A. (2012) · Diabetes · doi:10.2337/db11-1300 · Cited by 803 · see citing works
Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 769 · see citing works
Molecular mechanisms of dietary restriction promoting health and longevity
Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714 · see citing works
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works
Calorie restriction in humans: An update
Most, J., Tosti, V., Redman, L. M., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.005 · Cited by 530 · see citing works
Francesco, A. D., Germanio, C. D., Bernier, M., & de Cabo, R. (2018) · Science · doi:10.1126/science.aau2095 · Cited by 497 · see citing works
Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice
Newman, J. C., Covarrubias, A. J., Zhao, M., Yu, X., Gut, P., Ng, C.-P., Huang, Y., Haldar, S., & Verdin, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.004 · Cited by 493 · see citing works
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.027 · Cited by 451 · see citing works
Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting
Tintignac, L. A. J., Brenner, H.-R., & Rüegg, M. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00033.2014 · Cited by 422 · see citing works
Fox transcription factors: from development to disease
Golson, M. L., & Kaestner, K. H. (2016) · Development · doi:10.1242/dev.112672 · Cited by 406 · see citing works
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
Yu, D., Richardson, N. E., Green, C. L., Spicer, A. B., Trautman, M. E., Flores, V., Jang, C., Kasza, I., Nikodémová, M., Wakai, M. H., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.025 · Cited by 388 · see citing works
“Control” laboratory rodents are metabolically morbid: Why it matters
Martin, B., Ji, S., Maudsley, S., & Mattson, M. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912955107 · Cited by 354 · see citing works
Animal models of aging research: implications for human aging and age-related diseases
Mitchell, S. J., Scheibye-Knudsen, M., Longo, D. L., & de Cabo, R. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-110829 · Cited by 328 · see citing works
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works
Intermittent and periodic fasting, longevity and disease
Longo, V. D., Tano, M. D., Mattson, M. P., & Guidi, N. (2021) · Nature Aging · doi:10.1038/s43587-020-00013-3 · Cited by 288 · see citing works
Autophagy and the hallmarks of aging
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285 · see citing works
The Genetics of Aging: A Vertebrate Perspective
Singh, P. P., Demmitt, B. A., Nath, R. D., & Brunet, A. (2019) · Cell · doi:10.1016/j.cell.2019.02.038 · Cited by 259 · see citing works
Richardson, N. E., Konon, E. N., Schuster, H. S., Mitchell, A. T., Boyle, C., Rodgers, A. C., Finke, M., Haider, L. R., Yu, D., Flores, V., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00006-2 · Cited by 260 · see citing works
Healthful aging mediated by inhibition of oxidative stress
Vatner, S. F., Zhang, J., Oydanich, M. K., Berkman, T., Naftalovich, R., & Vatner, D. E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101194 · Cited by 239 · see citing works
Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.006 · Cited by 230 · see citing works
The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer
Anisimov, V. N., & Bartke, A. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.01.005 · Cited by 222 · see citing works
Comparative and meta‐analytic insights into life extension via dietary restriction
Nakagawa, S., Lagisz, M., Hector, K. L., & Spencer, H. G. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00798.x · Cited by 219 · see citing works
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
Dietrich, M. O., & Horváth, T. L. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3739 · Cited by 202 · see citing works
Dietary restriction impacts health and lifespan of genetically diverse mice
Francesco, A. D., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L. L., Garland, G., Donato, H., Vincent, M. J., Schott, W., et al. (2024) · Nature · doi:10.1038/s41586-024-08026-3 · Cited by 200 · see citing works
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., Wright, K. M., et al. (2023) · doi:10.1101/2023.11.28.568901 · Cited by 194 · see citing works
Dietary Restriction and Aging: A Unifying Perspective
Piper, M. D. W., Partridge, L., Raubenheimer, D., & Simpson, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.013 · Cited by 190 · see citing works
Seo, A. Y., Lau, P., Feliciano, D., Sengupta, P., Gros, M. A. L., Cinquin, B. P., Larabell, C. A., & Lippincott‐Schwartz, J. (2017) · eLife · doi:10.7554/elife.21690 · Cited by 179 · see citing works
The effects of dietary restriction on oxidative stress in rodents
Walsh, M. E., Shi, Y., & Van Remmen, H. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.037 · Cited by 181 · see citing works
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Xie, S., Xu, S., Deng, W., & Tang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01378-8 · Cited by 185 · see citing works
The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities
Vanhooren, V., & Libert, C. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.010 · Cited by 180 · see citing works
Caloric restriction and the aging process: a critique
Sohal, R. S., & Forster, M. J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.015 · Cited by 178 · see citing works
Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis
Swindell, W. R., Michaels, K. A., Sutter, A. J., Diaconu, D., Fritz, Y., Xing, X., Sarkar, M. K., Liang, Y., Tsoi, L. C., Gudjonsson, J. E., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0415-3 · Cited by 177 · see citing works
Dietary restriction with and without caloric restriction for healthy aging
Lee, C. D., & Longo, V. D. (2016) · F1000Research · doi:10.12688/f1000research.7136.1 · Cited by 169 · see citing works
Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171 · see citing works
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
D’Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.034 · Cited by 159 · see citing works
Ramis, M. R., Esteban, S., Miralles, A., Tan, D., & Reiter, R. J. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.008 · Cited by 164 · see citing works
Molecular mechanisms underlying genotype‐dependent responses to dietary restriction
Schleit, J., Johnson, S. C., Bennett, C. F., Simko, M., Trongtham, N., Castanza, A., Hsieh, E. J., Moller, R. M., Wasko, B. M., Delaney, J. R., et al. (2013) · Aging Cell · doi:10.1111/acel.12130 · Cited by 159 · see citing works
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Rizza, W., Veronese, N., & Fontana, L. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.11.002 · Cited by 160 · see citing works
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 164 · see citing works
Mediterranean diet and inflammaging within the hormesis paradigm
Martucci, M., Ostan, R., Biondi, F., Bellavista, E., Fabbri, C., Bertarelli, C., Salvioli, S., Capri, M., Franceschi, C., & Santoro, A. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux013 · Cited by 161 · see citing works
Resveratrol and life extension
Agarwal, B., & Baur, J. A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05850.x · Cited by 160 · see citing works
Epigenetic linkage of aging, cancer and nutrition
Daniel, M. G., & Tollefsbol, T. O. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107110 · Cited by 158 · see citing works
Fasting and Caloric Restriction in Cancer Prevention and Treatment
Brandhorst, S., & Longo, V. D. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_12 · Cited by 158 · see citing works
Zhu, C.-T., Ingelmo, P., & Rand, D. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004354 · Cited by 149 · see citing works
Gensous, N., Garagnani, P., Santoro, A., Giuliani, C., Ostan, R., Fabbri, C., Milazzo, M., Gentilini, D., Blasio, A. M. D., Pietruszka, B., et al. (2020) · GeroScience · doi:10.1007/s11357-019-00149-0 · Cited by 148 · see citing works
Dietary Protein, Metabolism, and Aging
Soultoukis, G. A., & Partridge, L. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014422 · Cited by 147 · see citing works
Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice
Aon, M. A., Bernier, M., Mitchell, S. J., Germanio, C. D., Mattison, J. A., Ehrlich, M. R., Colman, R. J., Anderson, R. M., & de Cabo, R. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.018 · Cited by 146 · see citing works
Surgical Stress Resistance Induced by Single Amino Acid Deprivation RequiresGcn2in Mice
Peng, W., Robertson, L. T., Gallinetti, J., Mejia, P., Vose, S. C., Charlip, A., Chu, T., & Mitchell, J. R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002629 · Cited by 146 · see citing works
Genome-environment interactions that modulate aging: powerful targets for drug discovery
de Magalhães, J. P., Wuttke, D., Wood, S. H., Plank, M., & Vora, C. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004499 · Cited by 136 · see citing works
Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index
Kane, A. E., Hilmer, S. N., Boyer, D., Gavin, K., Nines, D., Howlett, S. E., de Cabo, R., & Mitchell, S. J. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu315 · Cited by 144 · see citing works
Lucanic, M., Plummer, W. T., Chen, E., Harke, J., Foulger, A., Onken, B., Coleman-Hulbert, A. L., Dumas, K. J., Guo, S., Johnson, E., et al. (2017) · Nature Communications · doi:10.1038/ncomms14256 · Cited by 134 · see citing works
Antiaging diets: Separating fact from fiction
Lee, M. B., Hill, C. M., Bitto, A., & Kaeberlein, M. R. (2021) · Science · doi:10.1126/science.abe7365 · Cited by 143 · see citing works
Adult-onset, short-term dietary restriction reduces cell senescence in mice
Wang, C., Maddick, M., Miwa, S., Jurk, D., Czapiewski, R., Saretzki, G., Langie, S. A. S., Godschalk, R. W. L., Cameron, K., & von Zglinicki, T. (2010) · Aging · doi:10.18632/aging.100196 · Cited by 142 · see citing works
Metformin for aging and cancer prevention
Anisimov, V. N. (2010) · Aging · doi:10.18632/aging.100230 · Cited by 140 · see citing works
Mice as a Mammalian Model for Research on the Genetics of Aging
Yuan, R., Peters, L. L., & Paigen, B. J. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.4 · Cited by 136 · see citing works
Macronutrients and caloric intake in health and longevity
Solon‐Biet, S. M., Mitchell, S. J., de Cabo, R., Raubenheimer, D., Couteur, D. G. L., & Simpson, S. J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0173 · Cited by 136 · see citing works
Neurogenesis in the aging brain
Apple, D. M., Fonseca, R. S., & Kokovay, E. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.116 · Cited by 140 · see citing works
Widespread sex dimorphism in aging and age-related diseases
Sampathkumar, N. K., Bravo, J. I., Chen, Y., Danthi, P. S., Donahue, E. K., Lai, R. W., Lu, R. J., Randall, L. T., Vinson, N. M., & Benayoun, B. A. (2019) · Human Genetics · doi:10.1007/s00439-019-02082-w · Cited by 127 · see citing works
Kaeberlein, M. R. (2013) · F1000Prime Reports · doi:10.12703/p5-5 · Cited by 131 · see citing works
Speakman, J. R., Mitchell, S. E., & Mazidi, M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.03.011 · Cited by 131 · see citing works
Hill, C. M., Albarado, D. C., Coco, L. G., Spann, R. A., Khan, M. S., Qualls-Creekmore, E., Burk, D. H., Burke, S. J., Collier, J. J., Yu, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29499-8 · Cited by 117 · see citing works
Mouse models of ageing and their relevance to disease
Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.001 · Cited by 125 · see citing works
Fat maintenance is a predictor of the murine lifespan response to dietary restriction
Liao, C., Rikke, B. A., Johnson, T. E., Gelfond, J. A. L., Diaz, V., & Nelson, J. F. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00702.x · Cited by 120 · see citing works
Self-citationMouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113 · see citing works
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
Ryu, S., Sidorov, S., Ravussin, É., Artyomov, M. N., Iwasaki, A., Wang, A., & Dixit, V. D. (2022) · Immunity · doi:10.1016/j.immuni.2022.07.007 · Cited by 121 · see citing works
Calorie restriction in rodents: Caveats to consider
Ingram, D. K., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.008 · Cited by 122 · see citing works
Sex-Specific Gene Expression and Life Span Regulation
Tower, J. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.07.002 · Cited by 118 · see citing works
Mitchell, S. E., Tang, Z., Kerbois, C., Delville, C., Konstantopedos, P., Bruel, A., Derous, D., Green, C., Aspden, R. M., Goodyear, S. R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4142 · Cited by 121 · see citing works
Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 120 · see citing works
Asynchronous, contagious and digital aging
Rando, T. A., & Wyss-Coray, T. (2021) · Nature Aging · doi:10.1038/s43587-020-00015-1 · Cited by 121 · see citing works
Dorling, J. L., Martin, C. K., & Redman, L. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101038 · Cited by 118 · see citing works
Wang, C., Wheeler, C. T., Alberico, T., Sun, X., Seeberger, J., Laslo, M., Spangler, E. L., Kern, B., de Cabo, R., & Zou, S. (2011) · AGE · doi:10.1007/s11357-011-9332-3 · Cited by 115 · see citing works
Vera, E., Bernardes de Jesus, B., Foronda, M., Flores, J. M., & Blasco, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053760 · Cited by 111 · see citing works
Green, C. L., Pak, H. H., Richardson, N. E., Flores, V., Yu, D., Tomasiewicz, J. L., Dumas, S. N., Kredell, K., Fan, J. W., Kirsh, C., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.018 · Cited by 99 · see citing works
Mitchell, S. E., Delville, C., Konstantopedos, P., Hurst, J. L., Derous, D., Green, C. L., Chen, L., Han, J., Wang, Y., Promislow, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4003 · Cited by 105 · see citing works
Resveratrol in mammals: effects on aging biomarkers, age‐related diseases, and life span
Marchal, J., Pifferi, F., & Aujard, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12214 · Cited by 99 · see citing works
Patel, S. A., Velingkaar, N., Makwana, K., Chaudhari, A., & Kondratov, R. V. (2016) · Scientific Reports · doi:10.1038/srep25970 · Cited by 99 · see citing works
Li, Y., & Tollefsbol, T. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017421 · Cited by 97 · see citing works
Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice
Flurkey, K., Astle, C. M., & Harrison, D. E. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq155 · Cited by 97 · see citing works
Imai, S. (2016) · npj Systems Biology and Applications · doi:10.1038/npjsba.2016.18 · Cited by 99 · see citing works
Aw, W. C., Towarnicki, S. G., Melvin, R. G., Youngson, N. A., Garvin, M. R., Hu, Y., Nielsen, S., Thomas, T., Pickford, R., Bustamante, S., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007735 · Cited by 95 · see citing works
Longevity effect of IGF ‐1 R +/− mutation depends on genetic background‐specific receptor activation
Xu, J., Gontier, G., Chaker, Z., Lacube, P., Dupont, J., & Holzenberger, M. (2013) · Aging Cell · doi:10.1111/acel.12145 · Cited by 93 · see citing works
Patel, S. A., Chaudhari, A., Gupta, R., Velingkaar, N., & Kondratov, R. V. (2016) · The FASEB Journal · doi:10.1096/fj.15-282475 · Cited by 94 · see citing works
Present and future of anti-ageing epigenetic diets
Bacalini, M. G., Friso, S., Olivieri, F., Pirazzini, C., Giuliani, C., Capri, M., Santoro, A., Franceschi, C., & Garagnani, P. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.006 · Cited by 94 · see citing works
The Geometric Framework for Nutrition as a tool in precision medicine
Simpson, S. J., Couteur, D. G. L., James, D. E., George, J., Gunton, J. E., Solon‐Biet, S. M., & Raubenheimer, D. (2017) · Nutrition and Healthy Aging · doi:10.3233/nha-170027 · Cited by 95 · see citing works
Regan, J. C., Froy, H., Walling, C. A., Moatt, J. P., & Nussey, D. H. (2019) · Functional Ecology · doi:10.1111/1365-2435.13418 · Cited by 93 · see citing works
Current nutritional and pharmacological anti-aging interventions
Ros, M., & Carrascosa, J. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 95 · see citing works
Aging: A mitochondrial DNA perspective, critical analysis and an update
Shokolenko, I. N. (2014) · World Journal of Experimental Medicine · doi:10.5493/wjem.v4.i4.46 · Cited by 99 · see citing works
Mihaylova, M. M., Chaix, A., Delibegović, M., Ramsey, J. J., Bass, J. T., Melkani, G. C., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.008 · Cited by 91 · see citing works
Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
Lin, A.-L., Zhang, W., Gao, X., & Watts, L. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.03.012 · Cited by 90 · see citing works
Metallothionein and the biology of aging
Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.007 · Cited by 89 · see citing works
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 87 · see citing works
Bartley, J. M., Zhou, X., Kuchel, G. A., Weinstock, G. M., & Haynes, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01164 · Cited by 87 · see citing works
Lu, J. Y., Simon, M. A., Zhao, Y., Ablaeva, J., Corson, N., Choi, Y., Yamada, K. Y. H., Schork, N. J., Hood, W. R., Hill, G. E., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.011 · Cited by 82 · see citing works
- Authors
- Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- University of Colorado Boulder (US)
- Corresponding author
- Nelson, James F.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2010-01-11
- Volume
- 9
- Issue
- 1
- Pages
- 92-95
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC3476836
- OpenAlex
- W2104438296
- Cited by
- 501
- References
- 26
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 25 · 2023: 24 · 2022: 32 · 2021: 34 · 2020: 39 · 2019: 33 · 2018: 30 · 2017: 31 · 2016: 41 · 2015: 39 · 2014: 30 · 2013: 31 · 2012: 21
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG024354)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- dietary restriction, lifespan, genetic variation, recombinant inbred mouse strains, lifespan extension, lifespan reduction, dietary intake, female fertility, sex differences in lifespan, genetic determinants of aging
- MeSH terms
- Animals, Female, Life Expectancy, Longevity, Male, Mice, Inbred Strains, Sex Characteristics, Genetic Variation, Caloric Restriction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
