Higgs, Douglas R.

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

Tufarelli, C., Stanley, J. A. S., Garrick, D., Sharpe, J. A., Ayyub, H., Wood, W. G., & Higgs, D. R. (2003) · Nature Genetics

Epigenetics and DNA MethylationCancer-related molecular mechanisms research

Cited by 547

α-thalassaemia

Harteveld, C. L., & Higgs, D. R. (2010) · Orphanet Journal of Rare Diseases

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 508

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment

Hughes, J. R., Roberts, N., McGowan, S., Hay, D., Giannoulatou, E., Lynch, M., De Gobbi, M., Taylor, S., Gibbons, R., & Higgs, D. R. (2014) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 461

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 373

The relationship between genome structure and function

Oudelaar, A. M., & Higgs, D. R. (2021) · Nature Reviews Genetics

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 304

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

Davies, J. O. J., Telenius, J. M., McGowan, S. J., Roberts, N. A., Taylor, S., Higgs, D. R., & Hughes, J. R. (2016) · Nature Methods

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 268

Intragenic Enhancers Act as Alternative Promoters

Kowalczyk, M. S., Hughes, J. R., Garrick, D., Lynch, M. D., Sharpe, J. A., Sloane-Stanley, J. A., McGowan, S. J., De Gobbi, M., Hosseini, M., Vernimmen, D., et al. (2012) · Molecular Cell

RNA Research and SplicingGenomics and Chromatin Dynamics

Cited by 267

Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression

Vernimmen, D., Gobbi, M. D., Sloane‐Stanley, J. A., Wood, W. G., & Higgs, D. R. (2007) · The EMBO Journal

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 244

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Hanssen, L. L. P., Kassouf, M. T., Oudelaar, A. M., Biggs, D., Preece, C., Downes, D. J., Gosden, M., Sharpe, J. A., Sloane-Stanley, J. A., Hughes, J. R., et al. (2017) · Nature Cell Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 219

Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA‐1 and GATA‐2

Anguita, E., Hughes, J., Heyworth, C., Blobel, G. A., Wood, W. G., & Higgs, D. R. (2004) · The EMBO Journal

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 207

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

Oudelaar, A. M., Davies, J. O. J., Hanssen, L. L. P., Telenius, J. M., Schwessinger, R., Liu, Y., Brown, J. M., Downes, D. J., Chiariello, A. M., Bianco, S., et al. (2018) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 196

Super-enhancers include classical enhancers and facilitators to fully activate gene expression

Blayney, J. W., Francis, H., Rampasekova, A., Camellato, B., Mitchell, L., Stolper, R., Cornell, L., Babbs, C., Boeke, J. D., Higgs, D. R., et al. (2023) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 196

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease

Jeziorska, D. M., Murray, R. J. S., De Gobbi, M., Gaentzsch, R., Garrick, D., Ayyub, H., Chen, T., Li, E., Telenius, J., Lynch, M., et al. (2017) · Proceedings of the National Academy of Sciences

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 166

Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate

Palii, C. G., Cheng, Q., Gillespie, M. A., Shannon, P., Mazurczyk, M., Napolitani, G., Price, N. D., Ranish, J. A., Morrissey, E., Higgs, D. R., et al. (2019) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationAdvanced Proteomics Techniques and Applications

Cited by 148

Dynamics of the 4D Genome during in Vivo Lineage Specification and Differentiation

Oudelaar, A. M., Beagrie, R. A., Gosden, M., de Ornellas, S., Georgiades, E., Kerry, J., Hidalgo, D., Carrelha, J., Shivalingam, A., El-Sagheer, A. H., et al. (2020) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 119

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

Lower, K. M., Hughes, J. R., De Gobbi, M., Henderson, S., Viprakasit, V., Fisher, C., Goriely, A., Ayyub, H., Sloane-Stanley, J., Vernimmen, D., et al. (2009) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 92

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

Oudelaar, A. M., Harrold, C. L., Hanssen, L. L. P., Telenius, J. M., Higgs, D. R., & Hughes, J. R. (2019) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 80

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

Brown, J. M., Roberts, N. A., Graham, B., Waithe, D., Lagerholm, C., Telenius, J. M., De Ornellas, S., Oudelaar, A. M., Scott, C., Szczerbal, I., et al. (2018) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 72

Identification of a conserved erythroid specific domain of histone acetylation across the α-globin gene cluster

Anguita, E., Johnson, C. A., Wood, W. G., Turner, B. M., & Higgs, D. R. (2001) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 70

Deletion of the mouse α-globin regulatory element (HS −26) has an unexpectedly mild phenotype

Anguita, E., Sharpe, J. A., Sloane-Stanley, J. A., Tufarelli, C., Higgs, D. R., & Wood, W. G. (2002) · Blood

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 58

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1α localization in erythroblasts

Renella, R., Roberts, N. A., Brown, J. M., De Gobbi, M., Bird, L. E., Hassanali, T., Sharpe, J. A., Sloane-Stanley, J., Ferguson, D. J. P., Cordell, J., et al. (2011) · Blood

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 54

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization

Oudelaar, A. M., Beagrie, R. A., Kassouf, M. T., & Higgs, D. R. (2021) · Current Opinion in Genetics & Development

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 27

Between form and function: the complexity of genome folding

Oudelaar, A. M., Hanssen, L. L. P., Hardison, R. C., Kassouf, M. T., Hughes, J. R., & Higgs, D. R. (2017) · Human Molecular Genetics

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 16

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference

Blobel, G. A., Bodine, D., Brand, M., Crispino, J., de Bruijn, M. F. T. R., Nathan, D., Papayannopoulou, T., Porcher, C., Strouboulis, J., Zon, L., et al. (2015) · Experimental Hematology

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 9