Between form and function: the complexity of genome folding
Open accessAbstract
It has been known for over a century that chromatin is not randomly distributed within the nucleus. However, the question of how DNA is folded and the influence of such folding on nuclear processes remain topics of intensive current research. A longstanding, unanswered question is whether nuclear organization is simply a reflection of nuclear processes such as transcription and replication, or whether chromatin is folded by independent mechanisms and this per se encodes function? Evidence is emerging that both may be true. Here, using the α-globin gene cluster as an illustrative model, we provide an overview of the most recent insights into the layers of genome organization across different scales and how this relates to gene activity.
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Incorporating specific chromatin modifications and boundary elements at distant regulatory sites has created a more complete picture of the underlying regulation at the α-globin locus.
“Incorporating specific chromatin modifications and boundary elements at these distant regulatory sites has created a more complete picture of the underlying regulation at this locus (Brown et al., 2018; Hanssen et al., 2017; Oudelaar et al., 2017).”
From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Oudelaar et al., 2017
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Self-citation
- Authors
- Oudelaar, A. M., Hanssen, L. L. P., Hardison, R. C., Kassouf, M. T., Hughes, J. R., & Higgs, D. R.
- Affiliations
- University of Oxford (GB)
- Pennsylvania State University (US)
- Corresponding author
- Higgs, Douglas R.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-08-16
- Volume
- 26
- Issue
- R2
- Pages
- R208-R215
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC5886466
- OpenAlex
- W2747734803
- Cited by
- 16
- References
- 69
- Citations by year
- 2023: 2 · 2022: 3 · 2020: 6 · 2019: 3 · 2018: 2
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Human Molecular Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (105281/Z/14/Z, 099684/Z/12/Z)
- Medical Research Council (4050189188)
- National Institutes of Health (R24DK106766)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromatin folding, nuclear organization, 3D genome organization, alpha-globin gene cluster, gene expression regulation, transcription, DNA replication, gene activity
- MeSH terms
- Animals, Cell Nucleus, Chromatin, DNA, DNA Replication, Multigene Family, Humans, Nucleic Acid Conformation, Transcription, Genetic, Genome, Genome Components, alpha-Globins
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