Sanjana, Neville E.

Improved vectors and genome-wide libraries for CRISPR screening

Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 5,239

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 5,234

Genome-scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening

Joung, J., Konermann, S., Gootenberg, J. S., Abudayyeh, O. O., Platt, R. J., Brigham, M. D., Sanjana, N. E., & Zhang, F. (2017) · Nature Protocols

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,243

High-throughput functional genomics using CRISPR-Cas9

Shalem, O., Sanjana, N. E., & Zhang, F. (2015) · Nature Reviews Genetics

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 1,233

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 886

Identification of essential genes for cancer immunotherapy

Patel, S. J., Sanjana, N. E., Kishton, R. J., Eidizadeh, A., Vodnala, S. K., Cam, M., Gartner, J. J., Jia, L., Steinberg, S. M., Yamamoto, T. N., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 870

Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells

Mimitou, E. P., Cheng, A., Montalbano, A., Hao, S., Stoeckius, M., Legut, M., Roush, T., Herrera, A., Papalexi, E., Ouyang, Z., et al. (2019) · Nature Methods

Single-cell and spatial transcriptomicsCRISPR and Genetic Engineering

Cited by 520

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

Parnas, O., Jovanovic, M., Eisenhaure, T. M., Herbst, R. H., Dixit, A., Ye, C. J., Przybylski, D., Platt, R. J., Tirosh, I., Sanjana, N. E., et al. (2015) · Cell

Immune Response and InflammationCRISPR and Genetic Engineering

Cited by 440

Autism genes converge on asynchronous development of shared neuron classes

Paulsen, B., Velasco, S., Kedaigle, A. J., Pigoni, M., Quadrato, G., Deo, A. J., Adiconis, X., Uzquiano, A., Sartore, R., Yang, S. M., et al. (2022) · Nature

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 439

Massively parallel Cas13 screens reveal principles for guide RNA design

Wessels, H.-H., Méndez-Mancilla, A., Guo, X., Legut, M., Daniloski, Z., & Sanjana, N. E. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 418

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

Zhou, Y., Kaiser, T., Monteiro, P., Zhang, X., Van der Goes, M. S., Wang, D., Barak, B., Zeng, M., Li, C., Lu, C., et al. (2016) · Neuron

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 325

Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens

Morris, J. A., Caragine, C., Daniloski, Z., Domingo, J., Barry, T., Lu, L., Davis, K., Ziosi, M., Glinos, D. A., Hao, S., et al. (2023) · Science

Genetic Associations and EpidemiologyCRISPR and Genetic Engineering

Cited by 208

Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens

Liscovitch-Brauer, N., Montalbano, A., Deng, J., Méndez-Mancilla, A., Wessels, H.-H., Moss, N. G., Kung, C.-Y., Sookdeo, A., Guo, X., Geller, E., et al. (2021) · Nature Biotechnology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 107

Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens

Guo, X., Rahman, J. A., Wessels, H.-H., Méndez-Mancilla, A., Haro, D., Chen, X., & Sanjana, N. E. (2021) · Cell Genomics

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 79

Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq

Wessels, H.-H., Méndez-Mancilla, A., Hao, Y., Papalexi, E., Mauck, W. M., Lu, L., Morris, J. A., Mimitou, E. P., Smibert, P., Sanjana, N. E., et al. (2023) · Nature Methods

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 79

Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells

Méndez-Mancilla, A., Wessels, H.-H., Legut, M., Kadina, A., Mabuchi, M., Walker, J., Robb, G. B., Holden, K., & Sanjana, N. E. (2022) · Cell Chemical Biology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 68

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

Domingo, J., Minaeva, M., Morris, J. A., Ghatan, S., Ziosi, M., Sanjana, N. E., & Lappalainen, T. (2024) · eLife

CRISPR and Genetic EngineeringGenomics and Chromatin Dynamics

Cited by 18

Non-linear transcriptional responses to gradual modulation of transcription factor dosage

Domingo, J., Minaeva, M., Morris, J. A., Ghatan, S., Ziosi, M., Sanjana, N. E., & Lappalainen, T. (2024) · eLife

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 6