Brain Iron Metabolism

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works

Iron, brain ageing and neurodegenerative disorders

Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801 · see citing works

Balancing Acts

Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736 · see citing works

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267 · see citing works

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159 · see citing works

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H., & Betsholtz, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.543 · Cited by 1,103 · see citing works

An iron-regulated ferric reductase associated with the absorption of dietary iron

McKie, A. T., Barrow, D., Latunde-Dada, G. O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., et al. (2001) · Science · doi:10.1126/science.1057206 · Cited by 1,101 · see citing works

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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The role of iron regulatory proteins in mammalian iron homeostasis and disease

Rouault, T. A. (2006) · Nature Chemical Biology · doi:10.1038/nchembio807 · Cited by 1,055 · see citing works

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

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Identification of an Intestinal Heme Transporter

Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F. E., Hider, R. C., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.025 · Cited by 755 · see citing works

Molecular Cloning of Transferrin Receptor 2

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

Wang, R.-H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.010 · Cited by 614 · see citing works

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

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Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works

Iron Metabolism and the IRE/IRP Regulatory System: An Update

Pantopoulos, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.001 · Cited by 505 · see citing works

Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation

Abbott, N. J. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-004-1374-y · Cited by 471 · see citing works

Identification of a Human Heme Exporter that Is Essential for Erythropoiesis

Quigley, J. G., Yang, Z., Worthington, M., Phillips, J. D., Sabo, K. M., Sabath, D. E., Berg, C. L., Sassa, S., Wood, B. L., & Abkowitz, J. L. (2004) · Cell · doi:10.1016/j.cell.2004.08.014 · Cited by 423 · see citing works

New roles for astrocytes: Gap junction hemichannels have something to communicate

Bennett, M. V. L., Contreras, J. E., Bukauskas, F. F., & Sáez, J. C. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.008 · Cited by 416 · see citing works

Transferrin and Transferrin Receptor Function in Brain Barrier Systems

Moos, T., & Morgan, E. H. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006948027674 · Cited by 394 · see citing works

Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system

Jeong, S. Y., & David, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301988200 · Cited by 377 · see citing works

Iron imports. IV. Hepcidin and regulation of body iron metabolism

Ganz, T., & Nemeth, E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2005 · Cited by 347 · see citing works

Transferrin receptor 1

Aisen, P. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.007 · Cited by 329 · see citing works

Neurodegeneration with brain iron accumulation

Hayflick, S. J., Kurian, M. A., & Hogarth, P. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63233-3.00019-1 · Cited by 323 · see citing works

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

Burdo, J. R., Menzies, S. L., Simpson, I. A., Garrick, L. M., Garrick, M. D., Dolan, K. G., Haile, D. J., Beard, J. L., & Connor, J. R. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1256 · Cited by 297 · see citing works

Uptake of metals in the brain via olfactory pathways.

Tjälve, H., & Henriksson, J. (1999) · PubMed · Cited by 291 · see citing works

Iron trafficking in the mitochondrion: novel pathways revealed by disease

Napier, I. A., Ponka, P., & Richardson, D. R. (2004) · Blood · doi:10.1182/blood-2004-10-3856 · Cited by 287 · see citing works

Transport of Iron in the Blood‐Brain‐Cerebrospinal Fluid System

Bradbury, M. W. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020443.x · Cited by 270 · see citing works

Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration

Hahn, P., Qian, Y., Dentchev, T., Chen, L., Beard, J., Harris, Z. L., & Dunaief, J. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405146101 · Cited by 264 · see citing works

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

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Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

Cooperman, S. S., Meyron-Holtz, E. G., Olivierre-Wilson, H., Ghosh, M. C., McConnell, J. P., & Rouault, T. A. (2005) · Blood · doi:10.1182/blood-2004-12-4703 · Cited by 235 · see citing works

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 222 · see citing works

Cellular management of iron in the brain

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Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier

Wu, L. J.-C., Leenders, A. G. M., Cooperman, S., Meyron-Holtz, E., Smith, S., Land, W., Tsai, R. Y. L., Berger, U. V., Sheng, Z.-H., & Rouault, T. A. (2004) · Brain Research · doi:10.1016/j.brainres.2003.10.066 · Cited by 210 · see citing works

Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia

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The rat blood-brain barrier transcriptome

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Organization of connections between the amygdaloid complex and the perirhinal and parahippocampal cortices in macaque monkeys

Stefanacci, L., Suzuki, W., & Amaral, D. G. (1996) · The Journal of comparative neurology · doi:10.1002/(sici)1096-9861(19961125)375:4 · Cited by 199 · see citing works

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

Bartzokis, G., Tishler, T. A., Shin, I., Lu, P. H., & Cummings, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.019 · Cited by 184 · see citing works

The critical component to establish in vitro BBB model: Pericyte

Lai, C.-H., & Kuo, K. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.07.004 · Cited by 182 · see citing works

Hallervorden‐Spatz disease: Cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus

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Aceruloplasminemia: An Inherited Neurodegenerative Disease with Impairment of Iron Homeostasis

XU, X., PIN, S., GATHINJI, M., FUCHS, R., & HARRIS, Z. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.024 · Cited by 160 · see citing works

Neurobehavioral analysis of developmental iron deficiency in rats

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Moderate iron deficiency in infancy: biology and behavior in young rats

Beard, J. L., Felt, B., Schallert, T., Burhans, M., Connor, J. R., & Georgieff, M. K. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.024 · Cited by 146 · see citing works

Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes

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Hemochromatosis: Genetics and Pathophysiology

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Iron accumulation, iron‐mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate

Hoepken, H. H., Korten, T., Robinson, S. R., & Dringen, R. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02236.x · Cited by 132 · see citing works

Transferrin, the transferrin receptor, and the uptake of iron by cells.

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The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain

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Recent advances in mammalian haem transport

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Metal transporters and disease

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Mechanisms and regulation of transferrin and iron transport in a model blood–brain barrier system

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Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter

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An autoradiographic study of the uptake and distribution of iron by the brain of the young rat

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Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism.

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REVIEW ARTICLE Neurodegeneration with brain iron accumulation

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Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: Comparison between immune-mediated demyelination and wallerian degeneration

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Innate immunity and brain inflammation: the key role of complement

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Detecting single atoms of calcium and iron in biological structures by electron energy‐loss spectrum‐imaging

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Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.

Hahn, P., Dentchev, T., Qian, Y., Rouault, T. A., Harris, Z. L., & Dunaief, J. L. (2004) · PubMed · Cited by 74 · see citing works

Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: a case report series

Costello, D. J. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.027441 · Cited by 70 · see citing works

Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain

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Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia

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Strong Labeling for Iron and the Iron-Handling Proteins Ferritin and Ferroportin in the Photoreceptor Layer in Age-Related Macular Degeneration

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Role of dietary iron restriction in a mouse model of Parkinson's disease

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Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism

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Brain iron uptake in hypotransferrinemic mice: Influence of systemic iron status

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Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death

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Iron Imports. VI. HFE and regulation of intestinal iron absorption

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Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain

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Reduction and Oxidation of the Active Site Iron in Tyrosine Hydroxylase: Kinetics and Specificity

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Characterization of lectin-mediated brain uptake of HIV-1 GP120

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Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin.

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The Intestinal Heme Transporter Revealed

Rouault, T. A. (2005) · Cell · doi:10.1016/j.cell.2005.08.027 · Cited by 47 · see citing works

Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia

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Inhaled iron, unlike manganese, is not transported to the rat brain via the olfactory pathway

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Effects of diet and development upon the uptake and distribution of cerebral iron

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Permeable Endothelium and the Interstitial Space of Brain

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Movement disorders in the Hfe knockout mouse

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Neurodegeneration with Brain Iron Accumulation

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[Hepcidin: a key peptide in iron metabolism].

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Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

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Iron Overload in Human Disease

Fleming, R. E., & Ponka, P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1004967 · Cited by 592 · see citing works

Iron metabolism in the CNS: implications for neurodegenerative diseases

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Surgery, neuroinflammation and cognitive impairment

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A delicate balance: Iron metabolism and diseases of the brain

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Iron trafficking inside the brain

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Iron and mechanisms of emotional behavior

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Alteration in Iron Metabolism during Retinal Degeneration in rd10 Mouse

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Manganese in Occupational Arc Welding Fumes—Aspects on Physiochemical Properties, with Focus on Solubility

Taube, F. (2012) · The Annals of Occupational Hygiene · doi:10.1093/annhyg/mes053 · Cited by 47 · see citing works

Iron metabolism in the central nervous system

Yoshida, K. (2012) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.52.943 · Cited by 3 · see citing works

Brain iron transport

Qian, Z., & Ke, Y. (2019) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12521 · Cited by 117 · see citing works

Mechanisms and regulation of transferrin and iron transport in a model blood–brain barrier system

Burdo, J. R., Antonetti, D. A., Wolpert, E. B., & Connor, J. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00590-6 · Cited by 106 · see citing works

A Novel Model for Brain Iron Uptake: Introducing the Concept of Regulation

Simpson, I. A., Ponnuru, P., Klinger, M., Myers, R. L., Devraj, K., Coe, C. L., Lubach, G. R., Carruthers, A., & Connor, J. R. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.168 · Cited by 139 · see citing works

The Metabolism of Neuronal Iron and Its Pathogenic Role in Neurological Disease: Review

Moos, T., & Morgan, E. H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.002 · Cited by 234 · see citing works