Fukumura, Dai

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 2,502

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

Fukumura, D., Kloepper, J., Amoozgar, Z., Duda, D. G., & Jain, R. K. (2018) · Nature Reviews Clinical Oncology

Angiogenesis and VEGF in CancerCancer Immunotherapy and Biomarkers

Cited by 2,027

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

Goel, S., Duda, D. G., Xu, L., Munn, L. L., Boucher, Y., Fukumura, D., & Jain, R. K. (2011) · Physiological Reviews

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 1,605

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

Winkler, F., Kozin, S. V., Tong, R. T., Chae, S.-S., Booth, M. F., Garkavtsev, I., Xu, L., Hicklin, D. J., Fukumura, D., di Tomaso, E., et al. (2004) · Cancer Cell

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 1,170

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology

Nanoparticle-Based Drug DeliveryAngiogenesis and VEGF in Cancer

Cited by 1,101

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

Huang, Y., Yuan, J., Righi, E., Kamoun, W. S., Ancukiewicz, M., Nezivar, J., Santosuosso, M., Martin, J. D., Martin, M. R., Vianello, F., et al. (2012) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerCancer Immunotherapy and Biomarkers

Cited by 1,099

Tumor Induction of VEGF Promoter Activity in Stromal Cells

Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E.-C., Lu, N., Selig, M., Nielsen, G., Taksir, T., Jain, R. K., et al. (1998) · Cell

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 996

Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences

Optical Imaging and Spectroscopy TechniquesSpectroscopy Techniques in Biomedical and Chemical Research

Cited by 721

Creation of long-lasting blood vessels

Koike, N., Fukumura, D., Gralla, O., Au, P., Schechner, J. S., & Jain, R. K. (2004) · Nature

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Cited by 701

Next-generation in vivo optical imaging with short-wave infrared quantum dots

Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering

Quantum Dots Synthesis And PropertiesOptical Imaging and Spectroscopy Techniques

Cited by 686

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

Huang, Y., Goel, S., Duda, D. G., Fukumura, D., & Jain, R. K. (2013) · Cancer Research

Angiogenesis and VEGF in CancerCancer Immunotherapy and Biomarkers

Cited by 669

Herceptin acts as an anti-angiogenic cocktail

Izumi, Y., Xu, L., di Tomaso, E., Fukumura, D., & Jain, R. K. (2002) · Nature

Angiogenesis and VEGF in CancerHER2/EGFR in Cancer Research

Cited by 623

Malignant cells facilitate lung metastasis by bringing their own soil

Duda, D. G., Duyverman, A. M. M. J., Kohno, M., Snuderl, M., Steller, E. J. A., Fukumura, D., & Jain, R. K. (2010) · Proceedings of the National Academy of Sciences

Cancer Cells and MetastasisMechanisms of cancer metastasis

Cited by 594

Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize

Fukumura, D., & Jain, R. K. (2007) · Journal of Cellular Biochemistry

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 584

The biology of brain metastases—translation to new therapies

Eichler, A. F., Chung, E., Kodack, D. P., Loeffler, J. S., Fukumura, D., & Jain, R. K. (2011) · Nature Reviews Clinical Oncology

Brain Metastases and TreatmentGlioma Diagnosis and Treatment

Cited by 567

Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis

Fukumura, D., Ushiyama, A., Duda, D. G., Xu, L., Tam, J., Krishna, V., Chatterjee, K., Garkavtsev, I., & Jain, R. K. (2003) · Circulation Research

Angiogenesis and VEGF in CancerAdipose Tissue and Metabolism

Cited by 365

Imaging Steps of Lymphatic Metastasis Reveals That Vascular Endothelial Growth Factor-C Increases Metastasis by Increasing Delivery of Cancer Cells to Lymph Nodes: Therapeutic Implications

Hoshida, T., Isaka, N., Hagendoorn, J., di Tomaso, E., Chen, Y.-L., Pytowski, B., Fukumura, D., Padera, T. P., & Jain, R. K. (2006) · Cancer Research

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 361

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Kloepper, J., Riedemann, L., Amoozgar, Z., Seano, G., Susek, K., Yu, V., Dalvie, N., Amelung, R. L., Datta, M., Song, J. W., et al. (2016) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerGlioma Diagnosis and Treatment

Cited by 357

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Peterson, T. E., Kirkpatrick, N. D., Huang, Y., Farrar, C. T., Marijt, K. A., Kloepper, J., Datta, M., Amoozgar, Z., Seano, G., Jung, K., et al. (2016) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerGlioma Diagnosis and Treatment

Cited by 317

Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice

Kamoun, W. S., Ley, C. D., Farrar, C. T., Duyverman, A. M., Lahdenranta, J., Lacorre, D. A., Batchelor, T. T., di Tomaso, E., Duda, D. G., Munn, L. L., et al. (2009) · Journal of Clinical Oncology

Angiogenesis and VEGF in CancerGlioma Diagnosis and Treatment

Cited by 309

Impaired lymphatic contraction associated with immunosuppression

Liao, S., Cheng, G., Conner, D. A., Huang, Y., Kucherlapati, R. S., Munn, L. L., Ruddle, N. H., Jain, R. K., Fukumura, D., & Padera, T. P. (2011) · Proceedings of the National Academy of Sciences

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 296

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

Whitley, M. J., Cardona, D. M., Lazarides, A. L., Spasojevic, I., Ferrer, J. M., Cahill, J., Lee, C.-L., Snuderl, M., Blazer, D. G., Hwang, E. S., et al. (2016) · Science Translational Medicine

Protease and Inhibitor MechanismsNanoplatforms for cancer theranostics

Cited by 296

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

Rahbari, N. N., Kedrin, D., Incio, J., Liu, H., Ho, W. W., Nia, H. T., Edrich, C. M., Jung, K., Daubriac, J., Chen, I., et al. (2016) · Science Translational Medicine

Angiogenesis and VEGF in CancerColorectal Cancer Treatments and Studies

Cited by 258

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Incio, J., Ligibel, J. A., McManus, D. T., Suboj, P., Jung, K., Kawaguchi, K., Pinter, M., Babykutty, S., Chin, S. M., Vardam, T. D., et al. (2018) · Science Translational Medicine

Angiogenesis and VEGF in CancerLymphatic System and Diseases

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