Akira, Shizuo

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 1,220

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature

Autophagy in Disease and TherapyCardiac Fibrosis and Remodeling

Cited by 1,201

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology

Immune cells in cancerParasites and Host Interactions

Cited by 1,156

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology

Vagus Nerve Stimulation ResearchCytokine Signaling Pathways and Interactions

Cited by 1,074

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

Loo, Y.-M., Fornek, J., Crochet, N., Bajwa, G., Perwitasari, O., Martinez-Sobrido, L., Akira, S., Gill, M. A., García-Sastre, A., Katze, M. G., et al. (2008) · Journal of Virology

interferon and immune responsesImmune Response and Inflammation

Cited by 1,071

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 1,019

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Michelsen, K. S., Wong, M. H., Shah, P. K., Zhang, W., Yano, J., Doherty, T. M., Akira, S., Rajavashisth, T. B., & Arditi, M. (2004) · Proceedings of the National Academy of Sciences

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 1,019

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysGenomics and Chromatin Dynamics

Cited by 959

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S., & Sofroniew, M. V. (2008) · The Journal of Neuroscience

Spinal Cord Injury ResearchCytokine Signaling Pathways and Interactions

Cited by 958

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine

Immune Response and InflammationInflammasome and immune disorders

Cited by 876

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer

Lesina, M., Kurkowski, M. U., Ludes, K., Rose-John, S., Treiber, M., Klöppel, G., Yoshimura, A., Reindl, W., Sipos, B., Akira, S., et al. (2011) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCytokine Signaling Pathways and Interactions

Cited by 862

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., et al. (2009) · Proceedings of the National Academy of Sciences

interferon and immune responsesImmune Response and Inflammation

Cited by 854

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 771

Targeted disruption of the chop gene delays endoplasmic reticulum stress-mediated diabetes

Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 752

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Bambouskova, M., Gorvel, L., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Korenfeld, D., Mathyer, M. E., Kim, H., Huang, L.-H., et al. (2018) · Nature

NF-κB Signaling PathwaysGenomics, phytochemicals, and oxidative stress

Cited by 713

Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus

Guillot, L., Le Goffic, R., Bloch, S., Escriou, N., Akira, S., Chignard, M., & Si-Tahar, M. (2005) · Journal of Biological Chemistry

Immune Response and Inflammationinterferon and immune responses

Cited by 689

The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

Hiratsuka, S., Watanabe, A., Sakurai, Y., Akashi-Takamura, S., Ishibashi, S., Miyake, K., Shibuya, M., Akira, S., Aburatani, H., & Maru, Y. (2008) · Nature Cell Biology

S100 Proteins and AnnexinsChemokine receptors and signaling

Cited by 642

IgG1 plasmacytosis in interleukin 6 transgenic mice

Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1989) · Proceedings of the National Academy of Sciences

Multiple Myeloma Research and TreatmentsLymphoma Diagnosis and Treatment

Cited by 586

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 584

Quantitative proteomics reveals subset-specific viral recognition in dendritic cells

Luber, C. A., Cox, J., Lauterbach, H., Fancke, B., Selbach, M., Tschopp, J., Akira, S., Wiegand, M., Hochrein, H., O'Keeffe, M., et al. (2010) · Immunity

Immunotherapy and Immune ResponsesAdvanced Proteomics Techniques and Applications

Cited by 576

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

Abdollahi-Roodsaz, S., Joosten, L. A. B., Koenders, M. I., Devesa, I., Roelofs, M. F., Radstake, T. R. D. J., Heuvelmans-Jacobs, M., Akira, S., Nicklin, M. J. H., Ribeiro-Dias, F., et al. (2008) · Journal of Clinical Investigation

Immune Response and InflammationRheumatoid Arthritis Research and Therapies

Cited by 527

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

Sano, S., Itami, S., Takeda, K., Tarutani, M., Yamaguchi, Y., Miura, H., Yoshikawa, K., Akira, S., & Takeda, J. (1999) · The EMBO Journal

Cytokine Signaling Pathways and InteractionsHair Growth and Disorders

Cited by 519

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

Matsunaga, K., Morita, E., Saitoh, T., Akira, S., Ktistakis, N. T., Izumi, T., Noda, T., & Yoshimori, T. (2010) · Journal of Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 456

Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

Amer, A., Franchi, L., Kanneganti, T.-D., Body-Malapel, M., Özören, N., Brady, G., Meshinchi, S., Jagirdar, R., Gewirtz, A., Akira, S., et al. (2006) · Journal of Biological Chemistry

Legionella and Acanthamoeba researchInflammasome and immune disorders

Cited by 453