Akira, Shizuo

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

Nairz, M., Theurl, I., Schroll, A., Theurl, M., Fritsche, G., Lindner, E., Seifert, M., Crouch, M.-L. V., Hantke, K., Akira, S., et al. (2009) · Blood

Iron Metabolism and DisordersSalmonella and Campylobacter epidemiology

Cited by 146

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Matsuda, T., Murao, N., Katano, Y., Juliandi, B., Kohyama, J., Akira, S., Kawai, T., & Nakashima, K. (2015) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 145

Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke, P., Takeuchi, O., Malley, R., Lien, E., Ingalls, R. R., Freeman, M. W., Mayadas, T., Nizet, V., Akira, S., Kasper, D. L., et al. (2002) · The Journal of Immunology

Immune Response and InflammationNeonatal and Maternal Infections

Cited by 145

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O., & Akira, S. (2005) · Biochemical and Biophysical Research Communications

Immune Response and InflammationInflammasome and immune disorders

Cited by 135

Lipocalin 2-Dependent Inhibition of Mycobacterial Growth in Alveolar Epithelium

Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., et al. (2008) · The Journal of Immunology

Tuberculosis Research and EpidemiologyImmune Response and Inflammation

Cited by 133

Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning

SMITH, R., SULEMAN, N., LACERDA, L., OPIE, L., AKIRA, S., CHIEN, K., & SACK, M. (2004) · Cardiovascular Research

Cardiac Ischemia and ReperfusionTransplantation: Methods and Outcomes

Cited by 128

Stat-3 is required for pulmonary homeostasis during hyperoxia

Hokuto, I., Ikegami, M., Yoshida, M., Takeda, K., Akira, S., Perl, A.-K. T., Hull, W. M., Wert, S. E., & Whitsett, J. A. (2004) · Journal of Clinical Investigation

Neonatal Respiratory Health ResearchRespiratory Support and Mechanisms

Cited by 128

TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

Fei, M., Bhatia, S., Oriss, T. B., Yarlagadda, M., Khare, A., Akira, S., Saijo, S., Iwakura, Y., Fallert Junecko, B. A., Reinhart, T. A., et al. (2011) · Proceedings of the National Academy of Sciences

Asthma and respiratory diseasesAntifungal resistance and susceptibility

Cited by 127

Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

Yasuda, K., Richez, C., Uccellini, M. B., Richards, R. J., Bonegio, R. G., Akira, S., Monestier, M., Corley, R. B., Viglianti, G. A., Marshak-Rothstein, A., et al. (2009) · The Journal of Immunology

Immune Response and InflammationSystemic Lupus Erythematosus Research

Cited by 118

Targeting dendritic cell signaling to regulate the response to immunization

Escors, D., Lopes, L., Lin, R., Hiscott, J., Akira, S., Davis, R. J., & Collins, M. K. (2008) · Blood

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 116

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling

Bourgeois, C., Majer, O., Frohner, I. E., Lesiak-Markowicz, I., Hildering, K.-S., Glaser, W., Stockinger, S., Decker, T., Akira, S., Müller, M., et al. (2011) · The Journal of Immunology

Immune Response and Inflammationinterferon and immune responses

Cited by 116

Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

Miyake, T., Kumagai, Y., Kato, H., Guo, Z., Matsushita, K., Satoh, T., Kawagoe, T., Kumar, H., Jang, M. H., Kawai, T., et al. (2009) · The Journal of Immunology

Immune Cell Function and Interactioninterferon and immune responses

Cited by 115

Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., & Nakanishi, Y. (2004) · The Journal of Immunology

Phagocytosis and Immune RegulationImmune Response and Inflammation

Cited by 112

Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice

Haga, S., Ogawa, W., Inoue, H., Terui, K., Ogino, T., Igarashi, R., Takeda, K., Akira, S., Enosawa, S., Furukawa, H., et al. (2005) · Journal of Hepatology

Liver physiology and pathologyOrgan Transplantation Techniques and Outcomes

Cited by 108

Calcineurin Negatively Regulates TLR-Mediated Activation Pathways

Kang, Y. J., Kusler, B., Otsuka, M., Hughes, M., Suzuki, N., Suzuki, S., Yeh, W.-C., Akira, S., Han, J., & Jones, P. P. (2007) · The Journal of Immunology

Immune Response and InflammationSignaling Pathways in Disease

Cited by 104

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis

Zou, J., Kawai, T., Tsuchida, T., Kozaki, T., Tanaka, H., Shin, K.-S., Kumar, H., & Akira, S. (2013) · Immunity

Immune Response and Inflammationinterferon and immune responses

Cited by 103

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Wilson, N. S., Young, L. J., Kupresanin, F., Naik, S. H., Vremec, D., Heath, W. R., Akira, S., Shortman, K., Boyle, J., Maraskovsky, E., et al. (2008) · Immunology & Cell Biology

Immunotherapy and Immune ResponsesImmune Response and Inflammation

Cited by 102

Prion pathogenesis in the absence of Toll-like receptor signalling

Prinz, M., Heikenwalder, M., Schwarz, P., Takeda, K., Akira, S., & Aguzzi, A. (2003) · The EMBO Reports

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 85

Contribution of Toll-like Receptor 9 Signaling to the Acute Inflammatory Response to Nonviral Vectors

Zhao, H., Hemmi, H., Akira, S., Cheng, S. H., Scheule, R. K., & Yew, N. S. (2004) · Molecular Therapy

RNA Interference and Gene DeliveryImmune Response and Inflammation

Cited by 85

Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

Quinton, L. J., Blahna, M. T., Jones, M. R., Allen, E., Ferrari, J. D., Hilliard, K. L., Zhang, X., Sabharwal, V., Algül, H., Akira, S., et al. (2012) · Journal of Clinical Investigation

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Cited by 84

Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model

Saijou, E., Enomoto, Y., Matsuda, M., Yuet‐Yin Kok, C., Akira, S., Tanaka, M., & Miyajima, A. (2018) · Hepatology Communications

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 84

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

Brenner, D., Sieverding, K., Bruno, C., Lüningschrör, P., Buck, E., Mungwa, S., Fischer, L., Brockmann, S. J., Ulmer, J., Bliederhäuser, C., et al. (2019) · Journal of Experimental Medicine

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 83

The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells

Shokouhi, B., Coban, C., Hasirci, V., Aydin, E., Dhanasingh, A., Shi, N., Koyama, S., Akira, S., Zenke, M., & Sechi, A. S. (2010) · Biomaterials

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 77

Intracellular Mycobacterium avium Intersect Transferrin in the Rab11+Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway

Halaas, Ø., Steigedal, M., Haug, M., Awuh, J. A., Ryan, L., Brech, A., Sato, S., Husebye, H., Cangelosi, G. A., Akira, S., et al. (2010) · The Journal of Infectious Diseases

Mycobacterium research and diagnosisTuberculosis Research and Epidemiology

Cited by 68