Akira, Shizuo

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R., & Aguzzi, A. (2004) · Nature Medicine

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 449

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

Netea, M. G., Joosten, L. A. B., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J., van Krieken, H., Kim, S.-H., Stalenhoef, A. F., et al. (2006) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 424

Dissecting negative regulation of Toll-like receptor signaling

Kondo, T., Kawai, T., & Akira, S. (2012) · Trends in Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 419

TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification

Oldenburg, M., Krüger, A., Ferstl, R., Kaufmann, A., Nees, G., Sigmund, A., Bathke, B., Lauterbach, H., Suter, M., Dreher, S., et al. (2012) · Science

Immune Response and InflammationRNA and protein synthesis mechanisms

Cited by 405

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H.-H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., et al. (2015) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 390

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S. S., Kirschnek, S., Gaffal, E., Landsberg, J., Hellmuth, J., et al. (2008) · Nature Medicine

RNA Interference and Gene Deliveryinterferon and immune responses

Cited by 387

Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., et al. (2004) · Nature Medicine

Cytokine Signaling Pathways and InteractionsMetabolism, Diabetes, and Cancer

Cited by 384

A Critical Role for Stat3 Signaling in Immune Tolerance

Cheng, F., Wang, H.-W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., Kerr, W. G., Takeda, K., Akira, S., Schoenberger, S. P., et al. (2003) · Immunity

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 377

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

Kinoshita, S., Akira, S., & Kishimoto, T. (1992) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 327

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Geng, J., Ito, Y., Shi, L., Amin, P., Chu, J., Ouchida, A. T., Mookhtiar, A. K., Zhao, H., Xu, D., Shan, B., et al. (2017) · Nature Communications

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 325

Identification of an atypical monocyte and committed progenitor involved in fibrosis

Satoh, T., Nakagawa, K., Sugihara, F., Kuwahara, R., Ashihara, M., Yamane, F., Minowa, Y., Fukushima, K., Ebina, I., Yoshioka, Y., et al. (2017) · Nature

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisImmune cells in cancer

Cited by 302

Microbial recognition by Toll-like receptors

Takeda, K., & Akira, S. (2004) · Journal of Dermatological Science

Immune Response and InflammationInflammasome and immune disorders

Cited by 285

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T., Kubota, N., Kaneko, K., Kobayashi, M., Iwane, A., Sasako, T., Okazaki, Y., et al. (2011) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 277

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O’Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., et al. (2016) · Proceedings of the National Academy of Sciences

Fibroblast Growth Factor ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 241

Pathogen recognition by innate immunity and its signaling

AKIRA, S. (2009) · Proceedings of the Japan Academy, Series B

Immune Response and Inflammationinterferon and immune responses

Cited by 240

A critical role of IL-33 in experimental allergic rhinitis

Haenuki, Y., Matsushita, K., Futatsugi-Yumikura, S., Ishii, K. J., Kawagoe, T., Imoto, Y., Fujieda, S., Yasuda, M., Hisa, Y., Akira, S., et al. (2012) · Journal of Allergy and Clinical Immunology

IL-33, ST2, and ILC PathwaysAllergic Rhinitis and Sensitization

Cited by 233

Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining

Akira, S., Okazaki, K., & Sakano, H. (1987) · Science

DNA Repair MechanismsT-cell and B-cell Immunology

Cited by 218

Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling

Bradley, L. M., Douglass, M. F., Chatterjee, D., Akira, S., & Baaten, B. J. G. (2012) · PLoS Pathogens

Influenza Virus Research StudiesProtease and Inhibitor Mechanisms

Cited by 207

Toll-Like Receptor 2 Is Required for Optimal Control of Listeria monocytogenes Infection

Torres, D., Barrier, M., Bihl, F., Quesniaux, V. J. F., Maillet, I., Akira, S., Ryffel, B., & Erard, F. (2004) · Infection and Immunity

Immune Response and InflammationImmune responses and vaccinations

Cited by 191

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

DeVorkin, L., Pavey, N., Carleton, G., Comber, A., Ho, C., Lim, J., McNamara, E., Huang, H., Kim, P., Zacharias, L. G., et al. (2019) · Cell Reports

Autophagy in Disease and TherapyT-cell and B-cell Immunology

Cited by 185

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

Hernandez-Cuellar, E., Tsuchiya, K., Hara, H., Fang, R., Sakai, S., Kawamura, I., Akira, S., & Mitsuyama, M. (2012) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 184

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella

Kageyama, S., Omori, H., Saitoh, T., Sone, T., Guan, J.-L., Akira, S., Imamoto, F., Noda, T., & Yoshimori, T. (2011) · Molecular Biology of the Cell

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 175

The Nuclear IκB Protein IκBNS Selectively Inhibits Lipopolysaccharide-Induced IL-6 Production in Macrophages of the Colonic Lamina Propria

Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., & Takeda, K. (2005) · The Journal of Immunology

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 167

Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

Hashimoto, A., Takeda, K., Inaba, M., Sekimata, M., Kaisho, T., Ikehara, S., Homma, Y., Akira, S., & Kurosaki, T. (2000) · The Journal of Immunology

T-cell and B-cell ImmunologyNF-κB Signaling Pathways

Cited by 155