Nureki, Osamu

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 2,825

Crystal structure of Cas9 in complex with guide RNA and target DNA

Nishimasu, H., Ran, F. A., Hsu, P. D., Konermann, S., Shehata, S. I., Dohmae, N., Ishitani, R., Zhang, F., & Nureki, O. (2014) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,306

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Nishimasu, H., Shi, X., Ishiguro, S., Gao, L., Hirano, S., Okazaki, S., Noda, T., Abudayyeh, O. O., Gootenberg, J. S., Mori, H., et al. (2018) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,100

Engineered Cpf1 variants with altered PAM specificities

Gao, L., Cox, D. B. T., Yan, W. X., Manteiga, J. C., Schneider, M. W., Yamano, T., Nishimasu, H., Nureki, O., Crosetto, N., & Zhang, F. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 460

Structure and function of a membrane component SecDF that enhances protein export

Tsukazaki, T., Mori, H., Echizen, Y., Ishitani, R., Fukai, S., Tanaka, T., Perederina, A., Vassylyev, D. G., Kohno, T., Maturana, A. D., et al. (2011) · Nature

Bacterial Genetics and BiotechnologyHeat shock proteins research

Cited by 219

Recurrent somatic mutations underlie corticotropin-independent Cushing’s syndrome

Sato, Y., Maekawa, S., Ishii, R., Sanada, M., Morikawa, T., Shiraishi, Y., Yoshida, K., Nagata, Y., Sato-Otsubo, A., Yoshizato, T., et al. (2014) · Science

Adrenal and Paraganglionic TumorsPituitary Gland Disorders and Treatments

Cited by 209

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

Hiraizumi, M., Yamashita, K., Nishizawa, T., & Nureki, O. (2019) · Science

Lipid Membrane Structure and BehaviorATP Synthase and ATPases Research

Cited by 185

Structural basis for the altered PAM specificities of engineered CRISPR-cas9

Hirano, S., Nishimasu, H., Ishitani, R., & Nureki, O. (2016) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 152

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

Kishi, K. E., Kim, Y. S., Fukuda, M., Inoue, M., Kusakizako, T., Wang, P. Y., Ramakrishnan, C., Byrne, E. F. X., Thadhani, E., Paggi, J. M., et al. (2022) · Cell

Photoreceptor and optogenetics researchIon channel regulation and function

Cited by 149

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

Taniguchi, R., Kato, H. E., Font, J., Deshpande, C. N., Wada, M., Ito, K., Ishitani, R., Jormakka, M., & Nureki, O. (2015) · Nature Communications

Iron Metabolism and DisordersProtein Structure and Dynamics

Cited by 120

Mg2+‐dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis

Hattori, M., Iwase, N., Furuya, N., Tanaka, Y., Tsukazaki, T., Ishitani, R., Maguire, M. E., Ito, K., Maturana, A., & Nureki, O. (2009) · The EMBO Journal

Ion channel regulation and functionMagnesium in Health and Disease

Cited by 109

Structural basis for the altered PAM recognition by engineered CRISPR-Cpf1

Nishimasu, H., Yamano, T., Gao, L., Zhang, F., Ishitani, R., & Nureki, O. (2017) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 102

Phototrophy by antenna-containing rhodopsin pumps in aquatic environments

Chazan, A., Das, I., Fujiwara, T., Murakoshi, S., Rozenberg, A., Molina-Márquez, A., Sano, F. K., Tanaka, T., Gómez-Villegas, P., Larom, S., et al. (2023) · Nature

Photoreceptor and optogenetics researchPhotosynthetic Processes and Mechanisms

Cited by 49

Regulation of Platelet Dense Granule Secretion by the Ral GTPase-Exocyst Pathway

Kawato, M., Shirakawa, R., Kondo, H., Higashi, T., Ikeda, T., Okawa, K., Fukai, S., Nureki, O., Kita, T., & Horiuchi, H. (2008) · Journal of Biological Chemistry

Cellular transport and secretionPlatelet Disorders and Treatments

Cited by 46

Structural basis for lysophosphatidylserine recognition by GPR34

Izume, T., Kawahara, R., Uwamizu, A., Chen, L., Yaginuma, S., Omi, J., Kawana, H., Hou, F., Sano, F. K., Tanaka, T., et al. (2024) · Nature Communications

Receptor Mechanisms and SignalingSphingolipid Metabolism and Signaling

Cited by 24

Structure of the human Bre1 complex bound to the nucleosome

Onishi, S., Uchiyama, K., Sato, K., Okada, C., Kobayashi, S., Hamada, K., Nishizawa, T., Nureki, O., Ogata, K., & Sengoku, T. (2024) · Nature Communications

Genomics and Chromatin DynamicsUbiquitin and proteasome pathways

Cited by 19

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I., & Osawa, M. (2018) · eLife

Ion channel regulation and functionMagnesium in Health and Disease

Cited by 17

Structure and dynamics of the RF-amide QRFP receptor GPR103

Nureki, O., Iwama, A., Akasaka, H., Sano, F., Oshima, H., & Shihoya, W. (2023) · Nature Communications

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 14

Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103

Iwama, A., Kise, R., Akasaka, H., Sano, F. K., Oshima, H. S., Inoue, A., Shihoya, W., & Nureki, O. (2024) · Nature Communications

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 14

Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport

Watanabe, S., Kise, Y., Yonezawa, K., Inoue, M., Shimizu, N., Nureki, O., & Inaba, K. (2024) · Nature Communications

Cellular transport and secretionAdvanced Electron Microscopy Techniques and Applications

Cited by 12

Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport

Watanabe, S., Kise, Y., Yonezawa, K., Inoue, M., Shimizu, N., Nureki, O., & Inaba, K. (2023) · Nature Communications

Cellular transport and secretionAdvanced Electron Microscopy Techniques and Applications

Cited by 12

Structural insights into light harvesting by antenna-containing rhodopsins in marine Asgard archaea

Tzlil, G., Marín, M. D. C., Matsuzaki, Y., Nag, P., Itakura, S., Mizuno, Y., Murakoshi, S., Tanaka, T., Larom, S., Konno, M., et al. (2025) · Nature Microbiology

Photoreceptor and optogenetics researchPhotosynthetic Processes and Mechanisms

Cited by 9

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

Shihoya, W., Akasaka, H., Jordan, P. A., Lechner, A., Okada, B. K., Costa Machado da Cruz, G., Sano, F. K., Tanaka, T., Kawahara, R., Chaudhari, R., et al. (2025) · Nature Communications

Receptor Mechanisms and SignalingChemical Synthesis and Analysis

Cited by 8

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

Nureki, O., Shihoya, W., Akasaka, H., Sano, F., Tanaka, T., Kawahara, R., Jordan, P., Lechner, A., Okada, B., Cruz, G. M. D., et al. (2024) · Nature Communications

Receptor Mechanisms and SignalingChemical Synthesis and Analysis

Cited by 8