Herrup, Karl

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 6,226

The case for rejecting the amyloid cascade hypothesis

Herrup, K. (2015) · Nature Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 768

The Control of Neuron Number

Williams, R. W., & Herrup, K. (1988) · Annual Review of Neuroscience

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 585

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

Busser, J., Geldmacher, D. S., & Herrup, K. (1998) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 543

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

Herrup, K., & Yang, Y. (2007) · Nature Reviews Neuroscience

Neurogenesis and neuroplasticity mechanismsCancer-related Molecular Pathways

Cited by 507

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer’s disease

Yang, Y., Mufson, E. J., & Herrup, K. (2003) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 483

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell

Genetics and Neurodevelopmental DisordersSchizophrenia research and treatment

Cited by 470

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

Samuels, I. S., Karlo, J. C., Faruzzi, A. N., Pickering, K., Herrup, K., Sweatt, J. D., Saitta, S. C., & Landreth, G. E. (2008) · Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 278

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

Li, J., Chen, J., Ricupero, C. L., Hart, R. P., Schwartz, M. S., Kusnecov, A., & Herrup, K. (2012) · Nature Medicine

Genetic Neurodegenerative DiseasesHistone Deacetylase Inhibitors Research

Cited by 210

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Bhaskar, K., Miller, M., Chludzinski, A., Herrup, K., Zagorski, M., & Lamb, B. T. (2009) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 177

Genomic integrity and the ageing brain

Chow, H.-M., & Herrup, K. (2015) · Nature Reviews Neuroscience

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 174

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

Chow, H.-M., Shi, M., Cheng, A., Gao, Y., Chen, G., Song, X., So, R. W. L., Zhang, J., & Herrup, K. (2019) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 171

Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences

Song, X., Ma, F., & Herrup, K. (2019) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 133

Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

Zhang, J., Cicero, S. A., Wang, L., Romito-DiGiacomo, R. R., Yang, Y., & Herrup, K. (2008) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsCancer-related Molecular Pathways

Cited by 113

DNA damage in the oligodendrocyte lineage and its role in brain aging

Tse, K.-H., & Herrup, K. (2017) · Mechanisms of Ageing and Development

Neurogenesis and neuroplasticity mechanismsDNA Repair Mechanisms

Cited by 108

Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex

Zhang, J., Li, H., Yabut, O., Fitzpatrick, H., D'Arcangelo, G., & Herrup, K. (2010) · The Journal of Neuroscience

Cancer-related Molecular PathwaysNeurogenesis and neuroplasticity mechanisms

Cited by 96

Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis

Luo, F., Herrup, K., Qi, X., & Yang, Y. (2017) · Experimental Neurology

Multiple Sclerosis Research StudiesMitochondrial Function and Pathology

Cited by 74

LATE to the PART-y

Josephs, K. A., Mackenzie, I., Frosch, M. P., Bigio, E. H., Neumann, M., Arai, T., Dugger, B. N., Ghetti, B., Grossman, M., Hasegawa, M., et al. (2019) · Brain

Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment Research

Cited by 66

The mouse Engrailed genes: A window into autism

KUEMERLE, B., GULDEN, F., CHEROSKY, N., WILLIAMS, E., & HERRUP, K. (2007) · Behavioural Brain Research

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 60

DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia

Tse, K., Cheng, A., Ma, F., & Herrup, K. (2018) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 56

Cdk5 and the non-catalytic arrest of the neuronal cell cycle

Zhang, J., & Herrup, K. (2008) · Cell Cycle

Cancer-related Molecular PathwaysNeurogenesis and neuroplasticity mechanisms

Cited by 44

Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte‐derived lipid transport

Mok, K. K., Yeung, S. H., Cheng, G. W., Ma, I. W., Lee, R. H., Herrup, K., & Tse, K. (2023) · Journal of Neurochemistry

Neurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Cited by 37

Apolipoprotein E ε4 Mediates Myelin Breakdown by Targeting Oligodendrocytes in Sporadic Alzheimer Disease

Cheng, G. W.-Y., Mok, K. K.-S., Yeung, S. H.-S., Kofler, J., Herrup, K., & Tse, K.-H. (2022) · Journal of Neuropathology & Experimental Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 36

Cdk5 Levels Oscillate during the Neuronal Cell Cycle

Zhang, J., Li, H., Zhou, T., Zhou, J., & Herrup, K. (2012) · Journal of Biological Chemistry

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 34