Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer’s disease
Open accessAbstract
Cell cycle events play a major role in the loss of neurons in advanced Alzheimer's disease (AD). It is currently unknown, however, whether the same is true for the neuronal losses in early disease stages. To explore this issue we analyzed brain autopsy material from individuals clinically categorized with mild cognitive impairment (MCI), many if not most of whom will progress to AD. Immunocytochemistry for three cell cycle-related proteins, proliferating cell nuclear antigen, cyclin D, and cyclin B, was performed on sections from hippocampus, basal nucleus of Meynert, and entorhinal cortex. The results obtained from MCI cases were compared with material from individuals diagnosed with AD and those without cognitive impairment. In both hippocampus and basal nucleus, there was a significant percentage of cell cycle immunopositive neurons in the MCI cases. These percentages were similar to those found in the AD cases but significantly higher than non-cognitively impaired controls. In entorhinal cortex, the density of cell cycle-positive neurons was greater in MCI than in AD. However, we observed large variations in the percentages of immunopositive neurons from individual to individual. These findings lend support to the hypothesis that both the mechanism of cell loss (a cell cycle-induced death) and the rate of cell loss (a slow atrophy over several months) are identical at all stages of the AD disease process. The implication of the findings for human clinical trials is discussed.
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There is growing evidence for an association between DNA damage and increased expression of cell-cycle markers in AD.
“There is also growing evidence for the association between DNA damage and increased expression of cell-cycle markers in AD [34], [38].”
From Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease (2014) · cites this paper as [34]
In brains of people who died with MCI, the percentage of hippocampal neurons positive for cell-cycle proteins (PCNA, cyclin D and cyclin B) was very close to that found in individuals who died in advanced stages of AD (demented).
“Yang et al. [34] showed that in brains of people who died with MCI, the percentage of hippocampal neurons positive for cell-cycle proteins (PCNA, cyclin D and cyclin B) was very close to that found in individuals who died in advanced stages of AD (demented).”
From Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease (2014) · cites this paper as [34]
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- Authors
- Yang, Y., Mufson, E. J., & Herrup, K.
- Affiliations
- University Hospitals of Cleveland (US)
- Rush University Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-04-01
- Volume
- 23
- Issue
- 7
- Pages
- 2557-2563
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6742098
- OpenAlex
- W1485747833
- Cited by
- 483
- References
- 48
- Citations by year
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- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- Blanchette Hooker Rockefeller Fund
- U.S. Public Health Service (A16668, A 09446)
- National Institute on Aging (AG-08012, AG 10161, AG-14449, P50AG008012, P01AG014449, P30AG010161)
- National Institute of Neurological Disorders and Stroke (R01NS020591, NS20591)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neuronal cell death, cell cycle, mild cognitive impairment, proliferating cell nuclear antigen, cyclin D, cyclin B, hippocampus, basal ganglia, entorhinal cortex, brain atrophy, disease progression
- MeSH terms
- Aged, Alzheimer Disease, Cell Count, Cell Cycle, Cognition Disorders, Female, Hippocampus, Humans, Immunohistochemistry, Male, Neurons, Cyclins, Cell Death, Disease Progression, Entorhinal Cortex, Proliferating Cell Nuclear Antigen, Cyclin B, Basal Nucleus of Meynert, Cyclin D
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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