DNA damage in the oligodendrocyte lineage and its role in brain aging

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works

Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers

Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease

Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works

The handbook of aging and cognition

Mitchell, D. B. (2001) · Applied Cognitive Psychology · doi:10.1002/acp.747 · Cited by 1,893 · see citing works

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works

Cortical demyelination and diffuse white matter injury in multiple sclerosis

Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836 · see citing works

Oligodendroglia metabolically support axons and contribute to neurodegeneration

Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664 · see citing works

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523 · see citing works

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Motor skill learning requires active central myelination

McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177 · see citing works

Inflammatory cortical demyelination in early multiple sclerosis.

Lucchinetti, C. F., Popescu, B. F. G., Bunyan, R. F., Moll, N. M., Roemer, S. F., Lassmann, H., Brück, W., Parisi, J. E., Scheithauer, B. W., Giannini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100648 · Cited by 1,103 · see citing works

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

Ilieva, H., Polymenidou, M., & Cleveland, D. W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908164 · Cited by 1,008 · see citing works

Untitled work

(2000) · Cited by 1,006 · see citing works

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961 · see citing works

Late Oligodendrocyte Progenitors Coincide with the Developmental Window of Vulnerability for Human Perinatal White Matter Injury

Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936 · see citing works

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927 · see citing works

Candidate mechanisms for chemotherapy-induced cognitive changes

Ahles, T. A., & Saykin, A. J. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2073 · Cited by 924 · see citing works

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799 · see citing works

Senescence and aging: the critical roles of p53

Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798 · see citing works

Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia

Back, S. A., Han, B. H., Luo, N. L., Chricton, C. A., Xanthoudakis, S., Tam, J., Arvin, K. L., & Holtzman, D. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00455.2002 · Cited by 795 · see citing works

The cognitive correlates of white matter abnormalities in normal aging: A quantitative review.

Gunning-Dixon, F. M., & Raz, N. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.2.224 · Cited by 794 · see citing works

The cognitive correlates of white matter abnormalities in normal aging: A quantitative review.

Gunning‐Dixon, F. M., & Raz, N. (2000) · Neuropsychology · doi:10.1037//0894-4105.14.2.224 · Cited by 790 · see citing works

The case for rejecting the amyloid cascade hypothesis

Herrup, K. (2015) · Nature Neuroscience · doi:10.1038/nn.4017 · Cited by 768 · see citing works

Oxidative damage in multiple sclerosis lesions

Haider, L., Fischer, M. T., Frischer, J., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C., Witztum, J., & Lassmann, H. (2011) · Brain : a journal of neurology · doi:10.1093/brain/awr128 · Cited by 754 · see citing works

The MRE11 complex: starting from the ends

Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734 · see citing works

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

Combs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721 · see citing works

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P.-C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.032 · Cited by 700 · see citing works

Prolonged myelination in human neocortical evolution

Miller, D. J., Duka, T., Stimpson, C. D., Schapiro, S. J., Baze, W. B., McArthur, M. J., Fobbs, A. J., Sousa, A. M. M., Šestan, N., Wildman, D. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117943109 · Cited by 699 · see citing works

Impaired adult myelination in the prefrontal cortex of socially isolated mice

Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M. K., Dietz, D. M., Nestler, E. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3263 · Cited by 685 · see citing works

Effects of age on volumes of cortex, white matter and subcortical structures

Walhovd, K. B., Fjell, A. M., Reinvang, I., Lundervold, A., Dale, A. M., Eilertsen, D. E., Quinn, B. T., Salat, D. H., Makris, N., & Fischl, B. R. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.020 · Cited by 647 · see citing works

Control of local protein synthesis and initial events in myelination by action potentials

Wake, H., Lee, P. R., & Fields, R. D. (2011) · Science · doi:10.1126/science.1206998 · Cited by 636 · see citing works

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1899 · Cited by 629 · see citing works

A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development

Barrès, A., Lazar, M. A., & RAFF, M. C. (1994) · Development · doi:10.1242/dev.120.5.1097 · Cited by 593 · see citing works

Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

Back, S. A., Gan, X., Li, Y., Rosenberg, P. A., & Volpe, J. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06241.1998 · Cited by 586 · see citing works

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564 · see citing works

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination

Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H., & Barres, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.031 · Cited by 559 · see citing works

Cortical Lesions and Atrophy Associated With Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis

Calabrese, M., Agosta, F., Rinaldi, F., Mattisi, I., Grossi, P., Favaretto, A., Atzori, M., Bernardi, V., Barachino, L., Rinaldi, L., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.174 · Cited by 556 · see citing works

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 486 · see citing works

Age-dependent fate and lineage restriction of single NG2 cells

Zhu, X., Hill, R. A., Dietrich, D., Komitova, M., Suzuki, R., & Nishiyama, A. (2011) · Development · doi:10.1242/dev.047951 · Cited by 464 · see citing works

Neuronal activity biases axon selection for myelination in vivo

Hines, J. H., Ravanelli, A. M., Schwindt, R. K., Scott, E. K., & Appel, B. (2015) · Nature Neuroscience · doi:10.1038/nn.3992 · Cited by 453 · see citing works

White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease

Bartzokis, G., Cummings, J. L., Sultzer, D. L., Henderson, V. W., Nuechterlein, K. H., & Mintz, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.393 · Cited by 415 · see citing works

White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging

Barber, R., Scheltens, P., Gholkar, A. R., Ballard, C. G., McKeith, I. G., Ince, P. G., Perry, R., & O'Brien, J. T. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.1.66 · Cited by 414 · see citing works

Prefrontal white matter volume is disproportionately larger in humans than in other primates

Schoenemann, P. T., Sheehan, M. J., & Glotzer, L. D. (2005) · Nature Neuroscience · doi:10.1038/nn1394 · Cited by 406 · see citing works

Patterns of oligodendroglia pathology in multiple sclerosis

Ozawa, K., Suchanek, G., Breitschopf, H., Br€ck, W., Budka, H., Jellinger, K. A., & Lassmann, H. (1994) · Brain · doi:10.1093/brain/117.6.1311 · Cited by 404 · see citing works

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3991 · Cited by 398 · see citing works

Astroglia in dementia and Alzheimer's disease

Rodriguez, J. J., Olabarria, M., Chvátal, A., & Verkhratsky, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.172 · Cited by 396 · see citing works

Diffusion tensor imaging of post mortem multiple sclerosis brain

Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395 · see citing works

Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress

Thorburne, S. K., & Juurlink, B. H. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031014.x · Cited by 390 · see citing works

Reimagining Alzheimer's Disease—An Age-Based Hypothesis

Herrup, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-10.2010 · Cited by 386 · see citing works

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382 · see citing works

Understanding White Matter Disease: Imaging-Pathological Correlations in Vascular Cognitive Impairment

Black, S., Gao, F., & Bilbao, J. (2009) · Stroke · doi:10.1161/strokeaha.108.537704 · Cited by 379 · see citing works

Role of myelin plasticity in oscillations and synchrony of neuronal activity

Pajevic, S., Basser, P. J., & Fields, R. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.007 · Cited by 378 · see citing works

Dwarfism with retinal atrophy and deafness

Cockayne, E. A. (1936) · Archives of Disease in Childhood · doi:10.1136/adc.11.61.1 · Cited by 377 · see citing works

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

Lee, J.-H., Choy, M. L., Ngo, L., Foster, S. S., & Marks, P. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008522107 · Cited by 364 · see citing works

Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation

Samanta, J., & Kessler, J. A. (2004) · Development · doi:10.1242/dev.01273 · Cited by 361 · see citing works

Widespread Demyelination in the Cerebellar Cortex in Multiple Sclerosis

Kutzelnigg, A., Faber-Rod, J. C., Bauer, J., Lucchinetti, C., Sørensen, P. S., Laursen, H., Stadelmann, C., Brück, W., Rauschka, H., Schmidbauer, M., et al. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00041.x · Cited by 343 · see citing works

Neuropathologic correlates of white matter hyperintensities

Young, V. G., Halliday, G. M., & Kril, J. J. (2008) · Neurology · doi:10.1212/01.wnl.0000319691.50117.54 · Cited by 336 · see citing works

Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition

van der Horst, G. T. J., STEEG, H. V., Berg, R. J. W., van Gool, A. J., de Wit, J., Weeda, G., Morreau, H., Beems, R. B., van Kreijl, C. F., de Gruijl, F. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80223-8 · Cited by 334 · see citing works

TFIIH: when transcription met DNA repair

Compe, E., & Egly, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3350 · Cited by 333 · see citing works

Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

Lu, F., Selak, M. A., O'Connor, J. J., Croul, S. E., Lorenzana, C., Butunoi, C., & Kálmán, B. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00343-9 · Cited by 331 · see citing works

Oligodendrocyte development and the onset of myelination in the human fetal brain

Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323 · see citing works

Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain

Shen, S., Li, J., & Casaccia‐Bonnefil, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412101 · Cited by 320 · see citing works

A common brain network links development, aging, and vulnerability to disease

Douaud, G., Groves, A. R., Tamnes, C. K., Westlye, L. T., Duff, E. P., Engvig, A., Walhovd, K. B., James, A., Gass, A., Monsch, A. U., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410378111 · Cited by 317 · see citing works

Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex

Salami, M., Itami, C., Tsumoto, T., & Kimura, F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937380100 · Cited by 314 · see citing works

Multiple sclerosis normal‐appearing white matter: Pathology–imaging correlations

Moll, N. M., Rietsch, A. M., Thomas, S., Ransohoff, A. J., Lee, J., Fox, R., Chang, A., Ransohoff, R. M., & Fisher, E. (2011) · Annals of Neurology · doi:10.1002/ana.22521 · Cited by 297 · see citing works

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

Scolding, N. J. (1998) · Brain · doi:10.1093/brain/121.12.2221 · Cited by 293 · see citing works

Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression

Marin‐Husstege, M., Muggironi, M., Liu, A., & Casaccia-Bonnefil, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10333.2002 · Cited by 293 · see citing works

Intracortical Myelin Links with Performance Variability across the Human Lifespan: Results from T1- and T2-Weighted MRI Myelin Mapping and Diffusion Tensor Imaging

Grydeland, H., Walhovd, K. B., Tamnes, C. K., Westlye, L. T., & Fjell, A. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2811-13.2013 · Cited by 290 · see citing works

Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

Gouw, A. A., Seewann, A., Vrenken, H., van der Flier, W. M., Rozemuller, J. M., Barkhof, F., Scheltens, P., & Geurts, J. J. G. (2008) · Brain · doi:10.1093/brain/awn265 · Cited by 281 · see citing works

Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey

Peters, A., & Sethares, C. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.10099 · Cited by 274 · see citing works

MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes

Bujalka, H., Koenning, M., Jackson, S., Perreau, V. M., Pope, B., Hay, C. M., Mitew, S., Hill, A. F., Lu, Q. R., Wegner, M., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001625 · Cited by 271 · cited 5× · see citing works

Response of Schwann Cells to Action Potentials in Development

Stevens, B. A., & Fields, R. D. (2000) · Science · doi:10.1126/science.287.5461.2267 · Cited by 267 · see citing works

Triple‐transgenic Alzheimer's disease mice exhibit region‐specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology

Desai, M. K., Sudol, K. L., Janelsins, M. C., Mastrangelo, M. A., Frazer, M. E., & Bowers, W. J. (2009) · Glia · doi:10.1002/glia.20734 · Cited by 266 · see citing works

The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation

He, Y., Dupree, J. L., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., & Casaccia‐Bonnefil, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.029 · Cited by 263 · see citing works

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin.

Mitew, S., Hay, C., Peckham, H., Xiao, J., Koenning, M., & Emery, B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.029 · Cited by 259 · see citing works

Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

Psachoulia, K., Jamen, F., Young, K. M., & Richardson, W. D. (2009) · Neuron Glia Biology · doi:10.1017/s1740925x09990354 · Cited by 257 · see citing works

Cockayne syndrome and xeroderma pigmentosum

Rapin, I., Lindenbaum, Y., Dickson, D. W., Kraemer, K. H., & Robbins, J. H. (2000) · Neurology · doi:10.1212/wnl.55.10.1442 · Cited by 255 · see citing works

Myelination, oligodendrocytes, and serious mental illness

Haroutunian, V. H., Katsel, P., Roussos, P., Davis, K. L., Altshuler, L. L., & Bartzokis, G. (2014) · Glia · doi:10.1002/glia.22716 · Cited by 247 · see citing works

Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

Mattson, M. P., & Liu, D. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:215 · Cited by 242 · see citing works

Ataxia telangiectasia mutated activation by transcription‐ and topoisomerase I‐induced DNA double‐strand breaks

Sordet, O., Redon, C. E., Guirouilh‐Barbat, J., Smith, S. H., Solier, S., Douarre, C., Conti, C., Nakamura, A., Das, B. B., Nicolas, E., et al. (2009) · EMBO Reports · doi:10.1038/embor.2009.97 · Cited by 239 · see citing works

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

Desai, M. K., Mastrangelo, M. A., Ryan, D. A., Sudol, K. L., Narrow, W. C., & Bowers, W. J. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100087 · Cited by 232 · see citing works

Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes

Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230 · see citing works

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative‐induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

Marchesi, V. T. (2011) · The FASEB Journal · doi:10.1096/fj.11-0102ufm · Cited by 223 · see citing works

Neuropathologic basis of white matter hyperintensity accumulation with advanced age

Erten‐Lyons, D., Woltjer, R. L., Kaye, J. A., Mattek, N., Dodge, H. H., Green, S., Tran, H. T. D., Howieson, D. B., Wild, K. V., & Silbert, L. C. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e45 · Cited by 222 · see citing works

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219 · see citing works

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

Kashiyama, K., Nakazawa, Y., Pilz, D. T., Guo, C., Shimada, M., Sasaki, K., Fawcett, H., Wing, J., Lewin, S. O., Carr, L., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.007 · Cited by 212 · see citing works

Myelin Gene Regulatory Factor Is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS

Koenning, M., Jackson, S., Hay, C., Faux, C. H., Kilpatrick, T., Willingham, M. M., & Emery, B. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1069-12.2012 · Cited by 211 · see citing works

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

Li, J., Chen, J., Ricupero, C. L., Hart, R. P., Schwartz, M. S., Kusnecov, A., & Herrup, K. (2012) · Nature Medicine · doi:10.1038/nm.2709 · Cited by 210 · see citing works

Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms.

Liu, Z., Hu, X.-M., Cai, J., Liu, B., Peng, X.-Z., Wegner, M., & Qiu, M.-S. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.007 · Cited by 200 · see citing works

Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging

Holland, C. M., Smith, E. E., Csapo, I., Gurol, M. E., Brylka, D. A., Killiany, R., Blacker, D., Albert, M., Guttmann, C. R. G., & Greenberg, S. M. (2008) · Stroke · doi:10.1161/strokeaha.107.497438 · Cited by 199 · see citing works

Arrested Oligodendrocyte Lineage Progression During Human Cerebral White Matter Development: Dissociation Between the Timing of Progenitor Differentiation and Myelinogenesis

Back, S. A., Luo, N. L., Borenstein, N. S., Volpe, J. J., & Kinney, H. C. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.2.197 · Cited by 196 · see citing works

White Matter Hyperintensities and Cerebral Amyloidosis: Necessary and Sufficient for Clinical Expression of Alzheimer Disease?

Provenzano, F. A., Muraskin, J., Tosto, G., Narkhede, A., Wasserman, B. T., Griffith, E. Y., Guzman, V. A., Meier, I. B., Zimmerman, M. E., Brickman, A. M., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1321 · Cited by 192 · see citing works

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

Li, J., Hart, R. P., Mallimo, E. M., Swerdel, M. R., Kusnecov, A. W., & Herrup, K. (2013) · Nature Neuroscience · doi:10.1038/nn.3564 · Cited by 177 · see citing works

Genomic integrity and the ageing brain

Chow, H.-M., & Herrup, K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4020 · Cited by 174 · see citing works

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169 · see citing works

Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

Pang, Y., Campbell, L., Zheng, B., Fan, L.-W., Cai, Z., & Rhodes, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.040 · Cited by 167 · see citing works

DNA damage stabilizes interaction of CSB with the transcription elongation machinery

van den Boom, V., Citterio, E., Hoogstraten, D., Zotter, A., Egly, J., van Cappellen, W. A., Hoeijmakers, J. H. J., Houtsmuller, A. B., & Vermeulen, W. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401056 · Cited by 166 · see citing works

Molecular Analysis of Mutations in the CSB(ERCC6) Gene in Patients with Cockayne Syndrome

Mallery, D. L., Tanganelli, B., Colella, S., Steingrimsdottir, H., van Gool, A. J., Troelstra, C., Stefanini, M., & Lehmann, A. R. (1998) · The American Journal of Human Genetics · doi:10.1086/301686 · Cited by 162 · see citing works

Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well

Brown, W. R., Moody, D. M., Thore, C. R., Challa, V. R., & Anstrom, J. A. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.015 · Cited by 162 · see citing works

Ataxia telangiectasia mutated is essential during adult neurogenesisPreprint

Allen, D. M., van Praag, H., Ray, J., Ohler, Z. W., Winrow, C. J., Carter, T. A., Braquet, R., Harrington, E. A., Ried, T., Brown, K. D., et al. (2001) · Genes & Development · doi:10.1101/gad.869001 · Cited by 159 · see citing works

Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain

Gururaj Joshi, A., Aluise, C. D., Cole, M. P., Rukhsana Sultana, A., Pierce, W. M. J., Vore, M. E., Clair, D. K. S., & Butterfield, D. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.021 · Cited by 156 · see citing works

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Katyal, S., Lee, Y., Nitiss, K. C., Downing, S. M., Li, Y., Shimada, M., Zhao, J., Russell, H. R., Petrini, J. H. J., Nitiss, J. L., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3715 · Cited by 148 · see citing works

The Cockayne Syndrome Group B Gene Product Is Involved in General Genome Base Excision Repair of 8-Hydroxyguanine in DNA

Tuo, J., Müftüoğlu, M., Chen, C., Jaruga, P., Selzer, R. R., Brosh, R. M., Rodriguez, H., Dizdaroğlu, M., & Bohr, V. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107888200 · Cited by 147 · see citing works

Minocycline alleviates hypoxic–ischemic injury to developing oligodendrocytes in the neonatal rat brain

Cai, Z., Lin, S., Fan, L.-W., Pang, Y., & Rhodes, P. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.023 · Cited by 141 · see citing works

White matter hyperintensities predict amyloid increase in Alzheimer's disease

Grimmer, T., Faust, M., Auer, F., Alexopoulos, P., Förstl, H., Henriksen, G., Perneczky, R., Sorg, C., Yousefi, B. H., Drzezga, A. E., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.01.016 · Cited by 139 · see citing works

Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death

Daroui, P., Desai, S. D., Li, T., Liu, A. A., & Liu, L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311370200 · Cited by 138 · see citing works

Oxidative damage to DNA in plaques of MS brains

Vladimirova, O. V., O'Connor, J. J., Cahill, A., Alder, H., Butunoi, C., & Kálmán, B. (1998) · Multiple Sclerosis Journal · doi:10.1177/135245859800400503 · Cited by 138 · see citing works

Differential aging of cerebral white matter in middle-aged and older adults: A seven-year follow-up

Bender, A. R., Voelkle, M. C., & Raz, N. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.030 · Cited by 133 · see citing works

Neurological symptoms and natural course of xeroderma pigmentosum

Anttinen, A., Koulu, L., Nikoskelainen, E., Portin, R., Kurki, T., Erkinjuntti, M., Jaspers, N. G. J., Raams, A., Green, M. H. L., Lehmann, A. R., et al. (2008) · Brain · doi:10.1093/brain/awn126 · Cited by 132 · see citing works

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells

Lyssiotis, C. A., Walker, J. R., Wu, C., Kondo, T., Schultz, P. G., & Wu, X. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707044104 · Cited by 132 · see citing works

A fourth type of neuroglial cell in the adult central nervous system

Peters, A. (2004) · Journal of Neurocytology · doi:10.1023/b:neur.0000044195.64009.27 · Cited by 131 · see citing works

Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism

Yang, Y. F., & Herrup, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4946-04.2005 · Cited by 130 · see citing works

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Stevnsner, T., Müftüoğlu, M., Aamann, M. D., & Bohr, V. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.009 · Cited by 129 · see citing works

Cockayne syndrome in adults: Review with clinical and pathologic study of a new case

Rapin, I., Weidenheim, K., Lindenbaum, Y., Rosenbaum, P., Merchant, S. N., Krishna, S., & Dickson, D. W. (2006) · Journal of Child Neurology · doi:10.1177/08830738060210110101 · Cited by 124 · see citing works

Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation

Liu, J., Magri, L., Zhang, F., Marsh, N. O., Albrecht, S., Huynh, J. L., Kaur, J., Kuhlmann, T., Zhang, W., Slesinger, P. A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2606-14.2015 · Cited by 123 · see citing works

Neuroimaging In Cockayne Syndrome

Koob, M., Laugel, V., Durand, M., Fothergill, H., Dalloz, C., Sauvanaud, F., Dollfus, H., Namer, I. J., & Dietemann, J. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2135 · Cited by 118 · see citing works

Morphometric Analysis of Arteriolar Tortuosity in Human Cerebral White Matter of Preterm, Young, and Aged Subjects

Thore, C. R., Anstrom, J. A., Moody, D. M., Challa, V. R., Marion, M. C., & Brown, W. R. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180537147 · Cited by 114 · see citing works

The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment

Tosto, G., Zimmerman, M. E., Hamilton, J. L., Carmichael, O. T., Brickman, A. M., & Initiative, A. D. N. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.014 · Cited by 112 · see citing works

Age-related myelin dynamics revealed by increased oligodendrogenesis and short internodes

Lasiene, J., Matsui, A., Sawa, Y., Wong, F., & Horner, P. J. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00462.x · Cited by 111 · see citing works

Valproic acid increases white matter repair and neurogenesis after stroke

Liu, X., Chopp, M., Kassis, H., Jia, L., Hozeska‐Solgot, A., Zhang, R. L., Chen, C., Cui, Y. S., & Zhang, Z. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.012 · Cited by 111 · see citing works

Thyroid Hormone Regulates Oligodendrocyte Accumulation in Developing Rat Brain White Matter Tracts

Schoonover, C. M., Seibel, M. M., Jolson, D. M., Stack, M. J., Rahman, R. J., Jones, S. A., Mariash, C. N., & Anderson, G. W. (2004) · Endocrinology · doi:10.1210/en.2004-0065 · Cited by 111 · see citing works

Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

Thurn, K. T., Thomas, S., Raha, P., Qureshi, I., & Münster, P. N. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1242 · Cited by 108 · see citing works

Cholesterol synthesis rate in human hippocampus declines with aging

Thelen, K. M., Falkai, P., Bayer, T. A., & Lütjohann, D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.034 · Cited by 107 · see citing works

Age‐Associated White Matter Lesions: The MRC C ognitive F unction and A geing S tudy

Wharton, S. B., Simpson, J. E., Brayne, C., & Ince, P. G. (2014) · Brain Pathology · doi:10.1111/bpa.12219 · Cited by 104 · see citing works

The Glial or Neuronal Fate Choice of Oligodendrocyte Progenitors Is Modulated by Their Ability to Acquire an Epigenetic Memory

Liu, A., Han, Y. R., Li, J., Sun, D., Ouyang, M., Plummer, M. R., & Casaccia‐Bonnefil, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1226-07.2007 · Cited by 97 · see citing works

Cockayne syndrome: Unusual neuropathological findings and review of the literature

Soffer, D., Grotsky, H. W., Rapin, I., & Suzuki, K. (1979) · Annals of Neurology · doi:10.1002/ana.410060407 · Cited by 93 · see citing works

Epigenetic memory loss in aging oligodendrocytes in the corpus callosum

Shen, S., Liu, A., Li, J., Wolubah, C., & Casaccia‐Bonnefil, P. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.026 · Cited by 92 · see citing works

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

Compe, E., Malerba, M., Soler, L., Marescaux, J., Borrelli, E., & Egly, J. (2007) · Nature Neuroscience · doi:10.1038/nn1990 · Cited by 91 · see citing works

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

Al‐Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., Brayne, C., Ince, P. G., Wharton, S. B., & Medical Research Council Cognitive Function and Ageing Study (2015) · Brain Pathology · doi:10.1111/bpa.12216 · Cited by 85 · see citing works

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency

Jiang, D., Zhang, Y., Hart, R. P., Chen, J., Herrup, K., & Li, J. (2015) · Brain · doi:10.1093/brain/awv284 · Cited by 84 · see citing works

Xeroderma pigmentosum/Cockayne syndrome complex: first neuropathological study and review of eight other cases

Lindenbaum, Y., Dickson, D. W., Rosenbaum, P. S., Kraemer, K. H., Robbins, J. H., & Rapin, I. (2001) · European Journal of Paediatric Neurology · doi:10.1053/ejpn.2001.0523 · Cited by 83 · see citing works

The entorhinal cortex: an examination of cyto- and myeloarchitectonic organization in humans

Krimer, L. S. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.8.722 · Cited by 81 · see citing works

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

Jaarsma, D., van der Pluijm, I., de Waard, M. C., Haasdijk, E. D., Brandt, R. M. C., Vermeij, M., Rijksen, Y., Maas, A., STEEG, H. V., Hoeijmakers, J. H. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002405 · Cited by 79 · see citing works

Age-related neuronal loss in the rat brain starts at the end of adolescence

Morterá, P., & Herculano-Houzel, S. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00045 · Cited by 79 · see citing works

p53 is Present in Synapses Where it Mediates Mitochondrial Dysfunction and Synaptic Degeneration in Response to DNA Damage, and Oxidative and Excitotoxic Insults

Gilman, C. P., Chan, S. L., Guo, Z., Zhu, X., Greig, N. H., & Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:3:159 · Cited by 77 · see citing works

Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH

Hashimoto, S., & Egly, J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp390 · Cited by 72 · see citing works

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Sordet, O., Khan, Q. A., Plo, I., Pourquier, P., Urasaki, Y., Yoshida, A., Antony, S., Kohlhagen, G., Solary, É., Saparbaev, M. K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410277200 · Cited by 71 · see citing works

ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

Alagöz, M., Chiang, S., Sharma, A. B., & El‐Khamisy, S. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058239 · Cited by 69 · see citing works

E2F1 Coregulates Cell Cycle Genes and Chromatin Components during the Transition of Oligodendrocyte Progenitors from Proliferation to Differentiation

Magri, L., Swiss, V. A., Jablonska, B., Liang, L., Pedré, X., Walsh, M. J., Zhang, W., Gallo, V., Canoll, P., & Casaccia, P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2840-13.2014 · Cited by 69 · see citing works

Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation

Conway, G. D., O’Bara, M. A., Vedia, B. H., Pol, S. U., & Sim, F. J. (2012) · Glia · doi:10.1002/glia.22410 · Cited by 69 · see citing works

Normal Appearing and Diffusely Abnormal White Matter in Patients with Multiple Sclerosis Assessed with Quantitative MR

West, J., Aalto, A., Tisell, A., Leinhard, O. D., Landtblom, A., Smedby, Ö., & Lundberg, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095161 · Cited by 68 · see citing works

DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression

Carlessi, L., Filippis, L. D., Lecis, D., Vescovi, A. L., & Delia, D. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.10 · Cited by 62 · see citing works

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4+and CD8+T‐cells

Havenith, C. E. G., Askew, D., & Walker, W. S. G. (1998) · Glia · doi:10.1002/(sici)1098-1136(199804)22:4 · Cited by 62 · see citing works

Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA

Shafirovich, V., Kropachev, K. Y., Anderson, T., Liu, Z., Kolbanovskiy, M., Martin, B. D., Sugden, K. D., Shim, Y., Chen, X., Min, J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.693218 · Cited by 62 · see citing works

Base excision repair in the mammalian brain: Implication for age related neurodegeneration

Sýkora, P., Wilson, D. M., & Bohr, V. A. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.005 · Cited by 59 · see citing works

HDACs and the senescent phenotype of WI-38 cells

Place, R. F., Noonan, E. J., & Giardina, C. A. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-37 · Cited by 57 · see citing works

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis

Rebbaa, A., Zheng, X. S., Chu, F., & Mirkin, B. L. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401895 · Cited by 56 · see citing works

ID2: A negative transcription factor regulating oligodendroglia differentiation

Chen, X., Zhang, Y., Cai, Q., & Yao, Z. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22826 · Cited by 54 · see citing works

Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors

Boda, E., Maria, S. D., Rosa, P., Taylor, V., Abbracchio, M. P., & Buffo, A. (2014) · Glia · doi:10.1002/glia.22750 · Cited by 53 · see citing works

Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function

Clement, A. B., Gamerdinger, M., Tamboli, I. Y., Lütjohann, D., Walter, J., Greeve, I., Gimpl, G., & Behl, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06360.x · Cited by 53 · see citing works

The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D)

Lai, J.-P., Liu, Y.-C., Alimchandani, M., Liu, Q., Aung, P. P., Matsuda, K. M., Lee, C. R., Tsokos, M., Hewitt, S. M., Rushing, E. J., et al. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-4 · Cited by 51 · see citing works

White matter mapping in Alzheimer's disease: A neuropathological study.

Sjöbeck, M., Haglund, M., & Englund, E. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.007 · Cited by 50 · see citing works

Premature aging-related peripheral neuropathy in a mouse model of progeria

Goss, J. R., Stolz, D. B., Robinson, A. R., Zhang, M., Arbujas, N., Robbins, P. D., Glorioso, J. C., & Niedernhofer, L. J. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.04.010 · Cited by 46 · see citing works

PERIPHERAL NEUROPATHY IN XERODERMA PIGMENTOSUM

Kanda, T., Oda, M., YONEZAWA, M., Tamagawa, K., Isa, F., Hanakago, R., & Tsukagoshi, H. (1990) · Brain · doi:10.1093/brain/113.4.1025 · Cited by 46 · see citing works

Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy

Keeney, J. T. R., Miriyala, S., Noel, T. J., Moscow, J. A., Clair, D. K. S., & Butterfield, D. A. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.023 · Cited by 45 · see citing works

Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1

He, Y., Sandoval, J., & Casaccia‐Bonnefil, P. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000057 · Cited by 42 · see citing works

Brain damage from anticancer treatments in adults

Ricard, D., Taillia, H., & Renard, J.-L. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328330c669 · Cited by 40 · see citing works

Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage

Hernandez, M., & Casaccia, P. (2015) · Glia · doi:10.1002/glia.22818 · Cited by 39 · see citing works

Histone deacetylases in replicative senescence: evidence for a senescence‐specific form of HDAC‐2

Wagner, M., Brosch, G., Zwerschke, W., Seto, E., Loidl, P., & Jansen‐Dürr, P. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02524-8 · Cited by 38 · see citing works

MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome.

Assaf, Y., Galron, R., Shapira, I., Nitzan, A., Blumenfeld-Katzir, T., Solomon, A., Holdengreber, V., Wang, Z.-Q., Shiloh, Y., & Barzilai, A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.09.021 · Cited by 33 · see citing works

The role of DNA base excision repair in brain homeostasis and disease

Akbari, M., Morevati, M., Croteau, D. L., & Bohr, V. A. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.04.029 · Cited by 33 · see citing works

A neurological phenotype in mice with DNA repair gene Ercc1 deficiency

Lawrence, N. J., Sacco, J. J., Brownstein, D. G., Gillingwater, T. H., & Melton, D. W. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.10.005 · Cited by 33 · see citing works

Trichothiodystrophy: Clinical Spectrum, Central Nervous System Imaging, and Biochemical Characterization of Two Siblings.

Chen, E., Cleaver, J. E., Weber, C. A., Packman, S., Barkovich, A. J., Koch, T., Williams, M. L. K., Golabi, M., & Price, V. H. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12399493 · Cited by 30 · see citing works

Cranial MRI in the Nijmegen breakage syndrome

Bekiesińska‐Figatowska, M., Chrzańowska, K., Sikorska, J., Walecki, J. M., Krajewska‐Walasek, M., wiak, S. J., & Kleijer, W. J. (2000) · Neuroradiology · doi:10.1007/s002340050011 · Cited by 28 · see citing works

Transcription factors Sox10 and Sox2 functionally interact with positive transcription elongation factor b in Schwann cells

Arter, J., & Wegner, M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.13013 · Cited by 27 · see citing works

Trichothiodystrophy: Clinical Spectrum, Central Nervous System Imaging, and Biochemical Characterization of Two Siblings

Cleaver, J. E., Weber, C. A., Barkovich, A. J., Koch, T., Williams, M. L. K., Price, V. H., Chen, E., Packman, S., & Golabi, M. (1994) · Journal of Investigative Dermatology · doi:10.1038/jid.1994.29 · Cited by 26 · see citing works

Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum

Dar, I., Yosha, G., Elfassy, R., Galron, R., Wang, Z., Shiloh, Y., & Barzilai, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204172 · Cited by 26 · see citing works

Identical male twins and brother with Cockayne syndrome

Houston, C. S., Zaleski, W. A., Rozdilsky, B., & Opitz, J. M. (1982) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320130212 · Cited by 25 · see citing works

Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome

Revet, I. M., Feeney, L., Tang, A. A., Huang, E. J., & Cleaver, J. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202621109 · Cited by 25 · see citing works

Reciprocally Regulated Chromatin Association of Cockayne Syndrome Protein B and p53 Protein

Lake, R. J., Basheer, A., & Fan, H.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252643 · Cited by 25 · see citing works

Postmortem Findings in the Nijmegen Breakage Syndrome

van de KAA, C. A., Weemaes, C. M. R., Wesseling, P., Schaafsma, H. E., Haraldsson, Á., & de Weger, R. A. (1994) · Pediatric Pathology · doi:10.3109/15513819409037676 · Cited by 24 · see citing works

Motor pathway degeneration in young ataxia telangiectasia patients: A diffusion tractography study

Sahama, I., Sinclair, K., Fiori, S., Doecke, J. D., Pannek, K., Reid, L. B., Lavin, M. F., & Rose, S. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.08.007 · Cited by 23 · see citing works

Comparison of MRI white matter changes with neuropsychologic impairment in Cockayne syndrome

Sugita, K., Takanashi, J., Ishii, M., & Niimi, H. (1992) · Pediatric Neurology · doi:10.1016/0887-8994(92)90369-a · Cited by 23 · see citing works

Cerebral White-Matter Changes Suggesting Leukodystrophy in Ataxia Telangiectasia

Chung, E. O., Bodensteiner, J. B., Noorani, P. A., & Schochet, S. S. (1994) · Journal of Child Neurology · doi:10.1177/088307389400900106 · Cited by 23 · see citing works

Xeroderma pigmentosum: Neurological, Neurophysiological and Morphological Studies

Hakamada, S., Watanabe, K., Sobue, G., Hara, K., & Miyazaki, S. (2008) · European Neurology · doi:10.1159/000115457 · Cited by 22 · see citing works

ATM-deficient human neural stem cells as an in vitro model system to study neurodegeneration

Carlessi, L., Poli, E., Filippis, L. D., & Delia, D. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.013 · Cited by 22 · see citing works

Quantitative evaluation of brain involvement in ataxia telangiectasia by diffusion weighted MR imaging

Fırat, A. K., Karakaş, H. M., Fırat, Y., & Yakıncı, C. (2005) · European Journal of Radiology · doi:10.1016/j.ejrad.2005.04.009 · Cited by 21 · see citing works

Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.

Baranes, K., Raz-Prag, D., Nitzan, A., Galron, R., Ashery-Padan, R., Rotenstreich, Y., Assaf, Y., Shiloh, Y., Wang, Z.-Q., Barzilai, A., et al. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.026 · Cited by 21 · see citing works

Abnormal white matter signal in ataxia telangiectasia.

Ciemins, J. J., & Horowitz, A. L. (2000) · PubMed · Cited by 21 · see citing works

Oxidative damage to DNA in plaques of MS brains

Vladimirova, O. O., O'Connor, J., Cahill, A., et al. (1998) · Multiple Sclerosis Journal · doi:10.1191/135245898678919456 · Cited by 21 · see citing works

A novel mutation and novel features in Nijmegen breakage syndrome

Maraschio, P., DANESINO, C., ANTOCCIA, A., RICORDY, R., TANZARELLA, C., VARON, R., REIS, A., BESANA, D., GUALA, A., & TIEPOLO, L. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.2.113 · Cited by 20 · see citing works

DNA damage and oxidative injury are associated with hypomyelination in the corpus callosum of newborn Nbn CNS‐del mice

Liu, B., Chen, X., Wang, Z. Q., & Tong, W. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23313 · Cited by 18 · see citing works

Magnetic resonance imaging of brain abnormalities in patients with the Nijmegen breakage syndrome

Bekiesińska‐Figatowska, M., Chrzańowska, K., Jurkiewicz, E., Wakulińska, A., Rysiewski, H., Gładkowska‐Dura, M., & Walecki, J. M. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1532 · Cited by 16 · see citing works

Trichothiodystrophy with Dysmyelination and Central Osteosclerosis

Harreld, J. H., Smith, E. C., Prose, N. S., Puri, P. K., & Barboriak, D. P. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1665 · Cited by 16 · see citing works

Altered corticomotor‐cerebellar integrity in young ataxia telangiectasia patients

Sahama, I., Sinclair, K., Fiori, S., Pannek, K., Lavin, M. F., & Rose, S. (2014) · Movement Disorders · doi:10.1002/mds.25970 · Cited by 15 · see citing works

MR Findings of Cerebral White Matter in Cockayne Syndrome

Adachi, M., Kawanami, T., Ohshima, F., & Hosoya, T. (2006) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.5.41 · Cited by 14 · see citing works

Trichothiodystrophy with severe cardiac and neurological involvement in two sisters

Toelle, S. P., Valsangiacomo, E. R., & Boltshauser, E. (2001) · European Journal of Pediatrics · doi:10.1007/s004310100845 · Cited by 14 · see citing works

Age-Related Changes in Frontal and Temporal Lobe Volumes in Men: A Magnetic Resonance Imaging Study

Bartzokis, G., Beckson, M., Lu, P. H., Nuechterlein, K. H., Edwards, N., & Mintz, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.461 · Cited by 14 · see citing works

Cerebellar and cerebral atrophy in trichothiodystrophy

Yoon, H.-K., Sargent, M. A., Prendiville, J., & Poskitt, K. J. (2005) · Pediatric Radiology · doi:10.1007/s00247-005-1495-6 · Cited by 12 · see citing works

Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes

Liu, B., Chen, X., Wang, Z., & Tong, W. (2013) · Glia · doi:10.1002/glia.22593 · Cited by 8 · see citing works

The Cerebro-Morphological Fingerprint of a Progeroid Syndrome: White Matter Changes Correlate with Neurological Symptoms in Xeroderma Pigmentosum

Kassubek, J., Sperfeld, A., Pinkhardt, E. H., Unrath, A., Müller, H., Scharffetter‐­Kochanek, K., Ludolph, A. C., & Berneburg, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030926 · Cited by 7 · see citing works

Absence of β-Amyloid Immunoreactivity in Mesial Temporal Lobe in Cockayne's Syndrome

Woody, R. C., Harding, B. N., Brumback, R. A., & Leech, R. W. (1991) · Journal of Child Neurology · doi:10.1177/088307389100600106 · Cited by 6 · see citing works

[Histological and radiobiological study on adult cases with ataxia telangiectasia].

Serizawa, M., Sakamoto, M., Hirabayashi, K., Fujiwara, Y., & Atsumi, T. (1994) · PubMed · Cited by 4 · see citing works

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works

White matter changes in Alzheimer’s disease: A focus on myelin and oligodendrocytes

Nasrabady, S. E., Rizvi, B., Goldman, J. E., & Brickman, A. M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0515-3 · Cited by 723 · see citing works

Astrocytes and Aging

Palmer, A. L., & Ousman, S. S. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00337 · Cited by 246 · see citing works

A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity

Pamies, D., Barrera, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K., et al. (2016) · ALTEX · doi:10.14573/altex.1609122 · Cited by 213 · see citing works

Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders

Spaas, J., van Veggel, L., Schepers, M., Tiane, A., van Horssen, J., Wilson, D. M., Moya, P. R., Piccart, E., Hellings, N., Eijnde, B. O., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03802-0 · Cited by 217 · see citing works

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Han, L., Wei, X., Liu, C., Volpe, G., Zhuang, Z., Zou, X., Wang, Z., Pan, T., Yuan, Y., Zhang, X., et al. (2022) · Nature · doi:10.1038/s41586-022-04587-3 · Cited by 209 · see citing works

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works

Flavonoids—Natural Gifts to Promote Health and Longevity

Fan, X., Fan, Z., Yang, Z., Huang, T., Tong, Y., Yang, D., Mao, X., & Yang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042176 · Cited by 127 · see citing works

Contributions of DNA Damage to Alzheimer’s Disease

Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117 · see citing works

Oligodendrocytes in the aging brain

Sams, E. C. (2021) · Neuronal Signaling · doi:10.1042/ns20210008 · Cited by 107 · see citing works

Re‐imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead

Tse, K., & Herrup, K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14079 · Cited by 104 · see citing works

Evidence and perspectives of cell senescence in neurodegenerative diseases

Si, Z., Sun, L., & Wang, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111327 · Cited by 105 · see citing works

DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

Thadathil, N., Delotterie, D. F., Xiao, J., Hori, R., McDonald, M. P., & Khan, M. M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02109-8 · Cited by 94 · see citing works

Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer’s disease

Rifaai, R. A., Mokhemer, S. A., Saber, E. A., El‐Aleem, S. A. A., & El‐Tahawy, N. F. G. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101795 · Cited by 88 · see citing works

Cellular senescence in the aging brain: A promising target for neurodegenerative diseases

Sahu, M. R., Rani, L., Subba, R., & Mondal, A. C. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111675 · Cited by 75 · see citing works

Demyelinating processes in aging and stroke in the central nervous system and the prospect of treatment strategy

Chen, D., Huang, Y., Shi, Z., Li, J., Zhang, Y., Wang, K., Smith, A. D., Gong, Y., & Gao, Y. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13497 · Cited by 70 · see citing works

Ageing in the brain: mechanisms and rejuvenating strategies

Gaspar-Silva, F., Trigo, D., & Magalhães, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04832-6 · Cited by 75 · see citing works

White Matter Injury After Intracerebral Hemorrhage

Fu, X., Zhou, G., Zhuang, J., Xu, C., Zhou, H., Peng, Y., Cao, Y., Zeng, H., Li, J., Yan, F., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.562090 · Cited by 65 · see citing works

Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice

Chapman, T. W., Olveda, G. E., Bame, X., Pereira, E., & Hill, R. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01271-1 · Cited by 65 · see citing works

ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses

Berger, N. D., Stanley, F. K. T., Moore, S., & Goodarzi, A. A. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0283 · Cited by 65 · see citing works

Iron Pathophysiology in Alzheimer’s Diseases

Wang, T., Xu, S.-F., Fan, Y.-G., Li, L.-B., & Guo, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_5 · Cited by 64 · see citing works

NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss

Schlett, J. S., Mettang, M., Skaf, A., Schweizer, P., Errerd, A., Mulugeta, E. A., Hein, T. M., Tsesmelis, K., Tsesmelis, M., Büttner, U. F. G., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00616-5 · Cited by 64 · see citing works

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

Ferrer, I. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.07.004 · Cited by 62 · see citing works

Oligodendrocytes in intracerebral hemorrhage

Kang, M., & Yao, Y. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13193 · Cited by 57 · see citing works

DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia

Tse, K., Cheng, A., Ma, F., & Herrup, K. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.010 · Cited by 56 · see citing works

The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration

Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Gillispie, G. J., Milligan, C., & Orr, M. E. (2021) · Life · doi:10.3390/life11030229 · Cited by 54 · see citing works

Overdosing on iron: Elevated iron and degenerative brain disorders

D’Mello, S. R., & Kindy, M. S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220953065 · Cited by 49 · see citing works

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works

Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury

Lu, Y., Jarrahi, A., Moore, N. D., Bartoli, M., Brann, D. W., Baban, B., & Dhandapani, K. M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106090 · Cited by 49 · see citing works

Cellular Senescence, Neurological Function, and Redox State

Maciel-Barón, L. Á., Moreno-Blas, D., Morales-Rosales, S. L., González‐Puertos, V. Y., López‐Díazguerrero, N. E., Torres, C. A., Castro‐Obregón, S., & Königsberg, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7112 · Cited by 45 · see citing works

Sleep quality relates to emotional reactivity via intracortical myelination

Toschi, N., Passamonti, L., & Bellesi, M. (2020) · SLEEP · doi:10.1093/sleep/zsaa146 · Cited by 44 · see citing works

Therapeutic efficacy and promise of stem cell-derived extracellular vesicles in Alzheimer’s disease and other aging-related disorders

Rather, H., Almousa, S., Craft, S., & Deep, G. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102088 · Cited by 44 · see citing works

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

Lai, J. F., Demirbas, D., Kim, J., Jeffries, A. M., Tolles, A. K., Park, J., Chittenden, T. W., Buckley, P. G., Yu, T. W., Lodato, M. A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113622 · Cited by 42 · see citing works

Cellular mechanisms in brain aging: Focus on physiological and pathological aging

Aguilar‐Hernández, L., Alejandre‐Aguilar, R., Morales‐Medina, J. C., Iannitti, T., & Flores, G. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102210 · Cited by 43 · see citing works

Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis

Wang, E., Yu, K., Cao, J., Wang, M., Katsel, P., Song, W., Wang, Z., Li, Y., Wang, X., Wang, Q., et al. (2025) · Cell · doi:10.1016/j.cell.2025.08.038 · Cited by 44 · see citing works

Evolvability of the actin cytoskeleton in oligodendrocytes during central nervous system development and aging

Seixas, A. I., Azevedo, M. M., de Faria, J. P., Fernandes, D. C., Pinto, I. M., & Relvas, J. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2915-8 · Cited by 40 · see citing works

Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation

Roggeri, A., Schepers, M., Tiane, A., Rombaut, B., van Veggel, L., Hellings, N., Prickaerts, J., Pittaluga, A., & Vanmierlo, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207537 · Cited by 40 · see citing works

White matter alterations in Alzheimer’s disease without concomitant pathologies

Ferrer, I., & Andrés‐Benito, P. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12618 · Cited by 40 · see citing works

Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys

Go, V., Sarıkaya, D., Zhou, Y., Bowley, B. G. E., Pessina, M. A., Rosene, D. L., Zhang, Z. G., Chopp, M., Finklestein, S. P., Medalla, M., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113540 · Cited by 41 · see citing works

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

Yang, A., Liu, C., Wu, J., Kou, X., & Shen, R. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173950 · Cited by 40 · see citing works

ER stress and genomic instability induced by gamma radiation in mice primary cultured glial cells

Chatterjee, J., Nairy, R. K., Langhnoja, J., Tripathi, A., Patil, R. K., Pillai, P. P., & Mustak, M. S. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0183-9 · Cited by 39 · see citing works

Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury

Baydyuk, M., Morrison, V. E., Gross, P. S., & Huang, J. K. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02967-7 · Cited by 41 · see citing works

Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte‐derived lipid transport

Mok, K. K., Yeung, S. H., Cheng, G. W., Ma, I. W., Lee, R. H., Herrup, K., & Tse, K. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15748 · Cited by 37 · see citing works

Apolipoprotein E ε4 Mediates Myelin Breakdown by Targeting Oligodendrocytes in Sporadic Alzheimer Disease

Cheng, G. W.-Y., Mok, K. K.-S., Yeung, S. H.-S., Kofler, J., Herrup, K., & Tse, K.-H. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac054 · Cited by 36 · see citing works

Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?

Zhang, X., Huang, N., Xiao, L., Wang, F., & Li, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.760200 · Cited by 31 · see citing works

Oligodendrocyte Maturation Alters the Cell Death Mechanisms That Cause Demyelination

Chapman, T. W., Kamen, Y., Piedra, E. T., & Hill, R. A. (2024) · The Journal of Neuroscience · doi:10.1523/jneurosci.1794-23.2024 · Cited by 33 · see citing works

Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies

Kurihara, M., Mano, T., Saito, Y., Murayama, S., Toda, T., & Iwata, A. (2019) · Brain Sciences · doi:10.3390/brainsci10010007 · Cited by 33 · see citing works

Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives

Schwab, N., Leung, E., & Hazrati, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.742632 · Cited by 33 · see citing works

JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Rivellini, C., Porrello, E., Dina, G., Mrakic-Sposta, S., Vezzoli, A., Bacigaluppi, M., Gullotta, G. S., Chaabane, L., Leocani, L., Marenna, S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145071 · Cited by 31 · see citing works

Neuroglia in Ageing

Verkhratsky, A., Zorec, R., Rodriguez, J. J., & Parpura, V. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_8 · Cited by 31 · see citing works

Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice

Zeng, M., Qi, L., Guo, Y., Zhu, X., Tang, X., Yong, T., Xie, Y., Wu, Q., Zhang, M., & Chen, D. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.628860 · Cited by 28 · see citing works

Neuron‐glia (mis)interactions in brain energy metabolism during aging

Mayorga-Weber, G. A., Rivera, F. J., & Castro, M. A. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25015 · Cited by 26 · see citing works

Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease

Fülöp, T., Tripathi, S., Rodrigues, S., Desroches, M., Bunt, T., Eiser, A. R., Bernier, F., Beauregard, P. B., Barron, A. E., Khalil, A., et al. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s264910 · Cited by 27 · see citing works

Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin

Dermitzakis, I., Manthou, M., Meditskou, S., Miliaras, D., Kesidou, E., Boziki, M., Petratos, S., Grigoriadis, N., & Theotokis, P. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44070222 · Cited by 26 · see citing works

Myelin, aging, and physical exercise

Graciani, A. L., Gutierre, M. U., Ribeiro, A. A. C. M., Arida, R. M., & Gutierre, R. C. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.03.009 · Cited by 26 · see citing works

Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS

Zhao, J., Wang, D.-X., Ma, X.-R., Dong, Z.-J., Wu, J., Wang, F., & Wu, Y. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102205 · Cited by 24 · see citing works

Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Lohrberg, M., Winkler, A., Franz, J., van der Meer, F., Ruhwedel, T., Sirmpilatze, N., Dadarwal, R., Löber-Handwerker, R., Esser, D. S., Wiegand, K., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01105-2 · Cited by 23 · see citing works

Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions

Kajitani, G. S., Nascimento, L. L. D. S., Neves, M. R. D. C., Leandro, G. D. S., Garcia, C. C. M., & Menck, C. F. M. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.10.009 · Cited by 22 · see citing works

Lamin B1 as a key modulator of the developing and aging brain

Koufi, F., Neri, I., Ramazzotti, G., Rusciano, I., Mongiorgi, S., Marvi, M. V., Fazio, A., Shin, M., Kosodo, Y., Cani, I., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1263310 · Cited by 22 · see citing works

Within-person changes in the aging white matter microstructure and their modifiers: A meta-analysis and systematic review of longitudinal diffusion tensor imaging studies

Colmenares, A. M., Prytherch, B., Thomas, M. L., & Burzynska, A. Z. (2023) · Imaging Neuroscience · doi:10.1162/imag_a_00045 · Cited by 23 · see citing works

Ferroptosis in Alzheimer's Disease: The Regulatory Role of Glial Cells.

Xu, J., Shen, R., Qian, M., Zhou, Z., Xie, B.-Q., Jiang, Y., Yu, Y., & Dong, W. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin25845 · Cited by 22 · see citing works

Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain

Vitantonio, A. T., Dimovasili, C., Mortazavi, F., Vaughan, K. L., Mattison, J. A., & Rosene, D. L. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.05.005 · Cited by 18 · see citing works

White matter damage in Alzheimer’s disease: contribution of oligodendrocytes

Zhou, J., Zhang, P., Zhang, B., & Kong, Y. (2022) · Current Alzheimer Research · doi:10.2174/1567205020666221021115321 · Cited by 18 · see citing works

Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury

Hsieh, C.-T., Yen, T., Chen, Y., Jan, J., Teng, R.-D., Yang, C., & Sun, J. (2023) · Antioxidants · doi:10.3390/antiox12020217 · Cited by 15 · see citing works

Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture

Schuster, K. H., Putka, A. F., & McLoughlin, H. S. (2022) · Cells · doi:10.3390/cells11162615 · Cited by 15 · see citing works

Transcriptomic reprogramming for neuronal age reversal

Pleşa, A. M., Shadpour, M., Boyden, E. S., & Church, G. M. (2023) · Human Genetics · doi:10.1007/s00439-023-02529-1 · Cited by 12 · see citing works

Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair

Leung, E., & Hazrati, L. (2021) · Brain Communications · doi:10.1093/braincomms/fcab117 · Cited by 12 · see citing works

Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain

Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12 · see citing works

Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution

Schaeffer, S. M., Pacholko, A. G., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.018 · Cited by 14 · see citing works

Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond

Perdaens, O., & Pesch, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312637 · Cited by 11 · see citing works

Porphyromonas Gingivalis May Seek the Alzheimer’s Disease Brain to Acquire Iron from Its Surplus

Olsen, I. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200272 · Cited by 11 · see citing works

Glial Cells and Aging: From the CNS to the Cerebellum

Sala, G. L., & Farini, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157553 · Cited by 11 · see citing works

White matter lipid alterations during aging in the rhesus monkey brain

Dimovasili, C., Vitantonio, A. T., Conner, B., Vaughan, K. L., Mattison, J. A., & Rosene, D. L. (2024) · GeroScience · doi:10.1007/s11357-024-01353-3 · Cited by 8 · see citing works

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9 · see citing works

Effects on Glial Cell Glycolysis in Schizophrenia: An Advanced Aging Phenotype?

Zuccoli, G. S., Guest, P. C., & Martins‐de‐Souza, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_2 · Cited by 9 · see citing works

The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer’s Disease

Liu, X., Lv, Z., Huang, Q., Lei, Y., Liu, H., & Xu, P. (2025) · Neurochemical Research · doi:10.1007/s11064-024-04325-3 · Cited by 9 · see citing works

Interplay Between Aging and Glial Cell Dysfunction: Implications for CNS Health

García‐Domínguez, M. (2025) · Life · doi:10.3390/life15101498 · Cited by 8 · see citing works

Investigating the mechanisms of inflammation and immune alterations in Parkinson's disease using spatial transcriptomics techniques

Zhang, S., Geng, Y., Jiang, X. Y., Sun, Z., Yan, M., Bi, J., Tian, X., & Wang, Q. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111076 · Cited by 7 · see citing works

ESHRD: deconvolution of brain homogenate RNA expression data to identify cell-type-specific alterations in Alzheimer’s disease

Piras, I. S., Bleul, C., Talboom, J. S., Both, M. D. D., Schrauwen, I., Halliday, G. M., Myers, A., Serrano, G. E., Beach, T. G., & Huentelman, M. J. (2020) · Aging · doi:10.18632/aging.102840 · Cited by 7 · see citing works

DNA Damage and Senescence in the Aging and Alzheimer’s Disease Cortex Are Not Uniformly Distributed

Gutta, G., Mehta, J., Kingston, R., Xie, J., Brenner, E., Ma, F., & Herrup, K. (2024) · Biomedicines · doi:10.3390/biomedicines12061327 · Cited by 6 · see citing works

Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter

Colmenares, A. M., Hefner, M. B., Calhoun, V. D., Salerno, E. A., Fanning, J. T., Gothe, N. P., McAuley, E., Kramer, A. F., & Burzynska, A. Z. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1094313 · Cited by 6 · see citing works

Clemastine enhances myelin formation in the striatum and medial prefrontal cortex and improves sociability in a neonatal rat hypoxic-ischemic model

Feng, Y., Ma, X., Zong, X., Jordan, J. D., Wu, C. Y., Tešić, V., Lee, R. H., & Zhang, Q. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117916 · Cited by 5 · see citing works

Prognostic factors in Tumefactive demyelinating lesions: A retrospective study

Plowman, R. S., & Varma, H. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117591 · Cited by 5 · see citing works

The Role of Oligodendrocytes in Alzheimer’s Disease Pathogenesis and Therapy

Guo, S., Yu, X., & Zhang, H. (2025) · Neuroglia · doi:10.3390/neuroglia6040046 · Cited by 5 · see citing works

The Interaction between Oligodendrocytes and Aβ in Alzheimer's Disease

Wang, W., Huang, X., Xu, Z., & Yu, C. (2025) · Current Alzheimer Research · doi:10.2174/0115672050401966250625171338 · Cited by 3 · see citing works

Diagnostic and therapeutic potential of microRNAs and long noncoding RNAs in the molecular mechanisms of Alzheimer disease

Kashif, O., & Said, M. (2025) · Discover Medicine · doi:10.1007/s44337-025-00455-x · Cited by 3 · see citing works

Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment

Yang, Z., Gong, M., Yang, C., Chen, C., & Zhang, K. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_697 · Cited by 3 · see citing works

Korean Red Ginseng and Rb1 restore altered social interaction, gene expressions in the medial prefrontal cortex, and gut metabolites under post-weaning social isolation in mice

Kwon, O. W., Park, Y. H., Kim, D., Kwon, H. Y., & Yang, H. (2024) · Journal of Ginseng Research · doi:10.1016/j.jgr.2024.03.005 · Cited by 2 · see citing works

Oligodendroglia in Ageing and Age-Dependent Neurodegenerative Diseases

Niu, J., Verkhratsky, A., Butt, A. M., & Yi, C. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-87919-7_13 · Cited by 3 · see citing works

Cellular Senescence in the Aging Brain

Mishra, R. (2025) · Springer eBooks · doi:10.1007/978-981-96-8873-9_4 · Cited by 2 · see citing works

Myelin pathology in ataxia-telangiectasia is the cell autonomous effect of ATM deficiency in oligodendrocytes

Tse, K.-H., Cheng, A., Yeung, S. H.-S., Ng, J.-N., Cheng, G. W.-Y., Wang, Q., Zhu, B., Cui, Y., Jiang, L., Kofler, J., et al. (2021) · doi:10.1101/2021.01.22.20245217 · Cited by 2 · see citing works

Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell ResolutionPreprint

Pacholko, A. G., Schaeffer, S. M., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.14.648770 · Cited by 2 · see citing works

Dying oligodendrocytes persist without mitochondriaPreprint

Bame, X., Gilani, S. Z., Kamen, Y., & Hill, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.699752 · Cited by 2 · see citing works

Histological Constituents of the Nervous System

Weis, S., Sonnberger, M., Dunzinger, A., Voglmayr, E., Aichholzer, M., Kleiser, R., & Strasser, P. (2019) · Springer eBooks · doi:10.1007/978-3-7091-1544-2_10 · Cited by 1 · see citing works

BEYİN YAŞLANMASINDA MOLEKÜLER MEKANİZMALAR

ÖZDEK, E., & Han, S. (2022) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1099963 · Cited by 1 · see citing works

Loopholes in the DNA contract kill neurons

Herrup, K., Tse, K., & Chow, H. (2017) · Nature Neuroscience · doi:10.1038/nn.4626 · Cited by 1 · see citing works

Cuprizone drives divergent neuropathological changes in different mouse models of Alzheimer’s diseasePreprint

Cheng, G. W., Ma, I. W.-T., Huang, J., Yeung, S. H., Ho, P., Chen, Z., Mak, H. K., Herrup, K., Chan, K. W. Y., & Tse, K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.24.547147 · Cited by 1 · see citing works

Age and axon-specific forms of cortical remyelination by divergent populations of NG2-gliaPreprint

Chapman, T. W., Olveda, G. E., Pereira, E., & Hill, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.09.414755

The Role of DNA Damage-induced Cellular Senescence in the Pathophysiology of mTBI

Schwab, N. (2019) · TSpace (University of Toronto)

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity_suppl1

Pamies, D. (2016) · ALTEX · doi:10.14573/altex.1609122s1

Oligodendrocytes and myelin in aging and disease

Sainz, A., Rojas, R., Ruiz, A., & Matute, C. (2025) · Ageing & Longevity · doi:10.47855/jal9020-2025-1-6 · Cited by 2 · see citing works

DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia

Tse, K., Cheng, A., Ma, F., & Herrup, K. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.010 · Cited by 56 · see citing works

Resolving the age-related decline in central nervous system myelin turnover and drug discovery for oligodendroglial rejuvenation

Rivera, A. D., Azim, K., & Butt, A. M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.338995 · Cited by 14 · see citing works

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9 · see citing works

DNA Damage, DNA Repair, Aging, and NeurodegenerationPreprint

Maynard, S., Fang, E. F., Scheibye‐Knudsen, M., Croteau, D. L., & Bohr, V. A. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025130 · Cited by 439 · see citing works