CoChat
Sign Up
Cited by 60Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

The mouse Engrailed genes: A window into autism

Open access
KUEMERLE, B, GULDEN, F, CHEROSKY, N, WILLIAMS, E, HERRUP, K·2007·Behavioural Brain Research
DOI 10.1016/j.bbr.2006.09.009PMC PMC2791532
Open this paper in CoChat — free account

Abstract

The complex behavioral symptoms and neuroanatomical abnormalities observed in autistic individuals strongly suggest a multi-factorial basis for this perplexing disease. Although not the perfect model, we believe the Engrailed genes provide an invaluable "window" into the elusive etiology of autism spectrum disorder. The Engrailed-2 gene has been associated with autism in genetic linkage studies. The En2 knock-out mouse harbors cerebellar abnormalities that are similar to those found in autistic individuals and, as we report here, has a distinct anterior shift in the position of the amygdala in the cerebral cortex. Our initial analysis of background effects in the En1 mouse knock-out provides insight as to possible molecular mechanisms and gender differences associated with autism. These findings further the connection between Engrailed and autism and provide new avenues to explore in the ongoing study of the biological basis of this multifaceted disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2006.09.009

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Animal models with disruptions to En2 and Met demonstrate the importance of these genes to normal cerebellar development.

    “and animal models involving disruptions to these genes have demonstrated their importance to normal cerebellar development [69, 250, 280].”

    From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [280]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [5]Bachevalier J. The amygdala, social cognition, and autism. In: Aggleton JP, editor. The Amygdala. New York: Oxford University Press; 2003. pp. 509–543. [Google Scholar]
  2. [50]Paxinos G, Franklin K. The Mouse Brain in Steriotactic Coordinates. New York: Academic Press; 2001. [Google Scholar]

Cited by

Sorted by citations

Related

Authors
KUEMERLE, B., GULDEN, F., CHEROSKY, N., WILLIAMS, E., & HERRUP, K.
Affiliations
  • Case Western Reserve University (US)
  • Children's Hospital of Pittsburgh (US)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
HERRUP, K
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2007-01-10
Volume
176
Issue
1
Pages
121-132
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2006.09.009
PMC
PMC2791532
OpenAlex
W2026199204
Cited by
60
References
66
Citations by year
2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 3
FWCI
2.59
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS18381, R01NS018381)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
engrailed, EN2, EN1, autism spectrum disorder, cerebellar abnormalities, cerebral cortex, genetic linkage, background effects, sex differences, neuroanatomical abnormalities
MeSH terms
Engrailed 2 Protein, Amygdala, Animals, Autistic Disorder, Cerebellum, Disease Models, Animal, Genetic Linkage, Mice, Inbred C57BL, Nerve Tissue Proteins, Organ Size, Social Behavior, Mice, Knockout, Homeodomain Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review