Luscombe, Nicholas M.

A census of human transcription factors: function, expression and evolution

Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics

Genomics and Chromatin DynamicsBioinformatics and Genomic Networks

Cited by 1,573

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

König, J., Zarnack, K., Rot, G., Curk, T., Kayikci, M., Zupan, B., Turner, D. J., Luscombe, N. M., & Ule, J. (2010) · Nature Structural & Molecular Biology

RNA Research and SplicingRNA regulation and disease

Cited by 1,126

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

Mifsud, B., Tavares-Cadete, F., Young, A. N., Sugar, R., Schoenfelder, S., Ferreira, L., Wingett, S. W., Andrews, S., Grey, W., Ewels, P. A., et al. (2015) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 990

Amino acid-base interactions: A three-dimensional analysis of protein-DNA interactions at an atomic level

Luscombe, N. M. (2001) · Nucleic Acids Research

DNA and Nucleic Acid ChemistryProtein Structure and Dynamics

Cited by 981

Protein–RNA interactions: new genomic technologies and perspectives

König, J., Zarnack, K., Luscombe, N. M., & Ule, J. (2012) · Nature Reviews Genetics

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 555

The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

Schoenfelder, S., Furlan-Magaril, M., Mifsud, B., Tavares-Cadete, F., Sugar, R., Javierre, B.-M., Nagano, T., Katsman, Y., Sakthidevi, M., Wingett, S. W., et al. (2015) · Genome Research

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 460

What is Bioinformatics? A Proposed Definition and Overview of the Field

Luscombe, N. M., Greenbaum, D., & Gerstein, M. (2001) · Methods of Information in Medicine

Genetics, Bioinformatics, and Biomedical ResearchGenomics and Phylogenetic Studies

Cited by 453

Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities

Jolma, A., Kivioja, T., Toivonen, J., Cheng, L., Wei, G., Enge, M., Taipale, M., Vaquerizas, J. M., Yan, J., Sillanpää, M. J., et al. (2010) · Genome Research

Genomics and Chromatin DynamicsAdvanced biosensing and bioanalysis techniques

Cited by 441

Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome

Schoenfelder, S., Sugar, R., Dimond, A., Javierre, B.-M., Armstrong, H., Mifsud, B., Dimitrova, E., Matheson, L., Tavares-Cadete, F., Furlan-Magaril, M., et al. (2015) · Nature Genetics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 398

What is AI? Applications of artificial intelligence to dermatology

Du‐Harpur, X., Watt, F. M., Luscombe, N. M., & Lynch, M. D. (2020) · British Journal of Dermatology

Cutaneous Melanoma Detection and ManagementAI in cancer detection

Cited by 355

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Hall, C. E., Yao, Z., Choi, M., Tyzack, G. E., Serio, A., Luisier, R., Harley, J., Preza, E., Arber, C., Crisp, S. J., et al. (2017) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells Research

Cited by 179

Transcriptional regulatory networks in bacteria: from input signals to output responses

Seshasayee, A. S., Bertone, P., Fraser, G. M., & Luscombe, N. M. (2006) · Current Opinion in Microbiology

Gene Regulatory Network AnalysisBacterial Genetics and Biotechnology

Cited by 140

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis

Poetsch, A. R., Boulton, S. J., & Luscombe, N. M. (2018) · Genome Biology

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 132

High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts

Chia, M., Li, C., Marques, S., Pelechano, V., Luscombe, N. M., & van Werven, F. J. (2021) · Genome Biology

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 47

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors

Vigilante, A., Laddach, A., Moens, N., Meleckyte, R., Leha, A., Ghahramani, A., Culley, O. J., Kathuria, A., Hurling, C., Vickers, A., et al. (2019) · Cell Reports

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 34

Clinically relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis

Du-Harpur, X., Arthurs, C., Ganier, C., Woolf, R., Laftah, Z., Lakhan, M., Salam, A., Wan, B., Watt, F. M., Luscombe, N. M., et al. (2021) · Journal of Investigative Dermatology

Cutaneous Melanoma Detection and ManagementAI in cancer detection

Cited by 31