Thum, Thomas

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature

Cardiac Fibrosis and RemodelingMicroRNA in disease regulation

Cited by 2,349

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

Ucar, A., Gupta, S. K., Fiedler, J., Erikci, E., Kardasinski, M., Batkai, S., Dangwal, S., Kumarswamy, R., Bang, C., Holzmann, A., et al. (2012) · Nature Communications

Cardiac Fibrosis and RemodelingMicroRNA in disease regulation

Cited by 610

MicroRNAs: novel regulators in cardiac development and disease

Thum, T., Catalucci, D., & Bauersachs, J. (2008) · Cardiovascular Research

MicroRNA in disease regulationCongenital heart defects research

Cited by 377

Long noncoding RNA Chast promotes cardiac remodeling

Viereck, J., Kumarswamy, R., Foinquinos, A., Xiao, K., Avramopoulos, P., Kunz, M., Dittrich, M., Maetzig, T., Zimmer, K., Remke, J., et al. (2016) · Science Translational Medicine

Cardiac Fibrosis and RemodelingCancer-related molecular mechanisms research

Cited by 370

Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis

Werner, C., Hanhoun, M., Widmann, T., Kazakov, A., Semenov, A., Pöss, J., Bauersachs, J., Thum, T., Pfreundschuh, M., Müller, P., et al. (2008) · Journal of the American College of Cardiology

Telomeres, Telomerase, and SenescenceCardiovascular Effects of Exercise

Cited by 239

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression

Gupta, S. K., Garg, A., Bär, C., Chatterjee, S., Foinquinos, A., Milting, H., Streckfuß-Bömeke, K., Fiedler, J., & Thum, T. (2018) · Circulation Research

Chemotherapy-induced cardiotoxicity and mitigationCircular RNAs in diseases

Cited by 227

MicroRNA-21: From Cancer to Cardiovascular Disease

Jazbutyte, V., & Thum, T. (2010) · Current Drug Targets

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 226

Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position Statement on Endomyocardial Biopsy

Seferović, P. M., Tsutsui, H., McNamara, D. M., Ristić, A. D., Basso, C., Bozkurt, B., Cooper, L. T., Filippatos, G., Ide, T., Inomata, T., et al. (2021) · European Journal of Heart Failure

Viral Infections and Immunology ResearchTransplantation: Methods and Outcomes

Cited by 219

MicroRNA therapeutics in cardiovascular medicine

Thum, T. (2012) · EMBO Molecular Medicine

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 193

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal

Atherosclerosis and Cardiovascular DiseasesTelomeres, Telomerase, and Senescence

Cited by 188

Preclinical development of a MicroRNA-based therapy for elderly patients with myocardial infarction

Gupta, S. K., Foinquinos, A., Thum, S., Remke, J., Zimmer, K., Bauters, C., de Groote, P., Boon, R. A., de Windt, L. J., Preissl, S., et al. (2016) · Journal of the American College of Cardiology

MicroRNA in disease regulationAutophagy in Disease and Therapy

Cited by 125

Cardiovascular Importance of the MicroRNA‐23/27/24 Family

BANG, C., FIEDLER, J., & THUM, T. (2012) · Microcirculation

MicroRNA in disease regulationAngiogenesis and VEGF in Cancer

Cited by 90

Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function

Ruiz-Meana, M., Bou-Teen, D., Ferdinandy, P., Gyongyosi, M., Pesce, M., Perrino, C., Schulz, R., Sluijter, J. P. G., Tocchetti, C. G., Thum, T., et al. (2020) · Cardiovascular Research

Cardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

Cited by 67

Telomerase therapy attenuates cardiotoxic effects of doxorubicin

Chatterjee, S., Hofer, T., Costa, A., Lu, D., Batkai, S., Gupta, S. K., Bolesani, E., Zweigerdt, R., Megias, D., Streckfuss-Bömeke, K., et al. (2021) · Molecular Therapy

Chemotherapy-induced cardiotoxicity and mitigationTelomeres, Telomerase, and Senescence

Cited by 63

Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation

Dutzmann, J., Koch, A., Weisheit, S., Sonnenschein, K., Korte, L., Haertlé, M., Thum, T., Bauersachs, J., Sedding, D. G., & Daniel, J.-M. (2017) · Cardiovascular Research

Hedgehog Signaling Pathway StudiesAtherosclerosis and Cardiovascular Diseases

Cited by 49

AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes

Rode, L., Bär, C., Groß, S., Rossi, A., Meumann, N., Viereck, J., Abbas, N., Xiao, K., Riedel, I., Gietz, A., et al. (2022) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 48

Non-coding RNAs in vascular disease – from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Fiedler, J., Baker, A. H., Dimmeler, S., Heymans, S., Mayr, M., & Thum, T. (2018) · Cardiovascular Research

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 40

Alternative strategies in cardiac preclinical research and new clinical trial formats

Kreutzer, F. P., Meinecke, A., Schmidt, K., Fiedler, J., & Thum, T. (2022) · Cardiovascular Research

Animal testing and alternatives3D Printing in Biomedical Research

Cited by 36

Genomic instability in the naturally and prematurely aged myocardium

De Majo, F., Martens, L., Hegenbarth, J.-C., Rühle, F., Hamczyk, M. R., Nevado, R. M., Andrés, V., Hilbold, E., Bär, C., Thum, T., et al. (2021) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 35

Biomarkers for the prediction of heart failure and cardiovascular events in patients with type 2 diabetes: a position statement from the Heart Failure Association of the European Society of Cardiology

Seferović, P., Farmakis, D., Bayes-Genis, A., Ben Gal, T., Böhm, M., Chioncel, O., Ferrari, R., Filippatos, G., Hill, L., Jankowska, E., et al. (2022) · European Journal of Heart Failure

Heart Failure Treatment and ManagementCardiovascular Function and Risk Factors

Cited by 24

Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity

Chatterjee, S., de Gonzalo-Calvo, D., Derda, A. A., Schimmel, K., Sonnenschein, K., Bavendiek, U., Bauersachs, J., Bär, C., & Thum, T. (2018) · Scientific Reports

Cardiomyopathy and Myosin StudiesTelomeres, Telomerase, and Senescence

Cited by 21

Non-coding RNAs in ageing

Thum, T. (2014) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsCancer-related molecular mechanisms research

Cited by 10

Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy

Derda, A. A., Abelmann, M., Sonnenschein, K., Sieweke, J.-T., Bavendiek, U., Bauersachs, J., Thum, T., & Berliner, D. (2024) · Frontiers in Cardiovascular Medicine

Cardiomyopathy and Myosin StudiesBlood Pressure and Hypertension Studies

Cited by 6