Kuchroo, Vijay K.

Proinflammatory T helper type 17 cells are effective B-cell helpers

Mitsdoerffer, M., Lee, Y., Jäger, A., Kim, H.-J., Korn, T., Kolls, J. K., Cantor, H., Bettelli, E., & Kuchroo, V. K. (2010) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 534

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., et al. (2021) · Cell

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 524

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T., & DeKruyff, R. H. (2001) · Nature Immunology

Asthma and respiratory diseasesAllergic Rhinitis and Sensitization

Cited by 501

IL-9 induces differentiation of T H 17 cells and enhances function of FoxP3 + natural regulatory T cells

Elyaman, W., Bradshaw, E. M., Uyttenhove, C., Dardalhon, V., Awasthi, A., Imitola, J., Bettelli, E., Oukka, M., van Snick, J., Renauld, J.-C., et al. (2009) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 498

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

Peters, A., Pitcher, L. A., Sullivan, J. M., Mitsdoerffer, M., Acton, S. E., Franz, B., Wucherpfennig, K., Turley, S., Carroll, M. C., Sobel, R. A., et al. (2011) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 480

Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells

Purwar, R., Schlapbach, C., Xiao, S., Kang, H. S., Elyaman, W., Jiang, X., Jetten, A. M., Khoury, S. J., Fuhlbrigge, R. C., Kuchroo, V. K., et al. (2012) · Nature Medicine

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 442

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

Chihara, N., Madi, A., Kondo, T., Zhang, H., Acharya, N., Singer, M., Nyman, J., Marjanovic, N. D., Kowalczyk, M. S., Wang, C., et al. (2018) · Nature

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 438

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion

Rangachari, M., Zhu, C., Sakuishi, K., Xiao, S., Karman, J., Chen, A., Angin, M., Wakeham, A., Greenfield, E. A., Sobel, R. A., et al. (2012) · Nature Medicine

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 394

The TIM gene family: emerging roles in immunity and disease

Kuchroo, V. K., Umetsu, D. T., DeKruyff, R. H., & Freeman, G. J. (2003) · Nature Reviews Immunology

T-cell and B-cell ImmunologyImmune Response and Inflammation

Cited by 388

CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1

Fourcade, J., Sun, Z., Pagliano, O., Guillaume, P., Luescher, I. F., Sander, C., Kirkwood, J. M., Olive, D., Kuchroo, V., & Zarour, H. M. (2012) · Cancer Research

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 372

Myelin oligodendrocyte glycoprotein–specific T and B cells cooperate to induce a Devic-like disease in mice

Bettelli, E., Baeten, D., Jäger, A., Sobel, R. A., & Kuchroo, V. K. (2006) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 336

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

Farez, M. F., Mascanfroni, I. D., Méndez-Huergo, S. P., Yeste, A., Murugaiyan, G., Garo, L. P., Balbuena Aguirre, M. E., Patel, B., Ysrraelit, M. C., Zhu, C., et al. (2015) · Cell

Multiple Sclerosis Research StudiesCircadian rhythm and melatonin

Cited by 318

TH17 cell heterogeneity and its role in tissue inflammation

Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 286

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

Lee, J., Su, E. W., Zhu, C., Hainline, S., Phuah, J., Moroco, J. A., Smithgall, T. E., Kuchroo, V. K., & Kane, L. P. (2011) · Molecular and Cellular Biology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 285

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

Xu, H., Ding, J., Porter, C. B. M., Wallrapp, A., Tabaka, M., Ma, S., Fu, S., Guo, X., Riesenfeld, S. J., Su, C., et al. (2019) · Immunity

IL-33, ST2, and ILC PathwaysMast cells and histamine

Cited by 273

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Schnell, A., Huang, L., Singer, M., Singaraju, A., Barilla, R. M., Regan, B. M. L., Bollhagen, A., Thakore, P. I., Dionne, D., Delorey, T. M., et al. (2021) · Cell

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 268

Th17 cells: from precursors to players in inflammation and infection

Awasthi, A., & Kuchroo, V. K. (2009) · International Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 241

Type 1 regulatory T cells (Tr1) in autoimmunity

Pot, C., Apetoh, L., & Kuchroo, V. K. (2011) · Seminars in Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 171

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs

Gupta, S., Thornley, T. B., Gao, W., Larocca, R., Turka, L. A., Kuchroo, V. K., & Strom, T. B. (2012) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyTransplantation: Methods and Outcomes

Cited by 139

Immunology of neuromyelitis optica: a T cell-B cell collaboration

Mitsdoerffer, M., Kuchroo, V., & Korn, T. (2013) · Annals of the New York Academy of Sciences

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 91

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 91

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., et al. (2025) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 85

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

Thakore, P. I., Schnell, A., Zhao, M., Huang, L., Hou, Y., Christian, E., Zaghouani, S., Wang, C., Singh, V., Ma, S., et al. (2022) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 57

Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling

Pawlak, M., DeTomaso, D., Schnell, A., Meyer zu Horste, G., Lee, Y., Nyman, J., Dionne, D., Regan, B. M. L., Singh, V., Delorey, T., et al. (2022) · Immunity

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 49