Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling
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Interleukin-23 receptor plays a critical role in inducing inflammation and autoimmunity. Here, we report that Th1-like cells differentiated in vitro with IL-12 + IL-21 showed similar IL-23R expression to that of pathogenic Th17 cells using eGFP reporter mice. Fate mapping established that these cells did not transition through a Th17 cell state prior to becoming Th1-like cells, and we observed their emergence in vivo in the T cell adoptive transfer colitis model. Using IL-23R-deficient Th1-like cells, we demonstrated that IL-23R was required for the development of a highly colitogenic phenotype. Single-cell RNA sequencing analysis of intestinal T cells identified IL-23R-dependent genes in Th1-like cells that differed from those expressed in Th17 cells. The perturbation of one of these regulators (CD160) in Th1-like cells inhibited the induction of colitis. We thus uncouple IL-23R as a purely Th17 cell-specific factor and implicate IL-23R signaling as a pathogenic driver in Th1-like cells inducing tissue inflammation.
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Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
SCANPY: large-scale single-cell gene expression data analysis
Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881 · see citing works
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Dimensionality reduction for visualizing single-cell data using UMAP
Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358 · see citing works
McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195 · see citing works
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722 · see citing works
Self-citationFinak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A. K., Slichter, C. K., Miller, H. W., McElrath, M. J., Prlic, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0844-5 · Cited by 3,159 · see citing works
A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works
Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis
Feagan, B. G., Rutgeerts, P. J., Sands, B. E., Hanauer, S. B., Colombel, J., Sandborn, W. J., Assche, G. V., Axler, J. L., Kim, H. J., Danese, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215734 · Cited by 2,892 · see citing works
Genetics and pathogenesis of inflammatory bowel disease
Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,629 · see citing works
Self-citationLiu, J. Z., van Sommeren, S., Huang, H., Ng, S. C., Alberts, R., Takahashi, A., Ripke, S., Lee, J. C., Jostins, L., Shah, T., et al. (2015) · Nature Genetics · doi:10.1038/ng.3359 · Cited by 2,603 · see citing works
Deep generative modeling for single-cell transcriptomics
Lopez, R., Regier, J., Cole, M. B., Jordan, M. I., & Yosef, N. (2018) · Nature Methods · doi:10.1038/s41592-018-0229-2 · Cited by 2,530 · see citing works
Self-citationSmart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358 · see citing works
Accelerating t-SNE using tree-based algorithms
van der Maaten, L. (2014) · Journal of machine learning research · doi:10.5555/2627435.2697068 · Cited by 2,207 · see citing works
Bonecchi, R., Bianchi, G., Panina‐Bordignon, P., D’Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.1.129 · Cited by 2,016 · see citing works
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature · doi:10.1038/nature25986 · Cited by 1,885 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works
Self-citationDivergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works
Hueber, W., Sands, B. E., Lewitzky, S., Vandemeulebroecke, M., Reinisch, W., Higgins, P. D. R., Wehkamp, J., Feagan, B. G., Yao, M. D., Karczewski, M., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301668 · Cited by 1,547 · see citing works
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works
de Lange, K. M., Moutsianas, L., Lee, J. C., Lamb, C. A., Luo, Y., Kennedy, N. A., Jostins, L., Rice, D. L., Gutierrez-Achury, J., Ji, S.-G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3760 · Cited by 1,445 · see citing works
CCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410 · see citing works
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388 · see citing works
Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis
Sands, B. E., Sandborn, W. J., Panaccione, R., O’Brien, C. D., Zhang, H., Johanns, J., Adedokun, O. J., Li, K., Peyrin‐Biroulet, L., Assche, G. V., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1900750 · Cited by 1,231 · see citing works
Fate mapping of IL-17-producing T cells in inflammatory responses
Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176 · see citing works
Induction and molecular signature of pathogenic TH17 cells
Lee, Y., Awasthi, A., Yosef, N., Quintana, F. J., Xiao, S., Peters, A., Wu, C., Kleinewietfeld, M., Kunder, S., Hafler, D. A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2416 · Cited by 1,174 · see citing works
Self-citationPowrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146 · see citing works
Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease
Sandborn, W. J., Gasink, C., Gao, L.-L., BLANK, M. A., Johanns, J., Guzzo, C. A., Sands, B. E., Hanauer, S. B., Targan, S. R., Rutgeerts, P. J., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203572 · Cited by 1,132 · see citing works
McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K., O'Shea, J. J., & Cua, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1698 · Cited by 1,074 · see citing works
The alarmin IL-33 promotes regulatory T-cell function in the intestine
Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works
Atarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., Kiguchi, Y., Yasuma, K., Watanabe, E., Tanoue, T., et al. (2017) · Science · doi:10.1126/science.aan4526 · Cited by 957 · see citing works
Self-citationFuchs, A. G., Vermi, W., Lee, J. S., Lonardi, S., Gilfillan, S., Newberry, R. D., Cella, M., & Colonna, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.010 · Cited by 904 · see citing works
Teng, M. W. L., Bowman, E. P., McElwee, J. J., Smyth, M. J., Casanova, J., Cooper, A. M., & Cua, D. J. (2015) · Nature Medicine · doi:10.1038/nm.3895 · Cited by 877 · see citing works
Unraveling the Complex Interplay Between T Cell Metabolism and Function
Geltink, R. I. K., Kyle, R. L., & Pearce, E. L. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053019 · Cited by 821 · see citing works
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Gagliani, N., Vesely, M. C. A., Iseppon, A., Brockmann, L., Xu, H. Y., Palm, N. W., de Zoete, M. R., Licona-Limón, P., Paiva, R., Ching, T. H., et al. (2015) · Nature · doi:10.1038/nature14452 · Cited by 797 · see citing works
Kowalczyk, M. S., Tirosh, I., Heckl, D., Rao, T. N., Dixit, A., Haas, B. J., Schneider, R. K., Wagers, A. J., Ebert, B. L., & Regev, A. (2015) · Genome Research · doi:10.1101/gr.192237.115 · Cited by 778 · see citing works
Self-citationVedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis
Sands, B. E., Peyrin‐Biroulet, L., Loftus, E. V., Danese, S., Colombel, J., Törüner, M., Jonaitis, L. V., Abhyankar, B., Chen, J., Rogers, R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1905725 · Cited by 759 · see citing works
Fine-mapping inflammatory bowel disease loci to single-variant resolution
International Inflammatory Bowel Disease Genetics Consortium, Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., et al. (2017) · Nature · doi:10.1038/nature22969 · Cited by 611 · see citing works
Self-citationTissue-Resident T Cells and Other Resident Leukocytes
Masopust, D., & Soerens, A. G. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053214 · Cited by 608 · see citing works
Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
Gaublomme, J. T., Yosef, N., Lee, Y., Gertner, R. S., Yang, L. V., Wu, C., Pandolfi, P. P., Mak, T., Satija, R., Shalek, A. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.009 · Cited by 575 · see citing works
Self-citationInterleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J., & Powrie, F. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.010 · Cited by 528 · see citing works
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.045 · Cited by 524 · see citing works
Self-citationEssential role for CD103 in the T cell–mediated regulation of experimental colitis
Annacker, O., Coombes, J. L., Malmström, V., Uhlig, H. H., Bourne, T., Johansson‐Lindbom, B., Agace, W. W., Parker, C. M., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040662 · Cited by 483 · see citing works
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
Patel, D. D., & Kuchroo, V. K. (2015) · Immunity · doi:10.1016/j.immuni.2015.12.003 · Cited by 481 · see citing works
Self-citationThe PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells
Amarnath, S., Mangus, C. W., Wang, J. C. M., Wei, F., He, A., Kapoor, V., Foley, J., Massey, P. R., Felizardo, T. C., Riley, J. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003130 · Cited by 449 · see citing works
Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
Harbour, S. N., Maynard, C. L., Zindl, C. L., Schoeb, T. R., & Weaver, C. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415675112 · Cited by 427 · see citing works
A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
Singer, M., Wang, C., Cong, L., Marjanovic, N. D., Kowalczyk, M. S., Zhang, H., Nyman, J., Sakuishi, K., Kurtuluş, S., Gennert, D. G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.052 · Cited by 414 · see citing works
Self-citationInterleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
Ízcue, A., Hüe, S., Buonocore, S. M., Arancibia-Cárcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., & Powrie, F. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.019 · Cited by 411 · see citing works
Mailand, N., & Diffley, J. (2005) · Cell · doi:10.1016/j.cell.2005.08.013 · Cited by 373 · see citing works
Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
Ito, R., Shin‐Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Kita, M., Ueda, Y., Iwakura, Y., et al. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03214.x · Cited by 365 · see citing works
Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells
Awasthi, A., Riol‐Blanco, L., Jäger, A., Korn, T., Pot, C., Galileos, G., Bettelli, E., Kuchroo, V. K., & Oukka, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900732 · Cited by 365 · see citing works
Self-citationGilfillan, S., Chan, C. J., Cella, M., Haynes, N. M., Rapaport, A. S., Boles, K. S., Andrews, D. M., Smyth, M. J., & Colonna, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081752 · Cited by 361 · see citing works
Cdc20: A WD40 Activator for a Cell Cycle Degradation Machine
Yu, H. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.009 · Cited by 355 · see citing works
Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines
Becattini, S., Latorre, D., Mele, F., Foglierini, M., Gregorio, C. D., Cassotta, A., Fernandez, B., Kelderman, S., Schumacher, T. N., Corti, D., et al. (2014) · Science · doi:10.1126/science.1260668 · Cited by 314 · see citing works
Co-stimulatory and Co-inhibitory Pathways in Autoimmunity
Zhang, Q., & Vignali, D. A. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.017 · Cited by 298 · see citing works
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
Schnell, A., Huang, L., Singer, M., Singaraju, A., Barilla, R. M., Regan, B. M. L., Bollhagen, A., Thakore, P. I., Dionne, D., Delorey, T. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.018 · Cited by 268 · see citing works
Self-citationFrequent mutations that converge on the NFKBIZ pathway in ulcerative colitis
Kakiuchi, N., Yoshida, K., Uchino, M., Kihara, T., Akaki, K., Inoue, Y., Kawada, K., Nagayama, S., Yokoyama, A., Yamamoto, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1856-1 · Cited by 259 · see citing works
Functional interpretation of single cell similarity maps
DeTomaso, D., Jones, M. G., Subramaniam, M., Ashuach, T., Ye, C., & Yosef, N. (2019) · Nature Communications · doi:10.1038/s41467-019-12235-0 · Cited by 251 · see citing works
Self-citationGeneration of gut‐homing T cells and their localization to the small intestinal mucosa
Johansson‐Lindbom, B., & Agace, W. W. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00482.x · Cited by 248 · see citing works
The translation of non-canonical open reading frames controls mucosal immunity
Jackson, R., Kroehling, L., Khitun, A., Bailis, W., Jarret, A., York, A. G., Khan, O. M., Brewer, J. R., Skadow, M. H., Duizer, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0794-7 · Cited by 242 · see citing works
Olfactory cortical neurons read out a relative time code in the olfactory bulb
Haddad, R., Lanjuin, A., Madisen, L., Zeng, H., Murthy, V. N., & Uchida, N. (2013) · Nature Neuroscience · doi:10.1038/nn.3407 · Cited by 216 · see citing works
Komuczki, J., Tuzlak, S., Friebel, E., Hartwig, T., Spath, S., Rosenstiel, P., Waisman, A., Opitz, L., Oukka, M., Schreiner, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.006 · Cited by 201 · see citing works
Molecular diversification of regulatory T cells in nonlymphoid tissues
DiSpirito, J. R., Zemmour, D., Ramanan, D., Cho, J., Žilionis, R., Klein, A. M., Benoist, C. O., & Mathis, D. J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat5861 · Cited by 163 · see citing works
Anumanthan, A., Bensussan, A., Boumsell, L., Christ, A. D., Blumberg, R. S., Voss, S. D., Patel, A. T., Robertson, M. J., Nadler, L. M., & Freeman, G. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.2780 · Cited by 155 · see citing works
Eomesodermin promotes the development of type 1 regulatory T (T R 1) cells
Zhang, P., Lee, J. S., Gartlan, K. H., Schuster, I. S., Comerford, I., Varelias, A., Ullah, M. A., Vučković, S., Koyama, M., Kuns, R. D., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aah7152 · Cited by 150 · see citing works
Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10−/− Mice
Singh, U. P., Singh, S., Taub, D. D., & Lillard, J. W. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1401 · Cited by 145 · see citing works
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
Grenningloh, R., Kang, B. Y., & Ho, I. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041330 · Cited by 128 · see citing works
CD160 is essential for NK-mediated IFN-γ production
Tu, T., Brown, N. K., Kim, T.-J., Wroblewska, J., Yang, X., Guo, X., Lee, S. H., Kumar, V., Lee, K., & Fu, Y. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20131601 · Cited by 124 · see citing works
Dardalhon, V., Schubart, A., Reddy, J., Meyers, J. H., Monney, L., Sabatos, C. A., Ahuja, R., Nguyen, K., Freeman, G., Greenfield, E., et al. (2005) · Journal of Immunology · doi:10.4049/jimmunol.175.3.1558 · Cited by 111 · see citing works
Self-citationGibbons, D. L., Abeler‐Dörner, L., Raine, T., Hwang, I., Jandke, A., Wencker, M., Deban, L., Rudd, C. E., Irving, P. M., Kehrl, J. H., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100833 · Cited by 102 · see citing works
Alfen, J. S., Larghi, P., Facciotti, F., Gagliani, N., Bosotti, R., Paroni, M., Maglie, S., Gruarin, P., Vasco, C., Ranzani, V., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.12.984 · Cited by 101 · see citing works
Gruarin, P., Maglie, S., De Simone, M., Häringer, B., Vasco, C., Ranzani, V., Bosotti, R., Noddings, J. S., Larghi, P., Facciotti, F., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201847722 · Cited by 92 · see citing works
Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108433 · Cited by 91 · see citing works
Self-citationGPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment
Wang, X., Sumida, H., & Cyster, J. G. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140646 · Cited by 86 · see citing works
Lamb, C. A., Mansfield, J. C., Tew, G. W., Gibbons, D. L., Long, A. K., Irving, P. M., Diehl, L. J., Eastham-Anderson, J., Price, M., O’Boyle, G., et al. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw189 · Cited by 67 · see citing works
An Ancient Family of RNA-Binding Proteins: Still Important!
Wells, M. L., Perera, L., & Blackshear, P. J. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.12.003 · Cited by 67 · see citing works
CD38 Is Expressed on Inflammatory Cells of the Intestine and Promotes Intestinal Inflammation
Schneider, M., Schumacher, V., Lischke, T., Lücke, K., Meyer-Schwesinger, C., Velden, J., Koch-Nolte, F., & Mittrücker, H.-W. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126007 · Cited by 62 · see citing works
Rasouli, J., Casella, G., Yoshimura, S., Zhang, W., Xiao, D., Garifallou, J., Gonzalez, M. V., Wiedeman, A., Kus, A., Mari, E. R., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba9953 · Cited by 57 · see citing works
Venema, W. T. U., Voskuil, M. D., Vila, A. V., van der Vries, G. B., Jansen, B. H., Jabrì, B., Faber, K. N., Dijkstra, G. D. H., Xavier, R. J., Wijmenga, C., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.10.046 · Cited by 56 · see citing works
Self-citationCytokine reporter mice in immunological research: perspectives and lessons learned
Croxford, A. L., & Buch, T. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03372.x · Cited by 42 · see citing works
Sato, K., Miyoshi, F., Yokota, K., Araki, Y., Asanuma, Y., Akiyama, Y., Yoh, K., Takahashi, S., Aburatani, H., & Mimura, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.218867 · Cited by 42 · see citing works
Tan, C. L., Peluso, M. J., Drijvers, J. M., Mera, C. M., Grande, S. M., Brown, K. E., Godec, J., Freeman, G. J., & Sharpe, A. H. (2018) · ImmunoHorizons · doi:10.4049/immunohorizons.1800039 · Cited by 33 · see citing works
CD48 Controls T-Cell and Antigen-Presenting Cell Functions in Experimental Colitis
Abadía‐Molina, A. C., Ji, H., Faubion, W. A., Julien, A., Latchman, Y. E., Yagita∥, H., Sharpe, A. H., Bhan, A. K., & Terhorst, C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.009 · Cited by 31 · see citing works
SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes
Hsu, C.-Y., Yeh, L., Fu, S., Chien, M., Liu, Y.-W., Miaw, S., Chang, D., & Sytwu, H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98786 · Cited by 26 · see citing works
Román, J., Planell, N., Lozano, J. J., Aceituno, M., Esteller, M., Pontes, C., Balsa, D., Merlos, M., Panés, J., & Salas, A. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.23020 · Cited by 23 · see citing works
Weder, B., Mozaffari, M., Biedermann, L., Mamie, C., Moncsek, A., Wang, L., Clarke, S. H., Rogler, G., McRae, B. L., Graff, C. L., et al. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13151 · Cited by 14 · see citing works
Kang, L., Schmalzl, A., Leupold, T., González-Acera, M., Atreya, R. N., Neurath, M. F., Becker, C., & Wirtz, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609400 · Cited by 14 · see citing works
Iwamoto, T., Suto, A., Tanaka, S., Takatori, H., Suzuki, K., Iwamoto, I., & Nakajima, H. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38658 · Cited by 7 · see citing works
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TH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
Self-citationIL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
Krueger, J. G., Eyerich, K., Kuchroo, V. K., Ritchlin, C. T., Abreu, M. T., Elloso, M. M., Fourie, A. M., Fakharzadeh, S. S., Sherlock, J. P., Yang, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331217 · Cited by 156 · see citing works
Self-citationOhara, D., Takeuchi, Y., & Hirota, K. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01218-x · Cited by 63 · see citing works
Thakore, P. I., Schnell, A., Zhao, M., Huang, L., Hou, Y., Christian, E., Zaghouani, S., Wang, C., Singh, V., Ma, S., et al. (2022) · doi:10.1101/2022.02.26.482041 · Cited by 57 · see citing works
Self-citationPrecision medicine in inflammatory bowel disease
Zeng, Z., Jiang, M., Li, X., Yuan, J., & Zhang, H. (2023) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbad033 · Cited by 41 · see citing works
Prophylactic IL-23 blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
Ju, M., Zhang, J., Deng, Z., Wei, M., Ma, L., Chen, T., & Lin, Z. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009345 · Cited by 30 · see citing works
Interleukin 23 receptor: Expression and regulation in immune cells
Mezghiche, I., Yahia‐Cherbal, H., Rogge, L., & Bianchi, E. (2023) · European Journal of Immunology · doi:10.1002/eji.202250348 · Cited by 31 · see citing works
Macrophage Functions in Psoriasis: Lessons from Mouse Models
Nazimek, K., & Bryniarski, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105306 · Cited by 27 · see citing works
CD160 receptor in CLL: Current state and future avenues
Oumeslakht, L., Aziz, A.-I., Bensussan, A., & Mkaddem, S. B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1028013 · Cited by 21 · see citing works
Stem‐like T cells in cancer and autoimmunity
Schnell, A. (2024) · Immunological Reviews · doi:10.1111/imr.13356 · Cited by 22 · see citing works
Self-citationHu, W., Wang, W., Jiang, X., Wang, Z., & Lin, R. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04028-3 · Cited by 18 · see citing works
The immunomodulatory of interleukin-33 in rheumatoid arthritis: A systematic review
Liu, R., Wang, F., Luo, X., Yang, F., Gao, J., Shen, H., & Zheng, Z. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110264 · Cited by 17 · see citing works
Th1 cells inducing IFNγ response improves immunotherapy efficacy in gastric cancer
Cao, Q., Xue, R., Zhang, N., & Yunnan Baiyao Group, K. 6. (2023) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2023.03.08 · Cited by 13 · see citing works
Zhao, M., Yu, S., Zhang, M., Huang, Y., Dou, Z., Tian, B., Yang, L., & Lu, J. (2026) · Journal of Innate Immunity · doi:10.1159/000550397 · Cited by 12 · see citing works
IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells
Camard, L., Stephen, T., Yahia‐Cherbal, H., Guillemot, V., Mella, S., Baillet, V., Lopez-Maestre, H., Capocefalo, D., Cantini, L., Leloup, C., et al. (2025) · iScience · doi:10.1016/j.isci.2025.111898 · Cited by 12 · see citing works
Binayke, A., Zaheer, A., Dandotiya, J., Gupta, S. K., Mani, S., Tripathi, M., Madan, U., Shrivastava, T., Kumar, Y., Pandey, A. K., et al. (2022) · Vaccines · doi:10.3390/vaccines10101762 · Cited by 12 · see citing works
Audia, S., Brescia, C., Dattilo, V., Torchia, N., Trapasso, F., & Amato, R. (2024) · Cancers · doi:10.3390/cancers17010055 · Cited by 10 · see citing works
Cao, H., Liu, H., Xiaoling, D., Shi, B., Yuan, J., Shan, J., & Lin, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118865 · Cited by 9 · see citing works
Johnson, B. M., Cheng, L., Koenitzer, J. D., Catlett, I. M., & Schafer, P. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1437512 · Cited by 10 · see citing works
Hadfield, M. J., Merkin, R. D., Rouhani, S. J., & Reynolds, K. L. (2025) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2025.101625 · Cited by 8 · see citing works
Grieger, K. M., Schröder, V., Dehmel, S., Neuhaus, V., Schaudien, D., Fuchs, M., Linge, H., Wagner, A., Kulik, U., Gundert, B., et al. (2025) · European Journal of Immunology · doi:10.1002/eji.70013 · Cited by 8 · see citing works
Strawn, D., Krueger, J. G., Bissonnette, R., Eyerich, K., Ferris, L. K., Paller, A. S., Pinter, A., Richards, D., Chen, E. Y., Paget, K., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.193563 · Cited by 8 · see citing works
CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
Dicker, M., Li, Y., Giles, D. A., Verstichel, G., Castelan, V. O. C., Ascui, G., Chou, T.-F., Pérez-Jeldres, T., Cheroutre, H., & Kronenberg, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1034648 · Cited by 7 · see citing works
Paul, S., Hmar, E. B. L., & Sharma, H. K. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100161 · Cited by 6 · see citing works
Interleukin-23 biology linking mucosal immunity to autoimmune diseases and cancer
Ahmed, A., & Sonnenberg, G. F. (2026) · Trends in Immunology · doi:10.1016/j.it.2025.12.005 · Cited by 5 · see citing works
Blauvelt, A., Langley, R. G. B., Branigan, P. J., Liu, X., Chen, Y., DePrimo, S. E., Ma, K., Scott, B., Campbell, K., Muñoz‐Elías, E. J., et al. (2024) · JID Innovations · doi:10.1016/j.xjidi.2024.100287 · Cited by 5 · see citing works
Cross, C. (2025) · European Medical Journal · doi:10.33590/emj/mwzp6306 · Cited by 3 · see citing works
Single-cell RNA sequencing indicates AP-1 as a potential therapeutic target for autoimmune uveitis.
Zhao, S., Wu, D.-T., Lu, Y., Zhu, L., Wang, S.-H. E., Li, Z.-H., Peng, X., Li, H., Xu, X.-F., & Su, W.-R. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116945 · Cited by 3 · see citing works
López‐Villalobos, E. F., García‐Espinoza, J. A., García‐Chagollán, M., Uribe-Martínez, J. F., Cerpa‐Cruz, S., Muñóz-Valle, J. F., Palafox‐Sánchez, C. A., & Oregon‐Romero, E. (2025) · Diagnostics · doi:10.3390/diagnostics15222909 · Cited by 2 · see citing works
Fan, Z. ‐., Zhang, L., & Yu, H. (2026) · MedComm · doi:10.1002/mco2.70658 · Cited by 2 · see citing works
IL23p19 therapies for moderately-to-severely active ulcerative colitis
Ahmed, N. S., & Ma, C. (2025) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2025.2480258 · Cited by 2 · see citing works
Salmonella -superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state
Luccia, B. D., Massis, L. M., Butler, D. S. C., Narasimhan, R., Ruddle, S. J., Pham, T. H. M., Vilches-Moure, J. G., & Monack, D. M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20242431 · Cited by 1 · see citing works
Cigarette smoke-primed citrullinated HLA-DR4 T cell reactivity is modulated by γδ-T cells
Jarlborg, M., Decruy, T., Manuello, T., Coudenys, J., der Cruyssen, R. V., Malfait, T. L. A., Meuris, L., Maes, T., Bracke, K. R., van der Woude, D., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.10.031 · Cited by 1 · see citing works
Ward, A., Bell, O. H., Robles, L., Lait, P. J. P., Chu, C. J., Copland, D. A., Dick, A. D., & Nicholson, L. B. (2025) · Discovery Immunology · doi:10.1093/discim/kyaf019 · Cited by 2 · see citing works
Kashtanjeva, L., Ruhland, C., Horstmeier, F. C., Thives-Kurenbach, F., Ettich, J., Padrini, G., Streuber, S., Scheller, J., Dittrich, A., & Floss, D. M. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-025-02593-2 · Cited by 2 · see citing works
Zhang, X., Zhang, L., Shi, C., Yan, L., Geng, Q., Yuan, S., He, X., & Lü, C. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70392 · Cited by 1 · see citing works
Han, P., Tang, J., Xu, X.-F., Meng, P., Wu, K., Sun, B.-Y., & Song, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130946 · Cited by 1 · see citing works
Tapping the keg of discovery to advance T cell therapy
Schulz, A. M., Zebley, C. C., Youngblood, B., & Zehn, D. (2023) · Nature Immunology · doi:10.1038/s41590-022-01401-0
Xu, X. L., Xie, J., Lu, S., Cai, S., & Song, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-3708002/v1
Hu, W., Wang, W., Jiang, X., Wang, Z., & Lin, R. (2024) · Figshare · doi:10.6084/m9.figshare.26578349
Hu, W., Wang, W., Jiang, X., Wang, Z., & Lin, R. (2024) · Figshare · doi:10.6084/m9.figshare.26578352
Li, M., Xian, H., Wen, H., & Lin, F. (2025) · International Journal of Clinical Practice · doi:10.1155/ijcp/1620972
Liang, Y., Wu, H., Qiu, Y., Mo, Q., Chen, P., Li, M., & Lin, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1744845
Xu, Z., Tao, S., Feng, S., Ye, X., Wang, T., Hu, H., Heidrich-O’Hare, E., Chen, W., & Duerr, R. H. (2026) · Nature Communications · doi:10.1038/s41467-026-71383-2
Human autosomal recessive IL-23R deficiency
Philippot, Q. (2023) · doi:10.70675/e98a1273zfdd5z4077zb648zd8ca28cf0f33
Distinguishing Th17 cells as a unique subset
McGeachy, M. J., Ghoreschi, K., & O’Shea, J. J. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag082
Chronic stress promotes sex-divergent Type 1, 2 and 17 responses in brain resident lymphocytesPreprint
Paris, S., Cao, K., Park, Y., Lee, K. J., Zhou, S., Uthayakumar, D., Novelo, M., Tuncer, A., Qian, C., & Wang, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.31.748329
Self-citationGene-environment interactions for plasma proteins improve disease predictionPreprint
Yu, C., Wang, Y., Wang, S., wang, Y., Liu, M., Qi, J., Wang, J., Xu, J., Xue, H., Liu, N., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9592234/v1
- Authors
- Pawlak, M., DeTomaso, D., Schnell, A., Meyer zu Horste, G., Lee, Y., Nyman, J., Dionne, D., Regan, B. M. L., Singh, V., Delorey, T., Schramm, M. A., Wang, C., Wallrapp, A., Burkett, P. R., Riesenfeld, S. J., Anderson, A. C., Regev, A., Xavier, R. J., Yosef, N., & Kuchroo, V. K.
- Affiliations
- Broad Institute (US)
- University of California, Berkeley (US)
- Brigham and Women's Hospital (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Corresponding author
- Xavier, Ramnik J.
- Yosef, Nir
- Kuchroo, Vijay K.
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 55
- Issue
- 9
- Pages
- 1663-1679.e6
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC9808605
- OpenAlex
- W4294770778
- Cited by
- 49
- References
- 93
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 8 · 2022: 3
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 629 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (1R01AI144166-01A1, 5P01AI039671-23, 5P01AI056299-17, 5P01AI073748-10)
- National Multiple Sclerosis Society (TA-1605-08590)
- Chan Zuckerberg Initiative
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- IL23R, colitis, Th17 cells, CD160, intestinal T cells, adoptive T cell therapy, fate mapping, single-cell RNA sequencing, T cell differentiation
- MeSH terms
- Animals, Colitis, Inflammation, Mice, Inbred C57BL, Phenotype, Receptors, Interleukin, Th1 Cells, Mice, Interleukin-23, Th17 Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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