Shaw, Albert C.

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Lucas, C., Wong, P., Klein, J., Castro, T. B. R., Silva, J., Sundaram, M., Ellingson, M. K., Mao, T., Oh, J. E., Israelow, B., et al. (2020) · Nature

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 2,074

Sex differences in immune responses that underlie COVID-19 disease outcomes

Takahashi, T., Ellingson, M. K., Wong, P., Israelow, B., Lucas, C., Klein, J., Silva, J., Mao, T., Oh, J. E., Tokuyama, M., et al. (2020) · Nature

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 1,459

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 1,061

Aging of the innate immune system

Shaw, A. C., Joshi, S., Greenwood, H., Panda, A., & Lord, J. M. (2010) · Current Opinion in Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 647

Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response

Panda, A., Qian, F., Mohanty, S., van Duin, D., Newman, F. K., Zhang, L., Chen, S., Towle, V., Belshe, R. B., Fikrig, E., et al. (2010) · The Journal of Immunology

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 548

Human innate immunosenescence: causes and consequences for immunity in old age

Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R. R., Lord, J. M., & Shaw, A. C. (2009) · Trends in Immunology

Immune responses and vaccinationsImmune Response and Inflammation

Cited by 502

β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports

Inflammasome and immune disordersGout, Hyperuricemia, Uric Acid

Cited by 370

Age-Associated Defect in Human TLR-1/2 Function

van Duin, D., Mohanty, S., Thomas, V., Ginter, S., Montgomery, R. R., Fikrig, E., Allore, H. G., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 352

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

Lucas, C., Vogels, C. B. F., Yildirim, I., Rothman, J. E., Lu, P., Monteiro, V., Gehlhausen, J. R., Campbell, M., Silva, J., Tabachnikova, A., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 226

Dysregulation of human Toll-like receptor function in aging

Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R. (2011) · Ageing Research Reviews

Immune Response and InflammationImmune responses and vaccinations

Cited by 215

Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis

Zhou, Y., Peng, H., Sun, H., Peng, X., Tang, C., Gan, Y., Chen, X., Mathur, A., Hu, B., Slade, M. D., et al. (2014) · Science Translational Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisStudies on Chitinases and Chitosanases

Cited by 215

Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults

van Duin, D., Allore, H. G., Mohanty, S., Ginter, S., Newman, F. K., Belshe, R. B., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Infectious Diseases

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 159

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

Molony, R. D., Nguyen, J. T., Kong, Y., Montgomery, R. R., Shaw, A. C., & Iwasaki, A. (2017) · Science Signaling

interferon and immune responsesImmune Response and Inflammation

Cited by 154

Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly

Qian, F., Wang, X., Zhang, L., Chen, S., Piecychna, M., Allore, H., Bockenstedt, L., Malawista, S., Bucala, R., Shaw, A. C., et al. (2012) · Aging Cell

Immune Response and InflammationInflammasome and immune disorders

Cited by 154

Paradoxical changes in innate immunity in aging: recent progress and new directions

Montgomery, R. R., & Shaw, A. C. (2015) · Journal of Leukocyte Biology

Immune Response and InflammationImmune responses and vaccinations

Cited by 147

Semaphorin 7a+ Regulatory T Cells Are Associated with Progressive Idiopathic Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-β1–induced Pulmonary Fibrosis

Reilkoff, R. A., Peng, H., Murray, L. A., Peng, X., Russell, T., Montgomery, R., Feghali-Bostwick, C., Shaw, A., Homer, R. J., Gulati, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 135

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults

Mohanty, S., Joshi, S. R., Ueda, I., Wilson, J., Blevins, T. P., Siconolfi, B., Meng, H., Devine, L., Raddassi, K., Tsang, S., et al. (2015) · Journal of Infectious Diseases

Immune responses and vaccinationsInfluenza Virus Research Studies

Cited by 67

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

Mishra, M., Kim, H.-H., Youm, Y.-H., Gonzalez-Hurtado, E., Zaitsev, K., Dlugos, T., Shchukina, I., Gliniak, C., Ravussin, E., Mohanty, S., et al. (2026) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsComplement system in diseases

Cited by 10