Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
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Age-related reduction of the adaptor protein TRAF3 compromises the innate immune response of monocytes from older individuals.
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Ageing compromises both the primary and secondary RIG-I signalling pathways that control expression of many type I interferon genes.
“ageing compromises both the primary and secondary RIG-I signaling pathways that control expression of many type I IFN genes115.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [115]
This RIG-I compromise is associated with reduced type I interferon production in people over 65, impairing their antiviral responses such as to influenza A virus.
“This is associated with reduced production of type I IFNs in those >65, impairing their anti-viral responses, like to respiratory influenza A virus115.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [115]
Monocytes from older adults show impaired primary and secondary RIG-I signalling, caused by lower levels of the adaptor protein TRAF3 and the transcription factor IRF8, respectively.
“there is an impairment of primary and secondary RIG-I signalling in monocytes from older adults, due to decreased abundance of the adaptor protein tumour necrosis factor receptor-associated factor 3 (TRAF3) and IFN regulatory transcription factor (IRF8) respectively (138).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [138]
The reduced type I interferon production is proposed as one reason older adults are more vulnerable to respiratory infections, since type I interferon is required for infection clearance.
“is thought to be one of the reasons that older people are more susceptible to respiratory infections, as type I interferon is necessary to clear infection (138).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [138]
This impairment leads to decreased production of type I interferon.
“This in turn results in reduced type I IFN production”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [138]
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- Authors
- Molony, R. D., Nguyen, J. T., Kong, Y., Montgomery, R. R., Shaw, A. C., & Iwasaki, A.
- Affiliations
- Yale University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Iwasaki, Akiko
- Venue
- Science Signaling
- Published
- 2017-12-12
- Volume
- 10
- Issue
- 509
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC6429941
- OpenAlex
- W2773620555
- Cited by
- 154
- References
- 55
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 9 · 2023: 18 · 2022: 22 · 2021: 37 · 2020: 22 · 2019: 6 · 2018: 6
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award306479, U19 AI089992, award339643, T32 AI007019-38, award339644, T32 AI055403, award339645, K24 AG042489, award339647, HHSN272201100019C)
- Howard Hughes Medical Institute (award306478)
- National Institute on Aging (award362220, P30 AG021342 Claude D. Pepper Older Americans Independence Center)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- aging, RIG-I signaling, type I interferon, monocytes, influenza A virus, TRAF3, IRF8, proteasomal degradation, antiviral immunity, innate immunity
- MeSH terms
- DEAD Box Protein 58, Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Immunity, Innate, Interferons, Male, Monocytes, Receptors, Immunologic, Signal Transduction
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