Cited by 218Immune Response and InflammationImmune responses and vaccinationsGenetics, Aging, and Longevity in Model Organisms

Dysregulation of human Toll-like receptor function in aging

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Shaw, Albert C., Panda, Alexander, Joshi, Samit R., Qian, Feng, Allore, Heather G., Montgomery, Ruth R.·2011·Ageing Research Reviews

Abstract

Studies addressing immunosenescence in the immune system have expanded to focus on the innate as well as the adaptive responses. In particular, aging results in alterations in the function of Toll-like receptors (TLRs), the first described pattern recognition receptor family of the innate immune system. Recent studies have begun to elucidate the consequences of aging on TLR function in human cohorts and add to existing findings performed in animal models. In general, these studies show that human TLR function is impaired in the context of aging, and in addition there is evidence for inappropriate persistence of TLR activation in specific systems. These findings are consistent with an overarching theme of age-associated dysregulation of TLR signaling that likely contributes to the increased morbidity and mortality from infectious diseases found in geriatric patients.

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Crossref · 10.1016/j.arr.2010.10.007

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  • Efficient TLR stimulation may overcome age-associated TLR signaling dysfunction.

    “Age-related variations in cytokine production are seen in the APC isolated from older donors and efficient TLR stimulation may overcome the age associated TLR signaling dysfunction (219).”
  • Age-related variations in cytokine production are seen in APCs isolated from older donors.

    “Age-related variations in cytokine production are seen in the APC isolated from older donors and efficient TLR stimulation may overcome the age associated TLR signaling dysfunction (219).”
  • Age-related alterations in pathogen recognition, decreased PRR expression, and diminished responses to secondary signaling may underlie increased susceptibility of older persons to infectious stimuli.

    “In addition, age-related alterations in pathogen recognition, decreased PRR expression, and diminished responses to secondary signaling may underlie increased susceptibility of older persons to infectious stimuli (109).”

    From Aging and Lung Disease (2020) · cites this paper as [109]

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Authors
Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R.
Affiliations
Yale University (US)
Corresponding author
Shaw, Albert C.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2011-07
Volume
10
Issue
3
Pages
346-353
ISSN
1568-1637 (ISSN-L)
OpenAlex
W1968377406
Cited by
215
References
91
Citations by year
2026: 5 · 2025: 7 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 20 · 2020: 13 · 2019: 16 · 2018: 19 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 21 · 2012: 13
FWCI
1.02
Type
journal article
Language
en
Open access
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01ai50031-6-0-1)
  • National Institute on Aging (T32 AG1934, P30AG021342)
  • National Institute of Allergy and Infectious Diseases (N01 AI500031, R01AI041440, N01 AI050031, N01-AI-50031, R01AI032947, U19AI089992)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
Toll-like receptors, immunosenescence, aging, innate immunity, pattern recognition receptors, elderly patients
MeSH terms
Aged, Aged, 80 and over, Aging, Dendritic Cells, Humans, Immunity, Innate, Macrophages, Signal Transduction, Toll-Like Receptors

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