Human innate immunosenescence: causes and consequences for immunity in old age

Panda, Alexander; Arjona, Alvaro; Sapey, Elizabeth; Bai, Fengwei; Fikrig, Erol; Montgomery, Ruth R.; Lord, Janet M.; Shaw, Albert C.

doi:10.1016/j.it.2009.05.004

Cited by 502Immune responses and vaccinationsImmune Response and InflammationGenetics, Aging, and Longevity in Model Organisms

Human innate immunosenescence: causes and consequences for immunity in old age

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Panda, Alexander, Arjona, Alvaro, Sapey, Elizabeth, Bai, Fengwei, Fikrig, Erol, Montgomery, Ruth R., Lord, Janet M., Shaw, Albert C.·2009·Trends in Immunology

DOI 10.1016/j.it.2009.05.004PMC PMC4067971

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Abstract

The past decade has seen an explosion in research focusing on innate immunity. Through a wide range of mechanisms including phagocytosis, intracellular killing and activation of proinflammatory or antiviral cytokine production, the cells of the innate immune system initiate and support adaptive immunity. The effects of aging on innate immune responses remain incompletely understood, particularly in humans. Here we review advances in the study of human immunosenescence in the diverse cells of the innate immune system, including neutrophils, monocytes, macrophages, natural killer and natural killer T (NKT) cells and dendritic cells-with a focus on consequences for the response to infection or vaccination in old age.

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Alterations to innate immunity with ageing include impaired phagocytosis and chemotaxis of neutrophils and monocytes/macrophages, with the latter exhibiting defective antigen processing and presentation, and an inflammatory phenotype.
“Alterations to innate immunity include impaired phagocytosis and chemotaxis of neutrophils and monocytes/macrophages, with the latter exhibiting defective antigen processing and presentation, and an inflammatory phenotype (Panda et al. 2009).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Panda et al. 2009
Although the number of natural killer (NK) cells increases with age, cytokine production and cytotoxicity on a per cell basis decreases.
“Although the number of natural killer (NK) cells increases with age, cytokine production and cytotoxicity on a per cell basis decreases (Panda et al. 2009).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Panda et al. 2009
Ageing is associated with a lower number and altered tissue distribution of dendritic cells, which exhibit impaired antigen processing and presentation, along with decreased co-stimulatory and migratory capacity.
“Ageing is also associated with a lower number, and altered tissue distribution of dendritic cells, which exhibit impaired antigen processing and presentation, along with decreased co-stimulatory and migratory capacity (Panda et al. 2009).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Panda et al. 2009
Ageing results in alterations to almost all aspects of innate and adaptive immune function.
“Ageing results in alterations to almost all aspects of innate and adaptive immune function, and these changes are typically assumed to reflect deregulation.”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Panda et al. 2009

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Authors: Panda, A., Arjona, A., Sapey, E., Bai, F., Fikrig, E., Montgomery, R. R., Lord, J. M., & Shaw, A. C.
Affiliations: Yale University (US)
University of Birmingham (GB)
Corresponding author: Lord, Janet M.
Shaw, Albert C.
ORCID: Sapey, Elizabeth
Bai, Fengwei
Fikrig, Erol
Montgomery, Ruth R.
Lord, Janet M.
Shaw, Albert C.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2009-07
Volume: 30
Issue: 7
Pages: 325-333
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2009.05.004
PMC: PMC4067971
OpenAlex: W2044159907
Cited by: 502
References: 115
Citations by year: 2026: 18 · 2025: 13 · 2024: 31 · 2023: 21 · 2022: 30 · 2021: 17 · 2020: 32 · 2019: 25 · 2018: 33 · 2017: 31 · 2016: 31 · 2015: 26 · 2014: 36 · 2013: 46 · 2012: 41
FWCI: 2.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Howard Hughes Medical Institute
John A. Hartford Foundation
Yale University
National Institutes of Health (n01ai50031-6-0-1)
National Institute on Aging (P30AG021342)
National Institute of Allergy and Infectious Diseases (N01 AI500031, N01 AI050031, N01-AI-50031, AI070343, U01AI070343)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: immunosenescence, innate immunity, aging, neutrophils, monocytes, macrophages, natural killer cells, NKT cells, dendritic cells, phagocytosis, cytokine production, infection response, vaccine response, older adults
MeSH terms: Aged, Aged, 80 and over, Aging, Basophils, Dendritic Cells, Eosinophils, Humans, Immunity, Innate, Killer Cells, Natural, Macrophages, Neutrophils, Signal Transduction, Cytokines, Toll-Like Receptors, Natural Killer T-Cells

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Human innate immunosenescence: causes and consequences for immunity in old age

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