Powrie, Fiona

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity

Inflammatory Bowel DiseaseT-cell and B-cell Immunology

Cited by 1,146

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

Schulthess, J., Pandey, S., Capitani, M., Rue-Albrecht, K. C., Arnold, I., Franchini, F., Chomka, A., Ilott, N. E., Johnston, D. G. W., Pires, E., et al. (2019) · Immunity

Gut microbiota and healthImmune cells in cancer

Cited by 1,037

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine

Inflammatory Bowel DiseasePsoriasis: Treatment and Pathogenesis

Cited by 823

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine

T-cell and B-cell ImmunologyResearch on Leishmaniasis Studies

Cited by 613

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

Kirchberger, S., Royston, D. J., Boulard, O., Thornton, E., Franchini, F., Szabady, R. L., Harrison, O., & Powrie, F. (2013) · Journal of Experimental Medicine

IL-33, ST2, and ILC PathwaysInflammatory Bowel Disease

Cited by 529

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J., & Powrie, F. (2010) · Immunity

Psoriasis: Treatment and PathogenesisInflammatory Bowel Disease

Cited by 528

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Miragaia, R. J., Gomes, T., Chomka, A., Jardine, L., Riedel, A., Hegazy, A. N., Whibley, N., Tucci, A., Chen, X., Lindeman, I., et al. (2019) · Immunity

T-cell and B-cell ImmunologySingle-cell and spatial transcriptomics

Cited by 499

Host–microbiota maladaptation in colorectal cancer

Janney, A., Powrie, F., & Mann, E. H. (2020) · Nature

Gut microbiota and healthColorectal Cancer Treatments and Studies

Cited by 445

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

Read, S., Greenwald, R., Izcue, A., Robinson, N., Mandelbrot, D., Francisco, L., Sharpe, A. H., & Powrie, F. (2006) · The Journal of Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 434

Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

Hegazy, A. N., West, N. R., Stubbington, M. J. T., Wendt, E., Suijker, K. I. M., Datsi, A., This, S., Danne, C., Campion, S., Duncan, S. H., et al. (2017) · Gastroenterology

Gut microbiota and healthInflammatory Bowel Disease

Cited by 338

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Ahern, D. J., Ai, Z., Ainsworth, M., Allan, C., Allcock, A., Angus, B., Ansari, M. A., Arancibia-Cárcamo, C. V., Aschenbrenner, D., Attar, M., et al. (2022) · Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 328

Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance

Aschenbrenner, D., Quaranta, M., Banerjee, S., Ilott, N., Jansen, J., Steere, B., Chen, Y.-H., Ho, S., Cox, K., Arancibia-Cárcamo, C. V., et al. (2021) · Gut

Inflammatory Bowel DiseasePsoriasis: Treatment and Pathogenesis

Cited by 123

A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages

Danne, C., Ryzhakov, G., Martínez-López, M., Ilott, N. E., Franchini, F., Cuskin, F., Lowe, E. C., Bullers, S. J., Arthur, J. S. C., & Powrie, F. (2017) · Cell Host & Microbe

Gut microbiota and healthHelicobacter pylori-related gastroenterology studies

Cited by 120

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

Alasoo, K., Martinez, F. O., Hale, C., Gordon, S., Powrie, F., Dougan, G., Mukhopadhyay, S., & Gaffney, D. J. (2015) · Scientific Reports

Pluripotent Stem Cells ResearchImmune cells in cancer

Cited by 102

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3

Steward-Tharp, S. M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A. V., Sciume, G., Kuchen, S., Resch, W., Wohlfert, E. A., Jiang, K., et al. (2014) · Blood

Immunodeficiency and Autoimmune DisordersCytokine Signaling Pathways and Interactions

Cited by 87

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Fenton, T. M., Kelly, A., Shuttleworth, E. E., Smedley, C., Atakilit, A., Powrie, F., Campbell, S., Nishimura, S. L., Sheppard, D., Levison, S., et al. (2017) · Mucosal Immunology

TGF-β signaling in diseasesInflammatory Bowel Disease

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