Jove, Richard

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer

Cytokine Signaling Pathways and InteractionsImmune cells in cancer

Cited by 4,383

The STATs of cancer — new molecular targets come of age

Yu, H., & Jove, R. (2004) · Nature Reviews Cancer

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 2,278

Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Yu, H., Lee, H., Herrmann, A., Buettner, R., & Jove, R. (2014) · Nature Reviews Cancer

Cytokine Signaling Pathways and InteractionsTGF-β signaling in diseases

Cited by 2,137

STATs in oncogenesis

Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 1,743

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity

Cytokine Signaling Pathways and InteractionsMultiple Myeloma Research and Treatments

Cited by 1,638

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

Niu, G., Wright, K. L., Huang, M., Song, L., Haura, E., Turkson, J., Zhang, S., Wang, T., Sinibaldi, D., Coppola, D., et al. (2002) · Oncogene

Angiogenesis and VEGF in CancerCytokine Signaling Pathways and Interactions

Cited by 1,207

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

Yu, C.-L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., & Jove, R. (1995) · Science

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 931

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

Lee, H., Herrmann, A., Deng, J.-H., Kujawski, M., Niu, G., Li, Z., Forman, S., Jove, R., Pardoll, D. M., & Yu, H. (2009) · Cancer Cell

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Cited by 683

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., & Jove, R. (1998) · Molecular and Cellular Biology

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 651

STAT proteins: novel molecular targets for cancer drug discovery

Turkson, J., & Jove, R. (2000) · Oncogene

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 643

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

Epling-Burnette, P. K., Liu, J. H., Catlett-Falcone, R., Turkson, J., Oshiro, M., Kothapalli, R., Li, Y., Wang, J.-M., Yang-Yen, H.-F., Karras, J., et al. (2001) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsCell death mechanisms and regulation

Cited by 633

Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

Gritsko, T., Williams, A., Turkson, J., Kaneko, S., Bowman, T., Huang, M., Nam, S., Eweis, I., Diaz, N., Sullivan, D., et al. (2006) · Clinical Cancer Research

Cytokine Signaling Pathways and InteractionsCell death mechanisms and regulation

Cited by 563

Activating SRC mutation in a subset of advanced human colon cancers

Irby, R. B., Mao, W., Coppola, D., Kang, J., Loubeau, J. M., Trudeau, W., Karl, R., Fujita, D. J., Jove, R., & Yeatman, T. J. (1999) · Nature Genetics

Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and Therapy

Cited by 489

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A., & Jove, R. (2001) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 488

Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer

Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., Jove, R., & Gabrilovich, D. (2004) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsImmune cells in cancer

Cited by 464

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

Niu, G., Bowman, T., Huang, M., Shivers, S., Reintgen, D., Daud, A., Chang, A., Kraker, A., Jove, R., & Yu, H. (2002) · Oncogene

Cytokine Signaling Pathways and InteractionsMelanoma and MAPK Pathways

Cited by 432

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

Lee, H., Deng, J., Kujawski, M., Yang, C., Liu, Y., Herrmann, A., Kortylewski, M., Horne, D., Somlo, G., Forman, S., et al. (2010) · Nature Medicine

Cytokine Signaling Pathways and InteractionsSphingolipid Metabolism and Signaling

Cited by 395

A Critical Role for Stat3 Signaling in Immune Tolerance

Cheng, F., Wang, H.-W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., Kerr, W. G., Takeda, K., Akira, S., Schoenberger, S. P., et al. (2003) · Immunity

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 377

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

Mao, W., Irby, R., Coppola, D., Fu, L., Wloch, M., Turner, J., Yu, H., Garcia, R., Jove, R., & Yeatman, T. J. (1997) · Oncogene

Protein Kinase Regulation and GTPase SignalingHER2/EGFR in Cancer Research

Cited by 200

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity

Turkson, J., Zhang, S., Palmer, J., Kay, H., Stanko, J., Mora, L. B., Sebti, S., Yu, H., & Jove, R. (2004) · Molecular Cancer Therapeutics

Metal complexes synthesis and propertiesCytokine Signaling Pathways and Interactions

Cited by 188

The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph− acute lymphoblastic leukemia cells

Scuto, A., Kirschbaum, M., Kowolik, C., Kretzner, L., Juhasz, A., Atadja, P., Pullarkat, V., Bhatia, R., Forman, S., Yen, Y., et al. (2008) · Blood

Histone Deacetylase Inhibitors ResearchAcute Lymphoblastic Leukemia research

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The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

Hillion, J., Dhara, S., Sumter, T. F., Mukherjee, M., Di Cello, F., Belton, A., Turkson, J., Jaganathan, S., Cheng, L., Ye, Z., et al. (2008) · Cancer Research

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 103

Identification of Src transformation fingerprint in human colon cancer

Malek, R. L., Irby, R. B., Guo, Q. M., Lee, K., Wong, S., He, M., Tsai, J., Frank, B., Liu, E. T., Quackenbush, J., et al. (2002) · Oncogene

Cancer Mechanisms and TherapyProtein Kinase Regulation and GTPase Signaling

Cited by 81

1,3-bis(3,5-dichlorophenyl) Urea Compound ‘COH-SR4’ Inhibits Proliferation and Activates Apoptosis in Melanoma

Singhal, S. S., Figarola, J., Singhal, J., Leake, K., Nagaprashantha, L., Lincoln, C., Gabriel Gugiu, B., Horne, D., Jove, R., Awasthi, S., et al. (2012) · Biochemical Pharmacology

Melanoma and MAPK PathwaysHeterocyclic Compound Synthesis and Bioactivity

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