Spiegelman, Bruce M.

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 1,174

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,162

Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 1,090

The role of exercise and PGC1α in inflammation and chronic disease

Handschin, C., & Spiegelman, B. M. (2008) · Nature

Exercise and Physiological ResponsesAdipose Tissue and Metabolism

Cited by 1,083

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 1,054

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science

Mesenchymal stem cell researchHippo pathway signaling and YAP/TAZ

Cited by 1,009

PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

Sandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 974

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 973

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 828

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 819

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., et al. (2018) · Science

Neurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Cited by 802

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

Kazak, L., Chouchani, E. T., Jedrychowski, M. P., Erickson, B. K., Shinoda, K., Cohen, P., Vetrivelan, R., Lu, G. Z., Laznik-Bogoslavski, D., Hasenfuss, S. C., et al. (2015) · Cell

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 787

Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J. C., Zhang, C.-Y., Krauss, S., Mootha, V. K., Lowell, B. B., & Spiegelman, B. M. (2001) · Molecular Cell

Adipose Tissue and MetabolismMuscle Physiology and Disorders

Cited by 732

An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

Handschin, C., Rhee, J., Lin, J., Tarr, P. T., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 729

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

Vazquez, F., Lim, J.-H., Chim, H., Bhalla, K., Girnun, G., Pierce, K., Clish, C. B., Granter, S. R., Widlund, H. R., Spiegelman, B. M., et al. (2013) · Cancer Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 715

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 703

Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 694

ERRα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St. Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., et al. (2004) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 688

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 677

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

Michael, L. F., Wu, Z., Cheatham, R. B., Puigserver, P., Adelmant, G., Lehman, J. J., Kelly, D. P., & Spiegelman, B. M. (2001) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 663

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 643

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 638

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 611

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

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