The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells

Ramos, Alexander D.; Andersen, Rebecca E.; Liu, Siyuan John; Nowakowski, Tomasz Jan; Hong, Sung Jun; Gertz, Caitlyn C.; Salinas, Ryan D.; Zarabi, Hosniya; Kriegstein, Arnold R.; Lim, Daniel A.

doi:10.1016/j.stem.2015.02.007

Cited by 374Neurogenesis and neuroplasticity mechanismsCancer-related molecular mechanisms researchDevelopmental Biology and Gene Regulation

The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells

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Ramos, Alexander D., Andersen, Rebecca E., Liu, Siyuan John, Nowakowski, Tomasz Jan, Hong, Sung Jun, Gertz, Caitlyn C., Salinas, Ryan D., Zarabi, Hosniya +2 more·2015·Cell stem cell

DOI 10.1016/j.stem.2015.02.007PMC PMC4388801

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Abstract

While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. Pnky is evolutionarily conserved and expressed in NSCs of the developing human brain. In the embryonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population. Pnky interacts with the splicing regulator PTBP1, and PTBP1 knockdown also enhances neurogenesis. In NSCs, Pnky and PTBP1 regulate the expression and alternative splicing of a core set of transcripts that relates to the cellular phenotype. These data thus unveil Pnky as a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations.

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Non-coding RNA processing and RNA splicing showed lateral wall enrichment.
“Lastly, non-coding RNA processing and RNA splicing showed lateral wall enrichment, consistent with the importance of non-coding RNAs in V-SVZ neurogenesis (Ramos et al., 2015; Figure 2C; Table S3).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Ramos et al., 2015

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246 · see citing works
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129 · see citing works
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,011 · see citing works
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925 · see citing works
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · see citing works
CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine
Kong, L., Zhang, Y., Ye, Z., Liu, X., Zhao, S.-Q., Wei, L., & Gao, G. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm391 · Cited by 2,773 · see citing works
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531 · see citing works
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,486 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Self-citation
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331 · see citing works
Exponentially Modified Protein Abundance Index (emPAI) for Estimation of Absolute Protein Amount in Proteomics by the Number of Sequenced Peptides per Protein
Ishihama, Y., Oda, Y., Tabata, T., Sato, T., Nagasu, T., Rappsilber, J., & Mann, M. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500061-mcp200 · Cited by 2,055 · see citing works
CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model
Wang, L., Park, H. J., Dasari, S., Wang, S., Kocher, J., & Li, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt006 · Cited by 2,003 · see citing works
Detecting differential usage of exons from RNA-seq data
Anders, S., Reyes, A., & Huber, W. (2012) · Genome Research · doi:10.1101/gr.133744.111 · Cited by 1,545 · see citing works
Structure and function of long noncoding RNAs in epigenetic regulation
Mercer, T. R., & Mattick, J. S. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2480 · Cited by 1,436 · see citing works
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works
Epigenetic Regulation by Long Noncoding RNAs
Lee, J. T. (2012) · Science · doi:10.1126/science.1231776 · Cited by 1,258 · see citing works
Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution
Ulitsky, I., Shkumatava, A., Jan, C. H., Sive, H. L., & Bartel, D. P. (2011) · Cell · doi:10.1016/j.cell.2011.11.055 · Cited by 1,162 · see citing works
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F. K., Petreanu, L., Caillé, I., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,048 · see citing works
PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regionsPreprint
Lin, M. F., Jungreis, I., & Kellis, M. (2010) · Nature Precedings · doi:10.1093/bioinformatics/btr209 · Cited by 1,008 · see citing works
PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update
Wang, X., Spandidos, A., Wang, H., & Seed, B. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1013 · Cited by 720 · see citing works
Multiple knockout mouse models reveal lincRNAs are required for life and brain development
Sauvageau, M., Goff, L. A., Lodato, S., Bonev, B., Groff, A. F., Gerhardinger, C., Sanchez-Gomez, D. B., Hacisuleyman, E., Li, E. V., Spence, M. C., et al. (2013) · eLife · doi:10.7554/elife.01749 · Cited by 675 · see citing works
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
Hacisuleyman, E., Goff, L. A., Trapnell, C., Williams, A., Henao‐Mejia, J., Sun, L., McClanahan, P. D., Hendrickson, D. G., Sauvageau, M., Kelley, D. R., et al. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2764 · Cited by 624 · see citing works
Cre-lox-regulated conditional RNA interference from transgenes
Ventura, A., Meissner, A., Dillon, C. P., McManus, M. T., Sharp, P. A., Parijs, L. V., Jaenisch, R., & Jacks, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403954101 · Cited by 623 · see citing works
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
Boutz, P. L., Stoilov, P., Li, Q., Lin, C.-H., Chawla, G., Ostrow, K., Shiue, L., Ares, M., & Black, D. L. (2007) · Genes & Development · doi:10.1101/gad.1558107 · Cited by 577 · see citing works
Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562 · see citing works
Standardization of real-time PCR gene expression data from independent biological replicates
Willems, E., Leyns, L., & Vandesompele, J. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.04.036 · Cited by 490 · see citing works
LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint
Dimitrova, N., Zamudio, J. R., Jong, R. M., Soukup, D., Resnick, R., Sarma, K., Ward, A. J., Raj, A., Lee, J. T., Sharp, P. A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.025 · Cited by 445 · see citing works
Role of spectral counting in quantitative proteomics
Lundgren, D. H., Hwang, S., Wu, L., & Han, D. K. M. (2010) · Expert Review of Proteomics · doi:10.1586/epr.09.69 · Cited by 425 · see citing works
The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
Ng, S., Bogu, G. K., Soh, B.-S., & Stanton, L. W. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.017 · Cited by 413 · see citing works
Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry
Bond, A. M., VanGompel, M. J. W., Sametsky, E. A., Clark, M. F., Savage, J. C., Disterhoft, J. F., & Kohtz, J. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2371 · Cited by 399 · see citing works
An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment
Lin, N., Chang, K., Li, Z., Gates, K. P., Rana, Z. A., Dang, J. W., Zhang, D., Han, T., Yang, C., Cunningham, T. J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.021 · Cited by 391 · see citing works
Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny
Pastrana, É., Cheng, L.-C., & Doetsch, F. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810407106 · Cited by 381 · see citing works
In vivo electroporation in the embryonic mouse central nervous system
Saito, T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.276 · Cited by 378 · see citing works
Lake-Front Property: A Unique Germinal Niche by the Lateral Ventricles of the Adult Brain
Ihrie, R. A., & Álvarez-Buylla, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.004 · Cited by 346 · see citing works
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
Holland, E. C., & VARMUS, H. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1218 · Cited by 305 · see citing works
Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention
Yap, K., Lim, Z. Q., Khandelia, P., Friedman, B., & Makeyev, E. V. (2012) · Genes & Development · doi:10.1101/gad.188037.112 · Cited by 286 · see citing works
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2
Zheng, S., Gray, E. E., Chawla, G., Porse, B. T., O'Dell, T. J., & Black, D. L. (2012) · Nature Neuroscience · doi:10.1038/nn.3026 · Cited by 254 · see citing works
Glial Tubes in the Rostral Migratory Stream of the Adult Rat
Peretto, P., Merighi, A., Fasolo, A., & Bonfanti, L. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00116-5 · Cited by 251 · see citing works
Integration of Genome-wide Approaches Identifies lncRNAs of Adult Neural Stem Cells and Their Progeny In Vivo
Ramos, A. D., Diaz, A. A., Nellore, A., Delgado, R. N., Park, K.-Y., Gonzales-Roybal, G., Oldham, M. C., Song, J. S., & Lim, D. A. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.03.003 · Cited by 240 · see citing works
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
Polydorides, A. D., Okano, H. J., Yang, Y. Y. L., Stefani, G., & Darnell, R. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110128397 · Cited by 230 · see citing works
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2
Keppetipola, N., Sharma, S., Li, Q., & Black, D. L. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.691456 · Cited by 201 · see citing works
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain
Licatalosi, D. D., Yano, M., Fak, J. J., Mele, A., Grabinski, S. E., Zhang, C., & Darnell, R. B. (2012) · Genes & Development · doi:10.1101/gad.191338.112 · Cited by 193 · see citing works
A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
Wallace, V. A., & RAFF, M. C. (1999) · Development · doi:10.1242/dev.126.13.2901 · Cited by 177 · see citing works
The long non-coding RNA Dali is an epigenetic regulator of neural differentiation
Chalei, V., Sansom, S. N., Kong, L., Lee, S., Montiel, J. F., Vance, K. W., & Ponting, C. P. (2014) · eLife · doi:10.7554/elife.04530 · Cited by 167 · see citing works
Necdin Promotes GABAergic Neuron Differentiation in Cooperation with Dlx Homeodomain Proteins
Kuwajima, T., Nishimura, I., & Yoshikawa, K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1262-06.2006 · Cited by 163 · see citing works
The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity
Rapicavoli, N. A., Poth, E. M., Zhu, H., & Blackshaw, S. (2011) · Neural Development · doi:10.1186/1749-8104-6-32 · Cited by 149 · see citing works
Activation of Neuronal Gene Expression by the JMJD3 Demethylase Is Required for Postnatal and Adult Brain Neurogenesis
Park, D. H., Hong, S. J., Salinas, R. D., Liu, S. J., Sun, S. W., Sgualdino, J., Testa, G., Matzuk, M. M., Iwamori, N., & Lim, D. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.060 · Cited by 136 · see citing works
Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression
Ferrarese, R., Harsh, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci68836 · Cited by 93 · see citing works
In‐Gel Digestion of Proteins for MALDI‐MS Fingerprint Mapping
Jiménez, C. R., Huang, L., Qiu, Y., & Burlingame, A. L. (1998) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps1604s14 · Cited by 90 · see citing works
Neural stem cells: From fly to vertebrates
Doe, C. Q., Fuerstenberg, S., & Peng, C. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2 · Cited by 85 · see citing works
PTB Deficiency Causes the Loss of Adherens Junctions in the Dorsal Telencephalon and Leads to Lethal Hydrocephalus
Shibasaki, T., Tokunaga, A., Sakamoto, R., Sagara, H., Noguchi, S., Sasaoka, T., & Yoshida, N. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs161 · Cited by 60 · see citing works
Lineage progression from stem cells to new neurons in the adult brain ventricular-subventricular zone
Ponti, G., Obernier, K., & Álvarez-Buylla, A. (2013) · Cell Cycle · doi:10.4161/cc.24984 · Cited by 49 · see citing works
Interaction of Fibronectin With Semen Amyloids Synergistically Enhances HIV Infection
Roan, N. R., Chu, S., Liu, H., Neidleman, J. A., Witkowska, H. E., & Greene, W. C. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu220 · Cited by 10 · see citing works

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Mechanisms of long noncoding RNA function in development and disease
Schmitz, S. U., Grote, P., & Herrmann, B. G. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2174-5 · Cited by 1,088 · see citing works
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Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791 · see citing works
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Liu, S. J., Horlbeck, M. A., Cho, S. W., Birk, H. S., Malatesta, M., He, D. X., Attenello, F. J., Villalta, J. E., Cho, M. Y., Chen, Y., et al. (2016) · Science · doi:10.1126/science.aah7111 · Cited by 734 · see citing works
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Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works
Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression
Sun, Q., Hao, Q., & Prasanth, K. V. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.11.005 · Cited by 567 · see citing works
Mechanisms of Long Non-coding RNAs in Mammalian Nervous System Development, Plasticity, Disease, and Evolution
Briggs, J., Wolvetang, E. J., Mattick, J. S., Rinn, J. L., & Barry, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.045 · Cited by 443 · see citing works
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Chen, L., & Kim, V. N. (2024) · Cell · doi:10.1016/j.cell.2024.10.024 · Cited by 441 · see citing works
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Jathar, S., Kumar, V., Srivastava, J. P., & Tripathi, V. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5203-3_10 · Cited by 348 · see citing works
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Jiang, C.-C., Lin, L., Long, S., Ke, X., Fukunaga, K., Lu, Y., & Han, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01081-0 · Cited by 272 · see citing works
Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages
Mizrak, D., Levitin, H. M., Delgado, A. C., Crotet, V., Yuan, J., Chaker, Z., Silva-Vargas, V., Sims, P. A., & Doetsch, F. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.044 · Cited by 248 · see citing works
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
Campo, E., Muñoz, J., Miquel, R., Palacı́n, A., Cardesa, A., Sloane, B. F., & Emmert‐Buck, M. R. (1994) · PubMed Central · Cited by 214 · see citing works
Defective control of pre–messenger RNA splicing in human disease
Chabot, B., & Shkreta, L. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201510032 · Cited by 209 · see citing works
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Kazimierczyk, M., Kasprowicz, M. K., Kasprzyk, M. E., & Wrzesiński, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031027 · Cited by 204 · see citing works
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Huan, L., Guo, T., Wu, Y., Xu, L., Huang, S., Xu, Y., Liang, L., & He, X. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1122-z · Cited by 177 · see citing works
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Salviano‐Silva, A., Lobo‐Alves, S. C., de Almeida, R. C., Malheiros, D., & Petzl‐Erler, M. L. (2018) · Non-Coding RNA · doi:10.3390/ncrna4010003 · Cited by 134 · see citing works
Long noncoding RNAs: regulation, function and cancer
Rafiee, A., Riazi‐Rad, F., Havaskary, M., & Nuri, F. (2018) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2018.1471566 · Cited by 126 · see citing works
Long non-coding RNAs in human early embryonic development and their potential in ART
Bouckenheimer, J., Assou, S., Riquier, S., Hou, C., Philippe, N., Sansac, C., Lavabre‐Bertrand, T., Commes, T., Lemaı̂tre, J.-M., Boureux, A., et al. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw035 · Cited by 119 · see citing works
Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases
Quan, Z., Zheng, D., & Qing, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00175 · Cited by 116 · see citing works
Neural stem cell niche heterogeneity
Andreotti, J. P., da Silva, W. N., Costa, A. C., Picoli, C. C., Bitencourt, F. C. O., Coimbra-Campos, L. M. C., Resende, R. R., Magno, L. A. V., Romano‐Silva, M. A., Mintz, A., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.005 · Cited by 115 · see citing works
Forging our understanding of lncRNAs in the brain
Andersen, R., & Lim, D. A. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2711-z · Cited by 112 · see citing works
RNA and liquid-liquid phase separation
Guo, Q., Shi, X., & Wang, X. (2021) · Non-coding RNA Research · doi:10.1016/j.ncrna.2021.04.003 · Cited by 116 · see citing works
Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities
Srinivas, T., Mathias, C., Oliveira-Mateos, C., & Guil, S. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.02.008 · Cited by 107 · see citing works
Function by Structure: Spotlights on Xist Long Non-coding RNA
Pintacuda, G., Young, A. N., & Cerase, A. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00090 · Cited by 101 · see citing works
Emerging Roles of Long Non-Coding RNAs as Drivers of Brain Evolution
Zimmer‐Bensch, G. (2019) · Cells · doi:10.3390/cells8111399 · Cited by 98 · see citing works
Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation
Fico, A., Fiorenzano, A., Pascale, E., Patriarca, E. J., & Minchiotti, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-3000-z · Cited by 97 · see citing works
Transcriptional gene silencing in humans
Weinberg, M. S., & Morris, K. V. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw139 · Cited by 95 · see citing works
Functions of long noncoding RNAs in the nucleus
Yu, B., & Shan, G. (2016) · Nucleus · doi:10.1080/19491034.2016.1179408 · Cited by 93 · see citing works
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer
Chen, X., Luo, R., Zhang, Y., Ye, S., Zeng, X., Liu, J., Huang, D., Liu, Y., Liu, Q., Luo, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34702-x · Cited by 94 · see citing works
LncRNA-OG Promotes the Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Under the Regulation of hnRNPK
Tang, S., Xie, Z., Wang, P., Li, J., Wang, S., Liu, W., Li, M., Wu, X., Su, H., Cen, S., et al. (2018) · Stem Cells · doi:10.1002/stem.2937 · Cited by 93 · see citing works
Non-coding transcript variants of protein-coding genes – what are they good for?
Dhamija, S., & Menon, M. B. (2018) · RNA Biology · doi:10.1080/15476286.2018.1511675 · Cited by 92 · see citing works
LncRNA Functions as a New Emerging Epigenetic Factor in Determining the Fate of Stem Cells
Chen, J., Wang, Y., Wang, C., Hu, J., & Li, W. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00277 · Cited by 92 · see citing works
Long non-coding RNAs: novel regulators of cellular physiology and function
Oo, J. A., Brandes, R. P., & Leisegang, M. S. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02641-z · Cited by 92 · see citing works
Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate the differentiation of cortical neural progenitors by repressing Sox2
Knauss, J. L., Miao, N., Kim, S., Nie, Y., Shi, Y., Wu, T., Pinto, H. B., Donohoe, M. E., & Sun, T. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0840-2 · Cited by 91 · see citing works
LncRNA UCA1 promotes tumor metastasis by inducing miR-203/ZEB2 axis in gastric cancer
Gong, P., Qiao, F., Wu, H., Cui, H., Li, Y., Zheng, Y., Zhou, M., & Fan, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1170-0 · Cited by 90 · see citing works
Role of lncRNAs in aging and age‐related diseases
He, J., Tu, C., & Liu, Y. (2018) · Aging Medicine · doi:10.1002/agm2.12030 · Cited by 86 · see citing works
Linc-POU3F3 promotes cell proliferation in gastric cancer via increasing T-reg distribution.
Xiong, G., Yang, L., Chen, Y., & Fan, Z. (2015) · PubMed Central · Cited by 88 · see citing works
Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis
Reon, B. J., Anaya, J., Zhang, Y., Mandell, J. W., Purow, B. W., Abounader, R., & Dutta, A. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002192 · Cited by 80 · see citing works
Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity
Cipolla, G. A., de Oliveira, J. C., Salviano‐Silva, A., Lobo‐Alves, S. C., Lemos, D. S., Oliveira, L., Jucoski, T. S., Mathias, C., Pedroso, G. A., Zambalde, É. P., et al. (2018) · Non-Coding RNA · doi:10.3390/ncrna4020013 · Cited by 80 · see citing works
Invited Review: Epigenetics in neurodevelopment
Salinas, R. D., Connolly, D. R., & Song, H. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12608 · Cited by 81 · see citing works
Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior
Yoshino, Y., & Dwivedi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.543893 · Cited by 82 · see citing works
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease
Monteiro, J. P., Rodor, J., Caudrillier, A., Scanlon, J. P., Spiroski, A., Dudnakova, T., Pflüger‐Müller, B., Shmakova, A., von Kriegsheim, A., Deng, L., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318124 · Cited by 78 · see citing works
Epigenetic regulation of alternative splicing.
Zhu, L., Zhu, Y., Dai, D., Wang, X., & Jin, H. (2018) · Europe PMC (PubMed Central) · Cited by 75 · see citing works
Non-coding RNAs in Nervous System Development and Disease
Salvatori, B., Biscarini, S., & Morlando, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00273 · Cited by 73 · see citing works
Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain
Lepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M. A., Hasler, J., Huttner, H. B., Vandenbroucke, R. E., Vandendriessche, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100481 · Cited by 72 · see citing works
Long Non-Coding RNAs in Neuronal Aging
Fernandes, D. P., Bitar, M., Jacobs, F. M. J., & Barry, G. (2018) · Non-Coding RNA · doi:10.3390/ncrna4020012 · Cited by 75 · see citing works
The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders
Ang, C. E., Ma, Q., Wapinski, O. L., Fan, S., Flynn, R. A., Lee, Q. Y., Coe, B. P., Onoguchi, M., Olmos, V. H., Do, B. T., et al. (2019) · eLife · doi:10.7554/elife.41770 · Cited by 73 · see citing works
Long non‐coding RNAs in corticogenesis: deciphering the non‐coding code of the brain
Aprea, J., & Calegari, F. (2015) · The EMBO Journal · doi:10.15252/embj.201592655 · Cited by 72 · see citing works
RNA on the brain: emerging layers of post‐transcriptional regulation in cerebral cortex development
Lennox, A. L., Mao, H., & Silver, D. L. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.290 · Cited by 70 · see citing works
Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
Mineo, M., Lyons, S. M., Zdioruk, M. I., von Spreckelsen, N., Ferrer-Luna, R., Ito, H., Alayo, Q. A., Kharel, P., Giantini-Larsen, A., Fan, W. Y., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.015 · Cited by 70 · see citing works
Nanomedicine Directs Neuronal Differentiation of Neural Stem Cells via Silencing Long Noncoding RNA for Stroke Therapy
Lin, B., Lu, L., Wang, Y., Zhang, Q., Wang, Z., Cheng, G., Duan, X., Zhang, F., Xie, M., Le, H., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04560 · Cited by 72 · see citing works
Modulating the expression of long non‐coding RNAs for functional studies
Liu, S. J., & Lim, D. A. (2018) · EMBO Reports · doi:10.15252/embr.201846955 · Cited by 72 · see citing works
Long non-coding RNA regulation of gene expression during differentiation
Lopez-Pajares, V. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1809-6 · Cited by 71 · see citing works
Uncovering the roles of long noncoding RNAs in neural development and glioma progression
Ramos, A. D., Attenello, F. J., & Lim, D. A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.025 · Cited by 70 · see citing works
The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo
Andersen, R., Hong, S. J., Lim, J. J., Cui, M., Harpur, B. A., Hwang, E. E., Delgado, R. N., Ramos, A. D., Liu, S. J., Blencowe, B. J., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.032 · Cited by 67 · see citing works
MALAT1 in human adipose stem cells modulates survival and alternative splicing of PKCδII in HT22 cells
Bassit, G. E., Patel, R. S., Carter, G., Shibu, V., Patel, A. A., Song, S., Murr, M. M., Cooper, D. R., Bickford, P. C., & Patel, N. A. (2016) · Endocrinology · doi:10.1210/en.2016-1819 · Cited by 66 · see citing works
Long non-coding RNAs in brain development, synaptic biology, and Alzheimer’s disease
Shi, C., Zhang, L., & Qin, C. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.010 · Cited by 64 · see citing works
Translating neural stem cells to neurons in the mammalian brain
Zahr, S. K., Kaplan, D. R., & Miller, F. D. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0411-9 · Cited by 63 · see citing works
From Junk to Function: LncRNAs in CNS Health and Disease
Policarpo, R., Sierksma, A. S. R., Strooper, B. D., & d’Ydewalle, C. V. O. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.714768 · Cited by 62 · see citing works
The therapeutic contribution of nanomedicine to treat neurodegenerative diseases via neural stem cell differentiation
Carradori, D., Eyer, J., Saulnier, P., Véronique Préat, A., & Rieux, A. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.032 · Cited by 63 · see citing works
The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts
Sun, Y., Cai, M., Zhong, J., Yang, L., Xiao, J., Jin, F., Xue, H. Y., Liu, X., Liu, H., Zhang, Y., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0053-8 · Cited by 62 · see citing works
Silencing LncRNA LOXL1-AS1 attenuates mesenchymal characteristics of glioblastoma via NF-κB pathway
Wang, H., Li, L., & Yin, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.133 · Cited by 62 · see citing works
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair
Huang, Y. H., Li, Y., Chen, J., Zhou, H., & Tan, S. H. D. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00586 · Cited by 60 · see citing works
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
Huang, W., Xiong, T., Zhao, Y., Heng, J., Han, G., Wang, P., Zhao, Z., Shi, M., Li, J., Wang, J., et al. (2024) · Nature Genetics · doi:10.1038/s41588-023-01620-7 · Cited by 60 · see citing works
Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing
Rosa, P. L., Bielli, P., Compagnucci, C., Cesari, E., Volpe, E., Vecchioli, S. F., & Sette, C. (2016) · eLife · doi:10.7554/elife.20750 · Cited by 60 · see citing works
Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke
Wang, G., Han, B., Shen, L., Wu, S., Yang, L., Liao, J., Wu, F., Li, M., Leng, S., Zang, F., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102660 · Cited by 61 · see citing works
Potential Role of Long Non‐Coding RNA in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
Qu, Q., Fang, F., Wu, B., Hu, Y., Chen, M., Deng, Z., Ma, D., Chen, T., Hao, Y., & Ge, Y. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.150592 · Cited by 59 · see citing works
Targeting Alzheimer's disease with gene and cell therapies
Loera‐Valencia, R., Piras, A., Ismail, M.-A.-M., Manchanda, S., Eyjolfsdottir, H., Saido, T. C., Johansson, J., Eriksdotter, M., Winblad, B. G., & Nilsson, P. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12759 · Cited by 57 · see citing works
MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma
Zhang, S., Wei, J. S., Li, S. Q., Badgett, T. C., Song, Y. K., Agarwal, S., Coarfa, C., Tolman, C., Hurd, L., Liao, H., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2015.11.045 · Cited by 58 · see citing works
Psychiatric Disorders and lncRNAs: A Synaptic Match
Rusconi, F., Battaglioli, E., & Venturin, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093030 · Cited by 59 · see citing works
LncRNAs: macromolecules with big roles in neurobiology and neurological diseases
Chen, Y., & Zhou, J. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-9965-8 · Cited by 57 · see citing works
A novel long noncoding RNA PGC1β-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p
Yuan, H., Xu, X., Feng, X., Zhu, E., Zhou, J., Wang, G., Tian, L., & Wang, B. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0296-7 · Cited by 57 · see citing works
Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression
Briata, P., & Gherzi, R. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030040 · Cited by 55 · see citing works
Long noncoding RNA mediates stroke-induced neurogenesis
Fan, B., Pan, W., Wang, X., Wei, M., He, A., Zhao, A., Chopp, M., Zhang, Z. G., & Liu, X. (2020) · Stem Cells · doi:10.1002/stem.3189 · Cited by 56 · see citing works
Identification of long non-coding RNAs involved in neuronal development and intellectual disability
D’haene, E., Jacobs, E., Volders, P., Meyer, T. D., Menten, B., & Vergult, S. (2016) · Scientific Reports · doi:10.1038/srep28396 · Cited by 55 · see citing works
Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy
Yin, J., Shen, Y., Si, Y., Zhang, Y., Du, J., Hu, X., Cai, M., Bao, H., & Xing, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01970-7 · Cited by 53 · see citing works
LncRNAs in Stem Cells
Hu, S., & Shan, G. (2016) · Stem Cells International · doi:10.1155/2016/2681925 · Cited by 53 · see citing works
Understanding the Role of lncRNAs in Nervous System Development
Clark, B. S., & Blackshaw, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5203-3_9 · Cited by 52 · see citing works
Long Noncoding RNAs in Human Stemness and Differentiation
Azad, F. M., Polignano, I. L., Proserpio, V., & Oliviero, S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.02.002 · Cited by 51 · see citing works
The emerging role of long non‐coding RNA in spinal cord injury
Shi, Z., Pan, B., & Feng, S. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13515 · Cited by 50 · see citing works
Silencing the lncRNA Maclpil in pro-inflammatory macrophages attenuates acute experimental ischemic stroke via LCP1 in mice
Wang, Y., Luo, Y., Yao, Y., Ji, Y., Feng, L., Du, F., Zheng, X., Tao, T., Zhai, X., Li, Y., et al. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19836118 · Cited by 49 · see citing works
Mediterranean diet enriched in extra-virgin olive oil or nuts modulates circulating exosomal non-coding RNAs
Mantilla-Escalante, D. C., Hazas, M. L. D. L., Crespo, M. C., Martín‐Hernández, R., Tomé‐Carneiro, J., del Pozo‐Acebo, L., Salas‐Salvadó, J., Bulló, M., & Dávalos, A. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02594-0 · Cited by 49 · see citing works
PTB: Not just a polypyrimidine tract‐binding protein
Dai, S., Wang, C., Zhang, C., Feng, L., Zhang, W., Zhou, X., He, Y., Xia, X., Chen, B., & Song, W. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30716 · Cited by 48 · see citing works
LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway
Zhang, S., Wan, H., & Zhang, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03141-1 · Cited by 48 · see citing works
The Emerging Role of Long Non-Coding RNAs and MicroRNAs in Neurodegenerative Diseases: A Perspective of Machine Learning
Fonseca, Á. Y. G., Martín-Jiménez, C., Barreto, G. E., Aristizábal-Pachón, A. F., & González, J. (2021) · Biomolecules · doi:10.3390/biom11081132 · Cited by 48 · see citing works
LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
Yang, Y., Ren, M., Song, C., Li, D., Soomro, S. H., Xiong, Y., Zhang, H., & Fu, H. Q. (2017) · Oncotarget · doi:10.18632/oncotarget.20340 · Cited by 46 · see citing works
PTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1
Zhu, L., Wei, Q., Qi, Y., Ruan, X., Wu, F., Li, L., Zhou, J., Liu, W., Jiang, T., Zhang, J., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.05.023 · Cited by 45 · see citing works
Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial–mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms
Rodríguez-Mateo, C., Torres, B., Gutiérrez, G., & Pintor‐Toro, J. A. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.9 · Cited by 45 · see citing works
The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum
Wang, F., Wang, Q., Liu, B., Mei, L., Ma, S.-S., Wang, S.-J., Wang, R.-Y., Zhang, Y., Niu, C.-S., Xiong, Z., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00774-3 · Cited by 39 · see citing works

The novel long noncoding RNA Pnky regulates neurogenesis and neural stem cell maintenance in vivo
Andersen, R. (2019) · eScholarship (California Digital Library) · Cited by 2 · see citing works
The lncRNA Pnky in the Brain
Cho, K., & Hsieh, J. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.015 · Cited by 13 · see citing works
The Role of Long Noncoding RNAs in Neurogenesis
Ramos, A. D. (2014) · eScholarship (California Digital Library)
In vivo regulators of neural stem cell development and function
Hong, S. J. (2020) · eScholarship (California Digital Library)
Identification of neural stem cell differentiation repressor complex Pnky-PTBP1
Grammatikakis, I., & Gorospe, M. (2016) · Stem Cell Investigation · doi:10.21037/sci.2016.03.05 · Cited by 22 · see citing works

Authors: Ramos, A. D., Andersen, R. E., Liu, S. J., Nowakowski, T. J., Hong, S. J., Gertz, C. C., Salinas, R. D., Zarabi, H., Kriegstein, A. R., & Lim, D. A.
Affiliations: University of California, San Francisco (US)
San Francisco VA Medical Center (US)
Corresponding author: Lim, Daniel A.
ORCID: Ramos, Alexander D.
Andersen, Rebecca E.
Liu, Siyuan John
Nowakowski, Tomasz Jan
Hong, Sung Jun
Salinas, Ryan D.
Kriegstein, Arnold R.
Lim, Daniel A.
Venue: Cell stem cell
Publisher: Elsevier BV
Published: 2015-04
Volume: 16
Issue: 4
Pages: 439-447
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2015.02.007
PMC: PMC4388801
OpenAlex: W1981435333
Cited by: 359
References: 56
Citations by year: 2026: 13 · 2025: 15 · 2024: 21 · 2023: 35 · 2022: 35 · 2021: 46 · 2020: 43 · 2019: 37 · 2018: 29 · 2017: 37 · 2016: 33 · 2015: 14
FWCI: 15.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (I01BX000252)
National Science Council
National Institutes of Health (1f31ns080501-01a1, 5f30ns092319-02, 1dp2od006505-01)
University of California, San Francisco
National Institute of General Medical Sciences (T32GM007618)
National Institute of Neurological Disorders and Stroke (R01NS035710, F30 NS092319, R01 NS35710, F31 NS080501, 1F31NS080501-01A1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007470)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: long non-coding RNA, neural stem cells, neurogenesis, neuronal differentiation, PTBP1, alternative splicing, transit amplifying cells, embryonic cortex, postnatal brain, RNA processing
MeSH terms: Animals, Base Sequence, Brain, Cells, Cultured, Embryo, Mammalian, Humans, Mice, Inbred C57BL, Molecular Sequence Data, Neurons, Alternative Splicing, Heterogeneous-Nuclear Ribonucleoproteins, RNA, Small Interfering, Polypyrimidine Tract-Binding Protein, Mice, Embryonic Stem Cells, Neurogenesis, Neural Stem Cells, RNA, Long Noncoding

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The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells

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