Nussinov, Ruth

Promiscuous and specific recognition among ephrins and Eph receptors

Dai, D., Huang, Q., Nussinov, R., & Ma, B. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Axon Guidance and Neuronal SignalingProtein Structure and Dynamics

Cited by 51

Exploiting Conformational Ensembles in Modeling Protein–Protein Interactions on the Proteome Scale

Kuzu, G., Gursoy, A., Nussinov, R., & Keskin, O. (2013) · Journal of Proteome Research

Protein Structure and DynamicsBioinformatics and Genomic Networks

Cited by 47

Druggable Orthosteric and Allosteric Hot Spots to Target Protein-protein Interactions

Ma, B., & Nussinov, R. (2014) · Current Pharmaceutical Design

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 45

Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms

Weismiller, H. A., Murphy, R., Wei, G., Ma, B., Nussinov, R., & Margittai, M. (2018) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 44

Single Mutations in Tau Modulate the Populations of Fibril Conformers through Seed Selection

Meyer, V., Dinkel, P. D., Luo, Y., Yu, X., Wei, G., Zheng, J., Eaton, G. R., Ma, B., Nussinov, R., Eaton, S. S., et al. (2014) · Angewandte Chemie International Edition

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 42

Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s disease

Qiu, Y., Hou, Y., Gohel, D., Zhou, Y., Xu, J., Bykova, M., Yang, Y., Leverenz, J. B., Pieper, A. A., Nussinov, R., et al. (2024) · Cell Reports

Alzheimer's disease research and treatmentsGut microbiota and health

Cited by 40

Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP

Muratcioglu, S., Presman, D. M., Pooley, J. R., Grøntved, L., Hager, G. L., Nussinov, R., Keskin, O., & Gursoy, A. (2015) · Biophysical Journal

Chromatin Remodeling and CancerGenomics and Chromatin Dynamics

Cited by 39

Artificial intelligence approaches to human-microbiome protein–protein interactions

Lim, H., Cankara, F., Tsai, C.-J., Keskin, O., Nussinov, R., & Gursoy, A. (2022) · Current Opinion in Structural Biology

Machine Learning in BioinformaticsBioinformatics and Genomic Networks

Cited by 39

Amplification of signaling via cellular allosteric relay and protein disorder

Ma, B., & Nussinov, R. (2009) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 36

Dynamic Protein Allosteric Regulation and Disease

Nussinov, R., Tsai, C.-J., & Jang, H. (2019) · Advances in Experimental Medicine and Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 18

Developments in integrative modeling with dynamical interfaces

Ozdemir, E. S., Nussinov, R., Gursoy, A., & Keskin, O. (2019) · Current Opinion in Structural Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 17

Investigation of the interactions between the EphB2 receptor and SNEW peptide variants

Ma, B., Kolb, S., Diprima, M., Karna, M., Tosato, G., Yang, Q., Huang, Q., & Nussinov, R. (2014) · Growth Factors

Axon Guidance and Neuronal SignalingComputational Drug Discovery Methods

Cited by 10

mTOR Variants Activation Discovers PI3K-like Cryptic Pocket, Expanding Allosteric, Mutant-Selective Inhibitor Designs

Liu, Y., Zhang, W., Jang, H., & Nussinov, R. (2025) · Journal of Chemical Information and Modeling

PI3K/AKT/mTOR signaling in cancerComputational Drug Discovery Methods

Cited by 10