Nussinov, Ruth

Structured disorder and conformational selection

Tsai, C., Ma, B., Sham, Y. Y., Kumar, S., & Nussinov, R. (2001) · Proteins: Structure, Function, and Bioinformatics

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 202

GTP-Dependent K-Ras Dimerization

Muratcioglu, S., Chavan, T. S., Freed, B. C., Jang, H., Khavrutskii, L., Freed, R. N., Dyba, M. A., Stefanisko, K., Tarasov, S. G., Gursoy, A., et al. (2015) · Structure

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 202

Allostery without a conformational change? Revisiting the paradigm

Nussinov, R., & Tsai, C.-J. (2015) · Current Opinion in Structural Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 202

AlphaFold, Artificial Intelligence (AI), and Allostery

Nussinov, R., Zhang, M., Liu, Y., & Jang, H. (2022) · The Journal of Physical Chemistry B

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 190

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

Lu, S., Jang, H., Gu, S., Zhang, J., & Nussinov, R. (2016) · Chemical Society Reviews

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 188

Principles of Allosteric Interactions in Cell Signaling

Nussinov, R., Tsai, C.-J., & Liu, J. (2014) · Journal of the American Chemical Society

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 154

Protein–protein interaction networks: how can a hub protein bind so many different partners?

Tsai, C.-J., Ma, B., & Nussinov, R. (2009) · Trends in Biochemical Sciences

Bioinformatics and Genomic NetworksProtein Structure and Dynamics

Cited by 138

Unraveling structural mechanisms of allosteric drug action

Nussinov, R., & Tsai, C.-J. (2014) · Trends in Pharmacological Sciences

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 119

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

Lu, W., Yu, W., He, J., Liu, W., Yang, J., Lin, X., Zhang, Y., Wang, X., Jiang, W., Luo, J., et al. (2021) · EMBO Molecular Medicine

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 112

The Design of Covalent Allosteric Drugs

Nussinov, R., & Tsai, C.-J. (2015) · Annual Review of Pharmacology and Toxicology

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 112

Point mutations and sequence variability in proteins: Redistributions of preexisting populations

Sinha, N., & Nussinov, R. (2001) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 110

A second molecular biology revolution? The energy landscapes of biomolecular function

Nussinov, R., & Wolynes, P. G. (2014) · Physical Chemistry Chemical Physics

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 104

AlphaFold, allosteric, and orthosteric drug discovery: Ways forward

Nussinov, R., Zhang, M., Liu, Y., & Jang, H. (2023) · Drug Discovery Today

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 96

Folding funnels and conformational transitions via hinge-bending motions

Kumar, S., Ma, B., Tsai, C.-J., Wolfson, H., & Nussinov, R. (1999) · Cell Biochemistry and Biophysics

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 94

Transition-state Ensemble in Enzyme Catalysis: Possibility, Reality, or Necessity?

MA, B., KUMAR, S., TSAI, C.-J., HU, Z., & NUSSINOV, R. (2000) · Journal of Theoretical Biology

Protein Structure and DynamicsPhysical Organic Chemistry and Reaction Kinetics

Cited by 86

Prism: Protein-Protein Interaction Prediction by Structural Matching

Keskin, O., Nussinov, R., & Gursoy, A. (2008) · Methods in Molecular Biology

Protein Structure and DynamicsBioinformatics and Genomic Networks

Cited by 80

High-affinity interaction of the K-Ras4B hypervariable region with the RAS active site

Chavan, T. S., Jang, H., Khavrutskii, L., Abraham, S. J., Banerjee, A., Freed, B. C., Johannessen, L., Tarasov, S. G., Gaponenko, V., Nussinov, R., et al. (2015) · Biophysical Journal

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 79

Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau

Siddiqua, A., Luo, Y., Meyer, V., Swanson, M. A., Yu, X., Wei, G., Zheng, J., Eaton, G. R., Ma, B., Nussinov, R., et al. (2012) · Journal of the American Chemical Society

Alzheimer's disease research and treatmentsElectron Spin Resonance Studies

Cited by 75

Inhibitors of Ras–SOS Interactions

Lu, S., Jang, H., Zhang, J., & Nussinov, R. (2016) · ChemMedChem

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 72

Visualizing RNA conformational and architectural heterogeneity in solution

Ding, J., Lee, Y.-T., Bhandari, Y., Schwieters, C. D., Fan, L., Yu, P., Tarosov, S. G., Stagno, J. R., Ma, B., Nussinov, R., et al. (2023) · Nature Communications

RNA and protein synthesis mechanismsProtein Structure and Dynamics

Cited by 66

Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Nussinov, R., Zhang, M., Maloney, R., Liu, Y., Tsai, C.-J., & Jang, H. (2022) · Journal of Molecular Biology

Protein Degradation and InhibitorsProtein Kinase Regulation and GTPase Signaling

Cited by 66

Protein dynamics and conformational selection in bidirectional signal transduction

Nussinov, R., & Ma, B. (2012) · BMC Biology

Axon Guidance and Neuronal SignalingProtein Structure and Dynamics

Cited by 65

“Pathway drug cocktail”: targeting Ras signaling based on structural pathways

Nussinov, R., Tsai, C.-J., & Mattos, C. (2013) · Trends in Molecular Medicine

Protein Kinase Regulation and GTPase SignalingBioinformatics and Genomic Networks

Cited by 62

Allosteric Conformational Barcodes Direct Signaling in the Cell

Nussinov, R., Ma, B., Tsai, C.-J., & Csermely, P. (2013) · Structure

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 55