Elledge, Stephen J.

Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J. (1996) · Science

DNA Repair MechanismsFungal and yeast genetics research

Cited by 585

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 578

Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

Gasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 542

Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms

Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M., & Elledge, S. J. (1999) · Science

DNA Repair MechanismsMicrotubule and mitosis dynamics

Cited by 536

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 529

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 512

Global Protein Stability Profiling in Mammalian Cells

Yen, H.-C. S., Xu, Q., Chou, D. M., Zhao, Z., & Elledge, S. J. (2008) · Science

Ubiquitin and proteasome pathwaysAdvanced Proteomics Techniques and Applications

Cited by 482

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

Mina, M. J., Kula, T., Leng, Y., Li, M., de Vries, R. D., Knip, M., Siljander, H., Rewers, M., Choy, D. F., Wilson, M. S., et al. (2019) · Science

Virology and Viral DiseasesImmune responses and vaccinations

Cited by 466

Transcriptional regulation and function during the human cell cycle

Cho, R. J., Huang, M., Campbell, M. J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S. J., Davis, R. W., & Lockhart, D. J. (2001) · Nature Genetics

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 455

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

Adamson, B., Smogorzewska, A., Sigoillot, F. D., King, R. W., & Elledge, S. J. (2012) · Nature Cell Biology

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 433

Replication protein A-mediated recruitment and activation of Rad17 complexes

Zou, L., Liu, D., & Elledge, S. J. (2003) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 431

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

Flores-Rozas, H., Kelman, Z., Dean, F. B., Pan, Z. Q., Harper, J. W., Elledge, S. J., O'Donnell, M., & Hurwitz, J. (1994) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 416

SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S. J., & Harper, J. W. (2003) · Genes & Development

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 340

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Westbrook, T. F., Hu, G., Ang, X. L., Mulligan, P., Pavlova, N. N., Liang, A., Leng, Y., Maehr, R., Shi, Y., Harper, J. W., et al. (2008) · Nature

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 311

Direct DNA binding by Brca1

Paull, T. T., Cortez, D., Bowers, B., Elledge, S. J., & Gellert, M. (2001) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 282

How autophagy both activates and inhibits cellular senescence

Kang, C., & Elledge, S. J. (2016) · Autophagy

Autophagy in Disease and TherapyTelomeres, Telomerase, and Senescence

Cited by 228

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

Hurov, K. E., Cotta-Ramusino, C., & Elledge, S. J. (2010) · Genes & Development

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 210

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

Bruno, P. M., Lu, M., Dennis, K. A., Inam, H., Moore, C. J., Sheehe, J., Elledge, S. J., Hemann, M. T., & Pritchard, J. R. (2020) · Proceedings of the National Academy of Sciences

Cancer therapeutics and mechanismsBioactive Compounds and Antitumor Agents

Cited by 175

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

Wang, B., Hurov, K., Hofmann, K., & Elledge, S. J. (2009) · Genes & Development

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 172

Design of 240,000 orthogonal 25mer DNA barcode probes

Xu, Q., Schlabach, M. R., Hannon, G. J., & Elledge, S. J. (2009) · Proceedings of the National Academy of Sciences

Gene expression and cancer classificationAdvanced biosensing and bioanalysis techniques

Cited by 170

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Lin, S.-Y., Li, K., Stewart, G. S., & Elledge, S. J. (2004) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 156

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

O'Connell, B. C., Adamson, B., Lydeard, J. R., Sowa, M. E., Ciccia, A., Bredemeyer, A. L., Schlabach, M., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2010) · Molecular Cell

DNA Repair MechanismsCancer therapeutics and mechanisms

Cited by 122

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS -, and NF1 -Mutant Melanomas

Maertens, O., Kuzmickas, R., Manchester, H. E., Emerson, C. E., Gavin, A. G., Guild, C. J., Wong, T. C., De Raedt, T., Bowman-Colin, C., Hatchi, E., et al. (2019) · Cancer Discovery

Melanoma and MAPK PathwaysChromatin Remodeling and Cancer

Cited by 95

Genetic and Physical Interactions Between DPB11 and DDC1 in the Yeast DNA Damage Response Pathway

Wang, H., & Elledge, S. J. (2002) · Genetics

DNA Repair MechanismsFungal and yeast genetics research

Cited by 79