Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Open accessAbstract
Despite the importance of the aberrant polymerization of Aβ in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of Aβ aggregation in vivo. Here we show that induction of cerebral β-amyloidosis can be achieved in many different brain areas of APP23 transgenic mice through the injection of dilute Aβ-containing brain extracts. Once the amyloidogenic process has been exogenously induced, the nature of the induced Aβ-deposition is determined by the brain region of the host. Because these observations are reminiscent of a prion-like mechanism, we then investigated whether cerebral β-amyloidosis also can be induced by peripheral and systemic inoculations or by the intracerebral implantation of stainless steel wires previously coated with minute amounts of Aβ-containing brain extract. Results reveal that oral, intravenous, intraocular, and intranasal inoculations yielded no detectable induction of cerebral β-amyloidosis in APP23 transgenic mice. In contrast, transmission of cerebral β-amyloidosis through the Aβ-contaminated steel wires was demonstrated. Notably, plasma sterilization, but not boiling of the wires before implantation, prevented the induction of β-amyloidosis. Our results suggest that minute amounts of Aβ-containing brain material in direct contact with the CNS can induce cerebral β-amyloidosis, but that systemic cellular mechanisms of prion uptake and transport to the CNS may not apply to Aβ.
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Cerebral β-amyloidosis can be exogenously induced by exposure to dilute brain extracts containing aggregated Aβ seeds.
“Experimentally, cerebral β-amyloidosis can be exogenously induced by exposure to dilute brain extracts containing aggregated Aβ seeds.”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [52]
β-amyloid induction can be triggered in transgenic mice by intracerebrally implanted stainless steel wires coated with minute amounts of brain extract rich in aggregated Aβ.
“Experimentally, β-amyloid induction can be triggered in transgenic mice by intracerebrally implanted stainless steel wires coated with minute amounts of brain extract rich in aggregated Aβ52 (Fig 2).”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [52]
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Self-citation
- Authors
- Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., & Jucker, M.
- Affiliations
- Hertie Institute for Clinical Brain Research (DE)
- Department of Pathology, Institute for Neuropathology, University Hospital, Zürich, CH-8091 Switzerland;
- Novartis (Switzerland) (CH)
- SMP GmbH, D-72072 Tübingen, Germany;
- University Hospital Zurich (CH)
- Emory University (US)
- German Center for Neurodegenerative Diseases (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-08-04
- Volume
- 106
- Issue
- 31
- Pages
- 12926-12931
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2722323
- OpenAlex
- W1928837524
- Cited by
- 279
- References
- 44
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 6 · 2022: 10 · 2021: 15 · 2020: 22 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 21 · 2014: 20 · 2013: 28 · 2012: 17
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- beta-amyloidosis, Alzheimer's disease, amyloid-beta aggregation, APP23 transgenic mice, intracerebral injection, prion-like transmission, plasma sterilization, brain region specificity, amyloid deposition
- MeSH terms
- Amyloidosis, Animals, Brain Diseases, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Amyloid beta-Peptides, Prion Diseases, Mice
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