The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Under pathological conditions, exosomes increase propagation of neurotoxic proteins in neurodegenerative diseases and aggravate brain tumor metastasis and progression.
“Under pathological conditions, exosomes have been found to increase the propagation of neurotoxic proteins in neurodegenerative diseases51,52,53, and aggravate brain tumor metastasis and progression14.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Li, J.-Y., Englund, E., Holton, J. L., Soulet, D., Hagell, P., Lees, A. J., Lashley, T., Quinn, N. P., Rehncrona, S., Björklund, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1746 · Cited by 1,845 · see citing works
Transmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803 · see citing works
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971 · see citing works
The inflammasome: a danger sensing complex triggering innate immunity
Pétrilli, V., Dostert, C., Muruve, D. A., & Tschopp, J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.09.002 · Cited by 700 · see citing works
Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
Frost, B., Ollesch, J., Wille, H., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805627200 · Cited by 224 · see citing works
Flagged first, then by citations
Research works printed but not linked: 20
- [1]1. Aguzzi, A. Cell biology: Beyond the prion principle Nature. 2009; 459:924-925 Crossref Scopus (164) PubMed Google Scholar
- [2]2. Aguzzi, A. ∙ Polymenidou, M. Mammalian prion biology: one century of evolving concepts Cell. 2004; 116:313-327 Full Text Full Text (PDF) Scopus (517) PubMed Google Scholar
- [3]3. Alcazar, O. ∙ Hawkridge, A.M. ∙ Collier, T.S. ... Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells Mol. Cell. Proteomics. 2009; 8:2201-2211 Crossref Scopus (40) PubMed Google Scholar
- [4]4. Andrei, C. ∙ Dazzi, C. ∙ Lotti, L. ... The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles Mol. Biol. Cell. 1999; 10:1463-1475 Crossref Scopus (408) PubMed Google Scholar
- [5]5. Asuni, A.A. ∙ Boutajangout, A. ∙ Quartermain, D. ... Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements J. Neurosci. 2007; 27:9115-9129 Crossref Scopus (434) PubMed Google Scholar
- [6]6. Beringue, V. ∙ Demoy, M. ∙ Lasmézas, C.I. ... Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis J. Pathol. 2000; 190:495-502 Crossref Scopus (129) PubMed Google Scholar
- [7]7. Blennow, K. ∙ Hampel, H. CSF markers for incipient Alzheimer's disease Lancet Neurol. 2003; 2:605-613 Full Text Full Text (PDF) Scopus (1098) PubMed Google Scholar
- [8]8. Brundin, P. ∙ Li, J.Y. ∙ Holton, J.L. ... Research in motion: the enigma of Parkinson's disease pathology spread Nat. Rev. Neurosci. 2008; 9:741-745 Crossref Scopus (275) PubMed Google Scholar
- [9]9. Chiti, F. ∙ Dobson, C.M. Protein misfolding, functional amyloid, and human disease Annu. Rev. Biochem. 2006; 75:333-366 Crossref Scopus (5461) PubMed Google Scholar
- [11]11. Cleves, A.E. ∙ Cooper, D.N. ∙ Barondes, S.H. ... A new pathway for protein export in Saccharomyces cerevisiae J. Cell Biol. 1996; 133:1017-1026 Crossref Scopus (187) PubMed Google Scholar
- [12]12. Cocucci, E. ∙ Racchetti, G. ∙ Meldolesi, J. Shedding microvesicles: artefacts no more Trends Cell Biol. 2009; 19:43-51 Full Text Full Text (PDF) Scopus (1509) PubMed Google Scholar
- [13]13. Cooper, D.N. ∙ Barondes, S.H. Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism J. Cell Biol. 1990; 110:1681-1691 Crossref Scopus (456) PubMed Google Scholar
- [14]14. Desplats, P. ∙ Lee, H.J. ∙ Bae, E.J. ... Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein Proc. Natl. Acad. Sci. USA. 2009; 106:13010-13015 Crossref Scopus (1193) PubMed Google Scholar
- [15]15. Elliott, G. ∙ O'Hare, P. Intercellular trafficking and protein delivery by a herpesvirus structural protein Cell. 1997; 88:223-233 Full Text Full Text (PDF) Scopus (928) PubMed Google Scholar
- [16]16. Engling, A. ∙ Backhaus, R. ∙ Stegmayer, C. ... Biosynthetic FGF-2 is targeted to non-lipid raft microdomains following translocation to the extracellular surface of CHO cells J. Cell Sci. 2002; 115:3619-3631 Crossref Scopus (72) PubMed Google Scholar
- [17]17. Fader, C.M. ∙ Sánchez, D. ∙ Furlán, M. ... Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells Traffic. 2008; 9:230-250 Crossref Scopus (373) PubMed Google Scholar
- [18]18. Falsig, J. ∙ Julius, C. ∙ Margalith, I. ... A versatile prion replication assay in organotypic brain slices Nat. Neurosci. 2008; 11:109-117 Crossref Scopus (117) PubMed Google Scholar
- [19]19. Fevrier, B. ∙ Vilette, D. ∙ Archer, F. ... Cells release prions in association with exosomes Proc. Natl. Acad. Sci. USA. 2004; 101:9683-9688 Crossref Scopus (830) PubMed Google Scholar
- [20]20. Flieger, O. ∙ Engling, A. ∙ Bucala, R. ... Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter FEBS Lett. 2003; 551:78-86 Full Text Full Text (PDF) Scopus (188) PubMed Google Scholar
- [21]21. Frankel, A.D. ∙ Pabo, C.O. Cellular uptake of the tat protein from human immunodeficiency virus Cell. 1988; 55:1189-1193
Cited by
Sorted by citations
The amyloid state and its association with protein misfolding diseases.
Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3810 · Cited by 2,382 · see citing works
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2013) · Nature · doi:10.1038/nature12481 · Cited by 1,663 · see citing works
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.047 · Cited by 986 · see citing works
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z.-Y., Roybon, L., Melki, R., & Li, J.-Y. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1343-6 · Cited by 925 · see citing works
Hansen, C., Angot, E., Bergström, A.-L., Steiner, J. A., Pieri, L., Paul, G., Outeiro, T. F., Melki, R., Kallunki, P., Fog, K., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43366 · Cited by 842 · see citing works
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works
Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609 · see citing works
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
Guo, J. L., & Lee, V. M.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209296 · Cited by 636 · see citing works
Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
Jucker, M., & Walker, L. C. (2011) · Annals of Neurology · doi:10.1002/ana.22615 · Cited by 622 · see citing works
“The intercellular transfer of cytosolic protein aggregates may also occur through nanotubes, exosomes, or microvesicles.(39) Like other pathogenic proteins, Ab can be taken up, modified, and secreted by cells in vitro,(92,93) and it also is present in the cerebrospinal fluid.”
BackgroundPeripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis
Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M. (2010) · Science · doi:10.1126/science.1194516 · Cited by 568 · see citing works
Jucker, M. (2010) · Nature Medicine · doi:10.1038/nm.2224 · Cited by 401 · see citing works
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
Xu, B., Zhang, Y., Du, X.-F., Li, J., Zi, H.-X., Bu, J.-W., Yan, Y., Han, H., & Du, J.-L. (2017) · Cell Research · doi:10.1038/cr.2017.62 · Cited by 354 · see citing works
The prion hypothesis in Parkinson's disease: braak to the future
Visanji, N. P., Brooks, P. L., Hazrati, L.-N., & Lang, A. E. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-2 · Cited by 278 · see citing works
Emerging roles of exosomes in neuron-glia communication
Frühbeis, C., Fröhlich, D., & Krämer-Albers, E.-M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00119 · Cited by 275 · see citing works
Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission
Moreno-Gonzalez, I., & Soto, C. (2011) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2011.04.002 · Cited by 252 · see citing works
Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain
Pegtel, D. M., Peferoen, L., & Amor, S. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0516 · Cited by 232 · see citing works
Soluble Aβ Seeds Are Potent Inducers of Cerebral β-Amyloid Deposition
Langer, F., Eisele, Y. S., Fritschi, S. K., Staufenbiel, M., Walker, L. C., & Jucker, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3088-11.2011 · Cited by 237 · see citing works
Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
George, S., Rey, N. L., Tyson, T., Esquibel, C., Meyerdirk, L., Schulz, E., Pierce, S., Burmeister, A. R., Madaj, Z., Steiner, J. A., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0335-3 · Cited by 229 · see citing works
Prion-like spread of protein aggregates in neurodegeneration
Polymenidou, M., & Cleveland, D. W. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120741 · Cited by 184 · see citing works
Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease
Vingtdeux, V., Sergeant, N., & Buée, L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00229 · Cited by 116 · see citing works
Sala Frigerio, C., Lau, P., Troakes, C., Deramecourt, V., Gele, P., Van Loo, P., Voet, T., & De Strooper, B. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.02.007 · Cited by 71 · see citing works
Filannino, F. M., Panaro, M. A., Benameur, T., Pizzolorusso, I., & Porro, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031629 · Cited by 60 · see citing works
Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease
Chiarini, A., Armato, U., Liu, D., & Dal Prà, I. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00134 · Cited by 51 · see citing works
Rönnbäck, A., Sagelius, H., Bergstedt, K. D., Näslund, J., Westermark, G. T., Winblad, B., & Graff, C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.012 · Cited by 43 · see citing works
Myeloid extracellular vesicles: messengers from the demented brain
Nigro, A., Colombo, F., Casella, G., Finardi, A., Verderio, C., & Furlan, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00017 · Cited by 26 · see citing works
Muth, C., Schröck, K., Madore, C., Hartmann, K., Fanek, Z., Butovsky, O., Glatzel, M., & Krasemann, S. (2017) · Brain Pathology · doi:10.1111/bpa.12441 · Cited by 23 · see citing works
- Authors
- Aguzzi, A., & Rajendran, L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 64
- Issue
- 6
- Pages
- 783-790
- ISSN
- 0896-6273
- Cited by
- 407
- References
- 5
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review