Cited by 471Mitochondrial Function and PathologyAutophagy in Disease and TherapyCongenital heart defects research

Mitochondrial biogenesis and dynamics in the developing and diseased heart

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Dorn, Gerald W., Vega, Rick B., Kelly, Daniel P.·2015·Genes & Development

Abstract

The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.

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Authors
Dorn, G. W., Vega, R. B., & Kelly, D. P.
Affiliations
  • Washington University in St. Louis (US)
  • Sanford Burnham Prebys Medical Discovery Institute (US)
Venue
Genes & Development
Published
2015-10-01
Volume
29
Issue
19
Pages
1981-1991
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2267961811
Cited by
470
References
106
Citations by year
2026: 32 · 2025: 38 · 2024: 53 · 2023: 59 · 2022: 54 · 2021: 76 · 2020: 46 · 2019: 36 · 2018: 25 · 2017: 29 · 2016: 21 · 2014: 1
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Genes & Development (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
Funders
National Institutes of Health (R01 DK045416, R01 HL058493, R01 HL59888, R01 HL128071)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
mitochondrial biogenesis, mitochondrial dynamics, heart development, heart disease, mitochondrial turnover, myocardial energy metabolism, ATP production, mitochondrial regulation
MeSH terms
Animals, Organelle Biogenesis, Heart, Heart Diseases, Humans, Mitochondria, Myocardium, Transcription Factors, Mitophagy

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