Stockwell, Brent R.

Multicomponent therapeutics for networked systems

Keith, C. T., Borisy, A. A., & Stockwell, B. R. (2005) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsGene Regulatory Network Analysis

Cited by 769

Regulated necrosis: disease relevance and therapeutic opportunities

Conrad, M., Angeli, J. P. F., Vandenabeele, P., & Stockwell, B. R. (2016) · Nature Reviews Drug Discovery

Cell death mechanisms and regulationFerroptosis and cancer prognosis

Cited by 630

Systematic discovery of multicomponent therapeutics

Borisy, A. A., Elliott, P. J., Hurst, N. W., Lee, M. S., Lehár, J., Price, E. R., Serbedzija, G., Zimmermann, G. R., Foley, M. A., Stockwell, B. R., et al. (2003) · Proceedings of the National Academy of Sciences

Computational Drug Discovery MethodsHistorical Medical Research and Treatments

Cited by 620

Regulation of lipid peroxidation and ferroptosis in diverse species

Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development

Ferroptosis and cancer prognosisAntioxidant Activity and Oxidative Stress

Cited by 544

Regulated cell death and inflammation: an auto-amplification loop causes organ failure

Linkermann, A., Stockwell, B. R., Krautwald, S., & Anders, H.-J. (2014) · Nature Reviews Immunology

Cell death mechanisms and regulationImmune Response and Inflammation

Cited by 522

The chemistry and biology of ferroptosis

Stockwell, B. R., & Jiang, X. (2020) · Cell chemical biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 429

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver physiology and pathology

Cited by 416

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

Woo, J. H., Shimoni, Y., Yang, W. S., Subramaniam, P., Iyer, A., Nicoletti, P., Rodríguez Martínez, M., López, G., Mattioli, M., Realubit, R., et al. (2015) · Cell

Bioinformatics and Genomic NetworksComputational Drug Discovery Methods

Cited by 351

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Chen, D., Chu, B., Yang, X., Liu, Z., Jin, Y., Kon, N., Rabadan, R., Jiang, X., Stockwell, B. R., & Gu, W. (2021) · Nature Communications

Ferroptosis and cancer prognosisCancer, Lipids, and Metabolism

Cited by 348

Activation of lysosomal iron triggers ferroptosis in cancer

Cañeque, T., Baron, L., Müller, S., Carmona, A., Colombeau, L., Versini, A., Solier, S., Gaillet, C., Sindikubwabo, F., Sampaio, J. L., et al. (2025) · Nature

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 287

Chemical combination effects predict connectivity in biological systems

Lehár, J., Zimmermann, G. R., Krueger, A. S., Molnar, R. A., Ledell, J. T., Heilbut, A. M., Short, G. F., Giusti, L. C., Nolan, G. P., Magid, O. A., et al. (2007) · Molecular Systems Biology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 275

Heat stress induces ferroptosis-like cell death in plants

Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., et al. (2017) · Journal of Cell Biology

Ferroptosis and cancer prognosisPlant Stress Responses and Tolerance

Cited by 268

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Weïwer, M., Bittker, J. A., Lewis, T. A., Shimada, K., Yang, W. S., MacPherson, L., Dandapani, S., Palmer, M., Stockwell, B. R., Schreiber, S. L., et al. (2012) · Bioorganic & Medicinal Chemistry Letters

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 237

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion

Youssef, L. A., Rebbaa, A., Pampou, S., Weisberg, S. P., Stockwell, B. R., Hod, E. A., & Spitalnik, S. L. (2018) · Blood

Phagocytosis and Immune RegulationIron Metabolism and Disorders

Cited by 186

Combination chemical genetics

Lehár, J., Stockwell, B. R., Giaever, G., & Nislow, C. (2008) · Nature Chemical Biology

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 172

Modulatory profiling identifies mechanisms of small molecule-induced cell death

Wolpaw, A. J., Shimada, K., Skouta, R., Welsch, M. E., Akavia, U. D., Pe'er, D., Shaik, F., Bulinski, J. C., & Stockwell, B. R. (2011) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationComputational Drug Discovery Methods

Cited by 133

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 133

Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay

Herman, A. G., Hayano, M., Poyurovsky, M. V., Shimada, K., Skouta, R., Prives, C., & Stockwell, B. R. (2011) · Cancer Discovery

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 100

Biological mechanism profiling using an annotated compound library

Root, D. E., Flaherty, S. P., Kelley, B. P., & Stockwell, B. R. (2003) · Chemistry & Biology

Computational Drug Discovery MethodsHeterocyclic Compound Synthesis and Bioactivity

Cited by 95

A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress

Thams, S., Lowry, E. R., Larraufie, M.-H., Spiller, K. J., Li, H., Williams, D. J., Hoang, P., Jiang, E., Williams, L. A., Sandoe, J., et al. (2019) · Molecular Therapy

Amyotrophic Lateral Sclerosis ResearchEndoplasmic Reticulum Stress and Disease

Cited by 51

Spatial pharmacology using mass spectrometry imaging

Rajbhandari, P., Neelakantan, T. V., Hosny, N., & Stockwell, B. R. (2024) · Trends in Pharmacological Sciences

Mass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry Studies

Cited by 49

Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis

More, S., Bonnereau, J., Wouters, D., Spotbeen, X., Karras, P., Rizzollo, F., Killian, T., Venken, T., Naulaerts, S., Vervoort, E., et al. (2024) · Science Advances

Ferroptosis and cancer prognosisCancer, Lipids, and Metabolism

Cited by 25

Design of small molecules that compete with nucleotide binding to an engineered oncogenic KRAS allele

Zhang, Y., Larraufie, M.-H., Musavi, L., Akkiraju, H., Brown, L. M., & Stockwell, B. R. (2018) · Biochemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 16