Regulation of lipid peroxidation and ferroptosis in diverse species
Open accessAbstract
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q 10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mitochondrial damage is involved in lipid peroxidation and imbalance of iron homeostasis in neurodegenerative diseases such as AD and PD.
“Mitochondrial damage has been found to be involved in lipid peroxidation and imbalance of iron homeostasis in neurodegenerative diseases such as AD and PD [34].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works
Self-citationRegulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works
Self-citationFerroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works
Self-citationGalluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works
Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works
Self-citationOxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029 · see citing works
Self-citationWendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works
Ascorbate and Glutathione: The Heart of the Redox Hub
Foyer, C. H., & Noctor, G. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.167569 · Cited by 2,502 · see citing works
Autophagy promotes ferroptosis by degradation of ferritin
Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332 · see citing works
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329 · see citing works
Self-citationShotgun metagenomics, from sampling to analysis
Quince, C., Walker, A. W., Simpson, J. T., Loman, N. J., & Segata, N. (2017) · Nature Biotechnology · doi:10.1038/nbt.3935 · Cited by 2,202 · see citing works
Autophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,165 · see citing works
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works
Self-citationQuantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084 · see citing works
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011 · see citing works
Self-citationBrigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904 · see citing works
Ferroptosis is an autophagic cell death process
Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899 · see citing works
Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works
Self-citationLipid peroxidation in cell death
Gaschler, M. M., & Stockwell, B. R. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.086 · Cited by 1,852 · see citing works
Self-citationConverging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
Ling, S.-C., Polymenidou, M., & Cleveland, D. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.033 · Cited by 1,811 · see citing works
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Ingold, I., Berndt, C., Schmitt, S., Doll, S. G., Poschmann, G., Buday, K., Roveri, A., Peng, X., Freitas, F. P., Seibt, T., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.048 · Cited by 1,685 · see citing works
Self-citationGlutathione in plants: an integrated overview
Noctor, G., Mhamdi, A., Chaouch, S., Han, Y., Neukermans, J., Márquez‐García, B., Queval, G., & Foyer, C. H. (2011) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2011.02400.x · Cited by 1,600 · see citing works
Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470 · see citing works
Self-citationGuerin, P. J. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.2.175 · Cited by 1,419 · see citing works
Ishimoto, T., Nagano, O., Yae, T., Tamada, M., Motohara, T., Oshima, H., Oshima, M., Ikeda, T., Asaba, R., Yagi, H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.038 · Cited by 1,192 · see citing works
Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146 · cited 1× · see citing works
“Some oviparous species predispose their young to excretion of metals in both the egg shell and contents (Burger 1994; Skrivan et al. 2005).”
BackgroundSelf-citationSynchronized renal tubular cell death involves ferroptosis
Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126 · see citing works
Self-citationIdentification of ACSL4 as a biomarker and contributor of ferroptosis
Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071 · cited 1× · see citing works
“Deletion of these genes causes resistance to ferroptosis in mammals (Dixon et al. 2015; Yuan et al. 2016; Doll et al. 2017; Kagan et al. 2017).”
BackgroundHuman Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043 · see citing works
Self-citationGlobal survey of cell death mechanisms reveals metabolic regulation of ferroptosis
Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017 · see citing works
Self-citationReactive Oxygen Species in Plant Cell Death
Breusegem, F. V., & Dat, J. F. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.078295 · Cited by 1,002 · see citing works
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Wenzel, S. E., Tyurina, Y. Y., Zhao, J., Croix, C. M. S., Dar, H. H., Mao, G., Tyurin, V. A., Anthonymuthu, T. S., Kapralov, A. A., Amoscato, A. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.044 · Cited by 960 · see citing works
Self-citationUrsini, F., Maiorino, M., Valente, M., Ferri, L., & Gregolin, C. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90150-3 · Cited by 884 · see citing works
Cellular and molecular mechanisms of mitochondrial function
Osellame, L. D., Blacker, T. S., & Duchen, M. R. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.05.003 · Cited by 871 · see citing works
Hambright, W. S., Fonseca, R. S., Chen, L., Na, R., & Ran, Q. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.021 · Cited by 851 · see citing works
Yant, L. J., Ran, Q., Rao, L., Van Remmen, H., Shibatani, T., Belter, J. G., Motta, L., Richardson, A., & Prolla, T. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01360-6 · Cited by 797 · see citing works
The antioxidant role of selenium and seleno-compounds
Tapiero, H., Townsend, D. M., & Tew, K. D. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00035-0 · Cited by 796 · see citing works
Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782 · see citing works
Oxygen radical chemistry of polyunsaturated fatty acids
Gardner, H. W. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90102-0 · Cited by 721 · see citing works
GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues
Maiorino, M., Conrad, M., & Ursini, F. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7115 · Cited by 709 · see citing works
Self-citationTau-mediated iron export prevents ferroptotic damage after ischemic stroke
Tuo, Q.-Z., Lei, P., Jackman, K. A., Li, X.-L., Xiong, H., Li, X.-L., Liuyang, Z.-Y., Roisman, L. C., Zhang, S.-T., Ayton, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.171 · Cited by 706 · see citing works
The interplay between cell signalling and the mevalonate pathway in cancer
Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 697 · see citing works
Inhibition of neuronal ferroptosis protects hemorrhagic brain
Li, Q., Han, X., Lan, X., Gao, Y., Wan, J., Durham, F., Cheng, T., Yang, J., Wang, Z., Jiang, C. Q., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90777 · Cited by 686 · see citing works
Self-citationT cell lipid peroxidation induces ferroptosis and prevents immunity to infection
Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · see citing works
Self-citationRegulated necrosis: disease relevance and therapeutic opportunities
Conrad, M., Angeli, J. P. F., Vandenabeele, P., & Stockwell, B. R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.6 · Cited by 630 · see citing works
Self-citationConrad, M., & Sato, H. (2011) · Amino Acids · doi:10.1007/s00726-011-0867-5 · Cited by 607 · see citing works
Self-citationIron‐dependent cell death of hepatocellular carcinoma cells exposed to sorafenib
Louandre, C., Ezzoukhry, Z., Godin, C., Barbare, J., Mazière, J., Chauffert, B., & Galmiche, A. (2013) · International Journal of Cancer · doi:10.1002/ijc.28159 · Cited by 602 · see citing works
Programmed cell death and aerenchyma formation in roots
DREW, M. C., He, C.-J., & Morgan, P. W. (2000) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01570-3 · Cited by 593 · see citing works
Morphological classification of plant cell deaths
van Doorn, W. G., Beers, E. P., Dangl, J. L., Franklin-Tong, V. E., Gallois, P., Hara-Nishimura, I., Jones, A. M., Kawai-Yamada, M., Lam, E., Mundy, J., et al. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.36 · Cited by 584 · see citing works
Ferroptosis Inhibition: Mechanisms and Opportunities
Angeli, J. P. F., Shah, R., Pratt, D. A., & Conrad, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.02.005 · Cited by 563 · see citing works
Self-citationCramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4232 · Cited by 541 · see citing works
Marty, F. (1999) · The Plant Cell · doi:10.1105/tpc.11.4.587 · Cited by 511 · see citing works
Chen, L., Hambright, W. S., Na, R., & Ran, Q. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680090 · Cited by 498 · see citing works
Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis
Dávalos, A., Miguel, M., Bartolomé, B., & López-Fandiño, R. (2004) · Journal of Food Protection · doi:10.4315/0362-028x-67.9.1939 · Cited by 495 · see citing works
Adaptations of archaeal and bacterial membranes to variations in temperature, pH and pressure
Siliakus, M. F., van der Oost, J., & Kengen, S. W. M. (2017) · Extremophiles · doi:10.1007/s00792-017-0939-x · Cited by 450 · see citing works
Autophagy is required for tolerance of drought and salt stress in plants
Liu, Y., Xiong, Y., & Bassham, D. C. (2009) · Autophagy · doi:10.4161/auto.5.7.9290 · Cited by 422 · cited 1× · see citing works
“Ferritin in rayfinned fish is equally important in defending against catalytic iron-induced damage, as observed in the big belly seahorse (Furlong et al. 2000), yellow snapper (ReyesBecerril et al. 2014), and channel catfish (Liu et al. 2010).”
BackgroundRedox imbalance in cystine/glutamate transporter-deficient mice
Sato, H., Shiiya, A., Kimata, M., Maebara, K., Tamba, M., Sakakura, Y., Makino, N., Sugiyama, F., Yagami, K.-I., Moriguchi, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506439200 · Cited by 422 · see citing works
Microbial Fatty Acids and Thermal Adaptation
Suutari, M. H., & Laakso, S. (1994) · Critical Reviews in Microbiology · doi:10.3109/10408419409113560 · Cited by 409 · see citing works
Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.
Lachaier, E., Louandre, C., Godin, C., Saidak, Z., Baert, M., Diouf, M., Chauffert, B., & Galmiche, A. (2014) · PubMed · Cited by 396 · see citing works
Fatty Acid Hydroperoxides and H2O2 in the Execution of Hypersensitive Cell Death in Tobacco Leaves
Montillet, J., Chamnongpol, S., Rustérucci, C., et al. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.059907 · Cited by 370 · see citing works
Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene
Imai, H., Hirao, F., Sakamoto, T., Sekine, K., Mizukura, Y., Saito, M., Kitamoto, T., Hayasaka, M., Hanaoka, K., & Nakagawa, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00734-4 · Cited by 357 · see citing works
Babin, P. J., & Vernier, J. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38342-5 · Cited by 354 · see citing works
Emerging roles of resolvins in the resolution of inflammation and pain
Ji, R., Xu, Z., Strichartz, G. R., & Serhan, C. N. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.005 · Cited by 345 · see citing works
Ascorbic Acid Deficiency Activates Cell Death and Disease Resistance Responses in Arabidopsis
Pavet, V., Olmos, E., Kiddle, G. A., Mowla, S., Kumar, S., ANTONIW, J. F., Álvarez, M. E., & Foyer, C. H. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.067686 · Cited by 344 · see citing works
Programmed Cell Death in Development and Defense
Jones, A. M. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.1.94 · Cited by 330 · see citing works
Mitochondrial glutathione peroxidase 4 disruption causes male infertility
Schneider, M., Förster, H., Boersma, A., Seiler, A., Wehnes, H., Sinowatz, F., Neumüller, C., Deutsch, M. J., Walch, A. K., de Angelis, M. H., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-132795 · Cited by 328 · see citing works
Self-citationXie, H., Wan, Z., Li, S., et al. (2014) · The Plant Cell · doi:10.1105/tpc.114.125427 · Cited by 323 · see citing works
Surai, P. F. (2000) · British Poultry Science · doi:10.1080/713654909 · Cited by 322 · see citing works
Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
Carlson, B. A., Tobe, R., Yefremova, E., Tsuji, P. A., Hoffmann, V. J., Schweizer, U., Gladyshev, V. N., Hatfield, D. L., & Conrad, M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.05.003 · Cited by 316 · see citing works
Self-citationSchoenmakers, E., Agostini, M., Mitchell, C., Schoenmakers, N., Papp, L., Rajanayagam, O., Padidela, R., Ceron-Gutierrez, L., Doffinger, R., Prevosto, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43653 · Cited by 315 · see citing works
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis
Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 309 · see citing works
Molecular enzymology of lipoxygenases
Ivanov, I., Heydeck, D., Hofheinz, K., et al. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.08.016 · Cited by 303 · see citing works
Shimada, K., Hayano, M., Pagano, N. C., & Stockwell, B. R. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.11.016 · Cited by 300 · see citing works
Self-citationMacLeod, A. K., McMahon, M. J., Plummer, S. M., Higgins, L. G., Penning, T. M., Igarashi, K., & Hayes, J. D. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp176 · Cited by 297 · see citing works
Glutathione peroxidase 4: a new player in neurodegeneration?
Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 281 · see citing works
Salt causes ion disequilibrium‐induced programmed cell death in yeast and plants
Huh, G., Damsz, B., Matsumoto, T. K., Reddy, M. P., Rus, A. M., Ibeas, J. I., Narasimhan, M. L., Bressan, R. A., & Hasegawa, P. M. (2002) · The Plant Journal · doi:10.1046/j.0960-7412.2001.01247.x · Cited by 280 · see citing works
Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation
Schneider, C. G., Porter, N. A., & BRASH, A. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800001200 · Cited by 275 · see citing works
The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation
Enyedi, B., Jelcic, M., & Niethammer, P. (2016) · Cell · doi:10.1016/j.cell.2016.04.016 · Cited by 274 · see citing works
Bacterial Membranes: Structure, Domains, and Function.
Strahl, H., & Errington, J. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095630 · Cited by 273 · see citing works
Conrad, M., Moreno, S. G., Sinowatz, F., Ursini, F., Kölle, S., Roveri, A., Brielmeier, M., Wurst, W., Maiorino, M., & Bornkamm, G. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7637-7644.2005 · Cited by 270 · see citing works
Self-citationHeat stress induces ferroptosis-like cell death in plants
Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201605110 · Cited by 268 · see citing works
Self-citationEmerging roles for lipids in non-apoptotic cell death
Magtanong, L., Ko, P., & Dixon, S. J. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.25 · Cited by 259 · see citing works
Choline, Other Methyl-Donors and Epigenetics
Zeisel, S. H. (2017) · Nutrients · doi:10.3390/nu9050445 · Cited by 252 · see citing works
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
Canli, Ö., Alankuş, Y. B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P. S., Schroeder, T., Vandenabeele, P., Bornkamm, G. W., & Greten, F. R. (2016) · Blood · doi:10.1182/blood-2015-06-654194 · Cited by 247 · see citing works
Wirth, E. K., Conrad, M., Winterer, J., Wozny, C., Carlson, B. A., Roth, S., Schmitz, D., Bornkamm, G. W., Coppola, V., Tessarollo, L., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-143974 · Cited by 237 · see citing works
Self-citationHen Egg as an Antioxidant Food Commodity: A Review
Nimalaratne, C., & Wu, J. (2015) · Nutrients · doi:10.3390/nu7105394 · Cited by 237 · see citing works
The structural basis for specificity in lipoxygenase catalysis
Newcomer, M. E., & BRASH, A. R. (2014) · Protein Science · doi:10.1002/pro.2626 · Cited by 226 · see citing works
Zoeller, M., Stingl, N. E., Krischke, M., Fekete, Á., Waller, F., Berger, S., & Mueller, M. J. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.202846 · Cited by 222 · see citing works
Ferroptosis is involved in acetaminophen induced cell death
Lőrincz, T., Jemnitz, K., Kardon, T., Mandl, J., & Szarka, A. (2015) · Pathology & Oncology Research · doi:10.1007/s12253-015-9946-3 · Cited by 219 · see citing works
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
LaMonte, G., Tang, X., Chen, J. L.-Y., Wu, J., Ding, C. C., Keenan, M. M., Sangokoya, C., Kung, H., Ilkayeva, O., Boros, L. G., et al. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-23 · Cited by 219 · see citing works
Xylem cell death: emerging understanding of regulation and function
Bollhöner, B., Prestele, J., & Tuominen, H. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err438 · Cited by 216 · see citing works
Hwang, I. S., & Hwang, B. K. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.147827 · Cited by 215 · see citing works
Heavy metals in avian eggshells: Another excretion method
Burger, J. (1994) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399409531837 · Cited by 199 · see citing works
Duan, Y., Zhang, W., Li, B., et al. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03207.x · Cited by 199 · see citing works
Saccharomyces cerevisiae Expresses Three Phospholipid Hydroperoxide Glutathione Peroxidases
Avery, A. M., & Avery, S. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105672200 · Cited by 197 · see citing works
Programmed Cell Death Remodels Lace Plant Leaf Shape during Development[W]
Gunawardena, A. H. L. A. N., Greenwood, J. S., & Dengler, N. G. (2004) · The Plant Cell · doi:10.1105/tpc.016188 · Cited by 196 · see citing works
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase
Vance, R. E., Hong, S., Gronert, K., Serhan, C. N., & Mekalanos, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307308101 · Cited by 192 · see citing works
Iron chemistry at the service of life
Sánchez, M., Sabio, L., Gálvez, N., Capdevila, M., & Dominguez-Vera, J. M. (2017) · IUBMB Life · doi:10.1002/iub.1602 · Cited by 191 · see citing works
Shah, R., Margison, K. D., & Pratt, D. A. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00730 · Cited by 188 · see citing works
Drews, G. N., & Koltunow, A. M. (2011) · The Arabidopsis Book · doi:10.1199/tab.0155 · Cited by 184 · see citing works
Takai, K., Sugai, A., Itoh, T., et al. (2000) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-50-2-489 · Cited by 183 · see citing works
Hensley, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.983 · Cited by 182 · see citing works
Zebrafish: gaining popularity in lipid research
Hölttä‐Vuori, M., Salo, V. T., Nyberg, L. K., Brackmann, C., Enejder, A. M. K., Panula, P., & Ikonen, E. (2010) · Biochemical Journal · doi:10.1042/bj20100293 · Cited by 180 · see citing works
Lipoxygenases and their involvement in programmed cell death
Maccarrone, M., Melino, G., & Finazzi‐Agrò, A. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400908 · Cited by 176 · see citing works
Ozgur, R., Türkan, İ., Uzilday, B., & Sekmen, A. H. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru034 · Cited by 175 · see citing works
A unique program for cell death in xylem fibers of Populus stem
Courtois-Moreau, C., Pesquet, E., Sjödin, A., Muñiz, L. M., Bollhöner, B., Kaneda, M., Samuels, L., Jansson, S., & Tuominen, H. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03777.x · Cited by 175 · see citing works
Activation of autophagy by unfolded proteins during endoplasmic reticulum stress
Yang, X., Srivastava, R., Howell, S. H., & Bassham, D. C. (2015) · The Plant Journal · doi:10.1111/tpj.13091 · Cited by 172 · see citing works
Mitochondrial Ferritin Expression in Adult Mouse Tissues
Santambrogio, P., Biasiotto, G., Sanvito, F., Olivieri, S., Arosio, P., & Levi, S. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7273.2007 · Cited by 168 · see citing works
Wortmann, M., Schneider, M., Pircher, J., Hellfritsch, J., Aichler, M., Naidu, V. M., Kölle, P., Kuhlencordt, P. J., Walch, A. K., Pohl, U., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.279984 · Cited by 160 · see citing works
Self-citationLeist, M., RAAB, B., Maurer, S., Rösick, U., & Brigelius‐Flohé, R. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00045-7 · Cited by 158 · see citing works
Chen, S., Vaghchhipawala, Z. E., Li, W., Asard, H., & Dickman, M. B. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.038091 · Cited by 153 · see citing works
Characterization of glutathione-S-transferases in zebrafish (Danio rerio)
Glišić, B., Mihaljević, I., Popović, M., Žaja, R., Lončar, J., Fent, K., Kovačević, R., & Smital, T. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.10.013 · Cited by 147 · see citing works
Doyle, S. M., Diamond, M., & McCabe, P. F. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/erp320 · Cited by 145 · see citing works
Glutathione, Glutaredoxins, and Iron
Berndt, C., & Lillig, C. H. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7132 · Cited by 141 · see citing works
Zhang, Q., Li, Y., Liu, Z., et al. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.06.018 · Cited by 140 · see citing works
Acidic pH amplifies iron-mediated lipid peroxidation in cells
Schafer, F. Q., & Buettner, G. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00319-1 · Cited by 134 · see citing works
Monroig, Ó., Rotllant, J., Sánchez, E., Cerdá‐Reverter, J. M., & Tocher, D. R. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.07.002 · Cited by 131 · see citing works
Pelka, K. E., Henn, K., Keck, A., et al. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.12.015 · Cited by 131 · see citing works
Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells
Ueta, T., Inoue, T., Furukawa, T., Tamaki, Y., Nakagawa, Y., Imai, H., & Yanagi, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335174 · Cited by 129 · see citing works
Ren, C., Hu, X., Li, X., & Zhou, Q. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.036 · Cited by 124 · see citing works
Genome-wide analysis of lipoxygenase gene family in Arabidopsis and rice
Umate, P. (2011) · Plant Signaling & Behavior · doi:10.4161/psb.6.3.13546 · Cited by 119 · see citing works
Cambier, S., Bénard, G., Mesmer‐Dudons, N., et al. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.008 · Cited by 116 · see citing works
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis
Zeisel, S. H. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0518 · Cited by 116 · see citing works
Dalto, D. B., & Matte, J. J. (2017) · Nutrients · doi:10.3390/nu9030189 · Cited by 111 · see citing works
Ibrahim, H. R., Hoq, M. I., & Aoki, T. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.08.005 · Cited by 110 · see citing works
Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation
Hill, S. A., Lamberson, C. R., Xu, L., To, R., Tsui, H. S., Shmanai, V. V., Bekish, A. V., Awad, A. M., Marbois, B. N., Cantor, C. R., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.06.004 · Cited by 109 · see citing works
Brütsch, S. H., Wang, C. C., Li, L., Stender, H., Neziroglu, N., Richter, C., Kühn, H., & Borchert, A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5967 · Cited by 108 · see citing works
Egg Yolk Phosvitin Inhibits Hydroxyl Radical Formation from the Fenton Reaction
ISHIKAWA, S.-I., Yano, Y., Arihara, K., & Makoto, I. T. O. H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.1324 · Cited by 108 · see citing works
LU, C.-L., & BAKER, R. C. (1986) · Poultry Science · doi:10.3382/ps.0652065 · Cited by 104 · see citing works
Liu, S., & Baoyu, H. (2010) · BMC Plant Biology · doi:10.1186/1471-2229-10-228 · Cited by 101 · see citing works
Conrad, M., Sandin, Å., Förster, H., Seiler, A., Frijhoff, J., Dagnell, M., Bornkamm, G. W., Rådmark, O., van Huijsduijnen, R. H., Aspenström, P., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007909107 · Cited by 99 · see citing works
Self-citationGarcía-Marcos, A., Pacheco, R., Manzano, A., et al. (2013) · Journal of Virology · doi:10.1128/jvi.03573-12 · Cited by 99 · see citing works
Gaber, A., Ogata, T., Maruta, T., et al. (2012) · Plant and Cell Physiology · doi:10.1093/pcp/pcs100 · Cited by 98 · see citing works
Dellagi, A., Segond, D., Rigault, M., Fagard, M., Simon, C., Saindrenan, P., & Expert, D. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.138636 · Cited by 96 · see citing works
Surai, P. F., Noble, R. C., & Speake, B. K. (1999) · British Poultry Science · doi:10.1080/00071669987520 · Cited by 96 · see citing works
Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling
Horn, T. L., Adel, S., Schumann, R. R., Sur, S., Kakularam, K. R., Aparoy, P., Reddanna, P., Kühn, H., & Heydeck, D. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.11.001 · Cited by 92 · see citing works
Adrenodoxin: The archetype of vertebrate-type [2Fe–2S] cluster ferredoxins
Ewen, K. M., Kleser, M., & Bernhardt, R. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.06.003 · Cited by 91 · see citing works
Skřivan, M., Skřivanová, V., & Marounek, M. (2005) · Poultry Science · doi:10.1093/ps/84.10.1570 · Cited by 91 · see citing works
Taylor, M. R., Hurley, J. B., Epps, H. A. V., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307074101 · Cited by 90 · see citing works
Wu, S. M., Liu, J.-H., Shu, L., et al. (2015) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2015.05.016 · Cited by 89 · see citing works
Lin, Y.-F., Tsai, H.-L., Lee, Y.-C., et al. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2457 · Cited by 88 · see citing works
Ingold, I., Aichler, M., Yefremova, E., Roveri, A., Buday, K., Doll, S. G., Tasdemir, A., Hoffard, N., Wurst, W., Walch, A. K., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656363 · Cited by 88 · see citing works
Self-citationSmith, A. C., Mears, A. J., Bunker, R., Ahmed, A., MacKenzie, M., Schwartzentruber, J. A., Beaulieu, C. L., Ferretti, E., FORGE Canada Consortium, Majewski, J., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-102218 · Cited by 87 · see citing works
α-Synuclein overexpression promotes aggregation of mutant huntingtin
Furlong, R. A., Narain, Y., Rankin, J., Wyttenbach, A., & Rubinsztein, D. C. (2000) · Biochemical Journal · doi:10.1042/bj3460577 · Cited by 86 · see citing works
Cerebellar Hypoplasia in Mice Lacking Selenoprotein Biosynthesis in Neurons
Wirth, E. K., Bharathi, B. S., Hatfield, D. L., Conrad, M., Brielmeier, M., & Schweizer, U. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-9920-z · Cited by 86 · see citing works
Self-citationYao, H., Zhao, W., Zhao, X., et al. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0125-2 · Cited by 83 · see citing works
Iron storage diseases in birds
Cork, S. C. (2000) · Avian Pathology · doi:10.1080/03079450094216 · Cited by 82 · see citing works
Avery, A. M., Willetts, S. A., & Avery, S. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408340200 · Cited by 78 · see citing works
Qualhato, G., Rocha, T. L., Lima, E. C. D. O., et al. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.05.061 · Cited by 78 · see citing works
Liu, J., Chen, Z., He, J., Zhang, Y., Zhang, T., & Jiang, Y. (2014) · Food & Function · doi:10.1039/c4fo00665h · Cited by 77 · see citing works
Muthukumar, K., Rajakumar, S., Sarkar, M., et al. (2011) · Antonie van Leeuwenhoek · doi:10.1007/s10482-011-9550-9 · Cited by 76 · see citing works
Embryonic growth and antioxidant provision in avian eggs
Deeming, D. C., & Pike, T. W. (2013) · Biology Letters · doi:10.1098/rsbl.2013.0757 · Cited by 76 · see citing works
Chowdhury, V. S., Tomonaga, S., Ikegami, T., Erwan, E., Ito, K., Cockrem, J. F., & Furuse, M. (2014) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2013.12.020 · Cited by 74 · see citing works
VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch
Maldonado, E. N. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00004 · Cited by 74 · see citing works
Dailey, F. E., McGraw, J. E., Jensen, B. J., et al. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.02266-15 · Cited by 71 · see citing works
Structural Identification and Cardiovascular Activities of Oxidized Phospholipids
Salomon, R. G. (2012) · Circulation Research · doi:10.1161/circresaha.112.275388 · Cited by 70 · see citing works
Sun, Y., Hayakawa, S., CHUAMANOCHAN, M., et al. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.598 · Cited by 70 · see citing works
Maccarrone, M., van Zadelhoff, G., Veldink, G. A., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01564.x · Cited by 68 · see citing works
Mitochondrial behavior during oogenesis in zebrafish: A confocal microscopy analysis
Zhang, Y., Ouyang, Y., Hou, Y., Schatten, H., Chen, D., & Sun, Q. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.00988.x · Cited by 67 · see citing works
Cambier, S., Gonzalez, P., Mesmer‐Dudons, N., et al. (2011) · BioMetals · doi:10.1007/s10534-011-9494-6 · Cited by 66 · see citing works
Vitamin C Deficiency Activates the Purine Nucleotide Cycle in Zebrafish
Kirkwood, J. S., Lebold, K. M., Miranda, C. L., Wright, C. L., Miller, G. W., Tanguay, R. L., Barton, C. L., Traber, M. G., & Stevens, J. F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316018 · Cited by 65 · see citing works
Self-citationEffect of age on the susceptibility of zebrafish eggs to industrial wastewater
Gellert, G. (2001) · Water Research · doi:10.1016/s0043-1354(01)00084-7 · Cited by 63 · see citing works
Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells
Maulucci, G., Daniel, B., Cohen, O., Avrahami, Y., & Sasson, S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.03.001 · Cited by 63 · see citing works
Choi, J., Leonard, S. W., Kasper, K., McDougall, M. Q., Stevens, J. F., Tanguay, R. L., & Traber, M. G. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m058941 · Cited by 62 · see citing works
Self-citationRui, B. R., Shibuya, F. Y., Kawaoku, A. J. T., et al. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.11.001 · Cited by 60 · see citing works
Banthiya, S., Kalms, J., Yoga, E. G., Ivanov, I., Carpena, X., Hámberg, M., Kühn, H., & Scheerer, P. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.002 · Cited by 59 · see citing works
Iron and thiols as two major players in carcinogenesis: friends or foes?
Toyokuni, S. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00200 · Cited by 57 · see citing works
Schriever, S. C., Zimprich, A., Pfuhlmann, K., Baumann, P., Giesert, F., Klaus, V., Kabra, D. G., Hafen, U., Romanov, A., Tschöp, M. H., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.050 · Cited by 57 · see citing works
Self-citationSenda, K., & Ogawa, K. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch179 · Cited by 53 · see citing works
Mammalian Trit1 is a tRNA[Ser]Sec-isopentenyl transferase required for full selenoprotein expression
Fradejas‐Villar, N., Carlson, B. A., Rijntjes, E., Becker, N., Tobe, R., & Schweizer, U. (2013) · Biochemical Journal · doi:10.1042/bj20121713 · Cited by 52 · see citing works
Zebrafish lipid droplets regulate embryonic ATP homeostasis to power early development
Dutta, A., & Sinha, D. K. (2017) · Open Biology · doi:10.1098/rsob.170063 · Cited by 51 · see citing works
Xu, S., Yao, H., Zhang, J., et al. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9552-0 · Cited by 47 · see citing works
The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis
Miller, G. W., Ulatowski, L. M., Labut, E. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047402 · Cited by 46 · see citing works
Roles of Iron in Plant Defence and Fungal Virulence
Greenshields, D. L., Liu, G., & Wei, Y. (2007) · Plant Signaling & Behavior · doi:10.4161/psb.2.4.4042 · Cited by 45 · see citing works
Lebold, K. M., Kirkwood, J. S., Taylor, A. W., Choi, J., Barton, C. L., Miller, G. W., Du, J. K. L., Jump, D. Β., Stevens, J. F., Tanguay, R. L., et al. (2013) · Redox Biology · doi:10.1016/j.redox.2013.12.007 · Cited by 45 · see citing works
Self-citationVitamin E Is Essential for Mouse Placentation but Not for Embryonic Development Itself
Jishage, K., Tachibe, T., Ito, T., et al. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.043018 · Cited by 45 · see citing works
Moravec, A., Siv, A. W., Hobby, C. R., Lindsay, E. N., Norbash, L. V., Shults, D. J., Symes, S. J. K., & Giles, D. K. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01415-17 · Cited by 45 · see citing works
Griffin, A., Parajes, S., Weger, M., Zaucker, A., TAYLOR, A. E. R., O’Neil, D. M., Müller, F., & Krone, N. P. (2015) · Endocrinology · doi:10.1210/en.2015-1480 · Cited by 41 · see citing works
Ito, F., Nishiyama, T., Shi, L., Mori, M., Hirayama, T., Nagasawa, H., Yasui, H., & Toyokuni, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.003 · Cited by 41 · see citing works
Grieger, J. A., Nowson, C. A., & Ackland, M. L. (2007) · PubMed · Cited by 39 · see citing works
Kariya, K., Demiral, T., Sasaki, T., Tsuchiya, Y., Türkan, İ., Sano, T., Hasezawa, S., & Yamamoto, Y. (2013) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2013.07.001 · Cited by 39 · see citing works
Ahmad, F., Liu, X., Zhou, Y., et al. (2015) · Environmental Toxicology · doi:10.1002/tox.22206 · Cited by 38 · see citing works
Tyurina, Y. Y., Shrivastava, I. H., Tyurin, V. A., Mao, G., Dar, H. H., Watkins, S. C., Epperly, M. W., Bahar, İ., Shvedova, A. A., Pitt, B. R., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7124 · Cited by 38 · see citing works
Self-citationExpressed transcripts associated with high rates of egg production in chicken ovarian follicles
Yang, K., Lin, C.-Y., Huang, H. L., et al. (2007) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2007.06.001 · Cited by 37 · see citing works
McDougall, M. Q., Choi, J., Stevens, J. F., Truong, L., Tanguay, R. L., & Traber, M. G. (2016) · Redox Biology · doi:10.1016/j.redox.2016.01.004 · Cited by 37 · see citing works
Self-citationMcDougall, M. Q., Choi, J., Truong, L., Tanguay, R. L., & Traber, M. G. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.012 · Cited by 37 · see citing works
Self-citationYolk vitamin E prevents oxidative damage in gull hatchlings
Parolini, M., Khoriauli, L., Possenti, C. D., Colombo, G., Caprioli, M., Santagostino, M., Nergadze, S. G., Milzani, A., Giulotto, E., & Saino, N. (2017) · Royal Society Open Science · doi:10.1098/rsos.170098 · Cited by 35 · see citing works
Liu, H., Takano, T., Peatman, E., Abernathy, J. W., Wang, S., Sha, Z., Kucuktas, H., Xu, D., Klesius, P. H., & Liu, Z. (2010) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.606 · Cited by 34 · see citing works
Cao, C., Fan, R., Zhao, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14971 · Cited by 33 · see citing works
Aldrovandi, M., Banthiya, S., Meckelmann, S. W., Zhou, Y., Heydeck, D., O’Donnell, V. B., & Kühn, H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.11.005 · Cited by 33 · see citing works
Kalms, J., Banthiya, S., Yoga, E. G., Hámberg, M., Holzhütter, H., Kühn, H., & Scheerer, P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.01.003 · Cited by 32 · see citing works
Kim, S. ‐., Noguera, J. C., Noguera, J. C., et al. (2013) · Journal of Evolutionary Biology · doi:10.1111/jeb.12136 · Cited by 29 · see citing works
Tyurina, Y. Y., Lou, W., Qu, F., Tyurin, V. A., Mohammadyani, D., Liu, J., Hüttemann, M., Frasso, M., Wipf, P., Bayır, H., et al. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00995 · Cited by 29 · see citing works
Self-citationAgbor, T. A., Demma, Z., Mrsny, R. J., Castillo, A., Boll, E. J., & McCormick, B. A. (2014) · Cellular Microbiology · doi:10.1111/cmi.12290 · Cited by 27 · see citing works
Schauser, K., Olsen, J. E., & Larsson, L. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0731-8 · Cited by 27 · see citing works
Antifungal Activity of the Lipophilic Antioxidant Ferrostatin‐1
Horwath, M. C., Bell‐Horwath, T. R., Lescano, V., Krishnan, K., Merino, E. J., & Deepe, G. S. (2017) · ChemBioChem · doi:10.1002/cbic.201700105 · Cited by 27 · see citing works
Effect of regional changes to shell conductance on oxygen consumption and growth of chicken embryos
Wagner-Amos, K., & Seymour, R. S. (2002) · Respiration Physiology · doi:10.1016/s0034-5687(01)00320-6 · Cited by 25 · see citing works
Gutiérrez, A. M., Reboredo, G. R., & Catalá, Á. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00007-9 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
Su, L.-J., Zhang, J.-H., Gomez, H., Murugan, R., Hong, X., Xu, D., Jiang, F., & Peng, Z.-Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5080843 · Cited by 2,166 · see citing works
Role of GPX4 in ferroptosis and its pharmacological implication
Seibt, T. M., Proneth, B., & Conrad, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.014 · Cited by 1,520 · see citing works
Self-citationRSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
Sui, X., Zhang, R., Liu, S., Duan, T., Zhai, L., Zhang, M., Han, X., Xiang, Y., Huang, X., Lin, H., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01371 · Cited by 703 · see citing works
Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J.-S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101947 · Cited by 683 · see citing works
“Mitochondrial damage has been found to be involved in lipid peroxidation and imbalance of iron homeostasis in neurodegenerative diseases such as AD and PD [34].”
BackgroundAmaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L., Mayer-Barber, K. D., Andrade, B. B., & Sher, A. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181776 · Cited by 464 · see citing works
Lipid Metabolism and Ferroptosis
Lee, J.-Y., Kim, W. K., Bae, K.-H., Lee, S. C., & Lee, E.-W. (2021) · Biology · doi:10.3390/biology10030184 · Cited by 374 · see citing works
Haddad, M., Hervé, V., Ben Khedher, M. R., Rabanel, J.-M., & Ramassamy, C. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8129 · Cited by 68 · see citing works
- Authors
- Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R.
- Affiliations
- Helmholtz Munich (DE)
- University of Pittsburgh (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Oregon State University (US)
- Columbia University (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2018-05-01
- Volume
- 32
- Issue
- 9-10
- Pages
- 602-619
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC6004068
- OpenAlex
- W2804102163
- Cited by
- 544
- References
- 224
- Citations by year
- 2026: 53 · 2025: 65 · 2024: 73 · 2023: 95 · 2022: 80 · 2021: 82 · 2020: 52 · 2019: 37 · 2018: 6
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Development (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Site cant be reached (submittedVersion, cc-by-nc)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (R35CA209896, P01CA087497, U19AI068021, NS076511, NS061817)
- Deutsche Forschungsgemeinschaft (CO 291/2-3, CO 291/5-1)
- Human Frontier Science Program (RGP0013)
- Agencia Nacional de Promoción Científica y Tecnológica
- Proyectos de Investigación Científica y Tecnológica (2013-1372, PICT 2016-0110)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- lipid peroxidation, ferroptosis, antioxidant defense, GPX4, vitamin E, coenzyme Q10, peroxy radicals, lipid hydroperoxides, non-apoptotic cell death, iron metabolism
- MeSH terms
- Animals, Antioxidants, Biological Evolution, Humans, Iron, Species Specificity, Lipid Peroxidation, Cell Death, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review