PreprintCited by 544Ferroptosis and cancer prognosisAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Regulation of lipid peroxidation and ferroptosis in diverse species

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Conrad, Marcus, Kagan, Valerian E., Bayir, Hülya, Pagnussat, Gabriela C., Head, Brian, Traber, Maret G., Stockwell, Brent R.·2018·Genes & Development

Abstract

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q 10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.

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Authors
Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R.
Affiliations
  • Helmholtz Munich (DE)
  • University of Pittsburgh (US)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
  • Oregon State University (US)
  • Columbia University (US)
Venue
Genes & Development
Published
2018-05-01
Volume
32
Issue
9-10
Pages
602-619
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2804102163
Cited by
544
References
224
Citations by year
2026: 53 · 2025: 65 · 2024: 73 · 2023: 95 · 2022: 80 · 2021: 82 · 2020: 52 · 2019: 37 · 2018: 6
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Genes & Development (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by-nc)
  • HighWire Press Open Archive (submittedVersion)
  • Site cant be reached (submittedVersion, cc-by-nc)
  • Conicet (submittedVersion, cc-by-nc-sa)
Funders
  • National Institutes of Health (R35CA209896, P01CA087497, U19AI068021, NS076511, NS061817)
  • Deutsche Forschungsgemeinschaft (CO 291/2-3, CO 291/5-1)
  • Human Frontier Science Program (RGP0013)
  • Agencia Nacional de Promoción Científica y Tecnológica
  • Proyectos de Investigación Científica y Tecnológica (2013-1372, PICT 2016-0110)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
lipid peroxidation, ferroptosis, antioxidant defense, GPX4, vitamin E, coenzyme Q10, peroxy radicals, lipid hydroperoxides, non-apoptotic cell death, iron metabolism
MeSH terms
Animals, Antioxidants, Biological Evolution, Humans, Iron, Species Specificity, Lipid Peroxidation, Cell Death, Reactive Oxygen Species

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