Modeling familial Alzheimer's disease with induced pluripotent stem cells

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Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

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Induced pluripotent stem cells from a spinal muscular atrophy patient

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

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Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

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ApoE Promotes the Proteolytic Degradation of Aβ

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Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

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Variation in the safety of induced pluripotent stem cell lines

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LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

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Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

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Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

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Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

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Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

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γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

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A functionally characterized test set of human induced pluripotent stem cells

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A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

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Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

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The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

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Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

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Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes

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Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

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Friedreich’s Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA•TTC Triplet Repeat Instability

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Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments

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CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production

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Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells

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Induced pluripotent stem cells: a new revolution for clinical neurology?

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Secretion of the Notch-1 Aβ-like Peptide during Notch Signaling

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Mutant Presenilin 2 Transgenic Mouse: Effect on an Age‐Dependent Increase of Amyloid β‐Protein 42 in the Brain

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Pharmacological Knock-down of the Presenilin 1 Heterodimer by a Novel γ-Secretase Inhibitor

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Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner

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Quantitative investigations into the histostructural nature of the human putamen

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Induced pluripotent stem cell technology: a decade of progress.

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A three-dimensional human neural cell culture model of Alzheimer’s disease

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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

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Pluripotent stem cells in disease modelling and drug discovery

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Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

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The multiplex model of the genetics of Alzheimer's disease

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Modeling Alzheimer’s disease with iPSC-derived brain cells

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Induced pluripotent stem cells: the new patient?

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Modeling amyloid beta and tau pathology in human cerebral organoids

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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

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The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

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Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

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Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development

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Genetic insights in Alzheimer's disease

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A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

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Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

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A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

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In vitro Models of Neurodegenerative Diseases

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Applications of CRISPR–Cas systems in neuroscience

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Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

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Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

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A 3D human neural cell culture system for modeling Alzheimer's disease

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2D versus 3D Human Induced Pluripotent Stem Cell-Derived Cultures for Neurodegenerative Disease Modelling

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Current status of pluripotent stem cells: moving the first therapies to the clinic

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Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

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Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

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Updates in Alzheimer's disease: from basic research to diagnosis and therapies

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